GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | K | 123 | 34x53 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ICL2 | K | 123 | 34x53 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM6 | Q | 219 | 6x29 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | Q | 219 | 6x29 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | Q | 219 | 6x29 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | E | 220 | 6x30 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM6 | E | 220 | 6x30 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | H8 | H | 289 | 8x48 | G.H5 | H | 368 | G.H5.17 |
Polar | ICL3 | S | 217 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL3 | S | 217 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | ICL2 | C | 120 | 34x50 | G.HN | S | 39 | G.HN.48 |
Hydrophobic | ICL2 | C | 120 | 34x50 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM3 | K | 119 | 3x56 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM3 | K | 119 | 3x56 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | TM3 | K | 119 | 3x56 | G.HN | K | 42 | G.HN.51 |
Polar | TM3 | R | 113 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | R | 113 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL1 | M | 45 | 12x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ICL1 | M | 45 | 12x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL4 | G | 287 | - | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL4 | G | 287 | - | G.H5 | M | 375 | G.H5.24 |
Polar | TM3 | I | 116 | 3x53 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM3 | I | 116 | 3x53 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM3 | I | 116 | 3x53 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM3 | F | 117 | 3x54 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM3 | F | 117 | 3x54 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | H8 | K | 292 | 8x51 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | H8 | K | 292 | 8x51 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM7 | G | 286 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | G | 286 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | W | 222 | 6x32 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM2 | T | 51 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | T | 51 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL3 | S | 214 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL3 | S | 214 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL3 | S | 214 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM6 | E | 220 | 6x30 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM6 | E | 220 | 6x30 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM3 | F | 117 | 3x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM3 | F | 117 | 3x54 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM3 | R | 113 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | R | 113 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | R | 113 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | D | 122 | 34x52 | G.hns1 | V | 45 | G.hns1.01 |
Polar | ICL2 | K | 123 | 34x53 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | K | 123 | 34x53 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ICL2 | K | 123 | 34x53 | G.H5 | Q | 373 | G.H5.22 |
Polar | ICL2 | C | 120 | 34x50 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | C | 120 | 34x50 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | C | 120 | 34x50 | G.HN | T | 43 | G.HN.52 |
Polar | TM3 | R | 113 | 3x50 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM3 | R | 113 | 3x50 | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL3 | H | 218 | - | G.hns1 | R | 47 | G.hns1.03 |
Aromatic | ICL3 | H | 218 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL3 | H | 218 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL3 | H | 218 | - | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM6 | Q | 219 | 6x29 | G.H5 | N | 370 | G.H5.19 |
Polar | TM6 | K | 226 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | K | 226 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | K | 226 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL3 | H | 218 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL3 | H | 218 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL3 | H | 218 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM6 | Q | 219 | 6x29 | G.S3 | V | 216 | G.S3.01 |
Polar | TM5 | K | 210 | 5x64 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM5 | L | 211 | 5x65 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM5 | L | 211 | 5x65 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM2 | T | 51 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | T | 51 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | K | 292 | 8x51 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | H8 | K | 292 | 8x51 | G.H5 | M | 375 | G.H5.24 |
Polar | TM6 | Q | 219 | 6x29 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM6 | Q | 219 | 6x29 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM6 | Q | 219 | 6x29 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL1 | N | 46 | 12x49 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | ICL1 | N | 46 | 12x49 | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | ICL1 | N | 46 | 12x49 | G.h3s5 | N | 283 | G.h3s5.02 |
Polar | TM2 | T | 52 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | D | 122 | 34x52 | G.h2s4 | S | 239 | G.h2s4.03 |
Hydrophobic | ICL2 | D | 122 | 34x52 | G.h2s4 | S | 239 | G.h2s4.03 |
Van-der-waals | ICL2 | D | 122 | 34x52 | G.h2s4 | S | 239 | G.h2s4.03 |
Polar | ICL3 | S | 217 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | TM6 | Q | 219 | 6x29 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM6 | Q | 219 | 6x29 | G.H5 | L | 374 | G.H5.23 |
Polar | ICL2 | C | 120 | 34x50 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ICL2 | C | 120 | 34x50 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ICL2 | C | 120 | 34x50 | G.HN | K | 42 | G.HN.51 |
Polar | TM5 | K | 210 | 5x64 | G.HN | R | 40 | G.HN.49 |
Van-der-waals | TM5 | K | 210 | 5x64 | G.HN | R | 40 | G.HN.49 |
Hydrophobic | TM5 | M | 207 | 5x61 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM5 | M | 207 | 5x61 | G.hns1 | R | 47 | G.hns1.03 |
Ionic | TM6 | E | 220 | 6x30 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM6 | E | 220 | 6x30 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | E | 220 | 6x30 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM6 | E | 220 | 6x30 | G.hns1 | R | 47 | G.hns1.03 |