Gi3 - GPR141 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 26.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 Q 219 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 Q 219 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 Q 219 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL1 M 45 12x48 G.H5 E 350 G.H5.22
Van-der-waals ICL1 M 45 12x48 G.H5 E 350 G.H5.22
Hydrophobic ICL1 R 48 12x51 G.hns1 K 32 G.hns1.03
Ionic TM4 R 128 4x38 G.HN E 25 G.HN.49
Polar TM4 R 128 4x38 G.HN E 25 G.HN.49
Hydrophobic TM4 R 128 4x38 G.HN E 25 G.HN.49
Van-der-waals TM4 R 128 4x38 G.HN E 25 G.HN.49
Polar TM6 Q 219 6x29 G.h4s6 E 318 G.h4s6.12
Polar H8 H 289 8x48 G.h4s6 K 317 G.h4s6.11
Hydrophobic H8 H 289 8x48 G.h4s6 K 317 G.h4s6.11
Van-der-waals H8 H 289 8x48 G.h4s6 K 317 G.h4s6.11
Polar TM3 R 113 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 113 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM2 T 52 2x40 G.H5 L 353 G.H5.25
Van-der-waals TM2 T 52 2x40 G.H5 L 353 G.H5.25
Hydrophobic TM7 F 283 7x53 G.H5 G 352 G.H5.24
Van-der-waals TM7 F 283 7x53 G.H5 G 352 G.H5.24
Hydrophobic H8 K 292 8x51 G.H5 K 349 G.H5.21
Van-der-waals H8 K 292 8x51 G.H5 K 349 G.H5.21
Hydrophobic TM6 A 223 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 A 223 6x33 G.H5 Y 354 G.H5.26
Hydrophobic TM2 T 51 2x39 G.H5 L 353 G.H5.25
Van-der-waals TM2 T 51 2x39 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 123 34x53 G.S3 L 194 G.S3.01
Van-der-waals ICL2 K 123 34x53 G.S3 L 194 G.S3.01
Polar TM6 Q 219 6x29 G.H5 K 349 G.H5.21
Hydrophobic TM6 Q 219 6x29 G.H5 K 349 G.H5.21
Van-der-waals TM6 Q 219 6x29 G.H5 K 349 G.H5.21
Ionic ICL2 D 122 34x52 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 D 122 34x52 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 D 122 34x52 G.s2s3 K 192 G.s2s3.01
Polar TM4 L 130 4x40 G.HN E 28 G.HN.52
Polar ICL1 N 46 12x49 G.hns1 A 31 G.hns1.02
Hydrophobic ICL1 N 46 12x49 G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 N 46 12x49 G.hns1 A 31 G.hns1.02
Polar TM3 R 113 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 113 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 113 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 123 34x53 G.H5 L 348 G.H5.20
Hydrophobic TM6 E 220 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 E 220 6x30 G.H5 K 345 G.H5.17
Ionic TM4 R 128 4x38 G.HN E 28 G.HN.52
Polar TM4 R 128 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 128 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 128 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL1 R 48 12x51 G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 R 48 12x51 G.hns1 A 31 G.hns1.02
Polar H8 Q 293 8x52 G.h4s6 K 314 G.h4s6.08
Hydrophobic H8 Q 293 8x52 G.h4s6 K 314 G.h4s6.08
Van-der-waals H8 Q 293 8x52 G.h4s6 K 314 G.h4s6.08
Polar ICL1 R 48 12x51 G.HN E 28 G.HN.52
Hydrophobic ICL1 R 48 12x51 G.HN E 28 G.HN.52
Van-der-waals ICL1 R 48 12x51 G.HN E 28 G.HN.52
Polar TM6 Q 219 6x29 G.H5 N 346 G.H5.18
Hydrophobic TM6 Q 219 6x29 G.H5 N 346 G.H5.18
Van-der-waals TM6 Q 219 6x29 G.H5 N 346 G.H5.18
Polar H8 H 289 8x48 G.h4s6 E 318 G.h4s6.12
Van-der-waals H8 H 289 8x48 G.h4s6 E 318 G.h4s6.12
Polar H8 Q 293 8x52 G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 Q 293 8x52 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 Q 293 8x52 G.h4s6 D 315 G.h4s6.09
Polar ICL1 R 48 12x51 G.HN G 27 G.HN.51
Hydrophobic ICL1 R 48 12x51 G.HN G 27 G.HN.51
Van-der-waals ICL1 R 48 12x51 G.HN G 27 G.HN.51
Hydrophobic ICL1 M 45 12x48 G.H5 C 351 G.H5.23
Van-der-waals ICL1 M 45 12x48 G.H5 C 351 G.H5.23
Hydrophobic ICL2 D 122 34x52 G.H5 I 344 G.H5.16
Van-der-waals ICL2 D 122 34x52 G.H5 I 344 G.H5.16
Polar H8 H 289 8x48 G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 H 289 8x48 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 H 289 8x48 G.h4s6 D 315 G.h4s6.09
Polar TM2 T 52 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM2 V 55 2x43 G.H5 L 353 G.H5.25
Van-der-waals TM2 V 55 2x43 G.H5 L 353 G.H5.25
Polar TM6 K 226 6x36 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 226 6x36 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 226 6x36 G.H5 Y 354 G.H5.26
Polar TM4 K 129 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 K 129 4x39 G.HN E 28 G.HN.52
Polar ICL1 N 46 12x49 G.H5 C 351 G.H5.23
Hydrophobic ICL1 N 46 12x49 G.H5 C 351 G.H5.23
Van-der-waals ICL1 N 46 12x49 G.H5 C 351 G.H5.23
Polar H8 H 289 8x48 G.h4s6 T 316 G.h4s6.10
Hydrophobic H8 H 289 8x48 G.h4s6 T 316 G.h4s6.10
Van-der-waals H8 H 289 8x48 G.h4s6 T 316 G.h4s6.10
Hydrophobic H8 W 290 8x49 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM2 S 49 2x37 G.H5 L 353 G.H5.25
Van-der-waals TM2 S 49 2x37 G.H5 L 353 G.H5.25
Hydrophobic TM4 L 130 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 L 130 4x40 G.HN R 24 G.HN.48
Polar TM6 Q 219 6x29 G.S6 Y 320 G.S6.02
Van-der-waals TM6 Q 219 6x29 G.S6 Y 320 G.S6.02
Hydrophobic TM4 K 129 4x39 G.hns1 A 31 G.hns1.02
Ionic ICL2 E 125 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 E 125 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 E 125 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 K 123 34x53 G.H5 I 344 G.H5.16