GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | Q | 219 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | Q | 219 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | Q | 219 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | H8 | K | 292 | 8x51 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | K | 292 | 8x51 | G.H5 | F | 354 | G.H5.26 |
Ionic | TM1 | K | 44 | 1x60 | G.h4s6 | D | 316 | G.h4s6.10 |
Polar | TM1 | K | 44 | 1x60 | G.h4s6 | D | 316 | G.h4s6.10 |
Van-der-waals | TM1 | K | 44 | 1x60 | G.h4s6 | D | 316 | G.h4s6.10 |
Hydrophobic | TM2 | T | 51 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | T | 51 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL2 | Y | 127 | 34x57 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | Y | 127 | 34x57 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | Y | 127 | 34x57 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM6 | Q | 219 | 6x29 | G.H5 | I | 342 | G.H5.14 |
Van-der-waals | TM6 | Q | 219 | 6x29 | G.H5 | I | 342 | G.H5.14 |
Hydrophobic | TM6 | W | 222 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | W | 222 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM7 | F | 283 | 7x53 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | K | 121 | 34x51 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | K | 121 | 34x51 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | K | 123 | 34x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | K | 123 | 34x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | A | 223 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | A | 223 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM2 | T | 51 | 2x39 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM2 | T | 51 | 2x39 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | ICL4 | G | 287 | - | G.H5 | K | 349 | G.H5.21 |
Polar | TM3 | R | 113 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | R | 113 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 113 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | T | 51 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Ionic | ICL3 | H | 218 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | H | 218 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | H | 218 | - | G.H5 | D | 341 | G.H5.13 |
Polar | TM2 | T | 52 | 2x40 | G.H5 | D | 350 | G.H5.22 |
Polar | TM2 | T | 52 | 2x40 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | A | 223 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL1 | N | 46 | 12x49 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL1 | N | 46 | 12x49 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL2 | D | 122 | 34x52 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | D | 122 | 34x52 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | D | 122 | 34x52 | G.S3 | L | 194 | G.S3.01 |
Ionic | ICL2 | K | 121 | 34x51 | G.HN | E | 28 | G.HN.52 |
Polar | ICL2 | K | 121 | 34x51 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | K | 121 | 34x51 | G.HN | E | 28 | G.HN.52 |
Ionic | ICL2 | D | 122 | 34x52 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | D | 122 | 34x52 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | D | 122 | 34x52 | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM2 | S | 49 | 2x37 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | S | 49 | 2x37 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | S | 49 | 2x37 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | H8 | K | 292 | 8x51 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | H8 | K | 292 | 8x51 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL2 | E | 125 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Ionic | ICL2 | K | 123 | 34x53 | G.H5 | D | 350 | G.H5.22 |
Polar | TM6 | Q | 219 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | Q | 219 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | Q | 219 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Ionic | H8 | H | 289 | 8x48 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | H8 | H | 289 | 8x48 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | H8 | H | 289 | 8x48 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | H8 | H | 289 | 8x48 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | H8 | H | 289 | 8x48 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | H8 | H | 289 | 8x48 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | H8 | H | 289 | 8x48 | G.H5 | K | 345 | G.H5.17 |
Polar | ICL2 | C | 120 | 34x50 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | C | 120 | 34x50 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | C | 120 | 34x50 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL1 | M | 45 | 12x48 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | D | 122 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 123 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | K | 123 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL4 | G | 287 | - | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | ICL4 | G | 287 | - | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | Q | 219 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | Q | 219 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL2 | Y | 127 | 34x57 | G.HN | L | 23 | G.HN.47 |
Van-der-waals | ICL2 | Y | 127 | 34x57 | G.HN | L | 23 | G.HN.47 |
Polar | TM2 | T | 52 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | T | 52 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | K | 226 | 6x36 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 226 | 6x36 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL1 | M | 45 | 12x48 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | ICL1 | M | 45 | 12x48 | G.H5 | G | 352 | G.H5.24 |
Polar | TM6 | K | 226 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | K | 226 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | K | 226 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | K | 123 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | K | 123 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | K | 123 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Polar | ICL2 | Y | 127 | 34x57 | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | ICL2 | Y | 127 | 34x57 | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | ICL2 | Y | 127 | 34x57 | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | ICL2 | Y | 127 | 34x57 | G.HN | A | 27 | G.HN.51 |
Van-der-waals | ICL2 | Y | 127 | 34x57 | G.HN | A | 27 | G.HN.51 |