GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 25.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | E | 275 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | E | 275 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | E | 275 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL2 | R | 128 | 34x51 | G.h3s5 | I | 285 | G.h3s5.03 |
Van-der-waals | ICL2 | R | 128 | 34x51 | G.h3s5 | I | 285 | G.h3s5.03 |
Polar | ICL3 | R | 269 | - | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | ICL3 | R | 269 | - | G.S6 | P | 361 | G.S6.03 |
Van-der-waals | ICL3 | R | 269 | - | G.S6 | P | 361 | G.S6.03 |
Polar | TM3 | I | 124 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM3 | I | 124 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | I | 124 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Polar | TM5 | R | 211 | 5x72 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM5 | R | 211 | 5x72 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM5 | R | 211 | 5x72 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM5 | F | 207 | 5x68 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | F | 207 | 5x68 | G.H5 | L | 393 | G.H5.25 |
Polar | TM5 | R | 215 | 5x76 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM5 | R | 215 | 5x76 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM5 | R | 215 | 5x76 | G.H5 | R | 380 | G.H5.12 |
Polar | ICL3 | R | 269 | - | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | ICL3 | R | 269 | - | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | ICL3 | R | 269 | - | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | TM5 | M | 214 | 5x75 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | TM5 | M | 214 | 5x75 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM5 | R | 211 | 5x72 | G.S1 | H | 41 | G.S1.02 |
Polar | ICL3 | R | 268 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL3 | R | 268 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | ICL3 | R | 268 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL2 | H | 127 | 34x50 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | ICL2 | H | 127 | 34x50 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL2 | H | 127 | 34x50 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL2 | H | 127 | 34x50 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | ICL2 | H | 127 | 34x50 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL3 | L | 219 | - | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | ICL3 | L | 219 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | K | 213 | 5x74 | G.s2s3 | K | 216 | G.s2s3.02 |
Hydrophobic | TM3 | A | 125 | 3x55 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM3 | A | 125 | 3x55 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | V | 272 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | ICL3 | V | 272 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL3 | A | 217 | - | G.H5 | N | 377 | G.H5.09 |
Van-der-waals | ICL3 | A | 217 | - | G.H5 | N | 377 | G.H5.09 |
Ionic | ICL3 | R | 269 | - | G.H5 | D | 378 | G.H5.10 |
Polar | ICL3 | R | 269 | - | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | ICL3 | R | 269 | - | G.H5 | D | 378 | G.H5.10 |
Polar | ICL2 | R | 128 | 34x51 | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | ICL2 | R | 128 | 34x51 | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | ICL2 | R | 128 | 34x51 | G.h3s5 | T | 284 | G.h3s5.02 |
Polar | TM3 | A | 123 | 3x53 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | A | 123 | 3x53 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM3 | A | 123 | 3x53 | G.H5 | L | 394 | G.H5.26 |
Polar | TM5 | M | 214 | 5x75 | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | TM5 | M | 214 | 5x75 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | TM5 | M | 214 | 5x75 | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | TM5 | R | 215 | 5x76 | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | ICL2 | F | 129 | 34x52 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | F | 129 | 34x52 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL2 | F | 129 | 34x52 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | R | 211 | 5x72 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | R | 211 | 5x72 | G.H5 | L | 388 | G.H5.20 |
Polar | ICL2 | R | 128 | 34x51 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM6 | E | 279 | 6x30 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | L | 273 | 6x24 | G.H5 | I | 382 | G.H5.14 |
Ionic | TM3 | H | 126 | 3x56 | G.H5 | E | 392 | G.H5.24 |
Polar | TM3 | H | 126 | 3x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | H | 126 | 3x56 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM3 | H | 126 | 3x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | K | 213 | 5x74 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | TM5 | K | 213 | 5x74 | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | TM6 | L | 273 | 6x24 | G.S6 | Y | 360 | G.S6.02 |
Polar | ICL3 | R | 268 | - | G.h4s6 | S | 349 | G.h4s6.02 |
Van-der-waals | ICL3 | R | 268 | - | G.h4s6 | S | 349 | G.h4s6.02 |
Hydrophobic | ICL3 | V | 272 | - | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | ICL3 | V | 272 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM5 | M | 214 | 5x75 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | TM5 | M | 214 | 5x75 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | ICL3 | L | 271 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL2 | R | 128 | 34x51 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL2 | R | 128 | 34x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | R | 268 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM5 | R | 211 | 5x72 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | R | 211 | 5x72 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | R | 269 | - | G.H5 | I | 382 | G.H5.14 |
Van-der-waals | ICL3 | R | 269 | - | G.H5 | I | 382 | G.H5.14 |
Hydrophobic | TM3 | H | 126 | 3x56 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM5 | M | 214 | 5x75 | G.S3 | F | 219 | G.S3.03 |
Van-der-waals | TM5 | M | 214 | 5x75 | G.S3 | F | 219 | G.S3.03 |
Aromatic | TM6 | F | 276 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | F | 276 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | F | 276 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL2 | R | 128 | 34x51 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM5 | M | 214 | 5x75 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM5 | M | 214 | 5x75 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM6 | F | 276 | 6x27 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | F | 276 | 6x27 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM5 | F | 207 | 5x68 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | F | 207 | 5x68 | G.H5 | L | 388 | G.H5.20 |
Polar | TM3 | I | 124 | 3x54 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | I | 124 | 3x54 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM3 | I | 124 | 3x54 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | F | 276 | 6x27 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM6 | F | 276 | 6x27 | G.H5 | L | 388 | G.H5.20 |
Polar | TM5 | R | 211 | 5x72 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM5 | R | 211 | 5x72 | G.hns1 | R | 38 | G.hns1.02 |
Ionic | TM6 | E | 275 | 6x26 | G.H5 | R | 389 | G.H5.21 |
Polar | TM6 | E | 275 | 6x26 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM6 | E | 275 | 6x26 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | TM6 | E | 275 | 6x26 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL3 | L | 219 | - | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | ICL3 | L | 219 | - | G.H5 | D | 378 | G.H5.10 |
Polar | ICL2 | H | 127 | 34x50 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | H | 127 | 34x50 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL2 | H | 127 | 34x50 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | L | 273 | 6x24 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | L | 273 | 6x24 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | L | 273 | 6x24 | G.H5 | R | 385 | G.H5.17 |
Polar | TM5 | R | 211 | 5x72 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL3 | V | 220 | - | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | ICL3 | V | 272 | - | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | ICL3 | V | 272 | - | G.S6 | Y | 360 | G.S6.02 |
Polar | ICL3 | R | 269 | - | G.S6 | H | 362 | G.S6.04 |
Aromatic | ICL3 | R | 269 | - | G.S6 | H | 362 | G.S6.04 |
Hydrophobic | ICL3 | R | 269 | - | G.S6 | H | 362 | G.S6.04 |
Van-der-waals | ICL3 | R | 269 | - | G.S6 | H | 362 | G.S6.04 |
Hydrophobic | ICL3 | L | 219 | - | G.H5 | I | 382 | G.H5.14 |
Polar | TM3 | A | 125 | 3x55 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM3 | A | 125 | 3x55 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | A | 125 | 3x55 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM3 | I | 124 | 3x54 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM3 | I | 124 | 3x54 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL3 | P | 216 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL3 | P | 216 | - | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | ICL3 | P | 216 | - | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | M | 214 | 5x75 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | M | 214 | 5x75 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | M | 214 | 5x75 | G.H5 | Q | 384 | G.H5.16 |