G12 - MAS1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 134 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 134 3x54 G.H5 L 371 G.H5.16
Polar TM4 Y 147 4x40 G.HN R 52 G.HN.52
Hydrophobic TM4 Y 147 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 Y 147 4x40 G.HN R 52 G.HN.52
Polar C-term V 319 - G.S2 E 213 G.S2.03
Hydrophobic ICL2 C 142 34x55 G.S1 V 58 G.S1.02
Polar TM5 W 219 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 W 219 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 W 219 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 V 229 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 229 6x36 G.H5 M 379 G.H5.24
Hydrophobic C-term F 303 - G.H2 Q 236 G.H2.05
Hydrophobic C-term L 299 - G.H3 T 279 G.H3.11
Polar H8 F 291 8x54 G.H3 K 284 G.H3.16
Hydrophobic H8 F 291 8x54 G.H3 K 284 G.H3.16
Van-der-waals H8 F 291 8x54 G.H3 K 284 G.H3.16
Ionic ICL2 R 141 34x54 G.H5 E 373 G.H5.18
Polar ICL2 R 141 34x54 G.H5 E 373 G.H5.18
Hydrophobic ICL2 R 141 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 R 141 34x54 G.H5 E 373 G.H5.18
Hydrophobic TM3 V 134 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 134 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 S 133 3x53 G.H5 I 378 G.H5.23
Polar ICL2 C 142 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 C 142 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 C 142 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM2 I 70 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 I 70 2x43 G.H5 L 380 G.H5.25
Ionic H8 E 293 8x56 G.H3 K 284 G.H3.16
Polar H8 E 293 8x56 G.H3 K 284 G.H3.16
Hydrophobic H8 E 293 8x56 G.H3 K 284 G.H3.16
Van-der-waals H8 E 293 8x56 G.H3 K 284 G.H3.16
Hydrophobic TM5 W 219 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 W 219 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 I 138 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 W 219 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 W 219 5x68 G.H5 L 371 G.H5.16
Hydrophobic H8 K 288 8x51 G.h3s5 F 287 G.h3s5.01
Hydrophobic ICL2 I 138 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 I 138 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM6 L 226 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 226 6x33 G.H5 M 379 G.H5.24
Hydrophobic C-term F 303 - G.H2 R 235 G.H2.04
Van-der-waals C-term F 303 - G.H2 R 235 G.H2.04
Hydrophobic TM2 F 66 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 H 143 34x56 G.S3 I 221 G.S3.01
Van-der-waals ICL2 H 143 34x56 G.S3 I 221 G.S3.01
Polar H8 S 286 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 286 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 I 138 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 I 138 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM7 Y 280 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 280 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 226 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 L 226 6x33 G.H5 I 378 G.H5.23
Hydrophobic TM2 T 67 2x40 G.H5 L 380 G.H5.25
Hydrophobic C-term M 307 - G.H2 Q 236 G.H2.05
Van-der-waals C-term M 307 - G.H2 Q 236 G.H2.05
Hydrophobic C-term V 325 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term V 325 - G.h1ha R 83 G.h1ha.02
Hydrophobic C-term V 325 - G.h1ha G 82 G.h1ha.01
Van-der-waals C-term V 325 - G.h1ha G 82 G.h1ha.01
Polar ICL2 H 143 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 143 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 143 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic TM2 F 66 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 F 66 2x39 G.H5 I 378 G.H5.23
Polar ICL3 H 222 - G.H5 Q 381 G.H5.26
Hydrophobic ICL3 H 222 - G.H5 Q 381 G.H5.26
Van-der-waals ICL3 H 222 - G.H5 Q 381 G.H5.26
Hydrophobic C-term V 321 - G.S2 V 212 G.S2.02
Hydrophobic C-term L 299 - G.H2 F 239 G.H2.08
Van-der-waals C-term L 299 - G.H2 F 239 G.H2.08
Hydrophobic H8 L 295 8x58 G.H3 L 285 G.H3.17
Van-der-waals H8 L 295 8x58 G.H3 L 285 G.H3.17
Hydrophobic H8 L 295 8x58 G.H3 K 284 G.H3.16
Hydrophobic TM6 K 225 6x32 G.H5 M 379 G.H5.24
Hydrophobic C-term T 323 - G.H1 R 78 G.H1.09
Polar TM2 N 64 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 N 64 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 N 64 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL2 P 137 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 137 34x50 G.H5 I 370 G.H5.15
Hydrophobic H8 L 295 8x58 G.H3 N 283 G.H3.15
Van-der-waals H8 L 295 8x58 G.H3 N 283 G.H3.15
Hydrophobic TM7 V 283 7x56 G.H5 M 379 G.H5.24
Aromatic C-term F 303 - G.H2 F 239 G.H2.08
Hydrophobic C-term F 303 - G.H2 F 239 G.H2.08
Van-der-waals C-term F 303 - G.H2 F 239 G.H2.08
Hydrophobic TM2 F 66 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 F 66 2x39 G.H5 D 377 G.H5.22
Hydrophobic ICL2 P 137 34x50 G.H5 L 371 G.H5.16
Polar H8 G 284 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 G 284 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 G 284 8x47 G.H5 Q 381 G.H5.26
Polar ICL2 P 137 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 137 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM5 W 219 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 226 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 226 6x33 G.H5 L 375 G.H5.20
Hydrophobic C-term A 302 - G.H3 T 279 G.H3.11
Van-der-waals C-term A 302 - G.H3 T 279 G.H3.11
Hydrophobic TM1 M 61 1x61 G.H5 L 380 G.H5.25
Van-der-waals TM1 M 61 1x61 G.H5 L 380 G.H5.25
Hydrophobic TM1 L 57 1x57 G.H5 L 380 G.H5.25
Hydrophobic ICL2 Y 140 34x53 G.H5 N 374 G.H5.19
Polar C-term T 323 - G.S2 D 215 G.S2.05
Van-der-waals C-term T 323 - G.S2 D 215 G.S2.05
Hydrophobic H8 G 284 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 G 284 8x47 G.H5 M 379 G.H5.24
Polar TM3 S 133 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 133 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 133 3x53 G.H5 N 374 G.H5.19
Polar C-term V 324 - G.h1ha R 83 G.h1ha.02
Hydrophobic C-term V 324 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term V 324 - G.h1ha R 83 G.h1ha.02
Hydrophobic C-term V 325 - G.H1 H 81 G.H1.12
Van-der-waals C-term V 325 - G.H1 H 81 G.H1.12
Hydrophobic ICL2 P 137 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 137 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM4 K 146 4x39 G.HN R 52 G.HN.52
Hydrophobic TM3 R 130 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 R 141 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 R 141 34x54 G.H5 I 370 G.H5.15
Polar ICL2 H 143 34x56 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 H 143 34x56 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 H 143 34x56 G.s2s3 K 220 G.s2s3.02
Polar C-term V 321 - G.S2 E 213 G.S2.03
Hydrophobic C-term L 299 - G.H3 N 283 G.H3.15
Van-der-waals C-term L 299 - G.H3 N 283 G.H3.15
Van-der-waals ICL2 R 141 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 C 142 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 134 3x54 G.H5 I 378 G.H5.23
Polar H8 S 285 8x48 G.H5 M 379 G.H5.24
Polar C-term C 316 - G.H2 Q 240 G.H2.09
Hydrophobic C-term C 316 - G.H2 Q 240 G.H2.09
Van-der-waals C-term C 316 - G.H2 Q 240 G.H2.09
Hydrophobic ICL2 I 138 34x51 G.H5 K 367 G.H5.12