Gi2 - MAS1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 W 219 5x68 G.H5 I 345 G.H5.16
Hydrophobic C-term L 299 - G.H3 W 259 G.H3.17
Van-der-waals C-term L 299 - G.H3 W 259 G.H3.17
Polar ICL3 S 221 - G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL3 S 221 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 S 221 - G.h4s6 K 315 G.h4s6.08
Van-der-waals H8 G 284 8x47 G.H5 F 355 G.H5.26
Hydrophobic H8 V 298 8x61 G.H3 K 258 G.H3.16
Hydrophobic ICL2 I 138 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 I 138 34x51 G.H5 F 337 G.H5.08
Ionic ICL2 H 143 34x56 G.s2s3 D 194 G.s2s3.02
Polar ICL2 H 143 34x56 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 H 143 34x56 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 H 143 34x56 G.s2s3 D 194 G.s2s3.02
Ionic C-term E 306 - G.H2 R 206 G.H2.01
Polar ICL2 C 142 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 C 142 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 C 142 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 I 138 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 Y 140 34x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 137 34x50 G.H5 I 344 G.H5.15
Polar TM5 W 219 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 W 219 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 W 219 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 W 219 5x68 G.H5 F 355 G.H5.26
Van-der-waals TM5 W 219 5x68 G.H5 F 355 G.H5.26
Polar ICL3 S 221 - G.h4s6 D 316 G.h4s6.09
Hydrophobic ICL3 S 221 - G.h4s6 D 316 G.h4s6.09
Polar TM3 S 133 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 S 133 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 S 133 3x53 G.H5 N 348 G.H5.19
Hydrophobic C-term F 303 - G.H2 K 210 G.H2.05
Hydrophobic TM6 I 230 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 137 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 137 34x50 G.H5 T 341 G.H5.12
Hydrophobic ICL2 R 141 34x54 G.H5 I 344 G.H5.15
Van-der-waals ICL2 R 141 34x54 G.H5 I 344 G.H5.15
Aromatic ICL2 H 143 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 W 219 5x68 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 226 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM2 F 66 2x39 G.H5 D 351 G.H5.22
Polar TM2 N 64 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM2 N 64 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM2 N 64 2x37 G.H5 D 351 G.H5.22
Hydrophobic ICL2 I 138 34x51 G.s2s3 D 194 G.s2s3.02
Polar TM3 R 130 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 C 352 G.H5.23
Polar H8 G 284 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 G 284 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 G 284 8x47 G.H5 G 353 G.H5.24
Polar ICL2 P 137 34x50 G.H5 N 348 G.H5.19
Hydrophobic H8 K 288 8x51 G.H5 K 350 G.H5.21
Hydrophobic ICL3 H 222 - G.h4s6 T 317 G.h4s6.10
Hydrophobic ICL2 C 142 34x55 G.S3 L 195 G.S3.01
Van-der-waals ICL2 C 142 34x55 G.S3 L 195 G.S3.01
Polar ICL2 R 141 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 141 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 141 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 137 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 137 34x50 G.H5 I 345 G.H5.16
Van-der-waals TM5 T 218 5x67 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 R 130 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 130 3x50 G.H5 L 354 G.H5.25
Aromatic TM5 W 219 5x68 G.H5 K 346 G.H5.17
Hydrophobic TM5 W 219 5x68 G.H5 K 346 G.H5.17
Van-der-waals TM5 W 219 5x68 G.H5 K 346 G.H5.17
Hydrophobic H8 L 295 8x58 G.H3 W 259 G.H3.17
Van-der-waals H8 L 295 8x58 G.H3 W 259 G.H3.17
Hydrophobic TM6 V 229 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 229 6x36 G.H5 L 354 G.H5.25
Ionic ICL3 H 222 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 L 226 6x33 G.H5 F 355 G.H5.26
Hydrophobic C-term L 299 - G.H2 I 213 G.H2.08
Van-der-waals C-term L 299 - G.H2 I 213 G.H2.08
Hydrophobic TM5 W 219 5x68 G.h4s6 E 319 G.h4s6.12
Hydrophobic C-term F 303 - G.H2 R 209 G.H2.04
Hydrophobic TM3 V 134 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM6 L 226 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 226 6x33 G.H5 L 354 G.H5.25
Aromatic ICL3 H 222 - G.H5 F 355 G.H5.26
Hydrophobic ICL3 H 222 - G.H5 F 355 G.H5.26
Van-der-waals ICL3 H 222 - G.H5 F 355 G.H5.26
Polar ICL2 R 141 34x54 G.hns1 A 30 G.hns1.01
Hydrophobic TM2 F 66 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 F 66 2x39 G.H5 C 352 G.H5.23
Polar TM5 N 217 5x66 G.H5 D 342 G.H5.13
Van-der-waals TM5 N 217 5x66 G.H5 D 342 G.H5.13
Polar ICL3 H 222 - G.H5 K 346 G.H5.17
Hydrophobic ICL3 H 222 - G.H5 K 346 G.H5.17
Van-der-waals ICL3 H 222 - G.H5 K 346 G.H5.17
Hydrophobic TM5 L 210 5x59 G.H5 L 349 G.H5.20
Hydrophobic TM5 L 210 5x59 G.H5 L 354 G.H5.25
Ionic H8 E 293 8x56 G.H3 K 258 G.H3.16
Polar H8 E 293 8x56 G.H3 K 258 G.H3.16
Van-der-waals H8 E 293 8x56 G.H3 K 258 G.H3.16
Polar ICL2 R 141 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 141 34x54 G.S1 E 33 G.S1.01
Hydrophobic TM3 V 134 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 134 3x54 G.H5 L 349 G.H5.20