GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 25.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL3 | S | 221 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL3 | S | 221 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | ICL3 | S | 221 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | TM4 | K | 146 | 4x39 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM4 | K | 146 | 4x39 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | K | 146 | 4x39 | G.HN | Q | 35 | G.HN.52 |
Polar | C-term | E | 306 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | E | 306 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | C-term | E | 306 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | P | 137 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL1 | R | 62 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL1 | R | 62 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | R | 62 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | ICL2 | C | 142 | 34x55 | G.S3 | N | 218 | G.S3.02 |
Hydrophobic | TM2 | P | 65 | 2x38 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | R | 141 | 34x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | R | 141 | 34x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | C-term | P | 309 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | TM2 | N | 64 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | N | 64 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Polar | C-term | D | 305 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | D | 305 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | C-term | D | 305 | - | G.H5 | L | 394 | G.H5.26 |
Polar | ICL3 | H | 222 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | ICL3 | H | 222 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | C-term | R | 311 | - | G.h4s6 | S | 349 | G.h4s6.02 |
Van-der-waals | C-term | R | 311 | - | G.h4s6 | S | 349 | G.h4s6.02 |
Polar | C-term | M | 307 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | M | 307 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | C-term | M | 307 | - | G.H5 | L | 394 | G.H5.26 |
Polar | ICL1 | R | 63 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | R | 63 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL3 | H | 222 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM6 | L | 226 | 6x33 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | K | 304 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | C-term | K | 304 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | R | 141 | 34x54 | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | R | 141 | 34x54 | G.hns1 | A | 39 | G.hns1.03 |
Polar | C-term | K | 304 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | C-term | K | 304 | - | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | C-term | K | 304 | - | G.H5 | Q | 390 | G.H5.22 |
Polar | ICL3 | S | 221 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | ICL3 | S | 221 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | ICL3 | S | 221 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | C-term | Q | 308 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | C-term | M | 307 | - | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | C-term | M | 307 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL2 | I | 138 | 34x51 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | ICL2 | I | 138 | 34x51 | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | ICL3 | H | 222 | - | G.H5 | R | 389 | G.H5.21 |
Ionic | H8 | K | 288 | 8x51 | G.h4s6 | D | 354 | G.h4s6.10 |
Polar | H8 | K | 288 | 8x51 | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | H8 | K | 288 | 8x51 | G.h4s6 | D | 354 | G.h4s6.10 |
Van-der-waals | H8 | K | 288 | 8x51 | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | ICL2 | C | 142 | 34x55 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | C | 142 | 34x55 | G.S3 | V | 217 | G.S3.01 |
Ionic | C-term | D | 305 | - | G.H5 | R | 389 | G.H5.21 |
Polar | C-term | D | 305 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | C-term | D | 305 | - | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | C-term | D | 305 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM3 | S | 133 | 3x53 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM3 | S | 133 | 3x53 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | Q | 308 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Van-der-waals | C-term | Q | 308 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Ionic | C-term | K | 304 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | K | 304 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | C-term | K | 304 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | A | 220 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | ICL3 | A | 220 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | H8 | K | 288 | 8x51 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | ICL2 | Y | 140 | 34x53 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | R | 141 | 34x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | ICL2 | R | 141 | 34x54 | G.H5 | L | 388 | G.H5.20 |
Polar | C-term | Q | 308 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | C-term | Q | 308 | - | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | C-term | Q | 308 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL3 | A | 220 | - | G.S6 | Y | 360 | G.S6.02 |
Polar | C-term | Q | 308 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | C-term | Q | 308 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | C-term | Q | 308 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | C-term | F | 303 | - | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | C-term | F | 303 | - | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | N | 217 | 5x66 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | H | 143 | 34x56 | G.s2s3 | K | 216 | G.s2s3.02 |
Van-der-waals | ICL2 | H | 143 | 34x56 | G.s2s3 | K | 216 | G.s2s3.02 |
Hydrophobic | TM2 | F | 66 | 2x39 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | N | 64 | 2x37 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM2 | N | 64 | 2x37 | G.H5 | L | 393 | G.H5.25 |
Polar | TM2 | N | 64 | 2x37 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | N | 64 | 2x37 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | I | 138 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | I | 138 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | C-term | M | 307 | - | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | C-term | M | 307 | - | G.H5 | R | 389 | G.H5.21 |
Polar | C-term | T | 300 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | T | 300 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | C-term | T | 300 | - | G.H5 | E | 392 | G.H5.24 |
Polar | TM4 | K | 146 | 4x39 | G.HN | Q | 31 | G.HN.48 |
Hydrophobic | ICL2 | C | 142 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Van-der-waals | ICL2 | C | 142 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Polar | C-term | Q | 308 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | C-term | Q | 308 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | C-term | Q | 308 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | C-term | E | 306 | - | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | C-term | E | 306 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL2 | Y | 140 | 34x53 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | F | 303 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | C-term | F | 303 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM1 | M | 61 | 1x61 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM1 | M | 61 | 1x61 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL2 | R | 141 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | R | 141 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | R | 141 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Polar | ICL3 | H | 222 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | ICL3 | H | 222 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | ICL3 | H | 222 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Polar | C-term | R | 311 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | C-term | R | 311 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | C-term | R | 311 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Polar | ICL2 | C | 142 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | ICL2 | C | 142 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | C | 142 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | C-term | M | 307 | - | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL1 | R | 62 | - | G.HN | K | 34 | G.HN.51 |
Hydrophobic | ICL2 | I | 138 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | I | 138 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Polar | TM5 | K | 213 | 5x62 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | K | 213 | 5x62 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | K | 213 | 5x62 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM3 | S | 133 | 3x53 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | S | 133 | 3x53 | G.H5 | L | 388 | G.H5.20 |
Polar | ICL2 | H | 143 | 34x56 | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | ICL2 | H | 143 | 34x56 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | ICL2 | H | 143 | 34x56 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | TM5 | W | 219 | 5x68 | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM3 | V | 134 | 3x54 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM3 | V | 134 | 3x54 | G.H5 | L | 394 | G.H5.26 |
Ionic | TM5 | K | 213 | 5x62 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | K | 213 | 5x62 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | K | 213 | 5x62 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | K | 213 | 5x62 | G.H5 | D | 381 | G.H5.13 |
Polar | ICL2 | R | 141 | 34x54 | G.H5 | H | 387 | G.H5.19 |
Aromatic | ICL2 | R | 141 | 34x54 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | R | 141 | 34x54 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | R | 141 | 34x54 | G.H5 | H | 387 | G.H5.19 |
Polar | C-term | F | 303 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | F | 303 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | C-term | F | 303 | - | G.H5 | L | 394 | G.H5.26 |
Polar | C-term | K | 304 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | C-term | K | 304 | - | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | C-term | K | 304 | - | G.H5 | R | 389 | G.H5.21 |
Polar | ICL2 | I | 138 | 34x51 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | I | 138 | 34x51 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | I | 138 | 34x51 | G.H5 | Q | 384 | G.H5.16 |
Polar | C-term | Q | 308 | - | G.S5 | S | 286 | G.S5.01 |