G14 - MRGPRE complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term L 307 - G.H3 Y 257 G.H3.15
Van-der-waals C-term L 307 - G.H3 Y 257 G.H3.15
Polar ICL2 S 132 34x54 G.H5 N 348 G.H5.19
Van-der-waals ICL2 S 132 34x54 G.H5 N 348 G.H5.19
Hydrophobic C-term R 304 - G.H3 W 259 G.H3.17
Van-der-waals C-term R 304 - G.H3 W 259 G.H3.17
Polar H8 Q 276 8x50 G.H5 V 355 G.H5.26
Hydrophobic H8 Q 276 8x50 G.H5 V 355 G.H5.26
Van-der-waals H8 Q 276 8x50 G.H5 V 355 G.H5.26
Hydrophobic ICL2 P 128 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 344 G.H5.15
Hydrophobic C-term L 307 - G.H3 P 258 G.H3.16
Polar C-term A 289 - G.H5 N 353 G.H5.24
Hydrophobic C-term A 289 - G.H5 N 353 G.H5.24
Van-der-waals C-term A 289 - G.H5 N 353 G.H5.24
Polar ICL2 R 134 34x56 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 R 134 34x56 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 R 134 34x56 G.s2s3 N 194 G.s2s3.02
Polar ICL3 R 209 - G.h4s6 E 317 G.h4s6.12
Van-der-waals ICL3 R 209 - G.h4s6 E 317 G.h4s6.12
Polar C-term A 311 - G.H2 R 210 G.H2.05
Polar ICL3 R 209 - G.S6 Y 321 G.S6.02
Hydrophobic TM5 V 203 5x63 G.H5 L 349 G.H5.20
Hydrophobic ICL2 C 133 34x55 G.S1 L 36 G.S1.02
Hydrophobic TM6 L 218 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL2 Y 131 34x53 G.H5 F 352 G.H5.23
Van-der-waals ICL2 Y 131 34x53 G.H5 F 352 G.H5.23
Hydrophobic TM3 A 124 3x53 G.H5 F 352 G.H5.23
Polar TM2 N 56 2x37 G.H5 E 351 G.H5.22
Hydrophobic TM2 N 56 2x37 G.H5 E 351 G.H5.22
Van-der-waals TM2 N 56 2x37 G.H5 E 351 G.H5.22
Hydrophobic ICL2 S 132 34x54 G.H5 I 344 G.H5.15
Van-der-waals ICL2 S 132 34x54 G.H5 I 344 G.H5.15
Hydrophobic ICL2 A 129 34x51 G.S3 I 195 G.S3.01
Van-der-waals ICL2 A 129 34x51 G.S3 I 195 G.S3.01
Hydrophobic TM2 F 58 2x39 G.H5 F 352 G.H5.23
Polar ICL3 R 209 - G.h4s6 V 319 G.h4s6.20
Hydrophobic ICL3 R 209 - G.h4s6 V 319 G.h4s6.20
Van-der-waals ICL3 R 209 - G.h4s6 V 319 G.h4s6.20
Hydrophobic TM5 P 207 5x67 G.H5 D 342 G.H5.13
Van-der-waals TM5 P 207 5x67 G.H5 D 342 G.H5.13
Hydrophobic ICL2 P 128 34x50 G.H5 L 345 G.H5.16
Hydrophobic TM6 P 212 6x30 G.H5 V 355 G.H5.26
Van-der-waals TM6 P 212 6x30 G.H5 V 355 G.H5.26
Hydrophobic TM3 E 120 3x49 G.H5 F 352 G.H5.23
Hydrophobic TM6 F 215 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 F 215 6x33 G.H5 L 354 G.H5.25
Polar H8 Q 276 8x50 G.H5 R 350 G.H5.21
Hydrophobic H8 Q 276 8x50 G.H5 R 350 G.H5.21
Hydrophobic TM6 F 215 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL2 Y 131 34x53 G.H5 N 348 G.H5.19
Polar C-term E 293 - G.h3s5 N 262 G.h3s5.02
Hydrophobic C-term E 293 - G.h3s5 N 262 G.h3s5.02
Van-der-waals C-term E 293 - G.h3s5 N 262 G.h3s5.02
Polar TM3 Q 121 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 Q 121 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 Q 121 3x50 G.H5 F 352 G.H5.23
Hydrophobic ICL2 A 129 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM6 I 219 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM3 A 125 3x54 G.H5 L 345 G.H5.16
Van-der-waals TM3 A 125 3x54 G.H5 L 345 G.H5.16
Polar ICL2 C 133 34x55 G.hns1 R 33 G.hns1.02
Hydrophobic ICL2 C 133 34x55 G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 C 133 34x55 G.hns1 R 33 G.hns1.02
Polar TM3 A 124 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 L 199 5x59 G.H5 L 354 G.H5.25
Hydrophobic TM7 L 272 7x56 G.H5 N 353 G.H5.24
Van-der-waals TM7 L 272 7x56 G.H5 N 353 G.H5.24
Hydrophobic ICL2 C 133 34x55 G.S3 I 195 G.S3.01
Hydrophobic TM5 L 199 5x59 G.H5 L 349 G.H5.20
Hydrophobic C-term S 303 - G.H3 P 258 G.H3.16
Hydrophobic TM3 Q 121 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 Q 121 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM4 R 137 4x39 G.hns1 R 33 G.hns1.02
Van-der-waals TM4 R 137 4x39 G.hns1 R 33 G.hns1.02
Polar ICL2 C 133 34x55 G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 C 133 34x55 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 C 133 34x55 G.hns1 R 34 G.hns1.03
Polar ICL2 P 128 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 128 34x50 G.H5 N 348 G.H5.19
Polar C-term R 300 - G.H3 W 259 G.H3.17
Aromatic C-term R 300 - G.H3 W 259 G.H3.17
Hydrophobic C-term R 300 - G.H3 W 259 G.H3.17
Van-der-waals C-term R 300 - G.H3 W 259 G.H3.17
Polar C-term R 300 - G.H3 P 258 G.H3.16
Hydrophobic C-term R 300 - G.H3 P 258 G.H3.16
Van-der-waals C-term R 300 - G.H3 P 258 G.H3.16
Hydrophobic TM2 F 58 2x39 G.H5 N 353 G.H5.24
Van-der-waals TM2 F 58 2x39 G.H5 N 353 G.H5.24