GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | R | 315 | - | G.H5 | R | 349 | G.H5.21 |
Van-der-waals | C-term | R | 315 | - | G.H5 | R | 349 | G.H5.21 |
Polar | ICL2 | W | 152 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | W | 152 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Ionic | TM5 | R | 227 | 5x66 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM6 | V | 240 | 6x36 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | W | 152 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM2 | F | 78 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | F | 78 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | V | 145 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | R | 153 | 34x55 | G.S3 | H | 196 | G.S3.02 |
Aromatic | ICL2 | R | 153 | 34x55 | G.S3 | H | 196 | G.S3.02 |
Hydrophobic | ICL2 | R | 153 | 34x55 | G.S3 | H | 196 | G.S3.02 |
Van-der-waals | ICL2 | R | 153 | 34x55 | G.S3 | H | 196 | G.S3.02 |
Hydrophobic | TM6 | L | 237 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | L | 237 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | L | 237 | 6x33 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | D | 316 | - | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | TM6 | S | 234 | 6x30 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM2 | F | 82 | 2x43 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | F | 82 | 2x43 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | S | 234 | 6x30 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | S | 234 | 6x30 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | S | 234 | 6x30 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 236 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 236 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 236 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Polar | C-term | A | 313 | - | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | A | 313 | - | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | C-term | A | 313 | - | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | I | 241 | 6x37 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | M | 333 | - | G.S2 | V | 186 | G.S2.02 |
Van-der-waals | C-term | M | 333 | - | G.S2 | V | 186 | G.S2.02 |
Hydrophobic | TM6 | L | 237 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | V | 240 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 240 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | Y | 151 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Ionic | ICL3 | R | 231 | - | G.H5 | D | 337 | G.H5.09 |
Polar | ICL3 | R | 231 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL3 | R | 231 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | ICL3 | R | 231 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | C-term | R | 312 | - | G.H5 | R | 349 | G.H5.21 |
Hydrophobic | TM7 | A | 294 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | A | 294 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | K | 236 | 6x32 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM7 | A | 294 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | K | 236 | 6x32 | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 236 | 6x32 | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | TM6 | V | 240 | 6x36 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | V | 240 | 6x36 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | D | 297 | 8x49 | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | H8 | D | 297 | 8x49 | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | TM4 | K | 157 | 4x39 | G.HN | I | 28 | G.HN.52 |
Van-der-waals | TM4 | K | 157 | 4x39 | G.HN | I | 28 | G.HN.52 |
Hydrophobic | ICL2 | A | 149 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | A | 149 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Ionic | ICL2 | R | 153 | 34x55 | G.S1 | D | 33 | G.S1.01 |
Polar | ICL2 | R | 153 | 34x55 | G.S1 | D | 33 | G.S1.01 |
Polar | ICL2 | R | 153 | 34x55 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | R | 153 | 34x55 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | R | 153 | 34x55 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM6 | L | 237 | 6x33 | G.H5 | A | 345 | G.H5.17 |
Polar | C-term | L | 314 | - | G.H5 | R | 349 | G.H5.21 |
Hydrophobic | C-term | L | 314 | - | G.H5 | R | 349 | G.H5.21 |
Van-der-waals | C-term | L | 314 | - | G.H5 | R | 349 | G.H5.21 |
Hydrophobic | TM6 | M | 244 | 6x40 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | M | 244 | 6x40 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM2 | F | 82 | 2x43 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | A | 313 | - | G.H5 | R | 349 | G.H5.21 |
Van-der-waals | C-term | A | 313 | - | G.H5 | R | 349 | G.H5.21 |
Hydrophobic | C-term | R | 312 | - | G.h4s6 | N | 316 | G.h4s6.10 |
Van-der-waals | C-term | R | 312 | - | G.h4s6 | N | 316 | G.h4s6.10 |
Polar | ICL2 | W | 152 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | W | 152 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | W | 152 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | S | 144 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | R | 233 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | R | 233 | - | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | R | 153 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | R | 153 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 153 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | C-term | L | 314 | - | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | C-term | L | 314 | - | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | L | 237 | 6x33 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL3 | R | 231 | - | G.H5 | Q | 333 | G.H5.05 |
Hydrophobic | ICL3 | R | 231 | - | G.H5 | Q | 333 | G.H5.05 |
Van-der-waals | ICL3 | R | 231 | - | G.H5 | Q | 333 | G.H5.05 |
Van-der-waals | TM7 | Y | 291 | 7x53 | G.H5 | G | 352 | G.H5.24 |
Ionic | TM5 | R | 227 | 5x66 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | A | 313 | - | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | A | 313 | - | G.H5 | G | 350 | G.H5.22 |
Polar | TM2 | N | 76 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | TM2 | N | 76 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM2 | N | 76 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Polar | ICL2 | R | 153 | 34x55 | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 153 | 34x55 | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 153 | 34x55 | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 141 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | M | 335 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | M | 335 | - | H.HA | Q | 68 | H.HA.06 |
Ionic | ICL3 | R | 233 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | R | 233 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | R | 233 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | R | 233 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | L | 314 | - | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | C-term | L | 314 | - | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM7 | Y | 291 | 7x53 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | R | 227 | 5x66 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | TM5 | R | 227 | 5x66 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM6 | M | 244 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 244 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | L | 314 | - | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | C-term | L | 314 | - | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | C-term | D | 316 | - | G.H5 | N | 346 | G.H5.18 |
Hydrophobic | TM6 | I | 241 | 6x37 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | I | 241 | 6x37 | G.H5 | L | 348 | G.H5.20 |
Polar | H8 | G | 295 | 8x47 | G.H5 | G | 352 | G.H5.24 |