Gz - MRGPRF complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 73.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM1 I 73 1x61 G.hns1 R 31 G.hns1.02
Hydrophobic TM1 I 73 1x61 G.hns1 R 31 G.hns1.02
Van-der-waals TM1 I 73 1x61 G.hns1 R 31 G.hns1.02
Hydrophobic ICL3 R 233 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 233 - G.h4s6 E 319 G.h4s6.12
Hydrophobic C-term D 316 - G.H5 I 352 G.H5.23
Van-der-waals C-term D 316 - G.H5 I 352 G.H5.23
Hydrophobic C-term E 319 - G.h2s4 G 218 G.h2s4.03
Hydrophobic TM2 F 78 2x39 G.H5 I 352 G.H5.23
Van-der-waals TM2 F 78 2x39 G.H5 I 352 G.H5.23
Hydrophobic TM6 I 241 6x37 G.H5 C 355 G.H5.26
Van-der-waals TM6 I 241 6x37 G.H5 C 355 G.H5.26
Hydrophobic C-term G 317 - G.H5 N 348 G.H5.19
Van-der-waals C-term G 317 - G.H5 N 348 G.H5.19
Polar ICL3 R 233 - G.h4s6 K 318 G.h4s6.11
Hydrophobic ICL3 R 233 - G.h4s6 K 318 G.h4s6.11
Van-der-waals ICL3 R 233 - G.h4s6 K 318 G.h4s6.11
Hydrophobic ICL2 Y 151 34x53 G.H5 L 349 G.H5.20
Polar ICL1 K 74 - G.hns1 Q 30 G.hns1.01
Hydrophobic ICL1 K 74 - G.hns1 Q 30 G.hns1.01
Van-der-waals ICL1 K 74 - G.hns1 Q 30 G.hns1.01
Polar C-term G 317 - G.h2s4 T 220 G.h2s4.05
Van-der-waals C-term G 317 - G.h2s4 T 220 G.h2s4.05
Hydrophobic H8 Q 300 8x52 G.h3s5 I 261 G.h3s5.01
Van-der-waals H8 Q 300 8x52 G.h3s5 I 261 G.h3s5.01
Hydrophobic C-term A 318 - G.hns1 R 31 G.hns1.02
Aromatic ICL2 R 153 34x55 G.S2 F 192 G.S2.08
Hydrophobic C-term A 313 - G.H5 I 352 G.H5.23
Polar TM3 R 141 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 141 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 141 3x50 G.H5 L 354 G.H5.25
Hydrophobic C-term R 312 - G.h3s5 N 262 G.h3s5.02
Van-der-waals C-term R 312 - G.h3s5 N 262 G.h3s5.02
Hydrophobic ICL2 W 152 34x54 G.H5 I 345 G.H5.16
Van-der-waals ICL2 W 152 34x54 G.H5 I 345 G.H5.16
Ionic ICL2 R 153 34x55 G.H5 D 338 G.H5.09
Polar ICL2 R 153 34x55 G.H5 D 338 G.H5.09
Van-der-waals ICL2 R 153 34x55 G.H5 D 338 G.H5.09
Hydrophobic TM2 F 78 2x39 G.H5 L 349 G.H5.20
Polar C-term A 313 - G.H5 G 353 G.H5.24
Hydrophobic C-term A 313 - G.H5 G 353 G.H5.24
Van-der-waals C-term A 313 - G.H5 G 353 G.H5.24
Hydrophobic C-term L 320 - G.HN S 27 G.HN.51
Van-der-waals C-term L 320 - G.HN S 27 G.HN.51
Hydrophobic TM2 F 78 2x39 G.H5 L 354 G.H5.25
Van-der-waals TM2 F 78 2x39 G.H5 L 354 G.H5.25
Polar ICL3 R 233 - G.S6 I 320 G.S6.01
Van-der-waals ICL3 R 233 - G.S6 I 320 G.S6.01
Hydrophobic ICL1 K 74 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL1 K 74 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 148 34x50 G.H5 I 345 G.H5.16
Polar TM1 S 72 1x60 G.hns1 R 31 G.hns1.02
Van-der-waals TM1 S 72 1x60 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 M 244 6x40 G.H5 C 355 G.H5.26
Van-der-waals TM6 M 244 6x40 G.H5 C 355 G.H5.26
Hydrophobic ICL2 R 153 34x55 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 153 34x55 G.s2s3 E 194 G.s2s3.02
Polar TM3 R 141 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM3 R 141 3x50 G.H5 G 353 G.H5.24
Van-der-waals TM3 R 141 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM3 S 144 3x53 G.H5 L 349 G.H5.20
Van-der-waals TM3 S 144 3x53 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 237 6x33 G.H5 C 355 G.H5.26
Van-der-waals TM6 L 237 6x33 G.H5 C 355 G.H5.26
Hydrophobic C-term R 312 - G.H5 Y 351 G.H5.22
Van-der-waals C-term R 312 - G.H5 Y 351 G.H5.22
Hydrophobic TM6 K 236 6x32 G.h4s6 T 317 G.h4s6.10
Van-der-waals TM6 K 236 6x32 G.h4s6 T 317 G.h4s6.10
Hydrophobic ICL2 W 152 34x54 G.H5 L 349 G.H5.20
Van-der-waals ICL2 W 152 34x54 G.H5 L 349 G.H5.20
Hydrophobic C-term M 335 - G.H3 R 249 G.H3.07
Van-der-waals C-term M 335 - G.H3 R 249 G.H3.07
Hydrophobic TM6 L 237 6x33 G.H5 K 350 G.H5.21
Van-der-waals TM6 L 237 6x33 G.H5 K 350 G.H5.21
Hydrophobic ICL1 R 75 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL1 R 75 - G.hns1 R 31 G.hns1.02
Hydrophobic TM2 N 76 2x37 G.H5 I 352 G.H5.23
Van-der-waals TM2 N 76 2x37 G.H5 I 352 G.H5.23
Hydrophobic C-term L 320 - G.hns1 Q 30 G.hns1.01
Van-der-waals C-term L 320 - G.hns1 Q 30 G.hns1.01
Ionic TM6 K 236 6x32 G.h4s6 E 316 G.h4s6.09
Polar TM6 K 236 6x32 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 K 236 6x32 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 K 236 6x32 G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL2 W 152 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 W 152 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL3 R 233 - G.h4s6 N 312 G.h4s6.02
Hydrophobic TM6 M 244 6x40 G.H5 G 353 G.H5.24
Van-der-waals TM6 M 244 6x40 G.H5 G 353 G.H5.24
Hydrophobic TM4 K 157 4x39 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 K 157 4x39 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 V 240 6x36 G.H5 C 355 G.H5.26
Van-der-waals TM6 V 240 6x36 G.H5 C 355 G.H5.26
Polar ICL3 R 233 - G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL3 R 233 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 R 233 - G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL2 R 153 34x55 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 R 153 34x55 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL1 K 74 - G.HN S 27 G.HN.51
Van-der-waals ICL1 K 74 - G.HN S 27 G.HN.51
Ionic TM4 K 157 4x39 G.s2s3 E 194 G.s2s3.02
Polar TM4 K 157 4x39 G.s2s3 E 194 G.s2s3.02
Van-der-waals TM4 K 157 4x39 G.s2s3 E 194 G.s2s3.02
Polar H8 D 297 8x49 G.h3s5 N 262 G.h3s5.02
Hydrophobic H8 D 297 8x49 G.h3s5 N 262 G.h3s5.02
Van-der-waals H8 D 297 8x49 G.h3s5 N 262 G.h3s5.02
Hydrophobic H8 D 297 8x49 G.h3s5 I 261 G.h3s5.01
Van-der-waals H8 D 297 8x49 G.h3s5 I 261 G.h3s5.01
Hydrophobic TM3 S 144 3x53 G.H5 L 354 G.H5.25
Van-der-waals TM3 S 144 3x53 G.H5 L 354 G.H5.25
Polar C-term R 315 - G.H5 I 352 G.H5.23
Hydrophobic C-term R 315 - G.H5 I 352 G.H5.23
Van-der-waals C-term R 315 - G.H5 I 352 G.H5.23
Polar H8 Q 300 8x52 G.H3 N 258 G.H3.16
Van-der-waals H8 Q 300 8x52 G.H3 N 258 G.H3.16