G13 -
NPFF2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | V | 249 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM6 | K | 371 | 6x30 | G.H5 | L | 367 | G.H5.16 |
Polar | H8 | N | 441 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | N | 441 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | N | 441 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Polar | H8 | N | 439 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | N | 439 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | N | 439 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Polar | TM5 | H | 355 | 5x72 | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | TM5 | H | 355 | 5x72 | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | TM6 | V | 367 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Polar | ICL2 | K | 256 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ICL2 | K | 256 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM5 | A | 351 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | A | 351 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL3 | Q | 363 | - | G.h4s6 | K | 340 | G.h4s6.19 |
Polar | C-term | I | 522 | - | G.s3h2 | G | 225 | G.s3h2.02 |
Van-der-waals | C-term | I | 522 | - | G.s3h2 | G | 225 | G.s3h2.02 |
Hydrophobic | ICL2 | P | 252 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | P | 255 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | K | 371 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Polar | TM6 | K | 370 | 6x29 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | K | 370 | 6x29 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | K | 370 | 6x29 | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL3 | N | 360 | - | G.S6 | L | 342 | G.S6.01 |
Hydrophobic | ICL2 | F | 253 | - | G.S3 | F | 218 | G.S3.03 |
Polar | C-term | I | 522 | - | G.s3h2 | Q | 226 | G.s3h2.03 |
Hydrophobic | TM3 | R | 245 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | C-term | I | 522 | - | G.H1 | K | 61 | G.H1.01 |
Hydrophobic | ICL3 | N | 360 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL2 | F | 253 | - | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | F | 253 | - | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | I | 522 | - | G.S1 | L | 54 | G.S1.07 |
Ionic | TM6 | K | 371 | 6x30 | G.H5 | D | 364 | G.H5.13 |
Polar | TM6 | K | 371 | 6x30 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM6 | K | 371 | 6x30 | G.H5 | D | 364 | G.H5.13 |
Ionic | C-term | E | 521 | - | G.H2 | R | 227 | G.H2.01 |
Polar | C-term | E | 521 | - | G.H2 | R | 227 | G.H2.01 |
Hydrophobic | C-term | E | 521 | - | G.H2 | R | 227 | G.H2.01 |
Van-der-waals | C-term | E | 521 | - | G.H2 | R | 227 | G.H2.01 |
Polar | C-term | S | 520 | - | G.H3 | E | 267 | G.H3.04 |
Hydrophobic | C-term | S | 520 | - | G.H3 | E | 267 | G.H3.04 |
Van-der-waals | C-term | S | 520 | - | G.H3 | E | 267 | G.H3.04 |
Polar | C-term | E | 521 | - | G.s1h1 | G | 57 | G.s1h1.03 |
Polar | TM6 | K | 370 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | K | 370 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM3 | C | 248 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Polar | C-term | S | 520 | - | G.H2 | R | 230 | G.H2.04 |
Van-der-waals | C-term | S | 520 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | TM5 | L | 348 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 348 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Polar | H8 | N | 441 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | N | 441 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | N | 441 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | H | 355 | 5x72 | G.S6 | H | 345 | G.S6.04 |
Polar | H8 | N | 439 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | H8 | N | 439 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | H8 | N | 439 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM2 | T | 182 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Polar | ICL2 | F | 253 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | I | 374 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | I | 374 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | P | 252 | - | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 252 | - | G.H5 | I | 366 | G.H5.15 |
Aromatic | ICL2 | F | 253 | - | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | F | 253 | - | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | F | 253 | - | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | H8 | R | 444 | 8x52 | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL2 | P | 252 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | C-term | I | 522 | - | G.H2 | R | 230 | G.H2.04 |
Van-der-waals | C-term | I | 522 | - | G.H2 | R | 230 | G.H2.04 |
Polar | ICL3 | Q | 363 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | ICL3 | Q | 363 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Polar | ICL3 | Q | 363 | - | G.h4s6 | R | 334 | G.h4s6.08 |
Van-der-waals | ICL3 | Q | 363 | - | G.h4s6 | R | 334 | G.h4s6.08 |
Polar | ICL2 | K | 256 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | K | 256 | - | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | K | 256 | - | G.H5 | N | 370 | G.H5.19 |
Polar | ICL3 | E | 362 | - | G.h4s6 | Q | 337 | G.h4s6.11 |
Van-der-waals | ICL3 | E | 362 | - | G.h4s6 | Q | 337 | G.h4s6.11 |
Ionic | ICL3 | K | 359 | - | G.H4 | E | 328 | G.H4.13 |
Polar | ICL3 | K | 359 | - | G.H4 | E | 328 | G.H4.13 |
Hydrophobic | ICL3 | K | 359 | - | G.H4 | E | 328 | G.H4.13 |
Van-der-waals | ICL3 | K | 359 | - | G.H4 | E | 328 | G.H4.13 |
Polar | ICL3 | Q | 363 | - | G.S6 | L | 342 | G.S6.01 |
Hydrophobic | TM3 | V | 249 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | V | 249 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM2 | T | 180 | 2x37 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | F | 253 | - | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | TM3 | V | 249 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | V | 249 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL1 | H | 179 | 12x51 | G.HN | M | 1 | G.HN.01 |
Polar | H8 | E | 440 | 8x48 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | I | 522 | - | G.s3h2 | G | 224 | G.s3h2.01 |
Van-der-waals | C-term | I | 522 | - | G.s3h2 | G | 224 | G.s3h2.01 |
Hydrophobic | ICL2 | F | 253 | - | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | F | 253 | - | G.H5 | K | 363 | G.H5.12 |
Polar | H8 | E | 440 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | E | 440 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | E | 440 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | K | 373 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL3 | K | 359 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | TM1 | M | 173 | 1x58 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM1 | M | 173 | 1x58 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM6 | I | 374 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | I | 374 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM5 | L | 348 | 5x65 | G.H5 | L | 367 | G.H5.16 |
Polar | TM3 | C | 248 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | C | 248 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | C | 248 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | F | 253 | - | G.H5 | V | 362 | G.H5.11 |
Hydrophobic | TM6 | K | 370 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | I | 522 | - | G.H3 | I | 271 | G.H3.08 |
Van-der-waals | C-term | I | 522 | - | G.H3 | I | 271 | G.H3.08 |
Hydrophobic | ICL2 | F | 253 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | F | 253 | - | G.S3 | V | 216 | G.S3.01 |
Polar | H8 | E | 440 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | E | 440 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL3 | N | 360 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ICL3 | N | 360 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | N | 360 | - | G.H4 | R | 331 | G.H4.16 |