GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 15.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | F | 640 | 6x37 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | V | 636 | 6x33 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | K | 520 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Polar | TM5 | T | 619 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | T | 619 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | T | 619 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | F | 528 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Polar | ICL2 | F | 528 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Aromatic | ICL2 | F | 528 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | F | 528 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | F | 528 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Polar | ICL2 | R | 532 | 34x55 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | R | 532 | 34x55 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL1 | N | 447 | 12x51 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM6 | R | 639 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | R | 639 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | R | 639 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | F | 528 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | ICL3 | E | 625 | - | G.S6 | P | 361 | G.S6.03 |
Van-der-waals | ICL3 | E | 625 | - | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | TM5 | I | 616 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Polar | TM6 | R | 627 | 6x24 | G.hgh4 | E | 322 | G.hgh4.12 |
Hydrophobic | TM6 | R | 627 | 6x24 | G.hgh4 | E | 322 | G.hgh4.12 |
Van-der-waals | TM6 | R | 627 | 6x24 | G.hgh4 | E | 322 | G.hgh4.12 |
Ionic | TM6 | R | 627 | 6x24 | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | TM6 | R | 627 | 6x24 | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM6 | R | 627 | 6x24 | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | TM6 | R | 627 | 6x24 | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | TM5 | S | 615 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | S | 615 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM6 | V | 636 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Polar | H8 | N | 696 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | H8 | N | 696 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | N | 696 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Polar | TM5 | T | 619 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM5 | T | 619 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM5 | T | 619 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Aromatic | ICL2 | F | 528 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | F | 528 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | F | 528 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Polar | TM3 | V | 525 | 3x55 | G.H5 | R | 380 | G.H5.12 |
Polar | ICL3 | E | 625 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | ICL3 | E | 625 | - | G.H4 | Y | 339 | G.H4.08 |
Van-der-waals | ICL3 | E | 625 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | ICL1 | N | 447 | 12x51 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM3 | K | 520 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | P | 527 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | P | 527 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Ionic | TM1 | R | 440 | 1x57 | G.H5 | E | 392 | G.H5.24 |
Polar | TM1 | R | 440 | 1x57 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM1 | R | 440 | 1x57 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM1 | R | 440 | 1x57 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL3 | T | 624 | - | G.S6 | P | 361 | G.S6.03 |
Polar | TM6 | R | 639 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | R | 639 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | R | 639 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Polar | TM5 | T | 623 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | T | 623 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | T | 619 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | T | 619 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | T | 623 | 5x72 | G.H5 | N | 377 | G.H5.09 |
Hydrophobic | H8 | F | 697 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | F | 528 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | F | 528 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM6 | F | 640 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Ionic | ICL1 | E | 446 | 12x50 | G.H5 | R | 389 | G.H5.21 |
Polar | ICL1 | E | 446 | 12x50 | G.H5 | R | 389 | G.H5.21 |
Polar | ICL3 | T | 624 | - | G.S6 | H | 362 | G.S6.04 |
Hydrophobic | ICL3 | T | 624 | - | G.S6 | H | 362 | G.S6.04 |
Van-der-waals | ICL3 | T | 624 | - | G.S6 | H | 362 | G.S6.04 |
Polar | TM5 | S | 615 | 5x64 | G.H5 | R | 380 | G.H5.12 |
Polar | TM6 | R | 632 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | R | 632 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | R | 632 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 527 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | V | 523 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | E | 519 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | E | 519 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | E | 519 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | I | 524 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | I | 524 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | T | 623 | 5x72 | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | TM5 | T | 623 | 5x72 | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | TM6 | V | 626 | 6x23 | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | TM3 | I | 524 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | N | 530 | 34x53 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | N | 530 | 34x53 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | N | 530 | 34x53 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM3 | I | 524 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Ionic | ICL3 | E | 625 | - | G.H4 | R | 342 | G.H4.12 |
Polar | ICL3 | E | 625 | - | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | ICL3 | E | 625 | - | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | ICL3 | E | 625 | - | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | ICL2 | F | 528 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | F | 528 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM6 | I | 643 | 6x40 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | R | 532 | 34x55 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | R | 532 | 34x55 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL2 | R | 532 | 34x55 | G.H5 | Q | 390 | G.H5.22 |
Polar | TM2 | H | 450 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Aromatic | TM2 | H | 450 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | H | 450 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | H | 450 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | V | 523 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | V | 523 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | V | 523 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | P | 527 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | P | 527 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Polar | TM5 | Q | 622 | 5x71 | G.H5 | N | 377 | G.H5.09 |
Hydrophobic | TM5 | Q | 622 | 5x71 | G.H5 | N | 377 | G.H5.09 |
Hydrophobic | ICL2 | N | 530 | 34x53 | G.hns1 | A | 39 | G.hns1.03 |
Polar | TM3 | I | 524 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 524 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 524 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL2 | R | 532 | 34x55 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | R | 532 | 34x55 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | R | 532 | 34x55 | G.H5 | H | 387 | G.H5.19 |
Polar | TM6 | C | 629 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | C | 629 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | C | 629 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Polar | H8 | T | 695 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | T | 695 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | T | 695 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | F | 528 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Polar | TM6 | R | 639 | 6x36 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL3 | E | 625 | - | G.S6 | F | 363 | G.S6.05 |