GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 23.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ECL2 | T | 181 | - | G.S6 | F | 347 | G.S6.02 |
Polar | ECL2 | P | 177 | - | G.H4 | Q | 328 | G.H4.08 |
Hydrophobic | ECL2 | P | 177 | - | G.H4 | Q | 328 | G.H4.08 |
Van-der-waals | ECL2 | P | 177 | - | G.H4 | Q | 328 | G.H4.08 |
Hydrophobic | ECL1 | P | 84 | - | G.h3s5 | F | 287 | G.h3s5.01 |
Van-der-waals | ECL1 | P | 84 | - | G.h3s5 | F | 287 | G.h3s5.01 |
Hydrophobic | ECL1 | M | 85 | - | G.h4s6 | N | 341 | G.h4s6.10 |
Van-der-waals | ECL1 | M | 85 | - | G.h4s6 | N | 341 | G.h4s6.10 |
Polar | ECL2 | H | 174 | - | G.h4s6 | R | 339 | G.h4s6.08 |
Hydrophobic | ECL2 | H | 174 | - | G.h4s6 | R | 339 | G.h4s6.08 |
Van-der-waals | ECL2 | H | 174 | - | G.h4s6 | R | 339 | G.h4s6.08 |
Polar | ECL2 | Q | 176 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | ECL2 | Q | 176 | - | G.S6 | H | 348 | G.S6.03 |
Polar | TM3 | P | 88 | 3x20 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | TM3 | P | 88 | 3x20 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | TM3 | P | 88 | 3x20 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | ECL2 | H | 174 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | ECL2 | H | 174 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | ECL2 | V | 180 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | ECL2 | V | 180 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | TM6 | P | 272 | 6x61 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | P | 272 | 6x61 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ECL3 | P | 273 | - | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | P | 272 | 6x61 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | P | 272 | 6x61 | G.H5 | M | 379 | G.H5.24 |
Polar | ECL2 | V | 180 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | ECL2 | V | 180 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | ECL2 | V | 180 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | ECL2 | L | 175 | - | G.H4 | Q | 333 | G.H4.13 |
Van-der-waals | ECL2 | L | 175 | - | G.H4 | Q | 333 | G.H4.13 |
Hydrophobic | TM3 | F | 87 | 3x19 | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | TM3 | F | 87 | 3x19 | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | ECL2 | L | 175 | - | G.H4 | R | 329 | G.H4.09 |
Hydrophobic | ECL2 | L | 175 | - | G.H4 | R | 329 | G.H4.09 |
Van-der-waals | ECL2 | L | 175 | - | G.H4 | R | 329 | G.H4.09 |
Van-der-waals | ECL2 | H | 174 | - | G.H4 | V | 332 | G.H4.12 |
Hydrophobic | TM6 | P | 272 | 6x61 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM6 | P | 272 | 6x61 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | ECL2 | V | 180 | - | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | ECL2 | T | 181 | - | G.H5 | A | 365 | G.H5.10 |
Van-der-waals | ECL2 | T | 181 | - | G.H5 | A | 365 | G.H5.10 |
Hydrophobic | TM6 | P | 272 | 6x61 | G.H5 | L | 375 | G.H5.20 |
Polar | TM7 | D | 275 | 7x31 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM7 | D | 275 | 7x31 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM7 | D | 275 | 7x31 | G.H5 | M | 379 | G.H5.24 |
Polar | ECL2 | N | 179 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | ECL2 | N | 179 | - | G.S6 | H | 349 | G.S6.04 |
Van-der-waals | ECL2 | N | 179 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | ECL2 | G | 182 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | ECL2 | G | 182 | - | G.S6 | F | 347 | G.S6.02 |
Polar | TM3 | A | 86 | 3x18 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | TM3 | A | 86 | 3x18 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | TM3 | A | 86 | 3x18 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | ECL3 | L | 274 | - | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | ECL3 | L | 274 | - | G.H5 | L | 380 | G.H5.25 |
Polar | ECL2 | T | 181 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | ECL2 | T | 181 | - | G.S6 | H | 349 | G.S6.04 |
Van-der-waals | ECL2 | T | 181 | - | G.S6 | H | 349 | G.S6.04 |
Polar | ECL2 | H | 174 | - | G.S6 | L | 346 | G.S6.01 |
Hydrophobic | ECL2 | H | 174 | - | G.S6 | L | 346 | G.S6.01 |
Van-der-waals | ECL2 | H | 174 | - | G.S6 | L | 346 | G.S6.01 |
Ionic | ECL2 | H | 174 | - | G.H4 | D | 336 | G.H4.16 |
Hydrophobic | ECL2 | T | 181 | - | G.H5 | V | 366 | G.H5.11 |
Hydrophobic | ECL1 | M | 85 | - | G.h3s5 | F | 287 | G.h3s5.01 |
Van-der-waals | ECL1 | M | 85 | - | G.h3s5 | F | 287 | G.h3s5.01 |
Polar | ECL2 | N | 179 | - | G.S6 | F | 350 | G.S6.05 |
Hydrophobic | ECL2 | N | 179 | - | G.S6 | F | 350 | G.S6.05 |
Van-der-waals | ECL2 | N | 179 | - | G.S6 | F | 350 | G.S6.05 |
Hydrophobic | ECL2 | D | 183 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ECL2 | D | 183 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM3 | F | 87 | 3x19 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | TM3 | F | 87 | 3x19 | G.h4s6 | S | 343 | G.h4s6.12 |
Polar | ECL2 | Y | 170 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | ECL2 | P | 177 | - | G.S6 | F | 350 | G.S6.05 |
Van-der-waals | ECL2 | P | 177 | - | G.S6 | F | 350 | G.S6.05 |
Hydrophobic | TM3 | F | 87 | 3x19 | G.h4s6 | K | 344 | G.h4s6.19 |
Van-der-waals | TM3 | F | 87 | 3x19 | G.h4s6 | K | 344 | G.h4s6.19 |
Polar | ECL2 | Y | 170 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | ECL2 | Y | 170 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | ECL2 | Y | 170 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | TM7 | F | 276 | 7x32 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ECL2 | P | 177 | - | G.H4 | E | 325 | G.H4.05 |
Van-der-waals | ECL2 | N | 179 | - | G.S6 | H | 348 | G.S6.03 |
Polar | ECL1 | M | 85 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | ECL1 | M | 85 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | ECL1 | M | 85 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | TM7 | D | 275 | 7x31 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | D | 275 | 7x31 | G.H5 | L | 380 | G.H5.25 |
Polar | ECL2 | Y | 170 | - | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | TM6 | I | 270 | 6x59 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | I | 270 | 6x59 | G.H5 | M | 379 | G.H5.24 |
Polar | ECL2 | D | 183 | - | G.H5 | T | 369 | G.H5.14 |
Polar | ECL2 | G | 182 | - | G.H5 | T | 369 | G.H5.14 |
Polar | ECL2 | W | 178 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | ECL2 | W | 178 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM3 | F | 87 | 3x19 | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | TM3 | F | 87 | 3x19 | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | ECL1 | P | 84 | - | G.h4s6 | S | 343 | G.h4s6.12 |