Gi2 - TAS2R60 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 C 301 8x48 G.H5 F 355 G.H5.26
Hydrophobic H8 C 301 8x48 G.H5 F 355 G.H5.26
Van-der-waals H8 C 301 8x48 G.H5 F 355 G.H5.26
Polar TM3 K 121 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 K 121 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 K 121 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL3 F 234 - G.H5 A 339 G.H5.10
Hydrophobic TM3 I 122 3x54 G.H5 C 352 G.H5.23
Van-der-waals TM3 I 122 3x54 G.H5 C 352 G.H5.23
Polar TM6 A 245 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 245 6x34 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 245 6x34 G.H5 L 354 G.H5.25
Polar TM7 S 299 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM7 S 299 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 S 299 7x56 G.H5 G 353 G.H5.24
Polar TM2 C 55 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM2 C 55 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 C 55 2x39 G.H5 C 352 G.H5.23
Polar TM4 K 136 4x37 G.HN R 24 G.HN.48
Aromatic ICL3 F 234 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 F 234 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 F 234 - G.S6 Y 321 G.S6.02
Polar TM5 T 230 5x75 G.H5 D 338 G.H5.09
Van-der-waals TM5 T 230 5x75 G.H5 D 338 G.H5.09
Hydrophobic ICL3 F 234 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 F 234 - G.H5 D 342 G.H5.13
Polar TM6 S 238 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 238 6x27 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 S 238 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 H 242 6x31 G.H5 L 349 G.H5.20
Hydrophobic TM6 A 241 6x30 G.H5 F 355 G.H5.26
Van-der-waals TM6 A 241 6x30 G.H5 F 355 G.H5.26
Hydrophobic ICL2 T 124 34x44 G.H5 I 345 G.H5.16
Van-der-waals ICL2 T 124 34x44 G.H5 I 345 G.H5.16
Hydrophobic TM3 I 122 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM3 I 122 3x54 G.H5 L 354 G.H5.25
Hydrophobic ICL3 F 234 - G.H5 D 338 G.H5.09
Polar H8 R 304 8x51 G.H5 F 355 G.H5.26
Van-der-waals H8 R 304 8x51 G.H5 F 355 G.H5.26
Polar TM7 S 299 7x56 G.H5 F 355 G.H5.26
Hydrophobic TM7 S 299 7x56 G.H5 F 355 G.H5.26
Van-der-waals TM7 S 299 7x56 G.H5 F 355 G.H5.26
Hydrophobic TM2 L 53 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM2 L 53 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM5 H 223 5x68 G.H5 T 341 G.H5.12
Ionic TM5 K 226 5x71 G.H5 D 338 G.H5.09
Polar TM5 K 226 5x71 G.H5 D 338 G.H5.09
Hydrophobic TM5 K 226 5x71 G.H5 D 338 G.H5.09
Van-der-waals TM5 K 226 5x71 G.H5 D 338 G.H5.09
Polar TM6 S 238 6x27 G.H5 D 342 G.H5.13
Hydrophobic TM6 S 238 6x27 G.H5 D 342 G.H5.13
Van-der-waals TM6 S 238 6x27 G.H5 D 342 G.H5.13
Hydrophobic TM5 L 220 5x65 G.H5 I 345 G.H5.16
Polar TM3 Y 118 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 Y 118 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 Y 118 3x50 G.H5 C 352 G.H5.23
Ionic ICL3 R 235 - G.H4 E 309 G.H4.16
Polar ICL3 R 235 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 R 235 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 R 235 - G.H4 E 309 G.H4.16
Hydrophobic TM6 P 237 6x26 G.h4s6 E 319 G.h4s6.12
Ionic ICL2 H 135 34x55 G.HN E 28 G.HN.52
Polar ICL2 H 135 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 H 135 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 H 135 34x55 G.HN E 28 G.HN.52
Van-der-waals TM5 K 226 5x71 G.H5 Q 334 G.H5.05
Hydrophobic TM3 I 122 3x54 G.H5 N 348 G.H5.19
Hydrophobic ICL2 H 135 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 H 223 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 H 223 5x68 G.H5 I 345 G.H5.16
Hydrophobic ICL2 F 131 34x51 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 F 131 34x51 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM5 T 231 5x76 G.S6 H 323 G.S6.04
Van-der-waals TM5 T 231 5x76 G.S6 H 323 G.S6.04
Hydrophobic TM6 H 242 6x31 G.H5 I 345 G.H5.16
Van-der-waals TM6 H 242 6x31 G.H5 I 345 G.H5.16
Hydrophobic TM3 Y 118 3x50 G.H5 L 354 G.H5.25
Ionic TM3 K 121 3x53 G.H5 D 351 G.H5.22
Polar TM3 K 121 3x53 G.H5 D 351 G.H5.22
Hydrophobic TM3 K 121 3x53 G.H5 D 351 G.H5.22
Van-der-waals TM3 K 121 3x53 G.H5 D 351 G.H5.22
Hydrophobic TM7 S 299 7x56 G.H5 L 354 G.H5.25
Polar H8 N 300 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 N 300 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 N 300 8x47 G.H5 G 353 G.H5.24
Ionic TM5 H 223 5x68 G.H5 D 342 G.H5.13
Polar TM5 H 223 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 H 223 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 H 223 5x68 G.H5 D 342 G.H5.13
Polar ICL2 H 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 135 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 K 121 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 K 121 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM6 A 248 6x37 G.H5 L 354 G.H5.25
Polar ICL2 P 128 34x48 G.s2s3 D 194 G.s2s3.02
Polar ICL2 H 135 34x55 G.HN K 29 G.HN.53
Ionic TM6 H 242 6x31 G.H5 D 342 G.H5.13
Polar TM6 H 242 6x31 G.H5 D 342 G.H5.13
Van-der-waals TM6 H 242 6x31 G.H5 D 342 G.H5.13
Hydrophobic ICL2 F 131 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 131 34x51 G.S3 L 195 G.S3.01
Ionic H8 R 302 8x49 G.H5 D 351 G.H5.22
Hydrophobic TM4 G 139 4x40 G.HN R 24 G.HN.48
Hydrophobic TM3 F 117 3x49 G.H5 C 352 G.H5.23
Hydrophobic TM5 T 230 5x75 G.H5 F 335 G.H5.06
Hydrophobic ICL3 F 234 - G.S6 H 323 G.S6.04
Hydrophobic TM3 I 122 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM6 L 249 6x38 G.H5 L 354 G.H5.25
Hydrophobic ICL2 T 124 34x44 G.H5 T 341 G.H5.12
Hydrophobic TM6 A 245 6x34 G.H5 L 349 G.H5.20
Van-der-waals TM6 A 245 6x34 G.H5 L 349 G.H5.20