Gt2 - TAAR6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 86.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 231 5x72 G.H5 F 354 G.H5.26
Van-der-waals TM5 I 231 5x72 G.H5 F 354 G.H5.26
Hydrophobic ICL2 T 142 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 P 137 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 138 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 138 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 141 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 P 141 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 I 231 5x72 G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 137 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM5 I 220 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 134 3x54 G.H5 C 351 G.H5.23
Polar TM6 T 259 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 259 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 T 259 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM5 T 234 5x75 G.S6 H 322 G.S6.04
Polar TM6 A 256 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 256 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 256 6x33 G.H5 L 353 G.H5.25
Polar TM3 A 133 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 133 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 133 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 141 34x54 G.S3 L 194 G.S3.01
Ionic TM6 R 252 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 252 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 252 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 252 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 A 224 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 231 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 I 231 5x72 G.h4s6 E 318 G.h4s6.12
Polar TM5 G 235 5x76 G.H4 K 304 G.H4.12
Hydrophobic TM5 G 235 5x76 G.H4 K 304 G.H4.12
Van-der-waals TM5 G 235 5x76 G.H4 K 304 G.H4.12
Hydrophobic TM4 T 145 4x38 G.hns1 K 32 G.hns1.03
Polar TM5 T 234 5x75 G.S6 S 321 G.S6.03
Hydrophobic TM5 T 234 5x75 G.S6 S 321 G.S6.03
Van-der-waals TM5 T 234 5x75 G.S6 S 321 G.S6.03
Ionic C-term E 343 - G.h4s6 R 313 G.h4s6.04
Hydrophobic ICL2 V 139 34x52 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 V 139 34x52 G.s2s3 K 192 G.s2s3.01
Ionic TM5 K 230 5x71 G.H5 D 341 G.H5.13
Polar TM5 K 230 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 230 5x71 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 230 5x71 G.H5 D 341 G.H5.13
Polar H8 Y 315 8x47 G.H5 C 351 G.H5.23
Hydrophobic H8 Y 315 8x47 G.H5 C 351 G.H5.23
Van-der-waals H8 Y 315 8x47 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 134 3x54 G.H5 I 344 G.H5.16
Polar TM5 T 234 5x75 G.H4 K 304 G.H4.12
Hydrophobic TM5 T 234 5x75 G.H4 K 304 G.H4.12
Van-der-waals TM5 T 234 5x75 G.H4 K 304 G.H4.12
Hydrophobic TM6 T 259 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 259 6x36 G.H5 L 353 G.H5.25
Polar H8 Y 315 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 Y 315 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 A 228 5x69 G.H5 F 354 G.H5.26
Polar H8 Y 315 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 Y 315 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 Y 315 8x47 G.H5 D 350 G.H5.22
Hydrophobic ICL2 L 138 34x51 G.S3 F 196 G.S3.03
Polar TM5 Q 227 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 227 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 227 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 231 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 I 231 5x72 G.S6 Y 320 G.S6.02
Polar TM3 R 130 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 138 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 138 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 137 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 137 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM4 V 146 4x39 G.HN Q 24 G.HN.48
Van-der-waals TM4 V 146 4x39 G.HN Q 24 G.HN.48
Hydrophobic ICL2 L 138 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 P 141 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 P 141 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 T 142 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 T 142 34x55 G.s2s3 D 193 G.s2s3.02
Polar TM6 K 255 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 255 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 255 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 260 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 260 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 223 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 Q 227 5x68 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 220 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 220 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 138 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 L 138 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 138 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 R 252 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 252 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 Q 227 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 Q 227 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 134 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 134 3x54 G.H5 L 348 G.H5.20