G12 - TAS1R2 complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 19.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL1 R 597 12x51 G.H5 M 379 G.H5.24
Hydrophobic TM3 Q 654 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 Q 654 3x53 G.H5 I 378 G.H5.23
Hydrophobic C-term I 831 - G.H5 L 375 G.H5.20
Van-der-waals C-term I 831 - G.H5 L 375 G.H5.20
Hydrophobic C-term I 831 - G.H5 L 371 G.H5.16
Van-der-waals C-term I 831 - G.H5 L 371 G.H5.16
Ionic C-term D 839 - G.s2s3 K 219 G.s2s3.01
Polar C-term D 839 - G.s2s3 K 219 G.s2s3.01
Van-der-waals C-term D 839 - G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL3 Y 756 - G.H5 M 379 G.H5.24
Van-der-waals ICL3 Y 756 - G.H5 M 379 G.H5.24
Hydrophobic TM3 F 659 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 F 659 3x58 G.H5 L 371 G.H5.16
Polar ICL2 Y 669 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 Y 669 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 Y 669 - G.H5 N 374 G.H5.19
Polar H8 N 828 8x55 G.h4s6 S 343 G.h4s6.12
Van-der-waals H8 N 828 8x55 G.h4s6 S 343 G.h4s6.12
Hydrophobic C-term T 835 - G.H5 K 367 G.H5.12
Hydrophobic TM2 P 602 2x37 G.H5 Q 381 G.H5.26
Van-der-waals TM2 P 602 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM3 A 658 3x57 G.H5 L 371 G.H5.16
Hydrophobic TM3 A 658 3x57 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 658 3x57 G.H5 I 378 G.H5.23
Polar C-term M 836 - G.H5 H 364 G.H5.09
Hydrophobic C-term M 836 - G.H5 H 364 G.H5.09
Van-der-waals C-term M 836 - G.H5 H 364 G.H5.09
Polar ICL2 Y 671 - G.HN R 52 G.HN.52
Polar C-term D 839 - G.H5 R 360 G.H5.05
Hydrophobic C-term D 839 - G.H5 R 360 G.H5.05
Van-der-waals C-term D 839 - G.H5 R 360 G.H5.05
Van-der-waals TM4 Y 679 4x33 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 A 662 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 A 662 - G.H5 N 374 G.H5.19
Hydrophobic C-term M 836 - G.H5 F 361 G.H5.06
Van-der-waals C-term M 836 - G.H5 F 361 G.H5.06
Hydrophobic TM3 I 655 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 V 673 - G.H5 D 377 G.H5.22
Hydrophobic ICL3 Y 756 - G.H5 L 375 G.H5.20
Hydrophobic TM3 A 658 3x57 G.H5 L 375 G.H5.20
Polar TM3 Q 654 3x53 G.H5 Q 381 G.H5.26
Van-der-waals TM3 Q 654 3x53 G.H5 Q 381 G.H5.26
Hydrophobic TM3 F 659 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 F 659 3x58 G.H5 L 375 G.H5.20
Polar C-term T 835 - G.H5 D 368 G.H5.13
Hydrophobic C-term T 835 - G.H5 D 368 G.H5.13
Van-der-waals C-term T 835 - G.H5 D 368 G.H5.13
Polar ICL2 V 673 - G.H5 Q 381 G.H5.26
Hydrophobic H8 N 828 8x55 G.h4s6 P 345 G.h4s6.20
Van-der-waals H8 N 828 8x55 G.h4s6 P 345 G.h4s6.20
Polar TM3 R 651 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 651 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 651 3x50 G.H5 I 378 G.H5.23
Hydrophobic C-term T 835 - G.H5 L 371 G.H5.16
Hydrophobic ICL2 R 667 - G.HN R 52 G.HN.52
Van-der-waals ICL2 R 667 - G.HN R 52 G.HN.52
Hydrophobic ICL2 P 666 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 666 - G.hns1 R 56 G.hns1.03
Hydrophobic C-term I 831 - G.H5 D 368 G.H5.13
Van-der-waals C-term I 831 - G.H5 D 368 G.H5.13
Hydrophobic C-term Q 832 - G.S6 F 347 G.S6.02
Van-der-waals C-term Q 832 - G.S6 F 347 G.S6.02
Polar TM3 A 658 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 658 3x57 G.H5 N 374 G.H5.19
Hydrophobic H8 P 824 8x51 G.h4s6 S 343 G.h4s6.12
Van-der-waals H8 P 824 8x51 G.h4s6 S 343 G.h4s6.12
Hydrophobic C-term Y 834 - G.H5 L 371 G.H5.16
Polar H8 N 828 8x55 G.H5 Q 372 G.H5.17
Hydrophobic H8 N 828 8x55 G.H5 Q 372 G.H5.17
Polar C-term Q 832 - G.H5 D 368 G.H5.13
Hydrophobic C-term Q 832 - G.H5 D 368 G.H5.13
Van-der-waals C-term Q 832 - G.H5 D 368 G.H5.13
Polar C-term T 835 - G.H5 H 364 G.H5.09
Hydrophobic C-term T 835 - G.H5 H 364 G.H5.09
Van-der-waals C-term T 835 - G.H5 H 364 G.H5.09
Hydrophobic C-term D 839 - G.H5 H 364 G.H5.09
Van-der-waals C-term D 839 - G.H5 H 364 G.H5.09
Ionic C-term D 839 - G.H5 K 367 G.H5.12
Polar C-term D 839 - G.H5 K 367 G.H5.12
Van-der-waals C-term D 839 - G.H5 K 367 G.H5.12
Polar ICL2 S 670 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 S 670 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 S 670 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 S 598 12x52 G.H5 M 379 G.H5.24
Polar H8 A 825 8x52 G.h4s6 S 343 G.h4s6.12
Hydrophobic H8 A 825 8x52 G.h4s6 S 343 G.h4s6.12
Van-der-waals H8 A 825 8x52 G.h4s6 S 343 G.h4s6.12
Hydrophobic C-term I 831 - G.H5 Q 372 G.H5.17