GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | Q | 832 | - | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | C-term | Q | 832 | - | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | C-term | Q | 832 | - | G.H5 | D | 337 | G.H5.13 |
Polar | ICL2 | Y | 669 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | Y | 669 | - | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | Y | 669 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM2 | G | 600 | 2x35 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM2 | G | 600 | 2x35 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | H8 | F | 827 | 8x54 | G.H5 | F | 350 | G.H5.26 |
Polar | TM3 | Q | 654 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL3 | Y | 756 | - | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | ICL3 | Y | 756 | - | G.H5 | L | 344 | G.H5.20 |
Polar | H8 | N | 828 | 8x55 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | H8 | N | 828 | 8x55 | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | H8 | N | 828 | 8x55 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | ICL2 | V | 673 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | C-term | Y | 834 | - | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | C-term | D | 839 | - | G.s2s3 | K | 188 | G.s2s3.01 |
Polar | C-term | T | 835 | - | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | C-term | T | 835 | - | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | C-term | T | 835 | - | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | ICL2 | P | 666 | - | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | P | 666 | - | G.hns1 | R | 28 | G.hns1.03 |
Polar | ICL2 | R | 667 | - | G.HN | L | 19 | G.HN.47 |
Hydrophobic | TM3 | A | 658 | 3x57 | G.H5 | L | 344 | G.H5.20 |
Polar | ICL2 | R | 667 | - | G.HN | A | 23 | G.HN.51 |
Hydrophobic | ICL2 | R | 667 | - | G.HN | A | 23 | G.HN.51 |
Van-der-waals | ICL2 | R | 667 | - | G.HN | A | 23 | G.HN.51 |
Hydrophobic | C-term | M | 836 | - | G.H5 | D | 333 | G.H5.09 |
Polar | ICL2 | R | 667 | - | G.HN | K | 20 | G.HN.48 |
Hydrophobic | ICL2 | R | 667 | - | G.HN | K | 20 | G.HN.48 |
Van-der-waals | ICL2 | R | 667 | - | G.HN | K | 20 | G.HN.48 |
Polar | ICL1 | S | 598 | 12x52 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL1 | S | 598 | 12x52 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | ICL1 | S | 598 | 12x52 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM3 | I | 655 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Polar | ICL2 | R | 664 | - | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | ICL2 | R | 664 | - | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | R | 664 | - | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | C-term | I | 831 | - | G.H5 | F | 350 | G.H5.26 |
Polar | ICL1 | R | 597 | 12x51 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | ICL1 | R | 597 | 12x51 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | ICL1 | R | 597 | 12x51 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | ICL2 | P | 666 | - | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | P | 666 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | V | 673 | - | G.H5 | C | 347 | G.H5.23 |
Polar | H8 | N | 828 | 8x55 | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | H8 | N | 828 | 8x55 | G.H5 | K | 341 | G.H5.17 |
Polar | C-term | T | 835 | - | G.s2s3 | K | 188 | G.s2s3.01 |
Van-der-waals | C-term | T | 835 | - | G.s2s3 | K | 188 | G.s2s3.01 |
Hydrophobic | TM3 | F | 659 | 3x58 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | TM3 | F | 659 | 3x58 | G.H5 | I | 340 | G.H5.16 |
Polar | ICL3 | Y | 756 | - | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL3 | Y | 756 | - | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | ICL3 | Y | 756 | - | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | I | 831 | - | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | ICL2 | R | 667 | - | G.hns1 | A | 27 | G.hns1.02 |
Ionic | C-term | R | 838 | - | G.s2s3 | D | 189 | G.s2s3.02 |
Polar | C-term | R | 838 | - | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | ICL1 | R | 597 | 12x51 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | ICL1 | R | 597 | 12x51 | G.H5 | L | 349 | G.H5.25 |
Polar | TM3 | A | 658 | 3x57 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | A | 658 | 3x57 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM3 | A | 658 | 3x57 | G.H5 | N | 343 | G.H5.19 |
Ionic | ICL2 | R | 667 | - | G.HN | E | 24 | G.HN.52 |
Polar | ICL2 | R | 667 | - | G.HN | E | 24 | G.HN.52 |
Hydrophobic | ICL2 | R | 667 | - | G.HN | E | 24 | G.HN.52 |
Van-der-waals | ICL2 | R | 667 | - | G.HN | E | 24 | G.HN.52 |
Aromatic | ICL2 | F | 665 | - | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | C-term | I | 831 | - | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM3 | Q | 654 | 3x53 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM3 | F | 659 | 3x58 | G.H5 | L | 344 | G.H5.20 |
Ionic | ICL2 | R | 664 | - | G.s2s3 | D | 189 | G.s2s3.02 |
Polar | ICL2 | R | 664 | - | G.s2s3 | D | 189 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 664 | - | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | ICL2 | S | 663 | - | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | S | 663 | - | G.S3 | L | 190 | G.S3.01 |
Polar | ICL2 | Y | 669 | - | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | Y | 669 | - | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | ICL2 | Y | 669 | - | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | C-term | I | 831 | - | G.H5 | L | 344 | G.H5.20 |
Polar | C-term | R | 838 | - | G.s2s3 | K | 188 | G.s2s3.01 |
Hydrophobic | C-term | R | 838 | - | G.s2s3 | K | 188 | G.s2s3.01 |
Van-der-waals | C-term | R | 838 | - | G.s2s3 | K | 188 | G.s2s3.01 |
Hydrophobic | C-term | T | 835 | - | G.H5 | T | 336 | G.H5.12 |
Van-der-waals | C-term | T | 835 | - | G.H5 | T | 336 | G.H5.12 |
Hydrophobic | C-term | T | 835 | - | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | C-term | T | 835 | - | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM3 | R | 651 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | ICL3 | Y | 756 | - | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | ICL2 | S | 663 | - | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | C-term | M | 836 | - | G.H5 | F | 330 | G.H5.06 |
Van-der-waals | C-term | M | 836 | - | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | ICL2 | A | 662 | - | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | A | 662 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | H8 | N | 828 | 8x55 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | H8 | N | 828 | 8x55 | G.H5 | F | 350 | G.H5.26 |