Refined structure (7TUZ) of Gi1 - GPR183

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 227 from structure (64.1%), 127 from model (35.9%)
Residue sidechains - 224 from structure (63.3%), 130 from model (36.7%)

REFINED GPCR RESIDUES

Residue backbones - 284 from structure (84.8%), 51 from model (15.2%)
Residue sidechains - 269 from structure (80.3%), 66 from model (19.7%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
E52G.HND09G.h4s6D09N19D22G24L25F26G.H5GproteinT2x39A7x56A3x53K8x48C8x47R8x52T6x36R4x38N5x72GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.HNG.h4s6G.H5GPCR segments:TM2TM3TM4TM5TM6TM7H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x372x393x503x533x5434x5134x554x385x615x655x685x726x296x326x336x366x376x407x568x478x488x52G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.21G.H5.20G.H5.19G.H5.17G.H5.16G.H5.13G.H5.12G.H5.10G.H5.09G.H5.06G.S6.02G.h4s6.12G.h4s6.10G.h4s6.09G.hns1.03G.HN.52G.HN.48Res. Pos.GPR183 (7TUZ_REFINED)- (7TUZ_REFINED)-----------------------NTRAVLKRILTNVKATIIACKRNTLKRAVRILTNVKATIIACKRLDCRELNLRIDTKFGKDTFADYE

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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