Refined structure (7WQ4) of Gq - GAL2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (60.4%), 142 from model (39.6%)
Residue sidechains - 114 from structure (31.8%), 245 from model (68.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure Structure
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure Structure
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure Structure
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure Structure
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 Structure Structure
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 Structure AF2
G.hfs2 186 T G.hfs2.05 Structure Structure
G.hfs2 187 T G.hfs2.06 Structure AF2
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure Structure
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 Structure Structure
G.hgh4 292 F G.hgh4.02 Structure Structure
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure Structure
G.hgh4 295 Y G.hgh4.05 Structure AF2
G.hgh4 296 D G.hgh4.06 Structure AF2
G.hgh4 297 G G.hgh4.07 Structure AF2
G.hgh4 298 P G.hgh4.08 Structure AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 277 from structure (87.1%), 41 from model (12.9%)
Residue sidechains - 277 from structure (87.1%), 41 from model (12.9%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 V - AF2 AF2
N-term 4 S - AF2 AF2
N-term 5 G - AF2 AF2
N-term 6 C - AF2 AF2
N-term 7 P - AF2 AF2
N-term 8 G - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 G - AF2 AF2
N-term 11 N - AF2 AF2
N-term 12 A - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 Q - AF2 AF2
N-term 15 A - AF2 AF2
N-term 16 G - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 G - AF2 AF2
N-term 19 G - AF2 AF2
N-term 20 G - AF2 AF2
N-term 21 W - AF2 AF2
N-term 22 H - AF2 AF2
TM1 23 P 1.30x30 AF2 AF2
TM1 24 E 1.31x31 AF2 AF2
TM1 25 A 1.32x32 AF2 AF2
TM1 26 V 1.33x33 AF2 AF2
TM1 27 I 1.34x34 Structure Structure
TM1 28 V 1.35x35 Structure Structure
TM1 29 P 1.36x36 Structure Structure
TM1 30 L 1.37x37 Structure Structure
TM1 31 L 1.38x38 Structure Structure
TM1 32 F 1.39x39 Structure Structure
TM1 33 A 1.40x40 Structure Structure
TM1 34 L 1.41x41 Structure Structure
TM1 35 I 1.42x42 Structure Structure
TM1 36 F 1.43x43 Structure Structure
TM1 37 L 1.44x44 Structure Structure
TM1 38 V 1.45x45 Structure Structure
TM1 39 G 1.46x46 Structure Structure
TM1 40 T 1.47x47 Structure Structure
TM1 41 V 1.48x48 Structure Structure
TM1 42 G 1.49x49 Structure Structure
TM1 43 N 1.50x50 Structure Structure
TM1 44 T 1.51x51 Structure Structure
TM1 45 L 1.52x52 Structure Structure
TM1 46 V 1.53x53 Structure Structure
TM1 47 L 1.54x54 Structure Structure
TM1 48 A 1.55x55 Structure Structure
TM1 49 V 1.56x56 Structure Structure
TM1 50 L 1.57x57 Structure Structure
TM1 51 L 1.58x58 Structure Structure
TM1 52 R 1.59x59 Structure Structure
TM1 53 G 1.60x60 Structure Structure
ICL1 54 G 12.48x48 Structure Structure
ICL1 55 Q 12.49x49 Structure Structure
ICL1 56 A 12.50x50 Structure Structure
ICL1 57 V 12.51x51 Structure Structure
TM2 58 S 2.37x37 Structure Structure
TM2 59 T 2.38x38 Structure Structure
TM2 60 T 2.39x39 Structure Structure
TM2 61 N 2.40x40 Structure Structure
TM2 62 L 2.41x41 Structure Structure
TM2 63 F 2.42x42 Structure Structure
TM2 64 I 2.43x43 Structure Structure
TM2 65 L 2.44x44 Structure Structure
TM2 66 N 2.45x45 Structure Structure
TM2 67 L 2.46x46 Structure Structure
TM2 68 G 2.47x47 Structure Structure
TM2 69 V 2.48x48 Structure Structure
TM2 70 A 2.49x49 Structure Structure
TM2 71 D 2.50x50 Structure Structure
TM2 72 L 2.51x51 Structure Structure
TM2 73 C 2.52x52 Structure Structure
TM2 74 F 2.53x53 Structure Structure
TM2 75 I 2.54x54 Structure Structure
TM2 76 L 2.55x55 Structure Structure
TM2 77 C 2.56x551 Structure Structure
TM2 78 C 2.57x56 Structure Structure
TM2 79 V 2.58x57 Structure Structure
TM2 80 P 2.59x58 Structure Structure
TM2 81 F 2.60x59 Structure Structure
TM2 82 Q 2.61x60 Structure Structure
TM2 83 A 2.62x61 Structure Structure
TM2 84 T 2.63x62 Structure Structure
TM2 85 I 2.64x63 Structure Structure
TM2 86 Y 2.65x64 Structure Structure
TM2 87 T 2.66x65 Structure Structure
TM2 88 L 2.67x66 Structure Structure
ECL1 89 D - Structure Structure
ECL1 90 G 23.49x49 Structure Structure
ECL1 91 W 23.50x50 Structure Structure
ECL1 92 V 23.51x51 Structure Structure
ECL1 93 F 23.52x52 Structure Structure
TM3 94 G 3.21x21 Structure Structure
TM3 95 S 3.22x22 Structure Structure
TM3 96 L 3.23x23 Structure Structure
TM3 97 L 3.24x24 Structure Structure
TM3 98 C 3.25x25 Structure Structure
TM3 99 K 3.26x26 Structure Structure
TM3 100 A 3.27x27 Structure Structure
TM3 101 V 3.28x28 Structure Structure
TM3 102 H 3.29x29 Structure Structure
TM3 103 F 3.30x30 Structure Structure
TM3 104 L 3.31x31 Structure Structure
TM3 105 I 3.32x32 Structure Structure
TM3 106 F 3.33x33 Structure Structure
TM3 107 L 3.34x34 Structure Structure
TM3 108 T 3.35x35 Structure Structure
TM3 109 M 3.36x36 Structure Structure
TM3 110 H 3.37x37 Structure Structure
TM3 111 A 3.38x38 Structure Structure
TM3 112 S 3.39x39 Structure Structure
TM3 113 S 3.40x40 Structure Structure
TM3 114 F 3.41x41 Structure Structure
TM3 115 T 3.42x42 Structure Structure
TM3 116 L 3.43x43 Structure Structure
TM3 117 A 3.44x44 Structure Structure
TM3 118 A 3.45x45 Structure Structure
TM3 119 V 3.46x46 Structure Structure
TM3 120 S 3.47x47 Structure Structure
TM3 121 L 3.48x48 Structure Structure
TM3 122 D 3.49x49 Structure Structure
TM3 123 R 3.50x50 Structure Structure
TM3 124 Y 3.51x51 Structure Structure
TM3 125 L 3.52x52 Structure Structure
TM3 126 A 3.53x53 Structure Structure
TM3 127 I 3.54x54 Structure Structure
TM3 128 R 3.55x55 Structure Structure
TM3 129 Y 3.56x56 Structure Structure
ICL2 130 P 34.50x50 Structure Structure
ICL2 131 L 34.51x51 Structure Structure
ICL2 132 H 34.52x52 Structure Structure
ICL2 133 S 34.53x53 Structure Structure
ICL2 134 R 34.54x54 Structure Structure
ICL2 135 E 34.55x55 Structure Structure
ICL2 136 L 34.56x56 Structure Structure
ICL2 137 R 34.57x57 Structure Structure
TM4 138 T 4.38x38 Structure Structure
TM4 139 P 4.39x39 Structure Structure
TM4 140 R 4.40x40 Structure Structure
TM4 141 N 4.41x41 Structure Structure
TM4 142 A 4.42x42 Structure Structure
TM4 143 L 4.43x43 Structure Structure
TM4 144 A 4.44x44 Structure Structure
TM4 145 A 4.45x45 Structure Structure
TM4 146 I 4.46x46 Structure Structure
TM4 147 G 4.47x47 Structure Structure
TM4 148 L 4.48x48 Structure Structure
TM4 149 I 4.49x49 Structure Structure
TM4 150 W 4.50x50 Structure Structure
TM4 151 G 4.51x51 Structure Structure
TM4 152 L 4.52x52 Structure Structure
TM4 153 S 4.53x53 Structure Structure
TM4 154 L 4.54x54 Structure Structure
TM4 155 L 4.55x55 Structure Structure
TM4 156 F 4.56x56 Structure Structure
TM4 157 S 4.57x57 Structure Structure
TM4 158 G 4.58x59 Structure Structure
TM4 159 P 4.59x60 Structure Structure
TM4 160 Y 4.60x61 Structure Structure
TM4 161 L 4.61x62 Structure Structure
TM4 162 S 4.62x63 Structure Structure
TM4 163 Y 4.63x64 Structure Structure
TM4 164 Y 4.64x65 Structure Structure
ECL2 165 R - Structure Structure
ECL2 166 Q - Structure Structure
ECL2 167 S - Structure Structure
ECL2 168 Q - Structure Structure
ECL2 169 L - Structure Structure
ECL2 170 A - Structure Structure
ECL2 171 N - Structure Structure
ECL2 172 L - Structure Structure
ECL2 173 T - Structure Structure
ECL2 174 V - Structure Structure
ECL2 175 C 45.50x50 Structure Structure
ECL2 176 H 45.51x51 Structure Structure
ECL2 177 P 45.52x52 Structure Structure
ECL2 178 A - Structure Structure
ECL2 179 W - Structure Structure
TM5 180 S 5.31x32 Structure Structure
TM5 181 A 5.32x33 Structure Structure
TM5 182 P 5.33x34 Structure Structure
TM5 183 R 5.34x35 Structure Structure
TM5 184 R 5.35x36 Structure Structure
TM5 185 R 5.36x37 Structure Structure
TM5 186 A 5.37x38 Structure Structure
TM5 187 M 5.38x39 Structure Structure
TM5 188 D 5.39x40 Structure Structure
TM5 189 I 5.40x41 Structure Structure
TM5 190 C 5.41x42 Structure Structure
TM5 191 T 5.42x43 Structure Structure
TM5 192 F 5.43x44 Structure Structure
TM5 193 V 5.44x45 Structure Structure
TM5 194 F 5.45x46 Structure Structure
TM5 195 S 5.46x461 Structure Structure
TM5 196 Y 5.47x47 Structure Structure
TM5 197 L 5.48x48 Structure Structure
TM5 198 L 5.49x49 Structure Structure
TM5 199 P 5.50x50 Structure Structure
TM5 200 V 5.51x51 Structure Structure
TM5 201 L 5.52x52 Structure Structure
TM5 202 V 5.53x53 Structure Structure
TM5 203 L 5.54x54 Structure Structure
TM5 204 G 5.55x55 Structure Structure
TM5 205 L 5.56x56 Structure Structure
TM5 206 T 5.57x57 Structure Structure
TM5 207 Y 5.58x58 Structure Structure
TM5 208 A 5.59x59 Structure Structure
TM5 209 R 5.60x60 Structure Structure
TM5 210 T 5.61x61 Structure Structure
TM5 211 L 5.62x62 Structure Structure
TM5 212 R 5.63x63 Structure Structure
TM5 213 Y 5.64x64 Structure Structure
TM5 214 L 5.65x65 Structure Structure
TM5 215 W 5.66x66 Structure Structure
TM5 216 R 5.67x67 Structure Structure
TM5 217 A 5.68x68 Structure Structure
TM5 218 V 5.69x69 Structure Structure
TM5 219 D 5.70x70 AF2 AF2
TM5 220 P 5.71x71 AF2 AF2
TM5 221 V 5.72x72 AF2 AF2
ICL3 222 A - AF2 AF2
ICL3 223 A - Structure Structure
TM6 224 G 6.23x23 Structure Structure
TM6 225 S 6.24x24 Structure Structure
TM6 226 G 6.25x25 Structure Structure
TM6 227 A 6.26x26 Structure Structure
TM6 228 R 6.27x27 Structure Structure
TM6 229 R 6.28x28 Structure Structure
TM6 230 A 6.29x29 Structure Structure
TM6 231 K 6.30x30 Structure Structure
TM6 232 R 6.31x31 Structure Structure
TM6 233 K 6.32x32 Structure Structure
TM6 234 V 6.33x33 Structure Structure
TM6 235 T 6.34x34 Structure Structure
TM6 236 R 6.35x35 Structure Structure
TM6 237 M 6.36x36 Structure Structure
TM6 238 I 6.37x37 Structure Structure
TM6 239 L 6.38x38 Structure Structure
TM6 240 I 6.39x39 Structure Structure
TM6 241 V 6.40x40 Structure Structure
TM6 242 A 6.41x41 Structure Structure
TM6 243 A 6.42x42 Structure Structure
TM6 244 L 6.43x43 Structure Structure
TM6 245 F 6.44x44 Structure Structure
TM6 246 C 6.45x45 Structure Structure
TM6 247 L 6.46x46 Structure Structure
TM6 248 C 6.47x47 Structure Structure
TM6 249 W 6.48x48 Structure Structure
TM6 250 M 6.49x49 Structure Structure
TM6 251 P 6.50x50 Structure Structure
TM6 252 H 6.51x51 Structure Structure
TM6 253 H 6.52x52 Structure Structure
TM6 254 A 6.53x53 Structure Structure
TM6 255 L 6.54x54 Structure Structure
TM6 256 I 6.55x55 Structure Structure
TM6 257 L 6.56x56 Structure Structure
TM6 258 C 6.57x57 Structure Structure
TM6 259 V 6.58x58 Structure Structure
TM6 260 W 6.59x59 Structure Structure
TM6 261 F 6.60x60 Structure Structure
TM6 262 G 6.61x61 Structure Structure
ECL3 263 Q - Structure Structure
ECL3 264 F - Structure Structure
ECL3 265 P - Structure Structure
ECL3 266 L - Structure Structure
TM7 267 T 7.28x27 Structure Structure
TM7 268 R 7.29x28 Structure Structure
TM7 269 A 7.30x29 Structure Structure
TM7 270 T 7.31x30 Structure Structure
TM7 271 Y 7.32x31 Structure Structure
TM7 272 A 7.33x32 Structure Structure
TM7 273 L 7.34x33 Structure Structure
TM7 274 R 7.35x34 Structure Structure
TM7 275 I 7.36x35 Structure Structure
TM7 276 L 7.37x36 Structure Structure
TM7 277 S 7.38x37 Structure Structure
TM7 278 H 7.39x38 Structure Structure
TM7 279 L 7.40x39 Structure Structure
TM7 280 V 7.41x40 Structure Structure
TM7 281 S 7.42x41 Structure Structure
TM7 282 Y 7.43x42 Structure Structure
TM7 283 A 7.44x43 Structure Structure
TM7 284 N 7.45x45 Structure Structure
TM7 285 S 7.46x46 Structure Structure
TM7 286 C 7.47x47 Structure Structure
TM7 287 V 7.48x48 Structure Structure
TM7 288 N 7.49x49 Structure Structure
TM7 289 P 7.50x50 Structure Structure
TM7 290 I 7.51x51 Structure Structure
TM7 291 V 7.52x52 Structure Structure
TM7 292 Y 7.53x53 Structure Structure
TM7 293 A 7.54x54 Structure Structure
TM7 294 L 7.55x55 Structure Structure
TM7 295 V 7.56x56 Structure Structure
H8 296 S 8.47x47 Structure Structure
H8 297 K 8.48x48 Structure Structure
H8 298 H 8.49x49 Structure Structure
H8 299 F 8.50x50 Structure Structure
H8 300 R 8.51x51 Structure Structure
H8 301 K 8.52x52 Structure Structure
H8 302 G 8.53x53 Structure Structure
H8 303 F 8.54x54 Structure Structure
H8 304 R 8.55x55 Structure Structure
H8 305 T 8.56x56 Structure Structure
H8 306 I 8.57x57 Structure Structure
H8 307 C 8.58x58 Structure Structure
H8 308 A 8.59x59 AF2 AF2
C-term 309 G - AF2 AF2
C-term 310 L - AF2 AF2
C-term 311 L - AF2 AF2
C-term 312 G - AF2 AF2
C-term 313 R - AF2 AF2
C-term 314 A - AF2 AF2
C-term 315 P - AF2 AF2
C-term 316 G - AF2 AF2
C-term 317 R - AF2 AF2
C-term 318 A - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 130 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 L 131 34x51 G.S1 L 40 G.S1.02
Polar TM6 V 234 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 V 234 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 234 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 V 234 6x33 G.H5 L 353 G.H5.20
Polar TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Ionic H8 K 297 8x48 G.h4s6 D 321 G.h4s6.12
Polar H8 K 297 8x48 G.h4s6 D 321 G.h4s6.12
Van-der-waals H8 K 297 8x48 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM4 T 138 4x38 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 T 138 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic TM5 P 220 5x71 G.H5 A 342 G.H5.09
Hydrophobic H8 F 299 8x50 G.H5 N 357 G.H5.24
Van-der-waals H8 F 299 8x50 G.H5 N 357 G.H5.24
Polar H8 S 296 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 296 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 296 8x47 G.H5 N 357 G.H5.24
Polar ICL2 E 135 34x55 G.hns1 R 37 G.hns1.02
Polar ICL2 R 137 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 137 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 137 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 131 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM5 P 220 5x71 G.H5 F 339 G.H5.06
Van-der-waals TM5 P 220 5x71 G.H5 F 339 G.H5.06
Polar ICL2 R 134 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 R 134 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic TM3 I 127 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM5 P 220 5x71 G.S6 Y 325 G.S6.02
Hydrophobic TM3 I 127 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 L 131 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 131 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM5 V 221 5x72 G.S6 Y 325 G.S6.02
Van-der-waals TM5 V 221 5x72 G.S6 Y 325 G.S6.02
Hydrophobic TM3 A 126 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 126 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM6 A 230 6x29 G.H5 V 359 G.H5.26
Hydrophobic ICL2 L 131 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 131 34x51 G.H5 F 341 G.H5.08
Polar ICL2 H 132 34x52 G.s2s3 Q 197 G.s2s3.01
Polar TM7 Y 292 7x53 G.H5 N 357 G.H5.24
Hydrophobic H8 H 298 8x49 G.H5 K 354 G.H5.21
Van-der-waals H8 H 298 8x49 G.H5 K 354 G.H5.21
Hydrophobic TM5 V 221 5x72 G.S6 I 324 G.S6.01
Van-der-waals TM5 V 221 5x72 G.S6 I 324 G.S6.01
Hydrophobic TM3 R 123 3x50 G.H5 L 358 G.H5.25
Hydrophobic H8 S 296 8x47 G.H5 V 359 G.H5.26
Hydrophobic TM5 V 221 5x72 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM2 T 60 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 60 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM5 P 220 5x71 G.H5 D 346 G.H5.13
Polar TM3 D 122 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 122 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 122 3x49 G.H5 Y 356 G.H5.23
Polar TM3 A 126 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 126 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 126 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 L 131 34x51 G.H5 K 345 G.H5.12
Polar ICL2 R 134 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 134 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM5 P 220 5x71 G.H5 A 343 G.H5.10
Polar TM2 T 60 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 T 60 2x39 G.H5 E 355 G.H5.22
Hydrophobic ICL2 P 130 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 K 345 G.H5.12
Polar TM5 P 220 5x71 G.S6 H 327 G.S6.04
Hydrophobic TM5 P 220 5x71 G.S6 H 327 G.S6.04
Van-der-waals TM5 P 220 5x71 G.S6 H 327 G.S6.04
Hydrophobic TM6 K 233 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 233 6x32 G.H5 V 359 G.H5.26