Refined structure (8IQ6) of Gs - FP receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 201 from structure (51.0%), 193 from model (49.0%)
Residue sidechains - 156 from structure (39.6%), 238 from model (60.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 AF2 AF2
G.HN 13 R G.HN.30 AF2 AF2
G.HN 14 N G.HN.31 AF2 AF2
G.HN 15 E G.HN.32 AF2 AF2
G.HN 16 E G.HN.33 AF2 AF2
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure AF2
G.HN 20 R G.HN.37 Structure AF2
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure AF2
G.HN 23 N G.HN.40 Structure AF2
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure AF2
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure AF2
G.HN 28 K G.HN.45 Structure AF2
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure AF2
G.HN 32 K G.HN.49 Structure AF2
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure AF2
G.HN 35 Q G.HN.52 Structure AF2
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure AF2
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure AF2
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 AF2 AF2
G.H1 58 K G.H1.06 AF2 AF2
G.H1 59 Q G.H1.07 AF2 AF2
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 AF2 AF2
G.hfs2 206 G G.hfs2.07 AF2 AF2
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure AF2
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure AF2
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure AF2
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure AF2
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure AF2
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure AF2
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure AF2
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure AF2
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure AF2
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 AF2 AF2
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 AF2 AF2
G.HG 307 K G.HG.14 AF2 AF2
G.HG 308 I G.HG.15 AF2 AF2
G.HG 309 E G.HG.16 AF2 AF2
G.HG 310 D G.HG.17 AF2 AF2
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure AF2
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure AF2
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure AF2
G.hgh4 323 D G.hgh4.13 Structure AF2
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 AF2 AF2
G.hgh4 327 E G.hgh4.17 AF2 AF2
G.hgh4 328 P G.hgh4.18 AF2 AF2
G.hgh4 329 G G.hgh4.19 AF2 AF2
G.hgh4 330 E G.hgh4.20 AF2 AF2
G.hgh4 331 D G.hgh4.21 AF2 AF2
G.H4 332 P G.H4.01 AF2 AF2
G.H4 333 R G.H4.02 AF2 AF2
G.H4 334 V G.H4.03 AF2 AF2
G.H4 335 T G.H4.04 AF2 AF2
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure AF2
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure AF2
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure AF2
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure AF2
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure AF2
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure AF2
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure AF2
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure AF2
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure AF2
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure AF2
G.H5 385 R G.H5.17 Structure AF2
G.H5 386 M G.H5.18 Structure AF2
G.H5 387 H G.H5.19 Structure AF2
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure AF2
G.H5 390 Q G.H5.22 Structure AF2
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure AF2
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure AF2

REFINED GPCR RESIDUES

Residue backbones - 271 from structure (80.4%), 66 from model (19.6%)
Residue sidechains - 241 from structure (71.5%), 96 from model (28.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 M - AF2 AF2
N-term 4 N - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 K - AF2 AF2
N-term 8 Q - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 V - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 P - AF2 AF2
N-term 13 A - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 A - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 S - AF2 AF2
N-term 19 N - AF2 AF2
N-term 20 T - AF2 AF2
N-term 21 T - AF2 AF2
N-term 22 C - AF2 AF2
N-term 23 Q - AF2 AF2
N-term 24 T - AF2 AF2
N-term 25 E - AF2 AF2
N-term 26 N - AF2 AF2
N-term 27 R - AF2 AF2
N-term 28 L - AF2 AF2
N-term 29 S - AF2 AF2
TM1 30 V 1.36x36 Structure Structure
TM1 31 F 1.37x37 Structure Structure
TM1 32 F 1.38x38 Structure Structure
TM1 33 S 1.39x39 Structure Structure
TM1 34 V 1.40x40 Structure Structure
TM1 35 I 1.41x41 Structure Structure
TM1 36 F 1.42x42 Structure Structure
TM1 37 M 1.43x43 Structure Structure
TM1 38 T 1.44x44 Structure Structure
TM1 39 V 1.45x45 Structure Structure
TM1 40 G 1.46x46 Structure Structure
TM1 41 I 1.47x47 Structure Structure
TM1 42 L 1.48x48 Structure Structure
TM1 43 S 1.49x49 Structure Structure
TM1 44 N 1.50x50 Structure Structure
TM1 45 S 1.51x51 Structure Structure
TM1 46 L 1.52x52 Structure Structure
TM1 47 A 1.53x53 Structure Structure
TM1 48 I 1.54x54 Structure Structure
TM1 49 A 1.55x55 Structure Structure
TM1 50 I 1.56x56 Structure Structure
TM1 51 L 1.57x57 Structure Structure
TM1 52 M 1.58x58 Structure Structure
TM1 53 K 1.59x59 Structure AF2
TM1 54 A 1.60x60 Structure Structure
TM1 55 Y 1.61x61 Structure Structure
TM1 56 Q 1.62x62 Structure Structure
TM1 57 R 1.63x63 Structure Structure
TM1 58 F 1.64x64 Structure Structure
TM1 59 R 1.65x65 Structure Structure
TM1 60 Q 1.66x66 Structure Structure
ICL1 61 K - Structure Structure
ICL1 62 S - Structure Structure
ICL1 63 K - Structure Structure
TM2 64 A 2.37x37 Structure Structure
TM2 65 S 2.38x38 Structure Structure
TM2 66 F 2.39x39 Structure Structure
TM2 67 L 2.40x40 Structure Structure
TM2 68 L 2.41x41 Structure Structure
TM2 69 L 2.42x42 Structure Structure
TM2 70 A 2.43x43 Structure Structure
TM2 71 S 2.44x44 Structure Structure
TM2 72 G 2.45x45 Structure Structure
TM2 73 L 2.46x46 Structure Structure
TM2 74 V 2.47x47 Structure Structure
TM2 75 I 2.48x48 Structure Structure
TM2 76 T 2.49x49 Structure Structure
TM2 77 D 2.50x50 Structure Structure
TM2 78 F 2.51x51 Structure Structure
TM2 79 F 2.52x52 Structure Structure
TM2 80 G 2.53x53 Structure Structure
TM2 81 H 2.54x54 Structure Structure
TM2 82 L 2.55x55 Structure Structure
TM2 83 I 2.56x56 Structure Structure
TM2 84 N 2.57x57 Structure Structure
TM2 85 G 2.58x58 Structure Structure
TM2 86 A 2.59x59 Structure Structure
TM2 87 I 2.60x60 Structure Structure
TM2 88 A 2.61x61 Structure Structure
TM2 89 V 2.62x62 Structure Structure
TM2 90 F 2.63x63 Structure Structure
TM2 91 V 2.64x64 Structure Structure
TM2 92 Y 2.65x65 Structure Structure
TM2 93 A 2.66x66 Structure Structure
TM2 94 S 2.67x67 Structure Structure
TM2 95 D 2.68x68 Structure AF2
ECL1 96 K - Structure Structure
ECL1 97 E 23.49x49 Structure AF2
ECL1 98 W 23.50x50 Structure Structure
ECL1 99 I 23.51x51 Structure AF2
ECL1 100 R 23.52x52 Structure AF2
ECL1 101 F - Structure Structure
ECL1 102 D - Structure AF2
ECL1 103 Q - Structure AF2
ECL1 104 S - Structure Structure
TM3 105 N 3.22x22 Structure Structure
TM3 106 V 3.23x23 Structure Structure
TM3 107 L 3.24x24 Structure Structure
TM3 108 C 3.25x25 Structure Structure
TM3 109 S 3.26x26 Structure Structure
TM3 110 I 3.27x27 Structure Structure
TM3 111 F 3.28x28 Structure Structure
TM3 112 G 3.29x29 Structure Structure
TM3 113 I 3.30x30 Structure Structure
TM3 114 C 3.31x31 Structure Structure
TM3 115 M 3.32x32 Structure Structure
TM3 116 V 3.33x33 Structure Structure
TM3 117 F 3.34x34 Structure Structure
TM3 118 S 3.35x35 Structure Structure
TM3 119 G 3.36x36 Structure Structure
TM3 120 L 3.37x37 Structure Structure
TM3 121 C 3.38x38 Structure Structure
TM3 122 P 3.39x39 Structure Structure
TM3 123 L 3.40x40 Structure Structure
TM3 124 L 3.41x41 Structure Structure
TM3 125 L 3.42x42 Structure Structure
TM3 126 G 3.43x43 Structure Structure
TM3 127 S 3.44x44 Structure Structure
TM3 128 V 3.45x45 Structure Structure
TM3 129 M 3.46x46 Structure Structure
TM3 130 A 3.47x47 Structure Structure
TM3 131 I 3.48x48 Structure Structure
TM3 132 E 3.49x49 Structure Structure
TM3 133 R 3.50x50 Structure Structure
TM3 134 C 3.51x51 Structure Structure
TM3 135 I 3.52x52 Structure Structure
TM3 136 G 3.53x53 Structure Structure
TM3 137 V 3.54x54 Structure Structure
TM3 138 T 3.55x55 Structure Structure
TM3 139 K 3.56x56 Structure AF2
ICL2 140 P 34.50x50 Structure Structure
ICL2 141 I 34.51x51 Structure Structure
ICL2 142 F 34.52x52 Structure Structure
ICL2 143 H 34.53x53 Structure Structure
ICL2 144 S 34.54x54 Structure Structure
ICL2 145 T 34.55x55 Structure Structure
ICL2 146 K 34.56x56 Structure Structure
ICL2 147 I 34.57x57 Structure Structure
TM4 148 T 4.38x38 Structure Structure
TM4 149 S 4.39x39 Structure Structure
TM4 150 K 4.40x40 Structure AF2
TM4 151 H 4.41x41 Structure Structure
TM4 152 V 4.42x42 Structure Structure
TM4 153 K 4.43x43 Structure Structure
TM4 154 M 4.44x44 Structure Structure
TM4 155 M 4.45x45 Structure Structure
TM4 156 L 4.46x46 Structure Structure
TM4 157 S 4.47x47 Structure Structure
TM4 158 G 4.48x48 Structure Structure
TM4 159 V 4.49x49 Structure Structure
TM4 160 C 4.50x50 Structure Structure
TM4 161 L 4.51x51 Structure Structure
TM4 162 F 4.52x52 Structure Structure
TM4 163 A 4.53x53 Structure Structure
TM4 164 V 4.54x54 Structure Structure
TM4 165 F 4.55x55 Structure Structure
TM4 166 I 4.56x56 Structure Structure
TM4 167 A 4.57x57 Structure Structure
TM4 168 L 4.58x58 Structure Structure
TM4 169 L 4.59x59 Structure Structure
TM4 170 P 4.60x60 Structure Structure
TM4 171 I 4.61x61 Structure Structure
TM4 172 L 4.62x62 Structure AF2
TM4 173 G 4.63x63 Structure Structure
ECL2 174 H - Structure AF2
ECL2 175 R - Structure AF2
ECL2 176 D - Structure AF2
ECL2 177 Y - Structure Structure
ECL2 178 K - Structure AF2
ECL2 179 I - Structure Structure
ECL2 180 Q - Structure Structure
ECL2 181 A - Structure Structure
ECL2 182 S - Structure Structure
ECL2 183 R - Structure Structure
ECL2 184 T - Structure Structure
ECL2 185 W - Structure Structure
ECL2 186 C 45.50x50 Structure Structure
ECL2 187 F 45.51x51 Structure Structure
ECL2 188 Y 45.52x52 Structure Structure
ECL2 189 N - Structure Structure
ECL2 190 T - Structure Structure
ECL2 191 E - Structure AF2
ECL2 192 D - Structure AF2
ECL2 193 I - Structure AF2
ECL2 194 K - Structure AF2
TM5 195 D 5.31x31 Structure AF2
TM5 196 W 5.32x32 Structure AF2
TM5 197 E 5.33x33 Structure AF2
TM5 198 D 5.34x34 Structure AF2
TM5 199 R 5.35x35 Structure Structure
TM5 200 F 5.36x36 Structure Structure
TM5 201 Y 5.37x37 Structure Structure
TM5 202 L 5.38x38 Structure Structure
TM5 203 L 5.39x39 Structure Structure
TM5 204 L 5.40x40 Structure Structure
TM5 205 F 5.41x41 Structure Structure
TM5 206 S 5.42x42 Structure Structure
TM5 207 F 5.43x43 Structure Structure
TM5 208 L 5.44x44 Structure Structure
TM5 209 G 5.45x45 Structure Structure
TM5 210 L 5.46x46 Structure Structure
TM5 211 L 5.47x47 Structure Structure
TM5 212 A 5.48x48 Structure Structure
TM5 213 L 5.49x49 Structure Structure
TM5 214 G 5.50x50 Structure Structure
TM5 215 V 5.51x51 Structure Structure
TM5 216 S 5.52x52 Structure Structure
TM5 217 L 5.53x53 Structure Structure
TM5 218 L 5.54x54 Structure Structure
TM5 219 C 5.55x55 Structure Structure
TM5 220 N 5.56x56 Structure Structure
TM5 221 A 5.57x57 Structure Structure
TM5 222 I 5.58x58 Structure Structure
TM5 223 T 5.59x59 Structure Structure
TM5 224 G 5.60x60 Structure Structure
TM5 225 I 5.61x61 Structure Structure
TM5 226 T 5.62x62 Structure Structure
TM5 227 L 5.63x63 Structure Structure
TM5 228 L 5.64x64 Structure Structure
TM5 229 R 5.65x65 Structure Structure
TM5 230 V 5.66x66 AF2 AF2
TM5 231 K 5.67x67 AF2 AF2
TM5 232 F 5.68x68 AF2 AF2
TM5 233 K 5.69x69 AF2 AF2
TM5 234 S 5.70x70 AF2 AF2
TM5 235 Q 5.71x71 AF2 AF2
ICL3 236 Q - AF2 AF2
ICL3 237 H - AF2 AF2
ICL3 238 R - AF2 AF2
ICL3 239 Q - AF2 AF2
ICL3 240 G - AF2 AF2
TM6 241 R 6.27x27 AF2 AF2
TM6 242 S 6.28x28 AF2 AF2
TM6 243 H 6.29x29 Structure Structure
TM6 244 H 6.30x30 Structure Structure
TM6 245 L 6.31x31 Structure Structure
TM6 246 E 6.32x32 Structure Structure
TM6 247 M 6.33x33 Structure Structure
TM6 248 V 6.34x34 Structure Structure
TM6 249 I 6.35x35 Structure Structure
TM6 250 Q 6.36x36 Structure Structure
TM6 251 L 6.37x37 Structure Structure
TM6 252 L 6.38x38 Structure Structure
TM6 253 A 6.39x39 Structure Structure
TM6 254 I 6.40x40 Structure Structure
TM6 255 M 6.41x41 Structure Structure
TM6 256 C 6.42x42 Structure Structure
TM6 257 V 6.43x43 Structure Structure
TM6 258 S 6.44x44 Structure Structure
TM6 259 C 6.45x45 Structure Structure
TM6 260 I 6.46x46 Structure Structure
TM6 261 C 6.47x47 Structure Structure
TM6 262 W 6.48x48 Structure Structure
TM6 263 S 6.49x49 Structure Structure
TM6 264 P 6.50x50 Structure Structure
TM6 265 F 6.51x51 Structure Structure
TM6 266 L 6.52x52 Structure Structure
TM6 267 V 6.53x53 Structure Structure
TM6 268 T 6.54x54 Structure Structure
TM6 269 M 6.55x55 Structure Structure
TM6 270 A 6.56x56 Structure Structure
TM6 271 N 6.57x57 Structure Structure
TM6 272 I 6.58x58 Structure Structure
TM6 273 G 6.59x59 Structure Structure
TM6 274 I 6.60x60 Structure Structure
TM6 275 N 6.61x61 Structure AF2
ECL3 276 G - Structure Structure
ECL3 277 N - Structure AF2
ECL3 278 H - Structure AF2
ECL3 279 S - Structure Structure
ECL3 280 L - Structure AF2
ECL3 281 E - Structure AF2
TM7 282 T 7.31x30 Structure AF2
TM7 283 C 7.32x31 Structure Structure
TM7 284 E 7.33x32 Structure AF2
TM7 285 T 7.34x33 Structure Structure
TM7 286 T 7.35x34 Structure Structure
TM7 287 L 7.36x35 Structure Structure
TM7 288 F 7.37x36 Structure Structure
TM7 289 A 7.38x37 Structure Structure
TM7 290 L 7.39x38 Structure Structure
TM7 291 R 7.40x39 Structure Structure
TM7 292 M 7.41x40 Structure Structure
TM7 293 A 7.42x41 Structure Structure
TM7 294 T 7.43x42 Structure Structure
TM7 295 W 7.44x43 Structure Structure
TM7 296 N 7.45x45 Structure Structure
TM7 297 Q 7.46x46 Structure Structure
TM7 298 I 7.47x47 Structure Structure
TM7 299 L 7.48x48 Structure Structure
TM7 300 D 7.49x49 Structure Structure
TM7 301 P 7.50x50 Structure Structure
TM7 302 W 7.51x51 Structure Structure
TM7 303 V 7.52x52 Structure Structure
TM7 304 Y 7.53x53 Structure Structure
TM7 305 I 7.54x54 Structure Structure
TM7 306 L 7.55x55 Structure Structure
TM7 307 L 7.56x56 Structure Structure
H8 308 R 8.47x47 Structure Structure
H8 309 K 8.48x48 Structure Structure
H8 310 A 8.49x49 Structure Structure
H8 311 V 8.50x50 Structure Structure
H8 312 L 8.51x51 Structure Structure
H8 313 K 8.52x52 Structure AF2
H8 314 N 8.53x53 AF2 AF2
H8 315 L 8.54x54 AF2 AF2
H8 316 Y 8.55x55 AF2 AF2
H8 317 K 8.56x56 AF2 AF2
H8 318 L 8.57x57 AF2 AF2
H8 319 A 8.58x58 AF2 AF2
H8 320 S 8.59x59 AF2 AF2
H8 321 Q 8.60x60 AF2 AF2
H8 322 C 8.61x61 AF2 AF2
H8 323 C 8.62x62 AF2 AF2
H8 324 G 8.63x63 AF2 AF2
H8 325 V 8.64x64 AF2 AF2
H8 326 H 8.65x65 AF2 AF2
H8 327 V 8.66x66 AF2 AF2
C-term 328 I - AF2 AF2
C-term 329 S - AF2 AF2
C-term 330 L - AF2 AF2
C-term 331 H - AF2 AF2
C-term 332 I - AF2 AF2
C-term 333 W - AF2 AF2
C-term 334 E - AF2 AF2
C-term 335 L - AF2 AF2
C-term 336 S - AF2 AF2
C-term 337 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 V 137 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 137 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 145 34x55 G.S1 H 41 G.S1.02
Hydrophobic ICL2 I 141 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM6 E 246 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 E 246 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM1 F 58 1x64 G.H5 L 394 G.H5.26
Van-der-waals TM1 F 58 1x64 G.H5 L 394 G.H5.26
Hydrophobic TM1 F 58 1x64 G.H5 R 389 G.H5.21
Hydrophobic H8 R 308 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 S 144 34x54 G.H5 I 383 G.H5.15
Hydrophobic TM6 H 244 6x30 G.H5 L 388 G.H5.20
Ionic TM3 E 132 3x49 G.H5 H 387 G.H5.19
Polar TM3 E 132 3x49 G.H5 H 387 G.H5.19
Hydrophobic TM3 V 137 3x54 G.H5 Y 391 G.H5.23
Polar ICL3 R 238 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 R 238 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 R 238 - G.h4s6 Y 358 G.h4s6.20
Polar ICL3 Q 239 - G.h4s6 Y 358 G.h4s6.20
Polar TM4 S 149 4x39 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 S 149 4x39 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 L 227 5x63 G.H5 L 388 G.H5.20
Van-der-waals ICL3 R 238 - G.H5 R 385 G.H5.17
Van-der-waals TM6 H 243 6x29 G.H5 E 392 G.H5.24
Polar ICL1 S 62 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 S 62 - G.H5 Q 390 G.H5.22
Hydrophobic TM3 V 137 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 I 141 34x51 G.S3 V 217 G.S3.01
Polar TM3 G 136 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 G 136 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 G 136 3x53 G.H5 H 387 G.H5.19
Polar ICL3 Q 239 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 Q 239 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 Q 239 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 M 247 6x33 G.H5 Y 391 G.H5.23
Van-der-waals TM6 M 247 6x33 G.H5 Y 391 G.H5.23
Hydrophobic TM1 F 58 1x64 G.H5 L 393 G.H5.25
Polar TM3 E 132 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 132 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 I 141 34x51 G.H5 R 380 G.H5.12
Aromatic TM2 F 66 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 F 66 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 F 66 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 L 67 2x40 G.H5 L 393 G.H5.25
Van-der-waals TM2 L 67 2x40 G.H5 L 393 G.H5.25
Hydrophobic TM3 V 137 3x54 G.H5 H 387 G.H5.19
Aromatic ICL2 H 143 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 H 143 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM4 T 148 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM7 I 305 7x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 140 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 140 34x50 G.H5 R 380 G.H5.12
Hydrophobic H8 A 310 8x49 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 140 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM1 A 54 1x60 G.H5 L 393 G.H5.25
Hydrophobic H8 A 310 8x49 G.H5 L 393 G.H5.25
Van-der-waals H8 A 310 8x49 G.H5 L 393 G.H5.25
Polar ICL3 H 237 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 H 237 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 H 237 - G.h4s6 Y 358 G.h4s6.20
Polar TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Hydrophobic H8 V 311 8x50 G.H5 L 393 G.H5.25
Van-der-waals H8 V 311 8x50 G.H5 L 393 G.H5.25
Hydrophobic TM1 F 58 1x64 G.H5 Q 390 G.H5.22
Van-der-waals TM1 F 58 1x64 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 I 141 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 I 141 34x51 G.S1 H 41 G.S1.02
Polar TM6 M 247 6x33 G.H5 E 392 G.H5.24
Hydrophobic TM6 M 247 6x33 G.H5 E 392 G.H5.24
Van-der-waals TM6 M 247 6x33 G.H5 E 392 G.H5.24
Hydrophobic ICL3 H 237 - G.H4 L 346 G.H4.16
Hydrophobic ICL3 R 238 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 G 240 - G.h4s6 G 355 G.h4s6.11
Ionic ICL3 R 238 - G.H5 D 381 G.H5.13
Polar ICL3 R 238 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 R 238 - G.H5 D 381 G.H5.13
Hydrophobic TM6 H 243 6x29 G.H5 L 388 G.H5.20
Polar TM1 R 57 1x63 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 140 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM6 H 243 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 H 243 6x29 G.H5 L 394 G.H5.26
Polar TM6 H 243 6x29 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM6 H 243 6x29 G.h4s6 G 355 G.h4s6.11