Refined structure (8U8F) of Gs - GPR3

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 231 from structure (58.6%), 163 from model (41.4%)
Residue sidechains - 221 from structure (56.1%), 173 from model (43.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 AF2 AF2
G.HN 13 R G.HN.30 AF2 AF2
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure AF2
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure Structure
G.H1 62 I G.H1.10 Structure Structure
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure AF2
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 263 from structure (81.4%), 60 from model (18.6%)
Residue sidechains - 263 from structure (81.4%), 60 from model (18.6%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 M - AF2 AF2
N-term 3 W - AF2 AF2
N-term 4 G - AF2 AF2
N-term 5 A - AF2 AF2
N-term 6 G - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 P - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 A - AF2 AF2
N-term 11 W - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 G - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 N - AF2 AF2
N-term 19 V - AF2 AF2
N-term 20 N - AF2 AF2
N-term 21 V - AF2 AF2
N-term 22 S - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 V - AF2 AF2
N-term 25 G - AF2 AF2
N-term 26 P - AF2 AF2
N-term 27 A - AF2 AF2
N-term 28 E - AF2 AF2
N-term 29 G - AF2 AF2
N-term 30 P - AF2 AF2
N-term 31 T - AF2 AF2
N-term 32 G - AF2 AF2
N-term 33 P - AF2 AF2
N-term 34 A - AF2 AF2
N-term 35 A - AF2 AF2
N-term 36 P - AF2 AF2
N-term 37 L - AF2 AF2
N-term 38 P - AF2 AF2
N-term 39 S - AF2 AF2
N-term 40 P - AF2 AF2
TM1 41 K 1.33x33 Structure Structure
TM1 42 A 1.34x34 Structure Structure
TM1 43 W 1.35x35 Structure Structure
TM1 44 D 1.36x36 Structure Structure
TM1 45 V 1.37x37 Structure Structure
TM1 46 V 1.38x38 Structure Structure
TM1 47 L 1.39x39 Structure Structure
TM1 48 C 1.40x40 Structure Structure
TM1 49 I 1.41x41 Structure Structure
TM1 50 S 1.42x42 Structure Structure
TM1 51 G 1.43x43 Structure Structure
TM1 52 T 1.44x44 Structure Structure
TM1 53 L 1.45x45 Structure Structure
TM1 54 V 1.46x46 Structure Structure
TM1 55 S 1.47x47 Structure Structure
TM1 56 C 1.48x48 Structure Structure
TM1 57 E 1.49x49 Structure Structure
TM1 58 N 1.50x50 Structure Structure
TM1 59 A 1.51x51 Structure Structure
TM1 60 L 1.52x52 Structure Structure
TM1 61 V 1.53x53 Structure Structure
TM1 62 V 1.54x54 Structure Structure
TM1 63 A 1.55x55 Structure Structure
TM1 64 I 1.56x56 Structure Structure
TM1 65 I 1.57x57 Structure Structure
TM1 66 V 1.58x58 Structure Structure
TM1 67 G 1.59x59 Structure Structure
TM1 68 T 1.60x60 Structure Structure
ICL1 69 P 12.48x48 Structure Structure
ICL1 70 A 12.49x49 Structure Structure
ICL1 71 F 12.50x50 Structure Structure
ICL1 72 R 12.51x51 Structure Structure
TM2 73 A 2.37x37 Structure Structure
TM2 74 P 2.38x38 Structure Structure
TM2 75 M 2.39x39 Structure Structure
TM2 76 F 2.40x40 Structure Structure
TM2 77 L 2.41x41 Structure Structure
TM2 78 L 2.42x42 Structure Structure
TM2 79 V 2.43x43 Structure Structure
TM2 80 G 2.44x44 Structure Structure
TM2 81 S 2.45x45 Structure Structure
TM2 82 L 2.46x46 Structure Structure
TM2 83 A 2.47x47 Structure Structure
TM2 84 V 2.48x48 Structure Structure
TM2 85 A 2.49x49 Structure Structure
TM2 86 D 2.50x50 Structure Structure
TM2 87 L 2.51x51 Structure Structure
TM2 88 L 2.52x52 Structure Structure
TM2 89 A 2.53x53 Structure Structure
TM2 90 G 2.54x54 Structure Structure
TM2 91 L 2.55x55 Structure Structure
TM2 92 G 2.56x56 Structure Structure
TM2 93 L 2.57x57 Structure Structure
TM2 94 V 2.58x58 Structure Structure
TM2 95 L 2.59x59 Structure Structure
TM2 96 H 2.60x60 Structure Structure
TM2 97 F 2.61x61 Structure Structure
TM2 98 A 2.62x62 Structure Structure
TM2 99 A 2.63x63 Structure Structure
TM2 100 V 2.64x64 Structure Structure
TM2 101 F 2.65x65 Structure Structure
ECL1 102 C - Structure Structure
ECL1 103 I - Structure Structure
ECL1 104 G - Structure Structure
TM3 105 S 3.21x21 Structure Structure
TM3 106 A 3.22x22 Structure Structure
TM3 107 E 3.23x23 Structure Structure
TM3 108 M 3.24x24 Structure Structure
TM3 109 S 3.25x25 Structure Structure
TM3 110 L 3.26x26 Structure Structure
TM3 111 V 3.27x27 Structure Structure
TM3 112 L 3.28x28 Structure Structure
TM3 113 V 3.29x29 Structure Structure
TM3 114 G 3.30x30 Structure Structure
TM3 115 V 3.31x31 Structure Structure
TM3 116 L 3.32x32 Structure Structure
TM3 117 A 3.33x33 Structure Structure
TM3 118 M 3.34x34 Structure Structure
TM3 119 A 3.35x35 Structure Structure
TM3 120 F 3.36x36 Structure Structure
TM3 121 T 3.37x37 Structure Structure
TM3 122 A 3.38x38 Structure Structure
TM3 123 S 3.39x39 Structure Structure
TM3 124 I 3.40x40 Structure Structure
TM3 125 G 3.41x41 Structure Structure
TM3 126 S 3.42x42 Structure Structure
TM3 127 L 3.43x43 Structure Structure
TM3 128 L 3.44x44 Structure Structure
TM3 129 A 3.45x45 Structure Structure
TM3 130 I 3.46x46 Structure Structure
TM3 131 T 3.47x47 Structure Structure
TM3 132 V 3.48x48 Structure Structure
TM3 133 D 3.49x49 Structure Structure
TM3 134 R 3.50x50 Structure Structure
TM3 135 Y 3.51x51 Structure Structure
TM3 136 L 3.52x52 Structure Structure
TM3 137 S 3.53x53 Structure Structure
TM3 138 L 3.54x54 Structure Structure
TM3 139 Y 3.55x55 Structure Structure
TM3 140 N 3.56x56 Structure Structure
ICL2 141 A 34.50x50 Structure Structure
ICL2 142 L 34.51x51 Structure Structure
ICL2 143 T 34.52x52 Structure Structure
ICL2 144 Y 34.53x53 Structure Structure
ICL2 145 Y 34.54x54 Structure Structure
TM4 146 S 4.35x35 Structure Structure
TM4 147 E 4.36x36 Structure Structure
TM4 148 T 4.37x37 Structure Structure
TM4 149 T 4.38x38 Structure Structure
TM4 150 V 4.39x39 Structure Structure
TM4 151 T 4.40x40 Structure Structure
TM4 152 R 4.41x41 Structure Structure
TM4 153 T 4.42x42 Structure Structure
TM4 154 Y 4.43x43 Structure Structure
TM4 155 V 4.44x44 Structure Structure
TM4 156 M 4.45x45 Structure Structure
TM4 157 L 4.46x46 Structure Structure
TM4 158 A 4.47x47 Structure Structure
TM4 159 L 4.48x48 Structure Structure
TM4 160 V 4.49x49 Structure Structure
TM4 161 W 4.50x50 Structure Structure
TM4 162 G 4.51x51 Structure Structure
TM4 163 G 4.52x52 Structure Structure
TM4 164 A 4.53x53 Structure Structure
TM4 165 L 4.54x54 Structure Structure
TM4 166 G 4.55x55 Structure Structure
TM4 167 L 4.56x56 Structure Structure
TM4 168 G 4.57x57 Structure Structure
TM4 169 L 4.58x58 Structure Structure
TM4 170 L 4.59x59 Structure Structure
TM4 171 P 4.60x60 Structure Structure
ECL2 172 V - Structure Structure
ECL2 173 L - Structure Structure
ECL2 174 A - Structure Structure
ECL2 175 W - Structure Structure
ECL2 176 N - Structure Structure
ECL2 177 C - Structure Structure
ECL2 178 L - Structure Structure
ECL2 179 D - Structure Structure
ECL2 180 G - Structure Structure
ECL2 181 L - Structure Structure
ECL2 182 T - Structure Structure
ECL2 183 T - Structure Structure
ECL2 184 C - Structure Structure
ECL2 185 G - Structure Structure
ECL2 186 V - Structure Structure
ECL2 187 V - Structure Structure
ECL2 188 Y - Structure Structure
ECL2 189 P - Structure Structure
ECL2 190 L - Structure Structure
TM5 191 S 5.36x36 Structure Structure
TM5 192 K 5.37x37 Structure Structure
TM5 193 N 5.38x38 Structure Structure
TM5 194 H 5.39x39 Structure Structure
TM5 195 L 5.40x40 Structure Structure
TM5 196 V 5.41x41 Structure Structure
TM5 197 V 5.42x42 Structure Structure
TM5 198 L 5.43x43 Structure Structure
TM5 199 A 5.44x44 Structure Structure
TM5 200 I 5.45x45 Structure Structure
TM5 201 A 5.46x46 Structure Structure
TM5 202 F 5.47x47 Structure Structure
TM5 203 F 5.48x48 Structure Structure
TM5 204 M 5.49x49 Structure Structure
TM5 205 V 5.50x50 Structure Structure
TM5 206 F 5.51x51 Structure Structure
TM5 207 G 5.52x52 Structure Structure
TM5 208 I 5.53x53 Structure Structure
TM5 209 M 5.54x54 Structure Structure
TM5 210 L 5.55x55 Structure Structure
TM5 211 Q 5.56x56 Structure Structure
TM5 212 L 5.57x57 Structure Structure
TM5 213 Y 5.58x58 Structure Structure
TM5 214 A 5.59x59 Structure Structure
TM5 215 Q 5.60x60 Structure Structure
TM5 216 I 5.61x61 Structure Structure
TM5 217 C 5.62x62 Structure Structure
TM5 218 R 5.63x63 Structure Structure
TM5 219 I 5.64x64 Structure Structure
TM5 220 V 5.65x65 Structure Structure
TM5 221 C 5.66x66 Structure Structure
TM5 222 R 5.67x67 Structure Structure
TM5 223 H 5.68x68 Structure Structure
TM5 224 A 5.69x69 Structure Structure
TM5 225 Q 5.70x70 Structure Structure
TM5 226 Q 5.71x71 Structure Structure
TM5 227 I 5.72x72 Structure Structure
TM5 228 A 5.73x73 Structure Structure
TM5 229 L 5.74x74 Structure Structure
TM5 230 Q 5.75x75 Structure Structure
TM5 231 R 5.76x76 Structure Structure
ICL3 232 H - Structure Structure
ICL3 233 L - AF2 AF2
TM6 234 L 6.22x22 AF2 AF2
TM6 235 P 6.23x23 AF2 AF2
TM6 236 A 6.24x24 AF2 AF2
TM6 237 S 6.25x25 AF2 AF2
TM6 238 H 6.26x26 AF2 AF2
TM6 239 Y 6.27x27 AF2 AF2
TM6 240 V 6.28x28 AF2 AF2
TM6 241 A 6.29x29 AF2 AF2
TM6 242 T 6.30x30 AF2 AF2
TM6 243 R 6.31x31 Structure Structure
TM6 244 K 6.32x32 Structure Structure
TM6 245 G 6.33x33 Structure Structure
TM6 246 I 6.34x34 Structure Structure
TM6 247 A 6.35x35 Structure Structure
TM6 248 T 6.36x36 Structure Structure
TM6 249 L 6.37x37 Structure Structure
TM6 250 A 6.38x38 Structure Structure
TM6 251 V 6.39x39 Structure Structure
TM6 252 V 6.40x40 Structure Structure
TM6 253 L 6.41x41 Structure Structure
TM6 254 G 6.42x42 Structure Structure
TM6 255 A 6.43x43 Structure Structure
TM6 256 F 6.44x44 Structure Structure
TM6 257 A 6.45x45 Structure Structure
TM6 258 A 6.46x46 Structure Structure
TM6 259 C 6.47x47 Structure Structure
TM6 260 W 6.48x48 Structure Structure
TM6 261 L 6.49x49 Structure Structure
TM6 262 P 6.50x50 Structure Structure
TM6 263 F 6.51x51 Structure Structure
TM6 264 T 6.52x52 Structure Structure
TM6 265 V 6.53x53 Structure Structure
TM6 266 Y 6.54x54 Structure Structure
TM6 267 C 6.55x55 Structure Structure
TM6 268 L 6.56x56 Structure Structure
TM6 269 L 6.57x57 Structure Structure
TM6 270 G 6.58x58 Structure Structure
ECL3 271 D - Structure Structure
ECL3 272 A - Structure Structure
ECL3 273 H - Structure Structure
ECL3 274 S - Structure Structure
TM7 275 P 7.31x30 Structure Structure
TM7 276 P 7.32x31 Structure Structure
TM7 277 L 7.33x32 Structure Structure
TM7 278 Y 7.34x33 Structure Structure
TM7 279 T 7.35x34 Structure Structure
TM7 280 Y 7.36x35 Structure Structure
TM7 281 L 7.37x36 Structure Structure
TM7 282 T 7.38x37 Structure Structure
TM7 283 L 7.39x38 Structure Structure
TM7 284 L 7.40x39 Structure Structure
TM7 285 P 7.41x40 Structure Structure
TM7 286 A 7.42x41 Structure Structure
TM7 287 T 7.43x42 Structure Structure
TM7 288 Y 7.44x43 Structure Structure
TM7 289 N 7.45x45 Structure Structure
TM7 290 S 7.46x46 Structure Structure
TM7 291 M 7.47x47 Structure Structure
TM7 292 I 7.48x48 Structure Structure
TM7 293 N 7.49x49 Structure Structure
TM7 294 P 7.50x50 Structure Structure
TM7 295 I 7.51x51 Structure Structure
TM7 296 I 7.52x52 Structure Structure
TM7 297 Y 7.53x53 Structure Structure
TM7 298 A 7.54x54 Structure Structure
TM7 299 F 7.55x55 Structure Structure
TM7 300 R 7.56x56 Structure Structure
H8 301 N 8.47x47 Structure Structure
H8 302 Q 8.48x48 Structure Structure
H8 303 D 8.49x49 Structure Structure
H8 304 V 8.50x50 Structure Structure
H8 305 Q 8.51x51 Structure Structure
H8 306 K 8.52x52 Structure Structure
H8 307 V 8.53x53 Structure Structure
H8 308 L 8.54x54 Structure Structure
H8 309 W 8.55x55 Structure Structure
H8 310 A 8.56x56 Structure Structure
H8 311 V 8.57x57 Structure Structure
H8 312 C 8.58x58 Structure Structure
H8 313 C 8.59x59 Structure Structure
C-term 314 C - AF2 AF2
C-term 315 C - AF2 AF2
C-term 316 S - AF2 AF2
C-term 317 S - AF2 AF2
C-term 318 S - AF2 AF2
C-term 319 K - AF2 AF2
C-term 320 I - AF2 AF2
C-term 321 P - AF2 AF2
C-term 322 F - AF2 AF2
C-term 323 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 142 34x51 G.H5 R 380 G.H5.12
Aromatic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 138 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 138 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 Q 230 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM5 Q 230 5x75 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 L 142 34x51 G.S3 V 217 G.S3.01
Ionic ICL3 H 232 - G.H4 D 343 G.H4.13
Polar ICL3 H 232 - G.H4 D 343 G.H4.13
Hydrophobic ICL2 L 142 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM5 V 220 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 220 5x65 G.H5 L 393 G.H5.25
Ionic ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Polar TM4 S 146 4x35 G.hns1 R 38 G.hns1.02
Hydrophobic TM4 S 146 4x35 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 S 146 4x35 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 L 138 3x54 G.H5 H 387 G.H5.19
Polar TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Polar ICL2 L 142 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 142 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 142 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 142 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 142 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM6 L 249 6x37 G.H5 L 393 G.H5.25
Polar TM6 T 248 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 248 6x36 G.H5 E 392 G.H5.24
Ionic TM4 E 147 4x36 G.hns1 R 38 G.hns1.02
Polar TM4 E 147 4x36 G.hns1 R 38 G.hns1.02
Hydrophobic TM4 E 147 4x36 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 E 147 4x36 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 219 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 141 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 141 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 Y 145 34x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 H 223 5x68 G.H5 L 394 G.H5.26
Polar TM6 G 245 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 245 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 245 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 A 141 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 142 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 I 216 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 216 5x61 G.H5 L 393 G.H5.25
Polar TM5 Q 230 5x75 G.S6 C 359 G.S6.01
Van-der-waals TM5 Q 230 5x75 G.S6 C 359 G.S6.01
Hydrophobic TM6 K 244 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 138 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 138 3x54 G.H5 Y 391 G.H5.23
Van-der-waals ICL3 L 233 - G.H4 R 347 G.H4.17
Hydrophobic TM5 I 227 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 H 223 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM5 V 220 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 220 5x65 G.H5 L 388 G.H5.20
Polar ICL2 Y 145 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Y 145 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 145 34x54 G.hns1 R 38 G.hns1.02
Ionic TM7 R 300 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 R 300 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 227 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 227 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 V 220 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM4 E 147 4x36 G.HN Q 35 G.HN.52
Hydrophobic TM5 H 223 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 223 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 229 5x74 G.hgh4 D 323 G.hgh4.13
Polar TM5 R 222 5x67 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 222 5x67 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 227 5x72 G.H5 R 385 G.H5.17
Polar TM3 L 138 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 138 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 143 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 Y 144 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 A 141 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 A 141 34x50 G.H5 Q 384 G.H5.16
Polar TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Polar H8 N 301 8x47 G.H5 Q 390 G.H5.22
Ionic TM5 H 223 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 223 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 223 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 223 5x68 G.H5 D 381 G.H5.13
Van-der-waals C-term R 323 - G.h2s4 N 239 G.h2s4.02