Refined structure (8WST) of Gq - MCH2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 205 from structure (57.1%), 154 from model (42.9%)
Residue sidechains - 107 from structure (29.8%), 252 from model (70.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure AF2
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure Structure
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure Structure
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 AF2 AF2
G.hfs2 187 T G.hfs2.06 AF2 AF2
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure Structure
G.s3h2 209 Q G.s3h2.03 Structure Structure
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 AF2 AF2
G.hgh4 292 F G.hgh4.02 AF2 AF2
G.hgh4 293 P G.hgh4.03 AF2 AF2
G.hgh4 294 E G.hgh4.04 AF2 AF2
G.hgh4 295 Y G.hgh4.05 AF2 AF2
G.hgh4 296 D G.hgh4.06 AF2 AF2
G.hgh4 297 G G.hgh4.07 AF2 AF2
G.hgh4 298 P G.hgh4.08 AF2 AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 287 from structure (86.4%), 45 from model (13.6%)
Residue sidechains - 281 from structure (84.6%), 51 from model (15.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 F - AF2 AF2
N-term 5 H - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 C - AF2 AF2
N-term 9 W - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 T - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 A - AF2 AF2
N-term 14 E - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 N - AF2 AF2
N-term 18 K - AF2 AF2
N-term 19 S - AF2 AF2
N-term 20 W - AF2 AF2
N-term 21 N - AF2 AF2
N-term 22 K - AF2 AF2
N-term 23 E - AF2 AF2
N-term 24 F - AF2 AF2
N-term 25 A - AF2 AF2
N-term 26 Y - AF2 AF2
N-term 27 Q - AF2 AF2
N-term 28 T - AF2 AF2
N-term 29 A - AF2 AF2
N-term 30 S - AF2 AF2
TM1 31 V 1.29x29 Structure Structure
TM1 32 V 1.30x30 Structure Structure
TM1 33 D 1.31x31 Structure Structure
TM1 34 T 1.32x32 Structure Structure
TM1 35 V 1.33x33 Structure Structure
TM1 36 I 1.34x34 Structure Structure
TM1 37 L 1.35x35 Structure Structure
TM1 38 P 1.36x36 Structure Structure
TM1 39 S 1.37x37 Structure Structure
TM1 40 M 1.38x38 Structure Structure
TM1 41 I 1.39x39 Structure Structure
TM1 42 G 1.40x40 Structure Structure
TM1 43 I 1.41x41 Structure Structure
TM1 44 I 1.42x42 Structure Structure
TM1 45 C 1.43x43 Structure Structure
TM1 46 S 1.44x44 Structure Structure
TM1 47 T 1.45x45 Structure Structure
TM1 48 G 1.46x46 Structure Structure
TM1 49 L 1.47x47 Structure Structure
TM1 50 V 1.48x48 Structure Structure
TM1 51 G 1.49x49 Structure Structure
TM1 52 N 1.50x50 Structure Structure
TM1 53 I 1.51x51 Structure Structure
TM1 54 L 1.52x52 Structure Structure
TM1 55 I 1.53x53 Structure Structure
TM1 56 V 1.54x54 Structure Structure
TM1 57 F 1.55x55 Structure Structure
TM1 58 T 1.56x56 Structure Structure
TM1 59 I 1.57x57 Structure Structure
TM1 60 I 1.58x58 Structure Structure
TM1 61 R 1.59x59 Structure Structure
TM1 62 S 1.60x60 Structure Structure
ICL1 63 R - Structure Structure
ICL1 64 K - Structure Structure
ICL1 65 K - Structure Structure
TM2 66 T 2.37x37 Structure Structure
TM2 67 V 2.38x38 Structure Structure
TM2 68 P 2.39x39 Structure Structure
TM2 69 D 2.40x40 Structure Structure
TM2 70 I 2.41x41 Structure Structure
TM2 71 Y 2.42x42 Structure Structure
TM2 72 I 2.43x43 Structure Structure
TM2 73 C 2.44x44 Structure Structure
TM2 74 N 2.45x45 Structure Structure
TM2 75 L 2.46x46 Structure Structure
TM2 76 A 2.47x47 Structure Structure
TM2 77 V 2.48x48 Structure Structure
TM2 78 A 2.49x49 Structure Structure
TM2 79 D 2.50x50 Structure Structure
TM2 80 L 2.51x51 Structure Structure
TM2 81 V 2.52x52 Structure Structure
TM2 82 H 2.53x53 Structure Structure
TM2 83 I 2.54x54 Structure Structure
TM2 84 V 2.55x55 Structure Structure
TM2 85 G 2.56x56 Structure Structure
TM2 86 M 2.57x57 Structure Structure
TM2 87 P 2.58x58 Structure Structure
TM2 88 F 2.59x59 Structure Structure
TM2 89 L 2.60x60 Structure Structure
TM2 90 I 2.61x61 Structure Structure
TM2 91 H 2.62x62 Structure Structure
TM2 92 Q 2.63x63 Structure Structure
TM2 93 W 2.64x64 Structure Structure
TM2 94 A 2.65x65 Structure Structure
TM2 95 R 2.66x66 Structure Structure
TM2 96 G 2.67x67 Structure Structure
ECL1 97 G - Structure Structure
ECL1 98 E 23.49x49 Structure Structure
ECL1 99 W 23.50x50 Structure Structure
ECL1 100 V 23.51x51 Structure Structure
ECL1 101 F 23.52x52 Structure Structure
TM3 102 G 3.21x21 Structure Structure
TM3 103 G 3.22x22 Structure Structure
TM3 104 P 3.23x23 Structure Structure
TM3 105 L 3.24x24 Structure Structure
TM3 106 C 3.25x25 Structure Structure
TM3 107 T 3.26x26 Structure Structure
TM3 108 I 3.27x27 Structure Structure
TM3 109 I 3.28x28 Structure Structure
TM3 110 T 3.29x29 Structure Structure
TM3 111 S 3.30x30 Structure Structure
TM3 112 L 3.31x31 Structure Structure
TM3 113 D 3.32x32 Structure Structure
TM3 114 T 3.33x33 Structure Structure
TM3 115 C 3.34x34 Structure Structure
TM3 116 N 3.35x35 Structure Structure
TM3 117 Q 3.36x36 Structure Structure
TM3 118 F 3.37x37 Structure Structure
TM3 119 A 3.38x38 Structure Structure
TM3 120 C 3.39x39 Structure Structure
TM3 121 S 3.40x40 Structure Structure
TM3 122 A 3.41x41 Structure Structure
TM3 123 I 3.42x42 Structure Structure
TM3 124 M 3.43x43 Structure Structure
TM3 125 T 3.44x44 Structure Structure
TM3 126 V 3.45x45 Structure Structure
TM3 127 M 3.46x46 Structure Structure
TM3 128 S 3.47x47 Structure Structure
TM3 129 V 3.48x48 Structure Structure
TM3 130 D 3.49x49 Structure Structure
TM3 131 R 3.50x50 Structure Structure
TM3 132 Y 3.51x51 Structure Structure
TM3 133 F 3.52x52 Structure Structure
TM3 134 A 3.53x53 Structure Structure
TM3 135 L 3.54x54 Structure Structure
TM3 136 V 3.55x55 Structure Structure
TM3 137 Q 3.56x56 Structure Structure
ICL2 138 P 34.50x50 Structure Structure
ICL2 139 F 34.51x51 Structure Structure
ICL2 140 R 34.52x52 Structure Structure
ICL2 141 L 34.53x53 Structure Structure
ICL2 142 T 34.54x54 Structure Structure
ICL2 143 R 34.55x55 Structure Structure
ICL2 144 W 34.56x56 Structure Structure
ICL2 145 R 34.57x57 Structure Structure
TM4 146 T 4.38x38 Structure Structure
TM4 147 R 4.39x39 Structure Structure
TM4 148 Y 4.40x40 Structure Structure
TM4 149 K 4.41x41 Structure Structure
TM4 150 T 4.42x42 Structure Structure
TM4 151 I 4.43x43 Structure Structure
TM4 152 R 4.44x44 Structure Structure
TM4 153 I 4.45x45 Structure Structure
TM4 154 N 4.46x46 Structure Structure
TM4 155 L 4.47x47 Structure Structure
TM4 156 G 4.48x48 Structure Structure
TM4 157 L 4.49x49 Structure Structure
TM4 158 W 4.50x50 Structure Structure
TM4 159 A 4.51x51 Structure Structure
TM4 160 A 4.52x52 Structure Structure
TM4 161 S 4.53x53 Structure Structure
TM4 162 F 4.54x54 Structure Structure
TM4 163 I 4.55x55 Structure Structure
TM4 164 L 4.56x56 Structure Structure
TM4 165 A 4.57x57 Structure Structure
TM4 166 L 4.58x59 Structure Structure
TM4 167 P 4.59x60 Structure Structure
TM4 168 V 4.60x61 Structure Structure
TM4 169 W 4.61x62 Structure Structure
TM4 170 V 4.62x63 Structure Structure
TM4 171 Y 4.63x64 Structure Structure
TM4 172 S 4.64x65 Structure Structure
ECL2 173 K - Structure Structure
ECL2 174 V - Structure Structure
ECL2 175 I - Structure Structure
ECL2 176 K - Structure Structure
ECL2 177 F - Structure Structure
ECL2 178 K - Structure Structure
ECL2 179 D - Structure Structure
ECL2 180 G - Structure Structure
ECL2 181 V - Structure Structure
ECL2 182 E - Structure AF2
ECL2 183 S - Structure Structure
ECL2 184 C 45.50x50 Structure Structure
ECL2 185 A 45.51x51 Structure Structure
ECL2 186 F 45.52x52 Structure Structure
ECL2 187 D - Structure Structure
ECL2 188 L - Structure Structure
ECL2 189 T - Structure Structure
TM5 190 S 5.31x32 Structure Structure
TM5 191 P 5.32x33 Structure Structure
TM5 192 D 5.33x34 Structure Structure
TM5 193 D 5.34x35 Structure Structure
TM5 194 V 5.35x36 Structure Structure
TM5 195 L 5.36x37 Structure Structure
TM5 196 W 5.37x38 Structure Structure
TM5 197 Y 5.38x39 Structure Structure
TM5 198 T 5.39x40 Structure Structure
TM5 199 L 5.40x41 Structure Structure
TM5 200 Y 5.41x42 Structure Structure
TM5 201 L 5.42x43 Structure Structure
TM5 202 T 5.43x44 Structure Structure
TM5 203 I 5.44x45 Structure Structure
TM5 204 T 5.45x46 Structure Structure
TM5 205 T 5.46x461 Structure Structure
TM5 206 F 5.47x47 Structure Structure
TM5 207 F 5.48x48 Structure Structure
TM5 208 F 5.49x49 Structure Structure
TM5 209 P 5.50x50 Structure Structure
TM5 210 L 5.51x51 Structure Structure
TM5 211 P 5.52x52 Structure Structure
TM5 212 L 5.53x53 Structure Structure
TM5 213 I 5.54x54 Structure Structure
TM5 214 L 5.55x55 Structure Structure
TM5 215 V 5.56x56 Structure Structure
TM5 216 C 5.57x57 Structure Structure
TM5 217 Y 5.58x58 Structure Structure
TM5 218 I 5.59x59 Structure Structure
TM5 219 L 5.60x60 Structure Structure
TM5 220 I 5.61x61 Structure Structure
TM5 221 L 5.62x62 Structure Structure
TM5 222 C 5.63x63 Structure Structure
TM5 223 Y 5.64x64 Structure Structure
TM5 224 T 5.65x65 Structure Structure
TM5 225 W 5.66x66 Structure Structure
TM5 226 E 5.67x67 Structure Structure
TM5 227 M 5.68x68 Structure Structure
TM5 228 Y 5.69x69 Structure Structure
TM5 229 Q 5.70x70 Structure Structure
TM5 230 Q 5.71x71 Structure Structure
TM5 231 N 5.72x72 Structure Structure
TM5 232 K 5.73x73 Structure Structure
ICL3 233 D - Structure Structure
ICL3 234 A - Structure Structure
ICL3 235 R - Structure AF2
ICL3 236 C - Structure Structure
ICL3 237 C - Structure Structure
TM6 238 N 6.22x22 Structure Structure
TM6 239 P 6.23x23 Structure Structure
TM6 240 S 6.24x24 Structure Structure
TM6 241 V 6.25x25 Structure Structure
TM6 242 P 6.26x26 Structure Structure
TM6 243 K 6.27x27 Structure AF2
TM6 244 Q 6.28x28 Structure AF2
TM6 245 R 6.29x29 Structure Structure
TM6 246 V 6.30x30 Structure Structure
TM6 247 M 6.31x31 Structure Structure
TM6 248 K 6.32x32 Structure Structure
TM6 249 L 6.33x33 Structure Structure
TM6 250 T 6.34x34 Structure Structure
TM6 251 K 6.35x35 Structure Structure
TM6 252 M 6.36x36 Structure Structure
TM6 253 V 6.37x37 Structure Structure
TM6 254 L 6.38x38 Structure Structure
TM6 255 V 6.39x39 Structure Structure
TM6 256 L 6.40x40 Structure AF2
TM6 257 V 6.41x41 Structure Structure
TM6 258 V 6.42x42 Structure Structure
TM6 259 V 6.43x43 Structure Structure
TM6 260 F 6.44x44 Structure Structure
TM6 261 I 6.45x45 Structure Structure
TM6 262 L 6.46x46 Structure Structure
TM6 263 S 6.47x47 Structure Structure
TM6 264 A 6.48x48 Structure Structure
TM6 265 A 6.49x49 Structure Structure
TM6 266 P 6.50x50 Structure Structure
TM6 267 Y 6.51x51 Structure Structure
TM6 268 H 6.52x52 Structure Structure
TM6 269 V 6.53x53 Structure Structure
TM6 270 I 6.54x54 Structure Structure
TM6 271 Q 6.55x55 Structure Structure
TM6 272 L 6.56x56 Structure Structure
TM6 273 V 6.57x57 Structure Structure
TM6 274 N 6.58x58 Structure Structure
TM6 275 L 6.59x59 Structure Structure
TM6 276 Q 6.60x60 Structure Structure
TM6 277 M 6.61x61 Structure Structure
ECL3 278 E - Structure Structure
ECL3 279 Q - Structure Structure
ECL3 280 P - Structure Structure
TM7 281 T 7.28x27 Structure Structure
TM7 282 L 7.29x28 Structure Structure
TM7 283 A 7.30x29 Structure Structure
TM7 284 F 7.31x30 Structure Structure
TM7 285 Y 7.32x31 Structure Structure
TM7 286 V 7.33x32 Structure Structure
TM7 287 G 7.34x33 Structure Structure
TM7 288 Y 7.35x34 Structure Structure
TM7 289 Y 7.36x35 Structure Structure
TM7 290 L 7.37x36 Structure Structure
TM7 291 S 7.38x37 Structure Structure
TM7 292 I 7.39x38 Structure Structure
TM7 293 C 7.40x39 Structure Structure
TM7 294 L 7.41x40 Structure Structure
TM7 295 S 7.42x41 Structure Structure
TM7 296 Y 7.43x42 Structure Structure
TM7 297 A 7.44x43 Structure Structure
TM7 298 S 7.45x45 Structure Structure
TM7 299 S 7.46x46 Structure Structure
TM7 300 S 7.47x47 Structure Structure
TM7 301 I 7.48x48 Structure Structure
TM7 302 N 7.49x49 Structure Structure
TM7 303 P 7.50x50 Structure Structure
TM7 304 F 7.51x51 Structure Structure
TM7 305 L 7.52x52 Structure Structure
TM7 306 Y 7.53x53 Structure Structure
TM7 307 I 7.54x54 Structure Structure
TM7 308 L 7.55x55 Structure Structure
TM7 309 L 7.56x56 Structure Structure
H8 310 S 8.47x47 Structure Structure
H8 311 G 8.48x48 Structure Structure
H8 312 N 8.49x49 Structure Structure
H8 313 F 8.50x50 Structure AF2
H8 314 Q 8.51x51 Structure Structure
H8 315 K 8.52x52 Structure Structure
H8 316 R 8.53x53 Structure Structure
H8 317 L 8.54x54 Structure Structure
H8 318 P 8.55x55 AF2 AF2
H8 319 Q 8.56x56 AF2 AF2
H8 320 I 8.57x57 AF2 AF2
H8 321 Q 8.58x58 AF2 AF2
H8 322 R 8.59x59 AF2 AF2
C-term 323 R - AF2 AF2
C-term 324 A - AF2 AF2
C-term 325 T - AF2 AF2
C-term 326 E - AF2 AF2
C-term 327 K - AF2 AF2
C-term 328 E - AF2 AF2
C-term 329 I - AF2 AF2
C-term 330 N - AF2 AF2
C-term 331 N - AF2 AF2
C-term 332 M - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 N 238 6x22 G.H4 V 314 G.H4.16
Hydrophobic H8 F 313 8x50 G.H5 N 357 G.H5.24
Hydrophobic ICL3 C 237 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 C 237 - G.H4 V 314 G.H4.16
Hydrophobic TM6 L 249 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 M 252 6x36 G.H5 Y 356 G.H5.23
Hydrophobic TM5 M 227 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 M 227 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM5 Y 223 5x64 G.H5 L 349 G.H5.16
Polar TM5 Y 223 5x64 G.H5 K 345 G.H5.12
Hydrophobic TM5 Y 223 5x64 G.H5 K 345 G.H5.12
Van-der-waals TM5 Y 223 5x64 G.H5 K 345 G.H5.12
Hydrophobic TM6 M 252 6x36 G.H5 N 357 G.H5.24
Hydrophobic ICL3 A 234 - G.S6 H 327 G.S6.04
Hydrophobic ICL2 F 139 34x51 G.H5 K 345 G.H5.12
Hydrophobic ICL3 R 235 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 R 235 - G.h4s6 I 323 G.h4s6.20
Hydrophobic TM3 L 135 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM6 Q 244 6x28 G.H5 V 359 G.H5.26
Van-der-waals TM6 Q 244 6x28 G.H5 V 359 G.H5.26
Hydrophobic TM3 L 135 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM5 M 227 5x68 G.H5 K 345 G.H5.12
Van-der-waals H8 S 310 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM3 R 131 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM2 P 68 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM4 K 149 4x41 G.HN R 34 G.HN.52
Hydrophobic TM6 N 238 6x22 G.H4 K 311 G.H4.13
Van-der-waals TM6 N 238 6x22 G.H4 K 311 G.H4.13
Van-der-waals ICL2 R 143 34x55 G.hns1 R 38 G.hns1.03
Polar TM5 N 231 5x72 G.H5 D 346 G.H5.13
Hydrophobic TM5 N 231 5x72 G.H5 D 346 G.H5.13
Van-der-waals TM5 N 231 5x72 G.H5 D 346 G.H5.13
Hydrophobic TM3 A 134 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 134 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM6 M 252 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 M 252 6x36 G.H5 L 358 G.H5.25
Hydrophobic ICL3 C 237 - G.H4 L 310 G.H4.12
Van-der-waals ICL3 C 237 - G.H4 L 310 G.H4.12
Hydrophobic TM2 P 68 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 P 68 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 T 142 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 F 139 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM6 V 253 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 139 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 F 139 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM3 L 135 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 L 135 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM6 L 249 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 249 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM5 M 227 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 M 227 5x68 G.H5 D 346 G.H5.13
Polar ICL2 R 143 34x55 G.HN R 34 G.HN.52
Hydrophobic ICL2 R 143 34x55 G.HN R 34 G.HN.52
Van-der-waals ICL2 R 143 34x55 G.HN R 34 G.HN.52
Hydrophobic TM3 R 131 3x50 G.H5 Y 356 G.H5.23
Polar TM7 Y 306 7x53 G.H5 N 357 G.H5.24
Polar TM3 D 130 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 130 3x49 G.H5 Y 356 G.H5.23
Polar TM3 A 134 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 F 139 34x51 G.S1 L 40 G.S1.02
Polar ICL3 R 235 - G.S6 Y 325 G.S6.02
Ionic ICL3 R 235 - G.H5 D 346 G.H5.13
Polar ICL3 R 235 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 R 235 - G.H5 D 346 G.H5.13
Polar H8 G 311 8x48 G.H5 N 357 G.H5.24
Hydrophobic TM3 L 135 3x54 G.H5 N 352 G.H5.19
Van-der-waals TM3 L 135 3x54 G.H5 N 352 G.H5.19
Polar TM4 T 146 4x38 G.HN R 34 G.HN.52
Hydrophobic ICL3 A 234 - G.S6 Y 325 G.S6.02
Hydrophobic ICL2 P 138 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 348 G.H5.15