Refined structure (8X17) of Gi1 - A3 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (61.3%), 137 from model (38.7%)
Residue sidechains - 215 from structure (60.7%), 139 from model (39.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 280 from structure (88.1%), 38 from model (11.9%)
Residue sidechains - 280 from structure (88.1%), 38 from model (11.9%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 P - AF2 AF2
N-term 3 N - AF2 AF2
N-term 4 N - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 L - AF2 AF2
TM1 9 S 1.29x29 Structure Structure
TM1 10 L 1.30x30 Structure Structure
TM1 11 A 1.31x31 Structure Structure
TM1 12 N 1.32x32 Structure Structure
TM1 13 V 1.33x33 Structure Structure
TM1 14 T 1.34x34 Structure Structure
TM1 15 Y 1.35x35 Structure Structure
TM1 16 I 1.36x36 Structure Structure
TM1 17 T 1.37x37 Structure Structure
TM1 18 M 1.38x38 Structure Structure
TM1 19 E 1.39x39 Structure Structure
TM1 20 I 1.40x40 Structure Structure
TM1 21 F 1.41x41 Structure Structure
TM1 22 I 1.42x42 Structure Structure
TM1 23 G 1.43x43 Structure Structure
TM1 24 L 1.44x44 Structure Structure
TM1 25 C 1.45x45 Structure Structure
TM1 26 A 1.46x46 Structure Structure
TM1 27 I 1.47x47 Structure Structure
TM1 28 V 1.48x48 Structure Structure
TM1 29 G 1.49x49 Structure Structure
TM1 30 N 1.50x50 Structure Structure
TM1 31 V 1.51x51 Structure Structure
TM1 32 L 1.52x52 Structure Structure
TM1 33 V 1.53x53 Structure Structure
TM1 34 I 1.54x54 Structure Structure
TM1 35 C 1.55x55 Structure Structure
TM1 36 V 1.56x56 Structure Structure
TM1 37 V 1.57x57 Structure Structure
TM1 38 K 1.58x58 Structure Structure
TM1 39 L 1.59x59 Structure Structure
TM1 40 N 1.60x60 Structure Structure
ICL1 41 P 12.48x48 Structure Structure
ICL1 42 S 12.49x49 Structure Structure
ICL1 43 L 12.50x50 Structure Structure
ICL1 44 Q 12.51x51 Structure Structure
TM2 45 T 2.37x37 Structure Structure
TM2 46 T 2.38x38 Structure Structure
TM2 47 T 2.39x39 Structure Structure
TM2 48 F 2.40x40 Structure Structure
TM2 49 Y 2.41x41 Structure Structure
TM2 50 F 2.42x42 Structure Structure
TM2 51 I 2.43x43 Structure Structure
TM2 52 V 2.44x44 Structure Structure
TM2 53 S 2.45x45 Structure Structure
TM2 54 L 2.46x46 Structure Structure
TM2 55 A 2.47x47 Structure Structure
TM2 56 L 2.48x48 Structure Structure
TM2 57 A 2.49x49 Structure Structure
TM2 58 D 2.50x50 Structure Structure
TM2 59 I 2.51x51 Structure Structure
TM2 60 A 2.52x52 Structure Structure
TM2 61 V 2.53x53 Structure Structure
TM2 62 G 2.54x54 Structure Structure
TM2 63 V 2.55x55 Structure Structure
TM2 64 L 2.56x551 Structure Structure
TM2 65 V 2.57x56 Structure Structure
TM2 66 M 2.58x57 Structure Structure
TM2 67 P 2.59x58 Structure Structure
TM2 68 L 2.60x59 Structure Structure
TM2 69 A 2.61x60 Structure Structure
TM2 70 I 2.62x61 Structure Structure
TM2 71 V 2.63x62 Structure Structure
TM2 72 V 2.64x63 Structure Structure
TM2 73 S 2.65x64 Structure Structure
TM2 74 L 2.66x65 Structure Structure
TM2 75 G 2.67x66 Structure Structure
ECL1 76 I 23.50x50 Structure Structure
ECL1 77 T 23.51x51 Structure Structure
ECL1 78 I 23.52x52 Structure Structure
TM3 79 H 3.21x21 Structure Structure
TM3 80 F 3.22x22 Structure Structure
TM3 81 Y 3.23x23 Structure Structure
TM3 82 S 3.24x24 Structure Structure
TM3 83 C 3.25x25 Structure Structure
TM3 84 L 3.26x26 Structure Structure
TM3 85 F 3.27x27 Structure Structure
TM3 86 M 3.28x28 Structure Structure
TM3 87 T 3.29x29 Structure Structure
TM3 88 C 3.30x30 Structure Structure
TM3 89 L 3.31x31 Structure Structure
TM3 90 L 3.32x32 Structure Structure
TM3 91 L 3.33x33 Structure Structure
TM3 92 I 3.34x34 Structure Structure
TM3 93 F 3.35x35 Structure Structure
TM3 94 T 3.36x36 Structure Structure
TM3 95 H 3.37x37 Structure Structure
TM3 96 A 3.38x38 Structure Structure
TM3 97 S 3.39x39 Structure Structure
TM3 98 I 3.40x40 Structure Structure
TM3 99 M 3.41x41 Structure Structure
TM3 100 S 3.42x42 Structure Structure
TM3 101 L 3.43x43 Structure Structure
TM3 102 L 3.44x44 Structure Structure
TM3 103 A 3.45x45 Structure Structure
TM3 104 I 3.46x46 Structure Structure
TM3 105 A 3.47x47 Structure Structure
TM3 106 V 3.48x48 Structure Structure
TM3 107 D 3.49x49 Structure Structure
TM3 108 R 3.50x50 Structure Structure
TM3 109 Y 3.51x51 Structure Structure
TM3 110 L 3.52x52 Structure Structure
TM3 111 R 3.53x53 Structure Structure
TM3 112 V 3.54x54 Structure Structure
TM3 113 K 3.55x55 Structure Structure
TM3 114 L 3.56x56 Structure Structure
ICL2 115 T 34.50x50 Structure Structure
ICL2 116 V 34.51x51 Structure Structure
ICL2 117 R 34.52x52 Structure Structure
ICL2 118 Y 34.53x53 Structure Structure
ICL2 119 K 34.54x54 Structure Structure
ICL2 120 R 34.55x55 Structure Structure
ICL2 121 V 34.56x56 Structure Structure
ICL2 122 T 34.57x57 Structure Structure
TM4 123 T 4.38x38 Structure Structure
TM4 124 H 4.39x39 Structure Structure
TM4 125 R 4.40x40 Structure Structure
TM4 126 R 4.41x41 Structure Structure
TM4 127 I 4.42x42 Structure Structure
TM4 128 W 4.43x43 Structure Structure
TM4 129 L 4.44x44 Structure Structure
TM4 130 A 4.45x45 Structure Structure
TM4 131 L 4.46x46 Structure Structure
TM4 132 G 4.47x47 Structure Structure
TM4 133 L 4.48x48 Structure Structure
TM4 134 C 4.49x49 Structure Structure
TM4 135 W 4.50x50 Structure Structure
TM4 136 L 4.51x51 Structure Structure
TM4 137 V 4.52x52 Structure Structure
TM4 138 S 4.53x53 Structure Structure
TM4 139 F 4.54x54 Structure Structure
TM4 140 L 4.55x55 Structure Structure
TM4 141 V 4.56x56 Structure Structure
TM4 142 G 4.57x57 Structure Structure
TM4 143 L 4.58x58 Structure Structure
TM4 144 T 4.59x59 Structure Structure
TM4 145 P 4.60x60 Structure Structure
TM4 146 M 4.61x61 Structure Structure
TM4 147 F 4.62x62 Structure Structure
TM4 148 G 4.63x63 Structure Structure
ECL2 149 W - Structure Structure
ECL2 150 N - Structure Structure
ECL2 151 M - Structure Structure
ECL2 152 K - Structure Structure
ECL2 153 L - Structure Structure
ECL2 154 T - Structure Structure
ECL2 155 S - Structure Structure
ECL2 156 E - Structure Structure
ECL2 157 Y - Structure Structure
ECL2 158 H - Structure Structure
ECL2 159 R - Structure Structure
ECL2 160 N - Structure Structure
ECL2 161 V - Structure Structure
ECL2 162 T - Structure Structure
ECL2 163 F - Structure Structure
ECL2 164 L - Structure Structure
ECL2 165 S - Structure Structure
ECL2 166 C 45.50x50 Structure Structure
ECL2 167 Q 45.51x51 Structure Structure
ECL2 168 F 45.52x52 Structure Structure
ECL2 169 V - Structure Structure
ECL2 170 S - Structure Structure
ECL2 171 V - Structure Structure
ECL2 172 M - Structure Structure
TM5 173 R 5.34x36 Structure Structure
TM5 174 M 5.35x37 Structure Structure
TM5 175 D 5.36x38 Structure Structure
TM5 176 Y 5.37x39 Structure Structure
TM5 177 M 5.38x40 Structure Structure
TM5 178 V 5.39x41 Structure Structure
TM5 179 Y 5.40x411 Structure Structure
TM5 180 F 5.41x42 Structure Structure
TM5 181 S 5.42x43 Structure Structure
TM5 182 F 5.43x44 Structure Structure
TM5 183 L 5.44x45 Structure Structure
TM5 184 T 5.45x46 Structure Structure
TM5 185 W 5.46x461 Structure Structure
TM5 186 I 5.47x47 Structure Structure
TM5 187 F 5.48x48 Structure Structure
TM5 188 I 5.49x49 Structure Structure
TM5 189 P 5.50x50 Structure Structure
TM5 190 L 5.51x51 Structure Structure
TM5 191 V 5.52x52 Structure Structure
TM5 192 V 5.53x53 Structure Structure
TM5 193 M 5.54x54 Structure Structure
TM5 194 C 5.55x55 Structure Structure
TM5 195 A 5.56x56 Structure Structure
TM5 196 I 5.57x57 Structure Structure
TM5 197 Y 5.58x58 Structure Structure
TM5 198 L 5.59x59 Structure Structure
TM5 199 D 5.60x60 Structure Structure
TM5 200 I 5.61x61 Structure Structure
TM5 201 F 5.62x62 Structure Structure
TM5 202 Y 5.63x63 Structure Structure
TM5 203 I 5.64x64 Structure Structure
TM5 204 I 5.65x65 Structure Structure
TM5 205 R 5.66x66 Structure Structure
TM5 206 N 5.67x67 Structure Structure
TM5 207 K 5.68x68 Structure Structure
TM5 208 L 5.69x69 Structure Structure
TM5 209 S 5.70x70 Structure Structure
TM5 210 L 5.71x71 Structure Structure
TM5 211 N 5.72x72 AF2 AF2
TM5 212 L 5.73x73 AF2 AF2
ICL3 213 S - AF2 AF2
ICL3 214 N - AF2 AF2
ICL3 215 S - AF2 AF2
ICL3 216 K - AF2 AF2
TM6 217 E 6.22x22 AF2 AF2
TM6 218 T 6.23x23 AF2 AF2
TM6 219 G 6.24x24 AF2 AF2
TM6 220 A 6.25x25 AF2 AF2
TM6 221 F 6.26x26 AF2 AF2
TM6 222 Y 6.27x27 AF2 AF2
TM6 223 G 6.28x28 Structure Structure
TM6 224 R 6.29x29 Structure Structure
TM6 225 E 6.30x30 Structure Structure
TM6 226 F 6.31x31 Structure Structure
TM6 227 K 6.32x32 Structure Structure
TM6 228 T 6.33x33 Structure Structure
TM6 229 A 6.34x34 Structure Structure
TM6 230 K 6.35x35 Structure Structure
TM6 231 S 6.36x36 Structure Structure
TM6 232 L 6.37x37 Structure Structure
TM6 233 F 6.38x38 Structure Structure
TM6 234 L 6.39x39 Structure Structure
TM6 235 V 6.40x40 Structure Structure
TM6 236 L 6.41x41 Structure Structure
TM6 237 F 6.42x42 Structure Structure
TM6 238 L 6.43x43 Structure Structure
TM6 239 F 6.44x44 Structure Structure
TM6 240 A 6.45x45 Structure Structure
TM6 241 L 6.46x46 Structure Structure
TM6 242 S 6.47x47 Structure Structure
TM6 243 W 6.48x48 Structure Structure
TM6 244 L 6.49x49 Structure Structure
TM6 245 P 6.50x50 Structure Structure
TM6 246 L 6.51x51 Structure Structure
TM6 247 S 6.52x52 Structure Structure
TM6 248 I 6.53x53 Structure Structure
TM6 249 I 6.54x54 Structure Structure
TM6 250 N 6.55x55 Structure Structure
TM6 251 C 6.56x56 Structure Structure
TM6 252 I 6.57x57 Structure Structure
TM6 253 I 6.58x58 Structure Structure
TM6 254 Y 6.59x59 Structure Structure
TM6 255 F 6.60x60 Structure Structure
TM6 256 N 6.61x61 Structure Structure
ECL3 257 G - Structure Structure
ECL3 258 E - Structure Structure
ECL3 259 V - Structure Structure
TM7 260 P 7.31x30 Structure Structure
TM7 261 Q 7.32x31 Structure Structure
TM7 262 L 7.33x32 Structure Structure
TM7 263 V 7.34x33 Structure Structure
TM7 264 L 7.35x34 Structure Structure
TM7 265 Y 7.36x35 Structure Structure
TM7 266 M 7.37x36 Structure Structure
TM7 267 G 7.38x37 Structure Structure
TM7 268 I 7.39x38 Structure Structure
TM7 269 L 7.40x39 Structure Structure
TM7 270 L 7.41x40 Structure Structure
TM7 271 S 7.42x41 Structure Structure
TM7 272 H 7.43x42 Structure Structure
TM7 273 A 7.44x43 Structure Structure
TM7 274 N 7.45x45 Structure Structure
TM7 275 S 7.46x46 Structure Structure
TM7 276 M 7.47x47 Structure Structure
TM7 277 M 7.48x48 Structure Structure
TM7 278 N 7.49x49 Structure Structure
TM7 279 P 7.50x50 Structure Structure
TM7 280 I 7.51x51 Structure Structure
TM7 281 V 7.52x52 Structure Structure
TM7 282 Y 7.53x53 Structure Structure
TM7 283 A 7.54x54 Structure Structure
TM7 284 Y 7.55x55 Structure Structure
TM7 285 K 7.56x56 Structure Structure
H8 286 I 8.47x47 Structure Structure
H8 287 K 8.48x48 Structure Structure
H8 288 K 8.49x49 Structure Structure
H8 289 F 8.50x50 Structure Structure
H8 290 K 8.51x51 Structure Structure
H8 291 E 8.52x52 Structure Structure
H8 292 T 8.53x53 Structure Structure
H8 293 Y 8.54x54 Structure Structure
H8 294 L 8.55x55 Structure Structure
H8 295 L 8.56x56 Structure Structure
H8 296 I 8.57x57 Structure Structure
H8 297 L 8.58x58 Structure Structure
H8 298 K 8.59x59 Structure Structure
H8 299 A 8.60x60 Structure Structure
H8 300 C 8.61x61 Structure Structure
H8 301 V 8.62x62 AF2 AF2
H8 302 V 8.63x63 AF2 AF2
H8 303 C 8.64x64 AF2 AF2
H8 304 H 8.65x65 AF2 AF2
H8 305 P 8.66x66 AF2 AF2
H8 306 S 8.67x67 AF2 AF2
H8 307 D 8.68x68 AF2 AF2
H8 308 S 8.69x69 AF2 AF2
C-term 309 L - AF2 AF2
C-term 310 D - AF2 AF2
C-term 311 T - AF2 AF2
C-term 312 S - AF2 AF2
C-term 313 I - AF2 AF2
C-term 314 E - AF2 AF2
C-term 315 K - AF2 AF2
C-term 316 N - AF2 AF2
C-term 317 S - AF2 AF2
C-term 318 E - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM5 N 211 5x72 G.H5 K 345 G.H5.17
Hydrophobic H8 I 286 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 232 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 108 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 108 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 112 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 108 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 108 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 108 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 T 115 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 T 115 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 K 207 5x68 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 116 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 116 34x51 G.S3 L 194 G.S3.01
Polar TM3 R 111 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 111 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 111 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 200 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 116 34x51 G.H5 T 340 G.H5.12
Polar TM2 T 45 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 45 2x37 G.H5 D 350 G.H5.22
Polar TM5 N 211 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 N 211 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 N 211 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals H8 K 287 8x48 G.H5 F 354 G.H5.26
Ionic TM4 H 124 4x39 G.HN E 28 G.HN.52
Polar TM4 H 124 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 H 124 4x39 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 120 34x55 G.hns1 R 32 G.hns1.03
Ionic TM5 K 207 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 207 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 224 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 224 6x29 G.H5 F 354 G.H5.26
Hydrophobic H8 K 287 8x48 G.H5 K 349 G.H5.21
Hydrophobic ICL2 V 116 34x51 G.H5 I 343 G.H5.15
Hydrophobic H8 I 286 8x47 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 47 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 204 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 204 5x65 G.H5 L 348 G.H5.20
Ionic TM6 E 217 6x22 G.h4s6 K 314 G.h4s6.08
Polar TM5 N 211 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 N 211 5x72 G.H5 D 341 G.H5.13
Polar TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 K 207 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 207 5x68 G.H5 I 344 G.H5.16