Refined structure (8XOR) of Gq - PAR1

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 209 from structure (58.2%), 150 from model (41.8%)
Residue sidechains - 104 from structure (29.0%), 255 from model (71.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 Structure Structure
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure Structure
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure Structure
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure Structure
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure AF2
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 Structure Structure
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 Structure Structure
G.hfs2 185 P G.hfs2.04 Structure AF2
G.hfs2 186 T G.hfs2.05 Structure Structure
G.hfs2 187 T G.hfs2.06 Structure AF2
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure AF2
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure Structure
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure AF2
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure AF2
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 AF2 AF2
G.hgh4 292 F G.hgh4.02 AF2 AF2
G.hgh4 293 P G.hgh4.03 AF2 AF2
G.hgh4 294 E G.hgh4.04 AF2 AF2
G.hgh4 295 Y G.hgh4.05 AF2 AF2
G.hgh4 296 D G.hgh4.06 AF2 AF2
G.hgh4 297 G G.hgh4.07 AF2 AF2
G.hgh4 298 P G.hgh4.08 AF2 AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure AF2
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure AF2
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure AF2
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 299 from structure (74.9%), 100 from model (25.1%)
Residue sidechains - 299 from structure (74.9%), 100 from model (25.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 G - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 R - AF2 AF2
N-term 5 R - AF2 AF2
N-term 6 L - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 V - AF2 AF2
N-term 10 A - AF2 AF2
N-term 11 A - AF2 AF2
N-term 12 C - AF2 AF2
N-term 13 F - AF2 AF2
N-term 14 S - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 C - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 L - AF2 AF2
N-term 20 L - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 R - AF2 AF2
N-term 24 T - AF2 AF2
N-term 25 R - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 R - AF2 AF2
N-term 28 R - AF2 AF2
N-term 29 P - AF2 AF2
N-term 30 E - AF2 AF2
N-term 31 S - AF2 AF2
N-term 32 K - AF2 AF2
N-term 33 A - AF2 AF2
N-term 34 T - AF2 AF2
N-term 35 N - AF2 AF2
N-term 36 A - AF2 AF2
N-term 37 T - AF2 AF2
N-term 38 L - AF2 AF2
N-term 39 D - AF2 AF2
N-term 40 P - AF2 AF2
N-term 41 R - AF2 AF2
N-term 42 S - AF2 AF2
N-term 43 F - AF2 AF2
N-term 44 L - AF2 AF2
N-term 45 L - AF2 AF2
N-term 46 R - AF2 AF2
N-term 47 N - AF2 AF2
N-term 48 P - AF2 AF2
N-term 49 N - AF2 AF2
N-term 50 D - AF2 AF2
N-term 51 K - AF2 AF2
N-term 52 Y - AF2 AF2
N-term 53 E - AF2 AF2
N-term 54 P - AF2 AF2
N-term 55 F - AF2 AF2
N-term 56 W - AF2 AF2
N-term 57 E - AF2 AF2
N-term 58 D - AF2 AF2
N-term 59 E - AF2 AF2
N-term 60 E - AF2 AF2
N-term 61 K - AF2 AF2
N-term 62 N - AF2 AF2
N-term 63 E - AF2 AF2
N-term 64 S - AF2 AF2
N-term 65 G - AF2 AF2
N-term 66 L - AF2 AF2
N-term 67 T - AF2 AF2
N-term 68 E - AF2 AF2
N-term 69 Y - AF2 AF2
N-term 70 R - AF2 AF2
N-term 71 L - AF2 AF2
N-term 72 V - AF2 AF2
N-term 73 S - AF2 AF2
N-term 74 I - AF2 AF2
N-term 75 N - AF2 AF2
N-term 76 K - AF2 AF2
N-term 77 S - AF2 AF2
N-term 78 S - AF2 AF2
N-term 79 P - AF2 AF2
N-term 80 L - AF2 AF2
N-term 81 Q - AF2 AF2
N-term 82 K - AF2 AF2
N-term 83 Q - AF2 AF2
N-term 84 L - AF2 AF2
N-term 85 P - Structure Structure
N-term 86 A - Structure Structure
N-term 87 F - Structure Structure
N-term 88 I - Structure Structure
N-term 89 S - Structure Structure
N-term 90 E - Structure Structure
N-term 91 D - Structure Structure
N-term 92 A - Structure Structure
N-term 93 S - Structure Structure
N-term 94 G - Structure Structure
N-term 95 Y - Structure Structure
N-term 96 L - Structure Structure
N-term 97 T - Structure Structure
N-term 98 S - Structure Structure
TM1 99 S 1.29x29 Structure Structure
TM1 100 W 1.30x30 Structure Structure
TM1 101 L 1.31x31 Structure Structure
TM1 102 T 1.32x32 Structure Structure
TM1 103 L 1.33x33 Structure Structure
TM1 104 F 1.34x34 Structure Structure
TM1 105 V 1.35x35 Structure Structure
TM1 106 P 1.36x36 Structure Structure
TM1 107 S 1.37x37 Structure Structure
TM1 108 V 1.38x38 Structure Structure
TM1 109 Y 1.39x39 Structure Structure
TM1 110 T 1.40x40 Structure Structure
TM1 111 G 1.41x41 Structure Structure
TM1 112 V 1.42x42 Structure Structure
TM1 113 F 1.43x43 Structure Structure
TM1 114 V 1.44x44 Structure Structure
TM1 115 V 1.45x45 Structure Structure
TM1 116 S 1.46x46 Structure Structure
TM1 117 L 1.47x47 Structure Structure
TM1 118 P 1.48x48 Structure Structure
TM1 119 L 1.49x49 Structure Structure
TM1 120 N 1.50x50 Structure Structure
TM1 121 I 1.51x51 Structure Structure
TM1 122 M 1.52x52 Structure Structure
TM1 123 A 1.53x53 Structure Structure
TM1 124 I 1.54x54 Structure Structure
TM1 125 V 1.55x55 Structure Structure
TM1 126 V 1.56x56 Structure Structure
TM1 127 F 1.57x57 Structure Structure
TM1 128 I 1.58x58 Structure Structure
TM1 129 L 1.59x59 Structure Structure
TM1 130 K 1.60x60 Structure Structure
ICL1 131 M 12.48x48 Structure Structure
ICL1 132 K 12.49x49 Structure Structure
ICL1 133 V 12.50x50 Structure Structure
ICL1 134 K 12.51x51 Structure Structure
TM2 135 K 2.37x37 Structure Structure
TM2 136 P 2.38x38 Structure Structure
TM2 137 A 2.39x39 Structure Structure
TM2 138 V 2.40x40 Structure Structure
TM2 139 V 2.41x41 Structure Structure
TM2 140 Y 2.42x42 Structure Structure
TM2 141 M 2.43x43 Structure Structure
TM2 142 L 2.44x44 Structure Structure
TM2 143 H 2.45x45 Structure Structure
TM2 144 L 2.46x46 Structure Structure
TM2 145 A 2.47x47 Structure Structure
TM2 146 T 2.48x48 Structure Structure
TM2 147 A 2.49x49 Structure Structure
TM2 148 D 2.50x50 Structure Structure
TM2 149 V 2.51x51 Structure Structure
TM2 150 L 2.52x52 Structure Structure
TM2 151 F 2.53x53 Structure Structure
TM2 152 V 2.54x54 Structure Structure
TM2 153 S 2.55x55 Structure Structure
TM2 154 V 2.56x56 Structure Structure
TM2 155 L 2.57x57 Structure Structure
TM2 156 P 2.58x58 Structure Structure
TM2 157 F 2.59x59 Structure Structure
TM2 158 K 2.60x60 Structure Structure
TM2 159 I 2.61x61 Structure Structure
TM2 160 S 2.62x62 Structure Structure
TM2 161 Y 2.63x63 Structure Structure
TM2 162 Y 2.64x64 Structure Structure
TM2 163 F 2.65x65 Structure Structure
TM2 164 S 2.66x66 Structure Structure
ECL1 165 G - Structure Structure
ECL1 166 S - Structure Structure
ECL1 167 D 23.49x49 Structure Structure
ECL1 168 W 23.50x50 Structure Structure
ECL1 169 Q 23.51x51 Structure Structure
ECL1 170 F 23.52x52 Structure Structure
TM3 171 G 3.21x21 Structure Structure
TM3 172 S 3.22x22 Structure Structure
TM3 173 E 3.23x23 Structure Structure
TM3 174 L 3.24x24 Structure Structure
TM3 175 C 3.25x25 Structure Structure
TM3 176 R 3.26x26 Structure Structure
TM3 177 F 3.27x27 Structure Structure
TM3 178 V 3.28x28 Structure Structure
TM3 179 T 3.29x29 Structure Structure
TM3 180 A 3.30x30 Structure Structure
TM3 181 A 3.31x31 Structure Structure
TM3 182 F 3.32x32 Structure Structure
TM3 183 Y 3.33x33 Structure Structure
TM3 184 C 3.34x34 Structure Structure
TM3 185 N 3.35x35 Structure Structure
TM3 186 M 3.36x36 Structure Structure
TM3 187 Y 3.37x37 Structure Structure
TM3 188 A 3.38x38 Structure Structure
TM3 189 S 3.39x39 Structure Structure
TM3 190 I 3.40x40 Structure Structure
TM3 191 L 3.41x41 Structure Structure
TM3 192 L 3.42x42 Structure Structure
TM3 193 M 3.43x43 Structure Structure
TM3 194 T 3.44x44 Structure Structure
TM3 195 V 3.45x45 Structure Structure
TM3 196 I 3.46x46 Structure Structure
TM3 197 S 3.47x47 Structure Structure
TM3 198 I 3.48x48 Structure Structure
TM3 199 D 3.49x49 Structure Structure
TM3 200 R 3.50x50 Structure Structure
TM3 201 F 3.51x51 Structure Structure
TM3 202 L 3.52x52 Structure Structure
TM3 203 A 3.53x53 Structure Structure
TM3 204 V 3.54x54 Structure Structure
TM3 205 V 3.55x55 Structure Structure
TM3 206 Y 3.56x56 Structure Structure
ICL2 207 P 34.50x50 Structure Structure
ICL2 208 M 34.51x51 Structure Structure
ICL2 209 Q 34.52x52 Structure Structure
ICL2 210 S 34.53x53 Structure Structure
ICL2 211 L 34.54x54 Structure Structure
ICL2 212 S 34.55x55 Structure Structure
ICL2 213 W 34.56x56 Structure Structure
ICL2 214 R 34.57x57 Structure Structure
TM4 215 T 4.38x38 Structure Structure
TM4 216 L 4.39x39 Structure Structure
TM4 217 G 4.40x40 Structure Structure
TM4 218 R 4.41x41 Structure Structure
TM4 219 A 4.42x42 Structure Structure
TM4 220 S 4.43x43 Structure Structure
TM4 221 F 4.44x44 Structure Structure
TM4 222 T 4.45x45 Structure Structure
TM4 223 C 4.46x46 Structure Structure
TM4 224 L 4.47x47 Structure Structure
TM4 225 A 4.48x48 Structure Structure
TM4 226 I 4.49x49 Structure Structure
TM4 227 W 4.50x50 Structure Structure
TM4 228 A 4.51x51 Structure Structure
TM4 229 L 4.52x52 Structure Structure
TM4 230 A 4.53x53 Structure Structure
TM4 231 I 4.54x54 Structure Structure
TM4 232 A 4.55x55 Structure Structure
TM4 233 G 4.56x56 Structure Structure
TM4 234 V 4.57x57 Structure Structure
TM4 235 V 4.58x59 Structure Structure
TM4 236 P 4.59x60 Structure Structure
TM4 237 L 4.60x61 Structure Structure
TM4 238 L 4.61x62 Structure Structure
TM4 239 L 4.62x63 Structure Structure
TM4 240 K 4.63x64 Structure Structure
ECL2 241 E - Structure Structure
ECL2 242 Q - Structure Structure
ECL2 243 T - Structure Structure
ECL2 244 I - Structure Structure
ECL2 245 Q - Structure Structure
ECL2 246 V - Structure Structure
ECL2 247 P - Structure Structure
ECL2 248 G - Structure Structure
ECL2 249 L - Structure Structure
ECL2 250 N - Structure Structure
ECL2 251 I - Structure Structure
ECL2 252 T - Structure Structure
ECL2 253 T - Structure Structure
ECL2 254 C 45.50x50 Structure Structure
ECL2 255 H 45.51x51 Structure Structure
ECL2 256 D 45.52x52 Structure Structure
ECL2 257 V - Structure Structure
ECL2 258 L - Structure Structure
ECL2 259 N - Structure Structure
ECL2 260 E - Structure Structure
ECL2 261 T - Structure Structure
ECL2 262 L - Structure Structure
ECL2 263 L - Structure Structure
TM5 264 E 5.32x32 Structure Structure
TM5 265 G 5.33x33 Structure Structure
TM5 266 Y 5.34x34 Structure Structure
TM5 267 Y 5.35x35 Structure Structure
TM5 268 A 5.36x36 Structure Structure
TM5 269 Y 5.37x37 Structure Structure
TM5 270 Y 5.38x38 Structure Structure
TM5 271 F 5.39x39 Structure Structure
TM5 272 S 5.40x40 Structure Structure
TM5 273 A 5.41x41 Structure Structure
TM5 274 F 5.42x42 Structure Structure
TM5 275 S 5.43x43 Structure Structure
TM5 276 A 5.44x44 Structure Structure
TM5 277 V 5.45x45 Structure Structure
TM5 278 F 5.46x46 Structure Structure
TM5 279 F 5.47x47 Structure Structure
TM5 280 F 5.48x48 Structure Structure
TM5 281 V 5.49x49 Structure Structure
TM5 282 P 5.50x50 Structure Structure
TM5 283 L 5.51x51 Structure Structure
TM5 284 I 5.52x52 Structure Structure
TM5 285 I 5.53x53 Structure Structure
TM5 286 S 5.54x54 Structure Structure
TM5 287 T 5.55x55 Structure Structure
TM5 288 V 5.56x56 Structure Structure
TM5 289 C 5.57x57 Structure Structure
TM5 290 Y 5.58x58 Structure Structure
TM5 291 V 5.59x59 Structure Structure
TM5 292 S 5.60x60 Structure Structure
TM5 293 I 5.61x61 Structure Structure
TM5 294 I 5.62x62 Structure Structure
TM5 295 R 5.63x63 Structure Structure
TM5 296 C 5.64x64 Structure Structure
TM5 297 L 5.65x65 Structure Structure
TM5 298 S 5.66x66 Structure Structure
TM5 299 S 5.67x67 Structure Structure
ICL3 300 S - Structure Structure
ICL3 301 A - Structure Structure
ICL3 302 V - Structure Structure
ICL3 303 A - Structure Structure
TM6 304 N 6.26x27 Structure Structure
TM6 305 R 6.27x28 Structure Structure
TM6 306 S 6.28x29 Structure Structure
TM6 307 K 6.29x30 Structure Structure
TM6 308 K 6.30x31 Structure Structure
TM6 309 S 6.31x32 Structure Structure
TM6 310 R 6.32x33 Structure Structure
TM6 311 A 6.33x34 Structure Structure
TM6 312 L 6.34x35 Structure Structure
TM6 313 F 6.35x36 Structure Structure
TM6 314 L 6.36x37 Structure Structure
TM6 315 S 6.37x38 Structure Structure
TM6 316 A 6.38x39 Structure Structure
TM6 317 A 6.39x40 Structure Structure
TM6 318 V 6.40x41 Structure Structure
TM6 319 F 6.41x42 Structure Structure
TM6 320 C 6.42x43 Structure Structure
TM6 321 I 6.43x44 Structure Structure
TM6 322 F 6.44x45 Structure Structure
TM6 323 I 6.45x46 Structure Structure
TM6 324 I 6.46x461 Structure Structure
TM6 325 C 6.47x47 Structure Structure
TM6 326 F 6.48x48 Structure Structure
TM6 327 G 6.49x49 Structure Structure
TM6 328 P 6.50x50 Structure Structure
TM6 329 T 6.51x51 Structure Structure
TM6 330 N 6.52x52 Structure Structure
TM6 331 V 6.53x53 Structure Structure
TM6 332 L 6.54x54 Structure Structure
TM6 333 L 6.55x55 Structure Structure
TM6 334 I 6.56x56 Structure Structure
TM6 335 A 6.57x57 Structure Structure
TM6 336 H 6.58x58 Structure Structure
TM6 337 Y 6.59x59 Structure Structure
TM6 338 S 6.60x60 Structure Structure
TM6 339 F 6.61x61 Structure Structure
TM6 340 L 6.62x62 Structure Structure
ECL3 341 S - Structure Structure
ECL3 342 H - Structure Structure
ECL3 343 T - Structure Structure
ECL3 344 S - Structure Structure
ECL3 345 T - Structure Structure
TM7 346 T 7.28x27 Structure Structure
TM7 347 E 7.29x28 Structure Structure
TM7 348 A 7.30x29 Structure Structure
TM7 349 A 7.31x30 Structure Structure
TM7 350 Y 7.32x31 Structure Structure
TM7 351 F 7.33x32 Structure Structure
TM7 352 A 7.34x33 Structure Structure
TM7 353 Y 7.35x34 Structure Structure
TM7 354 L 7.36x35 Structure Structure
TM7 355 L 7.37x36 Structure Structure
TM7 356 C 7.38x37 Structure Structure
TM7 357 V 7.39x38 Structure Structure
TM7 358 C 7.40x39 Structure Structure
TM7 359 V 7.41x40 Structure Structure
TM7 360 S 7.42x41 Structure Structure
TM7 361 S 7.43x42 Structure Structure
TM7 362 I 7.44x43 Structure Structure
TM7 363 S 7.45x45 Structure Structure
TM7 364 C 7.46x46 Structure Structure
TM7 365 C 7.47x47 Structure Structure
TM7 366 I 7.48x48 Structure Structure
TM7 367 D 7.49x49 Structure Structure
TM7 368 P 7.50x50 Structure Structure
TM7 369 L 7.51x51 Structure Structure
TM7 370 I 7.52x52 Structure Structure
TM7 371 Y 7.53x53 Structure Structure
TM7 372 Y 7.54x54 Structure Structure
TM7 373 Y 7.55x55 Structure Structure
TM7 374 A 7.56x56 Structure Structure
H8 375 S 8.47x47 Structure Structure
H8 376 S 8.48x48 Structure Structure
H8 377 E 8.49x49 Structure Structure
H8 378 C 8.50x50 Structure Structure
H8 379 Q 8.51x51 Structure Structure
H8 380 R 8.52x52 Structure Structure
H8 381 Y 8.53x53 Structure Structure
H8 382 V 8.54x54 Structure Structure
H8 383 Y 8.55x55 Structure Structure
H8 384 S 8.56x56 AF2 AF2
H8 385 I 8.57x57 AF2 AF2
H8 386 L 8.58x58 AF2 AF2
H8 387 C 8.59x59 AF2 AF2
H8 388 C 8.60x60 AF2 AF2
H8 389 K 8.61x61 AF2 AF2
C-term 390 E - AF2 AF2
C-term 391 S - AF2 AF2
C-term 392 S - AF2 AF2
C-term 393 D - AF2 AF2
C-term 394 P - AF2 AF2
C-term 395 S - AF2 AF2
C-term 396 S - AF2 AF2
C-term 397 Y - AF2 AF2
C-term 398 N - AF2 AF2
C-term 399 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 314 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM3 R 200 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 200 3x50 G.H5 L 358 G.H5.25
Ionic ICL2 R 214 34x57 G.H5 E 355 G.H5.22
Polar ICL2 R 214 34x57 G.H5 E 355 G.H5.22
Hydrophobic ICL2 R 214 34x57 G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 214 34x57 G.H5 E 355 G.H5.22
Hydrophobic ICL2 M 208 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 M 208 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM6 K 308 6x31 G.H5 L 349 G.H5.16
Van-der-waals TM6 K 308 6x31 G.H5 L 349 G.H5.16
Ionic TM6 K 308 6x31 G.H5 D 346 G.H5.13
Polar TM6 K 308 6x31 G.H5 D 346 G.H5.13
Van-der-waals TM6 K 308 6x31 G.H5 D 346 G.H5.13
Hydrophobic TM6 K 308 6x31 G.H5 L 353 G.H5.20
Hydrophobic ICL2 P 207 34x50 G.H5 I 348 G.H5.15
Ionic H8 R 380 8x52 G.h4s6 D 319 G.h4s6.10
Polar H8 R 380 8x52 G.h4s6 D 319 G.h4s6.10
Van-der-waals TM2 M 141 2x43 G.H5 N 357 G.H5.24
Hydrophobic ICL2 M 208 34x51 G.H5 V 344 G.H5.11
Van-der-waals ICL2 M 208 34x51 G.H5 V 344 G.H5.11
Hydrophobic TM6 S 306 6x29 G.H5 Q 350 G.H5.17
Van-der-waals TM6 S 306 6x29 G.H5 Q 350 G.H5.17
Hydrophobic TM6 R 305 6x28 G.H5 A 342 G.H5.09
Hydrophobic TM6 R 310 6x33 G.H5 L 358 G.H5.25
Polar TM6 A 311 6x34 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 311 6x34 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 311 6x34 G.H5 L 358 G.H5.25
Polar TM7 Y 371 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 371 7x53 G.H5 N 357 G.H5.24
Hydrophobic ICL2 M 208 34x51 G.S3 F 201 G.S3.03
Hydrophobic ICL2 M 208 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM3 V 204 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 V 204 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 P 207 34x50 G.H5 K 345 G.H5.12
Hydrophobic TM6 R 310 6x33 G.H5 V 359 G.H5.26
Polar TM7 Y 372 7x54 G.H5 N 357 G.H5.24
Polar H8 S 375 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 375 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 375 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM3 A 203 3x53 G.H5 Y 356 G.H5.23
Polar TM6 S 306 6x29 G.H5 D 346 G.H5.13
Hydrophobic TM6 S 306 6x29 G.H5 D 346 G.H5.13
Van-der-waals TM6 S 306 6x29 G.H5 D 346 G.H5.13
Polar TM6 S 306 6x29 G.S6 Y 325 G.S6.02
Van-der-waals TM6 S 306 6x29 G.S6 Y 325 G.S6.02
Polar TM3 D 199 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 199 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 199 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 207 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 196 3x46 G.H5 Y 356 G.H5.23
Polar TM3 A 203 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 203 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 203 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM2 K 135 2x37 G.H5 E 355 G.H5.22
Polar TM3 R 200 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 200 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM6 R 305 6x28 G.H5 D 346 G.H5.13
Hydrophobic TM2 A 137 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 A 137 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 V 302 - G.H5 L 349 G.H5.16
Hydrophobic TM6 S 306 6x29 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 S 306 6x29 G.h4s6 I 323 G.h4s6.20
Polar TM2 P 136 2x38 G.H5 E 355 G.H5.22
Hydrophobic TM2 P 136 2x38 G.H5 E 355 G.H5.22
Hydrophobic TM6 A 311 6x34 G.H5 V 359 G.H5.26
Hydrophobic ICL2 M 208 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 M 208 34x51 G.H5 K 345 G.H5.12
Hydrophobic H8 S 376 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 S 376 8x48 G.H5 V 359 G.H5.26
Hydrophobic TM6 R 305 6x28 G.S6 Y 325 G.S6.02
Hydrophobic ICL2 M 208 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL2 L 211 34x54 G.H5 I 348 G.H5.15
Polar ICL2 R 214 34x57 G.H5 N 352 G.H5.19
Polar TM2 A 137 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 A 137 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 A 137 2x39 G.H5 E 355 G.H5.22
Hydrophobic ICL2 L 211 34x54 G.S1 L 40 G.S1.02
Hydrophobic ICL2 L 211 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 M 208 34x51 G.H5 I 348 G.H5.15
Polar ICL2 S 210 34x53 G.H5 N 352 G.H5.19
Hydrophobic TM5 L 297 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM3 V 204 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM6 K 308 6x31 G.H5 Q 350 G.H5.17
Hydrophobic TM6 A 311 6x34 G.H5 L 353 G.H5.20
Polar C-term N 398 - G.h3s5 Q 265 G.h3s5.01
Hydrophobic C-term N 398 - G.h3s5 Q 265 G.h3s5.01
Van-der-waals C-term N 398 - G.h3s5 Q 265 G.h3s5.01
Hydrophobic ICL2 S 212 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 S 212 34x55 G.hns1 R 38 G.hns1.03