Refined structure (8Y53) of Gq - BB3 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-11-26

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 207 from structure (57.7%), 152 from model (42.3%)
Residue sidechains - 110 from structure (30.6%), 249 from model (69.4%)

REFINED GPCR RESIDUES

Residue backbones - 298 from structure (83.7%), 58 from model (16.3%)
Residue sidechains - 298 from structure (83.7%), 58 from model (16.3%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
R02G.hns1I01G.S6N19Y23N24G.H5GproteinK3x52P34x50R34x53S34x56E-N2x40GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.S6G.H5GPCR segments:TM2ICL2TM3ICL3

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null12x502x392x403x493x503x523x533x5434x5034x5134x5334x5534x565x655x726x226x256x266x296x306x337x537x568x47G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.08G.S6.04G.S6.02G.S6.01G.h4s6.20G.h4s6.13G.h4s6.11G.h4s6.09G.H4.16G.H4.13G.S3.01G.hns1.02G.HN.51Res. Pos.BB3 (8Y53_REFINED)- (8Y53_REFINED)-------------------------MPNDRKAVPLRPSLIHKQSRILLSMPNPLRPSDRKAVLIHKQSRILLSQNEYKILNFVKRLLDYPKISQVKVIH

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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