Refined structure (8Y53) of Gq - BB3 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 207 from structure (57.7%), 152 from model (42.3%)
Residue sidechains - 110 from structure (30.6%), 249 from model (69.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 Structure Structure
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure Structure
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure Structure
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure Structure
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 Structure Structure
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 Structure Structure
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure Structure
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 AF2 AF2
G.hgh4 292 F G.hgh4.02 AF2 AF2
G.hgh4 293 P G.hgh4.03 AF2 AF2
G.hgh4 294 E G.hgh4.04 AF2 AF2
G.hgh4 295 Y G.hgh4.05 AF2 AF2
G.hgh4 296 D G.hgh4.06 AF2 AF2
G.hgh4 297 G G.hgh4.07 AF2 AF2
G.hgh4 298 P G.hgh4.08 AF2 AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure AF2
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 298 from structure (83.7%), 58 from model (16.3%)
Residue sidechains - 298 from structure (83.7%), 58 from model (16.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 Q - AF2 AF2
N-term 4 R - AF2 AF2
N-term 5 Q - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 H - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 P - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 Q - AF2 AF2
N-term 12 T - AF2 AF2
N-term 13 L - AF2 AF2
N-term 14 I - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 I - AF2 AF2
N-term 17 T - AF2 AF2
N-term 18 N - AF2 AF2
N-term 19 D - AF2 AF2
N-term 20 T - AF2 AF2
N-term 21 E - AF2 AF2
N-term 22 S - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 S - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 V - AF2 AF2
N-term 27 V - AF2 AF2
N-term 28 S - AF2 AF2
N-term 29 N - AF2 AF2
N-term 30 D - AF2 AF2
N-term 31 N - AF2 AF2
N-term 32 T - AF2 AF2
N-term 33 N - AF2 AF2
N-term 34 K - AF2 AF2
N-term 35 G - AF2 AF2
N-term 36 W - AF2 AF2
N-term 37 S - AF2 AF2
N-term 38 G - AF2 AF2
N-term 39 D - AF2 AF2
N-term 40 N - AF2 AF2
N-term 41 S - AF2 AF2
N-term 42 P - AF2 AF2
N-term 43 G - AF2 AF2
TM1 44 I 1.29x29 AF2 AF2
TM1 45 E 1.30x30 AF2 AF2
TM1 46 A 1.31x31 AF2 AF2
TM1 47 L 1.32x32 AF2 AF2
TM1 48 C 1.33x33 Structure Structure
TM1 49 A 1.34x34 Structure Structure
TM1 50 I 1.35x35 Structure Structure
TM1 51 Y 1.36x36 Structure Structure
TM1 52 I 1.37x37 Structure Structure
TM1 53 T 1.38x38 Structure Structure
TM1 54 Y 1.39x39 Structure Structure
TM1 55 A 1.40x40 Structure Structure
TM1 56 V 1.41x41 Structure Structure
TM1 57 I 1.42x42 Structure Structure
TM1 58 I 1.43x43 Structure Structure
TM1 59 S 1.44x44 Structure Structure
TM1 60 V 1.45x45 Structure Structure
TM1 61 G 1.46x46 Structure Structure
TM1 62 I 1.47x47 Structure Structure
TM1 63 L 1.48x48 Structure Structure
TM1 64 G 1.49x49 Structure Structure
TM1 65 N 1.50x50 Structure Structure
TM1 66 A 1.51x51 Structure Structure
TM1 67 I 1.52x52 Structure Structure
TM1 68 L 1.53x53 Structure Structure
TM1 69 I 1.54x54 Structure Structure
TM1 70 K 1.55x55 Structure Structure
TM1 71 V 1.56x56 Structure Structure
TM1 72 F 1.57x57 Structure Structure
TM1 73 F 1.58x58 Structure Structure
TM1 74 K 1.59x59 Structure Structure
TM1 75 T 1.60x60 Structure Structure
ICL1 76 K 12.48x48 Structure Structure
ICL1 77 S 12.49x49 Structure Structure
ICL1 78 M 12.50x50 Structure Structure
ICL1 79 Q 12.51x51 Structure Structure
TM2 80 T 2.37x37 Structure Structure
TM2 81 V 2.38x38 Structure Structure
TM2 82 P 2.39x39 Structure Structure
TM2 83 N 2.40x40 Structure Structure
TM2 84 I 2.41x41 Structure Structure
TM2 85 F 2.42x42 Structure Structure
TM2 86 I 2.43x43 Structure Structure
TM2 87 T 2.44x44 Structure Structure
TM2 88 S 2.45x45 Structure Structure
TM2 89 L 2.46x46 Structure Structure
TM2 90 A 2.47x47 Structure Structure
TM2 91 F 2.48x48 Structure Structure
TM2 92 G 2.49x49 Structure Structure
TM2 93 D 2.50x50 Structure Structure
TM2 94 L 2.51x51 Structure Structure
TM2 95 L 2.52x52 Structure Structure
TM2 96 L 2.53x53 Structure Structure
TM2 97 L 2.54x54 Structure Structure
TM2 98 L 2.55x55 Structure Structure
TM2 99 T 2.56x551 Structure Structure
TM2 100 C 2.57x56 Structure Structure
TM2 101 V 2.58x57 Structure Structure
TM2 102 P 2.59x58 Structure Structure
TM2 103 V 2.60x59 Structure Structure
TM2 104 D 2.61x60 Structure Structure
TM2 105 A 2.62x61 Structure Structure
TM2 106 T 2.63x62 Structure Structure
TM2 107 H 2.64x63 Structure Structure
TM2 108 Y 2.65x64 Structure Structure
TM2 109 L 2.66x65 Structure Structure
TM2 110 A 2.67x66 Structure Structure
ECL1 111 E - Structure Structure
ECL1 112 G 23.49x49 Structure Structure
ECL1 113 W 23.50x50 Structure Structure
ECL1 114 L 23.51x51 Structure Structure
ECL1 115 F 23.52x52 Structure Structure
TM3 116 G 3.21x21 Structure Structure
TM3 117 R 3.22x22 Structure Structure
TM3 118 I 3.23x23 Structure Structure
TM3 119 G 3.24x24 Structure Structure
TM3 120 C 3.25x25 Structure Structure
TM3 121 K 3.26x26 Structure Structure
TM3 122 V 3.27x27 Structure Structure
TM3 123 L 3.28x28 Structure Structure
TM3 124 S 3.29x29 Structure Structure
TM3 125 F 3.30x30 Structure Structure
TM3 126 I 3.31x31 Structure Structure
TM3 127 R 3.32x32 Structure Structure
TM3 128 L 3.33x33 Structure Structure
TM3 129 T 3.34x34 Structure Structure
TM3 130 S 3.35x35 Structure Structure
TM3 131 V 3.36x36 Structure Structure
TM3 132 G 3.37x37 Structure Structure
TM3 133 V 3.38x38 Structure Structure
TM3 134 S 3.39x39 Structure Structure
TM3 135 V 3.40x40 Structure Structure
TM3 136 F 3.41x41 Structure Structure
TM3 137 T 3.42x42 Structure Structure
TM3 138 L 3.43x43 Structure Structure
TM3 139 T 3.44x44 Structure Structure
TM3 140 I 3.45x45 Structure Structure
TM3 141 L 3.46x46 Structure Structure
TM3 142 S 3.47x47 Structure Structure
TM3 143 A 3.48x48 Structure Structure
TM3 144 D 3.49x49 Structure Structure
TM3 145 R 3.50x50 Structure Structure
TM3 146 Y 3.51x51 Structure Structure
TM3 147 K 3.52x52 Structure Structure
TM3 148 A 3.53x53 Structure Structure
TM3 149 V 3.54x54 Structure Structure
TM3 150 V 3.55x55 Structure Structure
TM3 151 K 3.56x56 Structure Structure
ICL2 152 P 34.50x50 Structure Structure
ICL2 153 L 34.51x51 Structure Structure
ICL2 154 E 34.52x52 Structure Structure
ICL2 155 R 34.53x53 Structure Structure
ICL2 156 Q 34.54x54 Structure Structure
ICL2 157 P 34.55x55 Structure Structure
ICL2 158 S 34.56x56 Structure Structure
ICL2 159 N 34.57x57 Structure Structure
TM4 160 A 4.38x38 Structure Structure
TM4 161 I 4.39x39 Structure Structure
TM4 162 L 4.40x40 Structure Structure
TM4 163 K 4.41x41 Structure Structure
TM4 164 T 4.42x42 Structure Structure
TM4 165 C 4.43x43 Structure Structure
TM4 166 V 4.44x44 Structure Structure
TM4 167 K 4.45x45 Structure Structure
TM4 168 A 4.46x46 Structure Structure
TM4 169 G 4.47x47 Structure Structure
TM4 170 C 4.48x48 Structure Structure
TM4 171 V 4.49x49 Structure Structure
TM4 172 W 4.50x50 Structure Structure
TM4 173 I 4.51x51 Structure Structure
TM4 174 V 4.52x52 Structure Structure
TM4 175 S 4.53x53 Structure Structure
TM4 176 M 4.54x54 Structure Structure
TM4 177 I 4.55x55 Structure Structure
TM4 178 F 4.56x56 Structure Structure
TM4 179 A 4.57x57 Structure Structure
TM4 180 L 4.58x59 Structure Structure
TM4 181 P 4.59x60 Structure Structure
TM4 182 E 4.60x61 Structure Structure
TM4 183 A 4.61x62 Structure Structure
TM4 184 I 4.62x63 Structure Structure
TM4 185 F 4.63x64 Structure Structure
TM4 186 S 4.64x65 Structure Structure
ECL2 187 N - Structure Structure
ECL2 188 V - Structure Structure
ECL2 189 Y - Structure Structure
ECL2 190 T - Structure Structure
ECL2 191 F - Structure Structure
ECL2 192 R - Structure Structure
ECL2 193 D - Structure Structure
ECL2 194 P - Structure Structure
ECL2 195 N - Structure Structure
ECL2 196 K - Structure Structure
ECL2 197 N - Structure Structure
ECL2 198 M - Structure Structure
ECL2 199 T - Structure Structure
ECL2 200 F - Structure Structure
ECL2 201 E - Structure Structure
ECL2 202 S - Structure Structure
ECL2 203 C 45.50x50 Structure Structure
ECL2 204 T 45.51x51 Structure Structure
ECL2 205 S 45.52x52 Structure Structure
ECL2 206 Y - Structure Structure
ECL2 207 P - Structure Structure
ECL2 208 V - Structure Structure
ECL2 209 S - Structure Structure
TM5 210 K 5.31x32 Structure Structure
TM5 211 K 5.32x33 Structure Structure
TM5 212 L 5.33x34 Structure Structure
TM5 213 L 5.34x35 Structure Structure
TM5 214 Q 5.35x36 Structure Structure
TM5 215 E 5.36x37 Structure Structure
TM5 216 I 5.37x38 Structure Structure
TM5 217 H 5.38x39 Structure Structure
TM5 218 S 5.39x40 Structure Structure
TM5 219 L 5.40x41 Structure Structure
TM5 220 L 5.41x42 Structure Structure
TM5 221 C 5.42x43 Structure Structure
TM5 222 F 5.43x44 Structure Structure
TM5 223 L 5.44x45 Structure Structure
TM5 224 V 5.45x46 Structure Structure
TM5 225 F 5.46x461 Structure Structure
TM5 226 Y 5.47x47 Structure Structure
TM5 227 I 5.48x48 Structure Structure
TM5 228 I 5.49x49 Structure Structure
TM5 229 P 5.50x50 Structure Structure
TM5 230 L 5.51x51 Structure Structure
TM5 231 S 5.52x52 Structure Structure
TM5 232 I 5.53x53 Structure Structure
TM5 233 I 5.54x54 Structure Structure
TM5 234 S 5.55x55 Structure Structure
TM5 235 V 5.56x56 Structure Structure
TM5 236 Y 5.57x57 Structure Structure
TM5 237 Y 5.58x58 Structure Structure
TM5 238 S 5.59x59 Structure Structure
TM5 239 L 5.60x60 Structure Structure
TM5 240 I 5.61x61 Structure Structure
TM5 241 A 5.62x62 Structure Structure
TM5 242 R 5.63x63 Structure Structure
TM5 243 T 5.64x64 Structure Structure
TM5 244 L 5.65x65 Structure Structure
TM5 245 Y 5.66x66 Structure Structure
TM5 246 K 5.67x67 Structure Structure
TM5 247 S 5.68x68 Structure Structure
TM5 248 T 5.69x69 Structure Structure
TM5 249 L 5.70x70 Structure Structure
TM5 250 N 5.71x71 Structure Structure
TM5 251 I 5.72x72 Structure Structure
ICL3 252 P - Structure Structure
ICL3 253 T - Structure Structure
ICL3 254 E - Structure Structure
ICL3 255 E - Structure Structure
ICL3 256 Q - Structure Structure
ICL3 257 S - Structure Structure
TM6 258 H 6.22x22 Structure Structure
TM6 259 A 6.23x23 Structure Structure
TM6 260 R 6.24x24 Structure Structure
TM6 261 K 6.25x25 Structure Structure
TM6 262 Q 6.26x26 Structure Structure
TM6 263 I 6.27x27 Structure Structure
TM6 264 E 6.28x28 Structure Structure
TM6 265 S 6.29x29 Structure Structure
TM6 266 R 6.30x30 Structure Structure
TM6 267 K 6.31x31 Structure Structure
TM6 268 R 6.32x32 Structure Structure
TM6 269 I 6.33x33 Structure Structure
TM6 270 A 6.34x34 Structure Structure
TM6 271 R 6.35x35 Structure Structure
TM6 272 T 6.36x36 Structure Structure
TM6 273 V 6.37x37 Structure Structure
TM6 274 L 6.38x38 Structure Structure
TM6 275 V 6.39x39 Structure Structure
TM6 276 L 6.40x40 Structure Structure
TM6 277 V 6.41x41 Structure Structure
TM6 278 A 6.42x42 Structure Structure
TM6 279 L 6.43x43 Structure Structure
TM6 280 F 6.44x44 Structure Structure
TM6 281 A 6.45x45 Structure Structure
TM6 282 L 6.46x46 Structure Structure
TM6 283 C 6.47x47 Structure Structure
TM6 284 W 6.48x48 Structure Structure
TM6 285 L 6.49x49 Structure Structure
TM6 286 P 6.50x50 Structure Structure
TM6 287 N 6.51x51 Structure Structure
TM6 288 H 6.52x52 Structure Structure
TM6 289 L 6.53x53 Structure Structure
TM6 290 L 6.54x54 Structure Structure
TM6 291 Y 6.55x55 Structure Structure
TM6 292 L 6.56x56 Structure Structure
TM6 293 Y 6.57x57 Structure Structure
TM6 294 H 6.58x58 Structure Structure
TM6 295 S 6.59x59 Structure Structure
TM6 296 F 6.60x60 Structure Structure
TM6 297 T 6.61x61 Structure Structure
TM6 298 S 6.62x62 Structure Structure
ECL3 299 Q - Structure Structure
ECL3 300 T - Structure Structure
ECL3 301 Y - Structure Structure
ECL3 302 V - Structure Structure
ECL3 303 D - Structure Structure
ECL3 304 P - Structure Structure
TM7 305 S 7.28x27 Structure Structure
TM7 306 A 7.29x28 Structure Structure
TM7 307 M 7.30x29 Structure Structure
TM7 308 H 7.31x30 Structure Structure
TM7 309 F 7.32x31 Structure Structure
TM7 310 I 7.33x32 Structure Structure
TM7 311 F 7.34x33 Structure Structure
TM7 312 T 7.35x34 Structure Structure
TM7 313 I 7.36x35 Structure Structure
TM7 314 F 7.37x36 Structure Structure
TM7 315 S 7.38x37 Structure Structure
TM7 316 R 7.39x38 Structure Structure
TM7 317 V 7.40x39 Structure Structure
TM7 318 L 7.41x40 Structure Structure
TM7 319 A 7.42x41 Structure Structure
TM7 320 F 7.43x42 Structure Structure
TM7 321 S 7.44x43 Structure Structure
TM7 322 N 7.45x45 Structure Structure
TM7 323 S 7.46x46 Structure Structure
TM7 324 C 7.47x47 Structure Structure
TM7 325 V 7.48x48 Structure Structure
TM7 326 N 7.49x49 Structure Structure
TM7 327 P 7.50x50 Structure Structure
TM7 328 F 7.51x51 Structure Structure
TM7 329 A 7.52x52 Structure Structure
TM7 330 L 7.53x53 Structure Structure
TM7 331 Y 7.54x54 Structure Structure
TM7 332 W 7.55x55 Structure Structure
TM7 333 L 7.56x56 Structure Structure
H8 334 S 8.47x47 Structure Structure
H8 335 K 8.48x48 Structure Structure
H8 336 S 8.49x49 Structure Structure
H8 337 F 8.50x50 Structure Structure
H8 338 Q 8.51x51 Structure Structure
H8 339 K 8.52x52 Structure Structure
H8 340 H 8.53x53 Structure Structure
H8 341 F 8.54x54 Structure Structure
H8 342 K 8.55x55 Structure Structure
H8 343 A 8.56x56 Structure Structure
H8 344 Q 8.57x57 Structure Structure
H8 345 L 8.58x58 Structure Structure
H8 346 F 8.59x59 AF2 AF2
C-term 347 C - AF2 AF2
C-term 348 C - AF2 AF2
C-term 349 K - AF2 AF2
C-term 350 A - AF2 AF2
C-term 351 E - AF2 AF2
C-term 352 R - AF2 AF2
C-term 353 P - AF2 AF2
C-term 354 E - AF2 AF2
C-term 355 P - AF2 AF2
C-term 356 P - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 251 5x72 G.S6 Y 325 G.S6.02
Hydrophobic TM5 I 251 5x72 G.H5 D 346 G.H5.13
Van-der-waals TM5 I 251 5x72 G.H5 D 346 G.H5.13
Hydrophobic ICL3 E 255 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 E 255 - G.H4 V 314 G.H4.16
Hydrophobic ICL2 P 152 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM3 V 149 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 V 149 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM2 P 82 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 P 82 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM3 R 145 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM6 I 269 6x33 G.H5 L 353 G.H5.20
Polar TM2 N 83 2x40 G.H5 N 357 G.H5.24
Hydrophobic TM2 N 83 2x40 G.H5 N 357 G.H5.24
Van-der-waals TM2 N 83 2x40 G.H5 N 357 G.H5.24
Hydrophobic ICL3 P 252 - G.S6 Y 325 G.S6.02
Polar ICL2 P 152 34x50 G.H5 N 352 G.H5.19
Hydrophobic TM6 Q 262 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 Q 262 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL3 Q 256 - G.H4 K 311 G.H4.13
Hydrophobic ICL2 P 157 34x55 G.hns1 R 37 G.hns1.02
Polar ICL3 E 255 - G.S6 I 324 G.S6.01
Hydrophobic ICL3 E 255 - G.S6 I 324 G.S6.01
Van-der-waals ICL3 E 255 - G.S6 I 324 G.S6.01
Polar TM3 K 147 3x52 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 P 252 - G.S6 H 327 G.S6.04
Hydrophobic TM6 I 269 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 I 269 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 S 265 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM2 P 82 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 P 82 2x39 G.H5 Y 356 G.H5.23
Hydrophobic H8 S 334 8x47 G.H5 L 358 G.H5.25
Hydrophobic TM3 V 149 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 V 149 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 R 155 34x53 G.H5 I 348 G.H5.15
Hydrophobic TM3 D 144 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL1 M 78 12x50 G.H5 N 357 G.H5.24
Van-der-waals ICL1 M 78 12x50 G.H5 N 357 G.H5.24
Hydrophobic ICL2 P 157 34x55 G.HN K 33 G.HN.51
Hydrophobic H8 S 334 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 334 8x47 G.H5 N 357 G.H5.24
Hydrophobic ICL2 L 153 34x51 G.S3 V 199 G.S3.01
Polar TM6 H 258 6x22 G.h4s6 K 322 G.h4s6.13
Van-der-waals TM6 H 258 6x22 G.h4s6 K 322 G.h4s6.13
Ionic TM6 R 266 6x30 G.H5 D 346 G.H5.13
Polar TM6 R 266 6x30 G.H5 D 346 G.H5.13
Hydrophobic TM6 R 266 6x30 G.H5 D 346 G.H5.13
Van-der-waals TM6 R 266 6x30 G.H5 D 346 G.H5.13
Polar H8 S 334 8x47 G.H5 V 359 G.H5.26
Hydrophobic H8 S 334 8x47 G.H5 V 359 G.H5.26
Van-der-waals H8 S 334 8x47 G.H5 V 359 G.H5.26
Hydrophobic TM5 L 244 5x65 G.H5 L 353 G.H5.20
Hydrophobic ICL2 P 152 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 152 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM6 R 266 6x30 G.H5 L 349 G.H5.16
Hydrophobic TM3 A 148 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 148 3x53 G.H5 Y 356 G.H5.23
Polar ICL2 S 158 34x56 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 S 158 34x56 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 H 258 6x22 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 H 258 6x22 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM3 A 148 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM6 K 261 6x25 G.h4s6 S 320 G.h4s6.11
Van-der-waals TM6 K 261 6x25 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM6 Q 262 6x26 G.H5 Q 350 G.H5.17
Hydrophobic ICL3 Q 256 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 Q 256 - G.H4 V 314 G.H4.16
Hydrophobic ICL2 P 152 34x50 G.H5 K 345 G.H5.12
Hydrophobic TM6 H 258 6x22 G.h4s6 P 318 G.h4s6.09
Hydrophobic TM7 L 333 7x56 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 153 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL3 E 255 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 E 255 - G.h4s6 I 323 G.h4s6.20
Ionic ICL2 R 155 34x53 G.H5 E 355 G.H5.22
Polar ICL2 R 155 34x53 G.H5 E 355 G.H5.22
Hydrophobic ICL2 R 155 34x53 G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 155 34x53 G.H5 E 355 G.H5.22
Polar ICL2 R 155 34x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 R 155 34x53 G.H5 N 352 G.H5.19
Van-der-waals ICL2 R 155 34x53 G.H5 N 352 G.H5.19
Hydrophobic TM7 L 330 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 L 330 7x53 G.H5 N 357 G.H5.24