Refined structure (8ZCJ) of Gi1 - SST5 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-27

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 222 from structure (62.7%), 132 from model (37.3%)
Residue sidechains - 161 from structure (45.5%), 193 from model (54.5%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure AF2
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure AF2
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure AF2
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure AF2
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure AF2
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure AF2
G.H1 53 M G.H1.08 Structure AF2
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure AF2
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure AF2
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure AF2
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure AF2
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure AF2
G.s4h3 231 D G.s4h3.05 Structure AF2
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure AF2
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure AF2
G.s4h3 237 D G.s4h3.11 Structure AF2
G.s4h3 238 E G.s4h3.12 Structure AF2
G.s4h3 239 E G.s4h3.13 Structure AF2
G.s4h3 240 M G.s4h3.14 Structure AF2
G.s4h3 241 N G.s4h3.15 Structure AF2
G.H3 242 R G.H3.01 Structure AF2
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure AF2
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure AF2
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure AF2
G.S5 269 N G.S5.07 Structure AF2
G.s5hg 270 K G.s5hg.01 Structure AF2
G.HG 271 K G.HG.01 Structure AF2
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure AF2
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure AF2
G.HG 276 E G.HG.06 Structure AF2
G.HG 277 K G.HG.07 Structure AF2
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure AF2
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure AF2
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure AF2
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure AF2
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure AF2
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure AF2
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure AF2
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure AF2
G.h4s6 313 R G.h4s6.04 Structure AF2
G.h4s6 314 K G.h4s6.08 Structure AF2
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure AF2
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure AF2
G.H5 330 K G.H5.02 Structure AF2
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure AF2
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure AF2

REFINED GPCR RESIDUES

Residue backbones - 275 from structure (83.3%), 55 from model (16.7%)
Residue sidechains - 200 from structure (60.6%), 130 from model (39.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 F - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 T - AF2 AF2
N-term 10 P - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 W - AF2 AF2
N-term 13 N - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 P - AF2 AF2
N-term 18 G - AF2 AF2
N-term 19 A - AF2 AF2
N-term 20 A - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 G - AF2 AF2
N-term 23 G - AF2 AF2
N-term 24 G - AF2 AF2
N-term 25 D - AF2 AF2
N-term 26 N - AF2 AF2
N-term 27 R - AF2 AF2
N-term 28 T - AF2 AF2
N-term 29 L - AF2 AF2
N-term 30 V - AF2 AF2
N-term 31 G - AF2 AF2
N-term 32 P - AF2 AF2
N-term 33 A - AF2 AF2
N-term 34 P - AF2 AF2
N-term 35 S - AF2 AF2
N-term 36 A - AF2 AF2
TM1 37 G 1.29x29 AF2 AF2
TM1 38 A 1.30x30 AF2 AF2
TM1 39 R 1.31x31 AF2 AF2
TM1 40 A 1.32x32 AF2 AF2
TM1 41 V 1.33x33 AF2 AF2
TM1 42 L 1.34x34 AF2 AF2
TM1 43 V 1.35x35 Structure AF2
TM1 44 P 1.36x36 Structure Structure
TM1 45 V 1.37x37 Structure AF2
TM1 46 L 1.38x38 Structure AF2
TM1 47 Y 1.39x39 Structure AF2
TM1 48 L 1.40x40 Structure AF2
TM1 49 L 1.41x41 Structure AF2
TM1 50 V 1.42x42 Structure AF2
TM1 51 C 1.43x43 Structure Structure
TM1 52 A 1.44x44 Structure Structure
TM1 53 A 1.45x45 Structure Structure
TM1 54 G 1.46x46 Structure Structure
TM1 55 L 1.47x47 Structure AF2
TM1 56 G 1.48x48 Structure Structure
TM1 57 G 1.49x49 Structure Structure
TM1 58 N 1.50x50 Structure Structure
TM1 59 T 1.51x51 Structure AF2
TM1 60 L 1.52x52 Structure Structure
TM1 61 V 1.53x53 Structure Structure
TM1 62 I 1.54x54 Structure AF2
TM1 63 Y 1.55x55 Structure AF2
TM1 64 V 1.56x56 Structure Structure
TM1 65 V 1.57x57 Structure Structure
TM1 66 L 1.58x58 Structure AF2
TM1 67 R 1.59x59 Structure AF2
TM1 68 F 1.60x60 Structure Structure
ICL1 69 A 12.48x48 Structure Structure
ICL1 70 K 12.49x49 Structure Structure
ICL1 71 M 12.50x50 Structure AF2
ICL1 72 K 12.51x51 Structure Structure
TM2 73 T 2.37x37 Structure Structure
TM2 74 V 2.38x38 Structure Structure
TM2 75 T 2.39x39 Structure Structure
TM2 76 N 2.40x40 Structure AF2
TM2 77 I 2.41x41 Structure Structure
TM2 78 Y 2.42x42 Structure Structure
TM2 79 I 2.43x43 Structure Structure
TM2 80 L 2.44x44 Structure AF2
TM2 81 N 2.45x45 Structure Structure
TM2 82 L 2.46x46 Structure Structure
TM2 83 A 2.47x47 Structure Structure
TM2 84 V 2.48x48 Structure AF2
TM2 85 A 2.49x49 Structure Structure
TM2 86 D 2.50x50 Structure Structure
TM2 87 V 2.51x51 Structure Structure
TM2 88 L 2.52x52 Structure Structure
TM2 89 Y 2.53x53 Structure Structure
TM2 90 M 2.54x54 Structure AF2
TM2 91 L 2.55x55 Structure AF2
TM2 92 G 2.56x56 Structure Structure
TM2 93 L 2.57x57 Structure AF2
TM2 94 P 2.58x58 Structure Structure
TM2 95 F 2.59x59 Structure AF2
TM2 96 L 2.60x60 Structure AF2
TM2 97 A 2.61x61 Structure Structure
TM2 98 T 2.62x62 Structure Structure
TM2 99 Q 2.63x63 Structure Structure
TM2 100 N 2.64x64 Structure AF2
TM2 101 A 2.65x65 Structure Structure
TM2 102 A 2.66x66 Structure Structure
ECL1 103 S - Structure Structure
ECL1 104 F 23.49x49 Structure AF2
ECL1 105 W 23.50x50 Structure Structure
ECL1 106 P 23.51x51 Structure Structure
ECL1 107 F 23.52x52 Structure AF2
TM3 108 G 3.21x21 Structure Structure
TM3 109 P 3.22x22 Structure Structure
TM3 110 V 3.23x23 Structure Structure
TM3 111 L 3.24x24 Structure Structure
TM3 112 C 3.25x25 Structure Structure
TM3 113 R 3.26x26 Structure AF2
TM3 114 L 3.27x27 Structure AF2
TM3 115 V 3.28x28 Structure Structure
TM3 116 M 3.29x29 Structure Structure
TM3 117 T 3.30x30 Structure AF2
TM3 118 L 3.31x31 Structure Structure
TM3 119 D 3.32x32 Structure Structure
TM3 120 G 3.33x33 Structure Structure
TM3 121 V 3.34x34 Structure AF2
TM3 122 N 3.35x35 Structure Structure
TM3 123 Q 3.36x36 Structure Structure
TM3 124 F 3.37x37 Structure Structure
TM3 125 T 3.38x38 Structure Structure
TM3 126 S 3.39x39 Structure Structure
TM3 127 V 3.40x40 Structure Structure
TM3 128 F 3.41x41 Structure Structure
TM3 129 C 3.42x42 Structure Structure
TM3 130 L 3.43x43 Structure Structure
TM3 131 T 3.44x44 Structure Structure
TM3 132 V 3.45x45 Structure Structure
TM3 133 M 3.46x46 Structure Structure
TM3 134 S 3.47x47 Structure Structure
TM3 135 V 3.48x48 Structure Structure
TM3 136 D 3.49x49 Structure Structure
TM3 137 R 3.50x50 Structure Structure
TM3 138 Y 3.51x51 Structure Structure
TM3 139 L 3.52x52 Structure Structure
TM3 140 A 3.53x53 Structure Structure
TM3 141 V 3.54x54 Structure Structure
TM3 142 V 3.55x55 Structure Structure
TM3 143 H 3.56x56 Structure Structure
ICL2 144 P 34.50x50 Structure Structure
ICL2 145 L 34.51x51 Structure Structure
ICL2 146 S 34.52x52 Structure Structure
ICL2 147 S 34.53x53 Structure Structure
ICL2 148 A 34.54x54 Structure Structure
ICL2 149 R 34.55x55 Structure AF2
ICL2 150 W 34.56x56 Structure AF2
ICL2 151 R 34.57x57 Structure Structure
TM4 152 R 4.38x38 Structure Structure
TM4 153 P 4.39x39 Structure Structure
TM4 154 R 4.40x40 Structure AF2
TM4 155 V 4.41x41 Structure Structure
TM4 156 A 4.42x42 Structure Structure
TM4 157 K 4.43x43 Structure Structure
TM4 158 L 4.44x44 Structure Structure
TM4 159 A 4.45x45 Structure Structure
TM4 160 S 4.46x46 Structure Structure
TM4 161 A 4.47x47 Structure Structure
TM4 162 A 4.48x48 Structure Structure
TM4 163 A 4.49x49 Structure Structure
TM4 164 W 4.50x50 Structure Structure
TM4 165 V 4.51x51 Structure Structure
TM4 166 L 4.52x52 Structure Structure
TM4 167 S 4.53x53 Structure Structure
TM4 168 L 4.54x54 Structure Structure
TM4 169 C 4.55x55 Structure Structure
TM4 170 M 4.56x56 Structure Structure
TM4 171 S 4.57x57 Structure Structure
TM4 172 L 4.58x59 Structure AF2
TM4 173 P 4.59x60 Structure Structure
TM4 174 L 4.60x61 Structure AF2
TM4 175 L 4.61x62 Structure AF2
TM4 176 V 4.62x63 Structure AF2
TM4 177 F 4.63x64 Structure AF2
TM4 178 A 4.64x65 Structure Structure
ECL2 179 D - Structure AF2
ECL2 180 V - Structure AF2
ECL2 181 Q - Structure AF2
ECL2 182 E - Structure AF2
ECL2 183 G - Structure Structure
ECL2 184 G - Structure Structure
ECL2 185 T - Structure Structure
ECL2 186 C 45.50x50 Structure Structure
ECL2 187 N 45.51x51 Structure AF2
ECL2 188 A 45.52x52 Structure Structure
ECL2 189 S - Structure Structure
ECL2 190 W - Structure Structure
ECL2 191 P - Structure Structure
ECL2 192 E - Structure AF2
TM5 193 P 5.30x31 Structure Structure
TM5 194 V 5.31x32 Structure Structure
TM5 195 G 5.32x33 Structure Structure
TM5 196 L 5.33x34 Structure Structure
TM5 197 W 5.34x35 Structure AF2
TM5 198 G 5.35x36 Structure Structure
TM5 199 A 5.36x37 Structure Structure
TM5 200 V 5.37x38 Structure AF2
TM5 201 F 5.38x39 Structure Structure
TM5 202 I 5.39x40 Structure Structure
TM5 203 I 5.40x41 Structure Structure
TM5 204 Y 5.41x42 Structure AF2
TM5 205 T 5.42x43 Structure Structure
TM5 206 A 5.43x44 Structure Structure
TM5 207 V 5.44x45 Structure AF2
TM5 208 L 5.45x46 Structure Structure
TM5 209 G 5.46x461 Structure Structure
TM5 210 F 5.47x47 Structure Structure
TM5 211 F 5.48x48 Structure AF2
TM5 212 A 5.49x49 Structure Structure
TM5 213 P 5.50x50 Structure Structure
TM5 214 L 5.51x51 Structure Structure
TM5 215 L 5.52x52 Structure AF2
TM5 216 V 5.53x53 Structure AF2
TM5 217 I 5.54x54 Structure AF2
TM5 218 C 5.55x55 Structure Structure
TM5 219 L 5.56x56 Structure Structure
TM5 220 C 5.57x57 Structure Structure
TM5 221 Y 5.58x58 Structure Structure
TM5 222 L 5.59x59 Structure Structure
TM5 223 L 5.60x60 Structure Structure
TM5 224 I 5.61x61 Structure Structure
TM5 225 V 5.62x62 Structure Structure
TM5 226 V 5.63x63 Structure AF2
TM5 227 K 5.64x64 Structure Structure
TM5 228 V 5.65x65 Structure Structure
TM5 229 R 5.66x66 Structure AF2
TM5 230 A 5.67x67 Structure Structure
TM5 231 A 5.68x68 Structure Structure
TM5 232 G 5.69x69 Structure Structure
TM5 233 V 5.70x70 Structure Structure
TM5 234 R 5.71x71 Structure AF2
TM5 235 V 5.72x72 Structure Structure
ICL3 236 G - Structure Structure
ICL3 237 C - Structure Structure
ICL3 238 V - Structure AF2
ICL3 239 R - Structure AF2
TM6 240 R 6.27x27 Structure AF2
TM6 241 R 6.28x28 Structure Structure
TM6 242 S 6.29x29 Structure Structure
TM6 243 E 6.30x30 Structure Structure
TM6 244 R 6.31x31 Structure AF2
TM6 245 K 6.32x32 Structure Structure
TM6 246 V 6.33x33 Structure Structure
TM6 247 T 6.34x34 Structure Structure
TM6 248 R 6.35x35 Structure AF2
TM6 249 M 6.36x36 Structure Structure
TM6 250 V 6.37x37 Structure Structure
TM6 251 L 6.38x38 Structure AF2
TM6 252 V 6.39x39 Structure Structure
TM6 253 V 6.40x40 Structure Structure
TM6 254 V 6.41x41 Structure Structure
TM6 255 L 6.42x42 Structure Structure
TM6 256 V 6.43x43 Structure Structure
TM6 257 F 6.44x44 Structure Structure
TM6 258 A 6.45x45 Structure Structure
TM6 259 G 6.46x46 Structure Structure
TM6 260 C 6.47x47 Structure Structure
TM6 261 W 6.48x48 Structure Structure
TM6 262 L 6.49x49 Structure AF2
TM6 263 P 6.50x50 Structure Structure
TM6 264 F 6.51x51 Structure Structure
TM6 265 F 6.52x52 Structure Structure
TM6 266 T 6.53x53 Structure Structure
TM6 267 V 6.54x54 Structure Structure
TM6 268 N 6.55x55 Structure Structure
TM6 269 I 6.56x56 Structure Structure
TM6 270 V 6.57x57 Structure AF2
TM6 271 N 6.58x58 Structure Structure
TM6 272 L 6.59x59 Structure Structure
TM6 273 A 6.60x60 Structure Structure
TM6 274 V 6.61x61 Structure AF2
ECL3 275 A - Structure Structure
ECL3 276 L - Structure AF2
ECL3 277 P - Structure Structure
ECL3 278 Q - Structure AF2
ECL3 279 E - Structure Structure
ECL3 280 P - Structure Structure
ECL3 281 A - Structure Structure
TM7 282 S 7.31x30 Structure Structure
TM7 283 A 7.32x31 Structure Structure
TM7 284 G 7.33x32 Structure Structure
TM7 285 L 7.34x33 Structure AF2
TM7 286 Y 7.35x34 Structure Structure
TM7 287 F 7.36x35 Structure Structure
TM7 288 F 7.37x36 Structure AF2
TM7 289 V 7.38x37 Structure Structure
TM7 290 V 7.39x38 Structure Structure
TM7 291 I 7.40x39 Structure AF2
TM7 292 L 7.41x40 Structure Structure
TM7 293 S 7.42x41 Structure Structure
TM7 294 Y 7.43x42 Structure Structure
TM7 295 A 7.44x43 Structure Structure
TM7 296 N 7.45x45 Structure AF2
TM7 297 S 7.46x46 Structure Structure
TM7 298 C 7.47x47 Structure Structure
TM7 299 A 7.48x48 Structure Structure
TM7 300 N 7.49x49 Structure Structure
TM7 301 P 7.50x50 Structure Structure
TM7 302 V 7.51x51 Structure Structure
TM7 303 L 7.52x52 Structure Structure
TM7 304 Y 7.53x53 Structure Structure
TM7 305 G 7.54x54 Structure Structure
TM7 306 F 7.55x55 Structure AF2
TM7 307 L 7.56x56 Structure Structure
H8 308 S 8.47x47 Structure Structure
H8 309 D 8.48x48 Structure AF2
H8 310 N 8.49x49 Structure Structure
H8 311 F 8.50x50 Structure AF2
H8 312 R 8.51x51 Structure AF2
H8 313 Q 8.52x52 Structure AF2
H8 314 S 8.53x53 Structure Structure
H8 315 F 8.54x54 Structure AF2
H8 316 Q 8.55x55 Structure Structure
H8 317 K 8.56x56 Structure Structure
H8 318 V 8.57x57 AF2 AF2
H8 319 L 8.58x58 AF2 AF2
H8 320 C 8.59x59 AF2 AF2
C-term 321 L - AF2 AF2
C-term 322 R - AF2 AF2
C-term 323 K - AF2 AF2
C-term 324 G - AF2 AF2
C-term 325 S - AF2 AF2
C-term 326 G - AF2 AF2
C-term 327 A - AF2 AF2
C-term 328 K - AF2 AF2
C-term 329 D - AF2 AF2
C-term 330 A - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 R 241 6x28 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 A 148 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 R 239 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 V 235 5x72 G.H5 D 337 G.H5.09
Polar TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 137 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 228 5x65 G.H5 I 344 G.H5.16
Ionic ICL2 R 151 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 151 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 A 148 34x54 G.HN E 28 G.HN.52
Van-der-waals TM4 R 152 4x38 G.HN R 24 G.HN.48
Hydrophobic ICL3 G 236 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 I 224 5x61 G.H5 L 348 G.H5.20
Polar H8 S 308 8x47 G.H5 L 353 G.H5.25
Hydrophobic H8 S 308 8x47 G.H5 L 353 G.H5.25
Polar ICL2 L 145 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 145 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 145 34x51 G.hns1 R 32 G.hns1.03
Ionic TM4 R 152 4x38 G.HN E 28 G.HN.52
Polar TM4 R 152 4x38 G.HN E 28 G.HN.52
Polar ICL3 C 237 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 C 237 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 C 237 - G.h4s6 E 318 G.h4s6.12
Polar H8 S 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 308 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 308 8x47 G.H5 G 352 G.H5.24
Ionic TM6 R 241 6x28 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 241 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 S 146 34x52 G.hns1 R 32 G.hns1.03
Polar ICL2 P 144 34x50 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 144 34x50 G.hns1 R 32 G.hns1.03
Polar H8 S 308 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 S 308 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM5 G 232 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 G 232 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM3 V 141 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 141 3x54 G.H5 I 344 G.H5.16
Hydrophobic H8 N 310 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 N 310 8x49 G.H5 G 352 G.H5.24
Polar TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 141 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 141 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 S 242 6x29 G.H5 F 354 G.H5.26
Polar TM3 D 136 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 136 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 136 3x49 G.H5 C 351 G.H5.23
Polar TM2 T 75 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM5 Y 221 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 141 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 M 249 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 249 6x36 G.H5 L 353 G.H5.25
Polar TM6 R 241 6x28 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 241 6x28 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 V 246 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 246 6x33 G.H5 F 354 G.H5.26
Polar TM6 K 245 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 245 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 245 6x32 G.H5 F 354 G.H5.26
Polar TM2 T 75 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 75 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 75 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 140 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 140 3x53 G.H5 C 351 G.H5.23