GAL2 receptor (galr2_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Galanin receptors GAL2 receptor
GENE
GALR2 (GALNR2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Galanin receptor type 2, GAL2-R, GALR-2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
V
|
S
|
G
|
C
|
P
|
G
|
A
|
G
|
10 |
N
|
A
|
S
|
Q
|
A
|
G
|
G
|
G
|
G
|
G
|
20 |
TM1 | |||||||||
W
|
H
|
P
|
E
|
A
|
V
|
I
|
V
|
P
|
L
|
30 |
L
|
F
|
A
|
L
|
I
|
F
|
L
|
V
|
G
|
T
|
40 |
V
|
G
|
N
|
T
|
L
|
V
|
L
|
A
|
V
|
L
|
50 |
ICL1 | TM2 | ||||||||
L
|
R
|
G
|
G
|
Q
|
A
|
V
|
S
|
T
|
T
|
60 |
N
|
L
|
F
|
I
|
L
|
N
|
L
|
G
|
V
|
A
|
70 |
D
|
L
|
C
|
F
|
I
|
L
|
C
|
C
|
V
|
P
|
80 |
F
|
Q
|
A
|
T
|
I
|
Y
|
T
|
L
|
D
|
G
|
90 |
ECL1 | TM3 | ||||||||
W
|
V
|
F
|
G
|
S
|
L
|
L
|
C
|
K
|
A
|
100 |
V
|
H
|
F
|
L
|
I
|
F
|
L
|
T
|
M
|
H
|
110 |
A
|
S
|
S
|
F
|
T
|
L
|
A
|
A
|
V
|
S
|
120 |
L
|
D
|
R
|
Y
|
L
|
A
|
I
|
R
|
Y
|
P
|
130 |
ICL2 | TM4 | ||||||||
L
|
H
|
S
|
R
|
E
|
L
|
R
|
T
|
P
|
R
|
140 |
N
|
A
|
L
|
A
|
A
|
I
|
G
|
L
|
I
|
W
|
150 |
G
|
L
|
S
|
L
|
L
|
F
|
S
|
G
|
P
|
Y
|
160 |
ECL2 | |||||||||
L
|
S
|
Y
|
Y
|
R
|
Q
|
S
|
Q
|
L
|
A
|
170 |
N
|
L
|
T
|
V
|
C
|
H
|
P
|
A
|
W
|
S
|
180 |
TM5 | |||||||||
A
|
P
|
R
|
R
|
R
|
A
|
M
|
D
|
I
|
C
|
190 |
T
|
F
|
V
|
F
|
S
|
Y
|
L
|
L
|
P
|
V
|
200 |
L
|
V
|
L
|
G
|
L
|
T
|
Y
|
A
|
R
|
T
|
210 |
L
|
R
|
Y
|
L
|
W
|
R
|
A
|
V
|
D
|
P
|
220 |
ICL3 | TM6 | ||||||||
V
|
A
|
A
|
G
|
S
|
G
|
A
|
R
|
R
|
A
|
230 |
K
|
R
|
K
|
V
|
T
|
R
|
M
|
I
|
L
|
I
|
240 |
V
|
A
|
A
|
L
|
F
|
C
|
L
|
C
|
W
|
M
|
250 |
P
|
H
|
H
|
A
|
L
|
I
|
L
|
C
|
V
|
W
|
260 |
ECL3 | TM7 | ||||||||
F
|
G
|
Q
|
F
|
P
|
L
|
T
|
R
|
A
|
T
|
270 |
Y
|
A
|
L
|
R
|
I
|
L
|
S
|
H
|
L
|
V
|
280 |
S
|
Y
|
A
|
N
|
S
|
C
|
V
|
N
|
P
|
I
|
290 |
H8 | |||||||||
V
|
Y
|
A
|
L
|
V
|
S
|
K
|
H
|
F
|
R
|
300 |
K
|
G
|
F
|
R
|
T
|
I
|
C
|
A
|
G
|
L
|
310 |
C-term | |||||||||
L
|
G
|
R
|
A
|
P
|
G
|
R
|
A
|
S
|
G
|
320 |
R
|
V
|
C
|
A
|
A
|
A
|
R
|
G
|
T
|
H
|
330 |
S
|
G
|
S
|
V
|
L
|
E
|
R
|
E
|
S
|
S
|
340 |
D
|
L
|
L
|
H
|
M
|
S
|
E
|
A
|
A
|
G
|
350 |
A
|
L
|
R
|
P
|
C
|
P
|
G
|
A
|
S
|
Q
|
360 |
P
|
C
|
I
|
L
|
E
|
P
|
C
|
P
|
G
|
P
|
370 |
S
|
W
|
Q
|
G
|
P
|
K
|
A
|
G
|
D
|
S
|
380 |
I
|
L
|
T
|
V
|
D
|
V
|
A
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
galanin, galanin-like peptide, spexin-1
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page