Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
5ht1e_human 7.39x38 330 TM7 T => N N/A N/A Adham N et al (1994)
5ht1e_human 7.39x38 330 TM7 T => N Increased effect K(i) (Binding - Radioligand competition/displacement) (-)-propranolol Adham N et al (1994) Vass M et al (2019)
5ht1e_human 7.39x38 330 TM7 T => N Increased effect K(i) (Binding - Radioligand competition/displacement) pindolol Adham N et al (1994) Vass M et al (2019)
5ht1e_human 7.39x38 330 TM7 T => N Gain of effect (wt had no effect) K(d) (Binding - Radioligand saturation) [125I]iodocyanopindolol Adham N et al (1994) Vass M et al (2019)
5ht1e_human 3.29x29 99 TM3 L => A 3.236↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 3.32x32 102 TM3 D => A Abolished pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 3.33x33 103 TM3 M => A 2.817↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 3.33x33 103 TM3 M => S 2.632↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 3.36x36 106 TM3 C => A 3.717↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 3.37x37 107 TM3 T => A 18.182↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 5.42x43 186 TM5 S => A 2.882↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 5.43x44 187 TM5 T => A 4.673↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 5.46x461 190 TM5 A => F 100.0↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 5.46x461 190 TM5 A => S 3.236↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 6.48x48 304 TM6 W => A 66.667↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 6.51x51 307 TM6 F => A 7.092↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 6.52x52 308 TM6 F => A 3.39↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 6.54x54 310 TM6 K => V 1.23↑ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 6.54x54 310 TM6 K => A 2.237↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 6.55x55 311 TM6 E => A 9.524↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 6.55x55 311 TM6 E => S 13.514↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 7.39x38 330 TM7 T => A 6.452↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 7.43x42 334 TM7 Y => A 50.0↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 7.43x42 334 TM7 Y => F 4.167↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 45.52x52 175 ECL2 I => A 6.024↓ pEC50 (Functional - Other) BRL-54443 Xu P et al (2021)
5ht1e_human 6.55x55 311 TM6 E => S 75.858↑ pEC50 (Functional - Other) 5-CT Xu P et al (2021)
5ht1e_human 6.55x55 311 TM6 E => A 165.959↑ pEC50 (Functional - Other) 5-CT Xu P et al (2021)
5ht1e_human 6.55x55 311 TM6 E => A 31.623↑ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht1e_human 6.55x55 311 TM6 E => S 6.31↑ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K K L H ICL1ECL1 R W K L ECL1ICL2 A I E Y A R K R ICL2ECL2 R S H R R L S P P P S Q C T I Q H D ECL2ICL3 H L S N R S T D S Q N S F A S C K L T Q T F C V S D F S T S D P T T E F E K F H A S I R I P P F D N D L D H P G E R Q ICL3ECL3 I Y T V ECL3N-term M N I T N C T T E A S M A I R P K N-termC-term I R C R E H T C-term T I T E K M L I C M T L V V I T T L T T L L N L A V I M A I G T T Q P A N Y L I C S L A V T D L L V A V L V M P L S I I Y I V M D G Y F L C E V W L S V D M T C C T C S I L H L C V I A L D R Y W A I T N T A K R A A L M I L T V W T I S I F I S M P P L F W H V I Y T I Y S T L G A F Y I P L T L I L I L Y Y R I Y H A A K S L Y Q K R G S S R Q I S S T R E R K A A R I L G L I L G A F I L S W L P F F I K E L I V G L S S S E V A D F L T W L G Y V N S L I N P L L Y T S F N E D F K K F K L A L
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L N L L T T L T T I V V L T M C I L M K 1 C S L A V T D L L V A L V V M P L S I I Y 2 V C L H L I S C T C C T M D V S L W V E 3 A A L M I L T V W T I S I F I S M P P L 4 Y L I L I L T L P I Y F A G L T S Y I T Y 5 G L I L G A F I L S W L P F F I K E L I 6 L P N I L S N V Y G L W T L F D A V E 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1E receptor
TM3
3x29 3.29x29 L99
3x32 3.32x32 D102
3x33 3.33x33 M103
3x36 3.36x36 C106
3x37 3.37x37 T107
TM5
5x43 5.42x43 S186
5x44 5.43x44 T187
5x461 5.46x461 A190
TM6
6x48 6.48x48 W304
6x51 6.51x51 F307
6x52 6.52x52 F308
6x54 6.54x54 K310
6x55 6.55x55 E311
TM7
7x38 7.39x38 T330
7x42 7.43x42 Y334