Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
5ht1f_human 7.39x38 333 TM7 A => N N/A N/A Adham N et al (1994)
5ht1f_human 7.39x38 333 TM7 A => N Increased effect K(i) (Binding - Radioligand competition/displacement) (-)-propranolol Adham N et al (1994) Vass M et al (2019)
5ht1f_human 7.39x38 333 TM7 A => N Increased effect K(i) (Binding - Radioligand competition/displacement) pindolol Adham N et al (1994) Vass M et al (2019)
5ht1f_human 3.50x50 121 TM3 R => A 2.237↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 3.54x54 125 TM3 I => A 2.754↑ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 34.51x51 129 ICL2 V => A 1.289↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 34.55x55 133 ICL2 R => A 1.549↑ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 5.61x61 204 TM5 I => A 2.291↑ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 6.29x29 287 TM6 R => A 1.862↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 6.37x37 295 TM6 L => A 1.698↑ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 8.47x47 351 H8 N => A 1.658↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 3.32x32 103 TM3 D => A N/A pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 3.33x33 104 TM3 I => A 58.824↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 3.36x36 107 TM3 C => A 32.258↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 3.37x37 108 TM3 T => A 10.526↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 5.39x40 182 TM5 T => A 5.618↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 5.42x43 185 TM5 S => A 1.585↑ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 5.43x44 186 TM5 T => A 1.023↑ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 6.48x48 306 TM6 W => A N/A pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 6.51x51 309 TM6 F => A 100.0↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 6.52x52 310 TM6 F => A N/A pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 6.54x54 312 TM6 K => A 1.096↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 6.55x55 313 TM6 E => A 15.385↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 6.59x59 317 TM6 N => A 1.862↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 7.43x42 337 TM7 Y => A N/A pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 45.52x52 174 ECL2 I => A 3.636↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 177 ECL2 D => A 1.779↓ pEC50 (Functional - Other) lasmiditan Huang S et al (2021)
5ht1f_human 6.55x55 313 TM6 E => A Abolished pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht1f_human 6.55x55 313 TM6 E => S Abolished pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R K L H ICL1ECL1 S W I M ECL1ICL2 A V E Y A R K R ICL2ECL2 Q G T S R D D E C I I K H D ECL2ICL3 I A K E E V N G Q V L L E S G E K S T K S V S T S Y V L E K S L S D P S T D F D K I H S T V R S L R S E F K H E K S W R R Q ICL3ECL3 D K C K I ECL3N-term M D F L N S S D Q N L T S E E L L N R N-termC-term V R C R C C-term M P S K I L V S L T L S G L A L M T T T I N S L V I A A I I V T H P A N Y L I C S L A V T D F L V A V L V M P F S I V Y I V R E G Q V V C D I W L S V D I T C C T C S I L H L S A I A L D R Y R A I T D T P K H A G I M I T I V W I I S V F I S M P P L F W R H H I V S T I Y S T F G A F Y I P L A L I L I L Y Y K I Y R A A K T L Y H K R Q A S R K I S G T R E R K A A T T L G L I L G A F V I C W L P F F V K E L V V N V C S E E M S N F L A W L G Y L N S L I N P L I Y T I F N E D F Q K F K K A L
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
S N I T T T M L A L G S L T L S V L I K 1 C S L A V T D F L V A L V V M P F S I V Y 2 A S L H L I S C T C C T I D V S L W I D 3 A G I M I T I V W I I S V F I S M P P L 4 Y L I L I L A L P I Y F A G F T S Y I T S 5 G L I L G A F V I C W L P F F V K E L V 6 L P N I L S N L Y G L W A L F N S M E 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1F receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 C107
3x37 3.37x37 T108
3x50 3.50x50 R121
3x54 3.54x54 I125
TM5
5x40 5.39x40 T182
5x43 5.42x43 S185
5x44 5.43x44 T186
5x61 5.61x61 I204
TM6
6x29 6.29x29 R287
6x37 6.37x37 L295
6x48 6.48x48 W306
6x51 6.51x51 F309
6x52 6.52x52 F310
6x54 6.54x54 K312
6x55 6.55x55 E313
6x59 6.59x59 N317
TM7
7x38 7.39x38 A333
7x42 7.43x42 Y337
H8
8x47 8.47x47 N351