Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
ccr3_human 6 N-term D => A 1.387↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 9 N-term E => A 1.368↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 18 N-term D => A 1.102↑ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 19 N-term D => A 1.315↑ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 25 N-term E => A 1.342↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 1.24x24 26 TM1 K => A 1.026↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 1.26x26 28 TM1 D => A 1.277↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 1.28x28 30 TM1 R => A 1.59↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 173 ECL2 E => A 1.318↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 175 ECL2 E => A Abolished IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 176 ECL2 E => A Abolished IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 179 ECL2 E => A 1.115↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 180 ECL2 E => A 1.225↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 189 ECL2 E => A 1.661↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 190 ECL2 D => A 2.155↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 5.35x36 196 TM5 R => A 1.592↓ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 7.24x23 272 TM7 D => A 2.02↑ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 7.26x25 274 TM7 E => A 1.811↑ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 7.27x26 275 TM7 R => A 1.848↑ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 7.29x28 277 TM7 K => A 1.649↑ IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 7.32x31 280 TM7 D => A Abolished IC50 (Binding - Radioligand competition/displacement) CCL11 Duchesnes CE et al (2006) Salam W et al (2025)
ccr3_human 3.49x49 130 TM3 D => A N/A N/A Auger GA et al (2002)
ccr3_human 3.49x49 130 TM3 D => E N/A N/A Auger GA et al (2002)
ccr3_human 3.49x49 130 TM3 D => N N/A N/A Auger GA et al (2002)
ccr3_human 3.50x50 131 TM3 R => K N/A N/A Auger GA et al (2002)
ccr3_human 3.50x50 131 TM3 R => L N/A N/A Auger GA et al (2002)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R R L R ICL1ECL1 N W V F ECL1ICL2 A V F A L R A R ICL2ECL2 E T E E L F E E T L C S A L Y P E D ECL2ICL3 P S ICL3ECL3 G N ECL3N-term M T T S L D T V E T F G T T S Y Y D D V G L L C E N-termC-term H L L M H L G R Y I P F L P S E K L E R T S S V S P S T A E P E L S I V F C-term K A D T R A L M A Q F V P P L Y S L V F T V G L L G N V V V V M I L I K Y I M T N I Y L L N L A I S D L L F L V T L P F W I H Y V R G H G H G M C K L L S G F Y H T G L Y S E I F F I I L L T I D R Y L A I V H T V T F G V I T S I V T W G L A V L A A L P E F I F Y T V Y S W R H F H T L R M T I F C L V L P L L V M A I C Y T G I I K T L L R C K K K Y K A I R L I F V I M A V F F I F W T P Y N V A I L L S S Y Q S I L F D C E R S K H L D L V M L V T E V I A Y S H C C M N P V I Y A F V G E R L R H F R K Y F F H R
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V N G L L G V T F V L S Y L P P V F Q A 1 L N L A I S D L L F L V T L P F W I H Y 2 L I I F F I E S Y L G T H Y F G S L L K 3 G V I T S I V T W G L A V L A A L P E 4 Y C I A M V L L P L V L C F I T M R L T H 5 F V I M A V F F I F W T P Y N V A I L L 6 V P N M C C H S Y A I V E T V L M V L 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR3
TM1
1x24 1.24x24 K26
1x26 1.26x26 D28
1x28 1.28x28 R30
TM3
3x49 3.49x49 D130
3x50 3.50x50 R131
TM5
5x36 5.35x36 R196
TM7
7x23 7.24x23 D272
7x25 7.26x25 E274
7x26 7.27x26 R275
7x28 7.29x28 K277
7x31 7.32x31 D280