Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
ccr8_human 1.39x39 42 TM1 Y => A 1.264↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.53x53 84 TM2 F => A 2.175↑ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.57x57 88 TM2 F => A 1.149↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.60x60 91 TM2 Q => W 7.937↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.28x28 109 TM3 V => A 1.061↑ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => A 5.437↑ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => H >111.111↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => W >111.111↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.31x31 112 TM3 F => A 1.891↑ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.32x32 113 TM3 Y => A 37.037↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.33x33 114 TM3 Y => A 15.152↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.42x42 123 TM3 F => A 1.977↑ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 4.60x61 168 TM4 L => D 1.379↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 4.64x65 172 TM4 Y => A 1.264↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.33x34 193 TM5 K => A 2.532↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.34x35 194 TM5 W => A 14.706↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.35x36 195 TM5 K => A 1.16↑ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => A 7.692↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => W Abolished EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => A 2.559↑ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => Q 1.318↑ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.51x51 254 TM6 F => A 12.5↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.55x55 258 TM6 L => A 3.106↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.59x59 262 TM6 S => A 1.673↑ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.36x35 283 TM7 H => A 1.379↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.39x38 286 TM7 E => A 1.379↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.42x41 289 TM7 S => A 2.07↓ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.43x42 290 TM7 F => A 1.45↑ EC50 (Functional - IP accumulation) CCL1 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 1.39x39 42 TM1 Y => A 14.286↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.53x53 84 TM2 F => A 1.272↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.57x57 88 TM2 F => A 9.804↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.60x60 91 TM2 Q => W 9.804↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.28x28 109 TM3 V => A 1.429↑ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => A 7.333↑ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => H >1000.0↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => W >1000.0↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.31x31 112 TM3 F => A 1.0 EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.32x32 113 TM3 Y => A >1000.0↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.33x33 114 TM3 Y => A 3.817↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.42x42 123 TM3 F => A 1.571↑ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 4.60x61 168 TM4 L => D 1.637↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 4.64x65 172 TM4 Y => A 1.908↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.33x34 193 TM5 K => A 1.294↑ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.34x35 194 TM5 W => A 1.447↑ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.35x36 195 TM5 K => A 1.774↑ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => A 1.727↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => W Abolished EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => A 4.0↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => Q 4.0↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.51x51 254 TM6 F => A 19.298↑ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.55x55 258 TM6 L => A 1.182↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.59x59 262 TM6 S => A 1.908↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.36x35 283 TM7 H => A 2.183↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.39x38 286 TM7 E => A >1000.0↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.42x41 289 TM7 S => A 1.453↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.43x42 290 TM7 F => A 1.818↓ EC50 (Functional - IP accumulation) CHEMBL5268017 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 1.39x39 42 TM1 Y => A 4.525↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 1.43x43 46 TM1 F => A 4.348↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.53x53 84 TM2 F => A 4.143↑ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.57x57 88 TM2 F => A 8.621↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.60x60 91 TM2 Q => W 12.658↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.28x28 109 TM3 V => A 1.172↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => A 4.833↑ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => H >333.333↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => W >333.333↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.31x31 112 TM3 F => A 1.757↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.32x32 113 TM3 Y => A >333.333↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.33x33 114 TM3 Y => A 14.925↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.42x42 123 TM3 F => A 1.381↑ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 4.64x65 172 TM4 Y => A 1.931↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.33x34 193 TM5 K => A 1.07↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.34x35 194 TM5 W => A 2.417↑ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.35x36 195 TM5 K => A 1.45↑ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => A 1.621↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => W Abolished EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => A 1.45↑ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => Q 1.318↑ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.51x51 254 TM6 F => A 9.615↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.55x55 258 TM6 L => A 11.364↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.59x59 262 TM6 S => A 2.105↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.35x34 282 TM7 T => A 2.653↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.36x35 283 TM7 H => A 1.034↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.39x38 286 TM7 E => A 333.333↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.42x41 289 TM7 S => A >7.299↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.43x42 290 TM7 F => A 1.414↓ EC50 (Functional - IP accumulation) CHEMBL5270110 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 1.39x39 42 TM1 Y => A 11.905↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 1.43x43 46 TM1 F => A 3.333↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.53x53 84 TM2 F => A 1.25↑ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.57x57 88 TM2 F => A 13.158↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.60x60 91 TM2 Q => W 12.048↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.28x28 109 TM3 V => A 1.875↑ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => A 7.5↑ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => H 500.0↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => W >500.0↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.31x31 112 TM3 F => A >1.154↑ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.32x32 113 TM3 Y => A 500.0↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.33x33 114 TM3 Y => A >12.658↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.42x42 123 TM3 F => A 1.25↑ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 4.64x65 172 TM4 Y => A 2.066↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.33x34 193 TM5 K => A 1.134↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.34x35 194 TM5 W => A 3.75↑ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.35x36 195 TM5 K => A 2.143↑ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => A 1.25↑ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => W Abolished EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => A 3.191↑ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => Q 1.0 EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.51x51 254 TM6 F => A 5.319↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.55x55 258 TM6 L => A 2.331↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.59x59 262 TM6 S => A 1.154↑ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.35x34 282 TM7 T => A 2.066↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.36x35 283 TM7 H => A 2.268↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.39x38 286 TM7 E => A 500.0↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.42x41 289 TM7 S => A >2.268↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.43x42 290 TM7 F => A 1.733↓ EC50 (Functional - IP accumulation) CHEMBL5272687 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 1.39x39 42 TM1 Y => A 19.231↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 1.43x43 46 TM1 F => A 4.785↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.53x53 84 TM2 F => A 1.875↑ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.57x57 88 TM2 F => A 3.448↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.60x60 91 TM2 Q => W 17.857↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.28x28 109 TM3 V => A 3.462↑ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => A 5.625↑ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => H 1000.0↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => W >1000.0↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.31x31 112 TM3 F => A >1.268↑ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.32x32 113 TM3 Y => A 1000.0↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.33x33 114 TM3 Y => A >62.5↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.42x42 123 TM3 F => A 1.8↑ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 4.64x65 172 TM4 Y => A 3.115↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.33x34 193 TM5 K => A 1.915↑ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.34x35 194 TM5 W => A 1.5↑ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.35x36 195 TM5 K => A 40.909↑ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => A 4.5↑ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => W Abolished EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => A 4.673↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => Q 1.111↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.51x51 254 TM6 F => A 1.111↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.55x55 258 TM6 L => A 7.246↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.59x59 262 TM6 S => A 1.011↑ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.35x34 282 TM7 T => A 4.444↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.36x35 283 TM7 H => A 1.89↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.39x38 286 TM7 E => A 1000.0↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.42x41 289 TM7 S => A >1.89↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.43x42 290 TM7 F => A 2.331↓ EC50 (Functional - IP accumulation) CHEMBL5277802 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 1.39x39 42 TM1 Y => A 6.623↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 1.43x43 46 TM1 F => A 1.733↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.53x53 84 TM2 F => A 4.425↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.57x57 88 TM2 F => A 3.135↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 2.60x60 91 TM2 Q => W 6.711↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.28x28 109 TM3 V => A 1.1↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => A 8.333↑ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => H 333.333↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.29x29 110 TM3 S => W >333.333↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.31x31 112 TM3 F => A >1.233↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.32x32 113 TM3 Y => A 333.333↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.33x33 114 TM3 Y => A >31.25↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 3.42x42 123 TM3 F => A 1.579↑ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 4.64x65 172 TM4 Y => A 3.096↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.33x34 193 TM5 K => A 1.0 EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.34x35 194 TM5 W => A 1.066↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.35x36 195 TM5 K => A 1.0 EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => A 2.066↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 5.46x461 206 TM5 G => W Abolished EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => A 1.034↑ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.48x48 251 TM6 W => Q 1.034↑ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.51x51 254 TM6 F => A 1.401↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.55x55 258 TM6 L => A 2.132↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 6.59x59 262 TM6 S => A 1.3↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.35x34 282 TM7 T => A 3.096↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.36x35 283 TM7 H => A 1.534↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.39x38 286 TM7 E => A 333.333↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.42x41 289 TM7 S => A >1.2↓ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
ccr8_human 7.43x42 290 TM7 F => A 1.034↑ EC50 (Functional - IP accumulation) CHEMBL5273480 Jensen PC et al (2007) Salam W et al (2025)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K K L R ICL1ECL1 Q W V F ECL1ICL2 A V Y A L K V R ICL2ECL2 Q V A S E D G V L Q C Y S F Y N Q Q ECL2ICL3 Q N ICL3ECL3 L D ECL3N-term M D Y T L D L S V T T V T D Y Y Y P D I F S S P C D A E L I N-termC-term S C S Q I F N Y L G R Q M P R E S C E K S S S C Q Q H S S R S S S V D Y I L C-term Q T N G K L L L A V F Y C L L F V F S L L G N S L V I L V L V V C S I T D V Y L L N L A L S D L L F V F S F P F Q T Y Y L L D G T V M C K V V S G F Y Y I G F Y S S M F F I T L M S V D R Y L A V V H T I R M G T T L C L A V W L T A I M A T I P L L V F Y T L K W K I F T N F K M N I L G L L I P F T I F M F C Y I K I L H Q L K R C H N K T K A I R L V L I V V I A S L L F W V P F N V V L F L T S L H S M H I G C S I S Q Q L T Y A T H V T E I I S F T H C C V N P V I Y A F V G E K L S E F K K H I F Q K
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
S N G L L S F V F L L C Y F V A L L L K 1 L N L A L S D L L F V F S F P F Q T Y Y 2 L T I F F M S S Y F G I Y Y F G S V V K 3 G T T L C L A V W L T A I M A T I P L 4 Y C F M F I T F P I L L G L I N M K F N T 5 L I V V I A S L L F W V P F N V V L F L 6 V P N V C C H T F S I I E T V H T A Y 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
CCR8
TM1
1x39 1.39x39 Y42
1x43 1.43x43 F46
TM2
2x53 2.53x53 F84
2x57 2.57x57 F88
2x60 2.60x60 Q91
TM3
3x28 3.28x28 V109
3x29 3.29x29 S110
3x31 3.31x31 F112
3x32 3.32x32 Y113
3x33 3.33x33 Y114
3x42 3.42x42 F123
TM4
4x61 4.60x61 L168
4x65 4.64x65 Y172
TM5
5x34 5.33x34 K193
5x35 5.34x35 W194
5x36 5.35x36 K195
5x461 5.46x461 G206
TM6
6x48 6.48x48 W251
6x51 6.51x51 F254
6x55 6.55x55 L258
6x59 6.59x59 S262
TM7
7x34 7.35x34 T282
7x35 7.36x35 H283
7x38 7.39x38 E286
7x41 7.42x41 S289
7x42 7.43x42 F290