Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
cxcr3_human 16 N-term V => - Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 27 N-term Y => F Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 29 N-term Y => F Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 4 N-term E => K 1.265↑ IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 21 N-term E => K 1.742↓ IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 2.63x63 112 TM2 D => K Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 2.63x63 112 TM2 D => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 197 ECL2 R => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 5.35x36 212 TM5 R => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 5.39x40 216 TM5 R => A 3.875↑ IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => K Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 6.62x62 282 TM6 D => K Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 6.62x62 282 TM6 D => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 7.28x27 293 TM7 E => K Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 7.28x27 293 TM7 E => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL10 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 16 N-term V => - Abolished IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 4 N-term E => K 2.398↓ IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 21 N-term E => K 3.636↓ IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 2.63x63 112 TM2 D => K Abolished IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 2.63x63 112 TM2 D => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 197 ECL2 R => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 5.35x36 212 TM5 R => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 5.39x40 216 TM5 R => A 2.703↓ IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => K Abolished IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 6.62x62 282 TM6 D => K Abolished IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 6.62x62 282 TM6 D => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 7.28x27 293 TM7 E => K Abolished IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 7.28x27 293 TM7 E => A Abolished IC50 (Binding - Radioligand competition/displacement) CXCL11 Colvin RA et al (2006) Arimont M et al (2017)
cxcr3_human 3.29x29 128 TM3 G => H 23.256↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => A 1000.0↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 3.36x36 135 TM3 F => L 58.824↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 4.60x61 186 TM4 D => N 1000.0↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 202 ECL2 H => A 62.5↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 5.35x36 212 TM5 R => A Abolished EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 5.35x36 212 TM5 R => H 20.408↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.48x48 268 TM6 W => A 52.632↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => A 1000.0↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => L 1000.0↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => N 1000.0↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => F 55.556↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => H 111.111↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => N 58.824↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 7.35x34 300 TM7 K => A 21.277↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => A 1000.0↓ EC50 (Functional - IP accumulation) Cu(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 3.29x29 128 TM3 G => H 8.85↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => A 20.408↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 3.36x36 135 TM3 F => L 4.878↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 4.60x61 186 TM4 D => N 5.291↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 202 ECL2 H => A 10.0↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 5.35x36 212 TM5 R => H 9.434↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.48x48 268 TM6 W => A 15.873↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => A 1.0 N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => L 1.308↑ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => N 3.289↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => F 4.464↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => H 5.65↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => N 7.634↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 7.35x34 300 TM7 K => A 2.469↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => A 4.348↓ N/A CXCL11 Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 3.29x29 128 TM3 G => H 25.119↑ N/A Zn(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => A 1.259↑ N/A Zn(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 4.60x61 186 TM4 D => N 1.0 N/A Zn(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 5.35x36 212 TM5 R => A 39.811↑ N/A Zn(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.48x48 268 TM6 W => A 6.31↑ N/A Zn(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => A 1.0 N/A Zn(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => N 6.31↑ N/A Zn(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 7.35x34 300 TM7 K => A 25.119↑ N/A Zn(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => A 1.995↑ N/A Zn(II)-Bipyridine Rosenkilde MM et al (2007) Arimont M et al (2017)
cxcr3_human 195 ECL2 D => N 1.0 K(d) (Binding - Radioligand competition/displacement) CXCL10 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 196 ECL2 E => Q 1.618↓ K(d) (Binding - Radioligand competition/displacement) CXCL10 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => N 6.579↓ K(d) (Binding - Radioligand competition/displacement) CXCL10 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 6.62x62 282 TM6 D => N 1.621↑ K(d) (Binding - Radioligand competition/displacement) CXCL10 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 7.28x27 293 TM7 E => Q 3.917↑ K(d) (Binding - Radioligand competition/displacement) CXCL10 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 7.32x31 297 TM7 D => N 1.511↓ K(d) (Binding - Radioligand competition/displacement) CXCL10 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 2.63x63 112 TM2 D => N 2.868↑ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 195 ECL2 D => N 1.468↓ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 196 ECL2 E => Q 27.25↑ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => N 4.192↑ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 6.62x62 282 TM6 D => N 7.786↑ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 7.28x27 293 TM7 E => Q 2.946↑ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 7.32x31 297 TM7 D => N 2.415↓ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2012) Arimont M et al (2017)
cxcr3_human 1.25x25 46 TM1 D => N 2.513↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.31x31 52 TM1 D => N 1.259↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 2.63x63 112 TM2 D => N 1.259↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 4.60x61 186 TM4 D => N 1.259↑ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 195 ECL2 D => N 1.259↑ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 196 ECL2 E => N 1.585↑ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => N 1.259↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.62x62 282 TM6 D => N Abolished pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.28x27 293 TM7 E => N 2.513↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.32x31 297 TM7 D => N 1.259↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.39x39 60 TM1 Y => A 1.259↑ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.39x39 60 TM1 Y => F 1.585↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 2.60x60 109 TM2 W => Q 1.585↑ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.29x29 128 TM3 G => H 5.0↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => A 1.259↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => H 1.259↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.36x36 135 TM3 F => A 1.996↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.48x48 268 TM6 W => Q 1.259↑ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => A 1.259↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.35x34 300 TM7 K => I 2.513↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.36x35 301 TM7 S => A 3.165↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => A 5.0↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => E 1.259↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => L 1.585↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => A 1.585↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => F 2.513↓ pK(d) (Binding - Radioligand competition/displacement) CXCL11 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.25x25 46 TM1 D => N 1.0 pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.31x31 52 TM1 D => N 1.995↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 2.63x63 112 TM2 D => N 12.658↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 4.60x61 186 TM4 D => N 3.162↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 195 ECL2 D => N 1.259↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 196 ECL2 E => N 1.996↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => N 3.162↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.62x62 282 TM6 D => N Abolished pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.28x27 293 TM7 E => N 1.585↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.32x31 297 TM7 D => N 2.512↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.39x39 60 TM1 Y => A 1.996↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.39x39 60 TM1 Y => F 1.259↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 2.60x60 109 TM2 W => Q <500.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.29x29 128 TM3 G => H 100.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => A 7.937↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => H 1.585↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.36x36 135 TM3 F => A 1.995↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.48x48 268 TM6 W => Q 1.585↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => A 6.329↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.35x34 300 TM7 K => I 1.585↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.36x35 301 TM7 S => A 1.996↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => A 1.259↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => E 76.923↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => L 20.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => A 31.25↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => F 3.165↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL1077819 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.25x25 46 TM1 D => N 1.0 pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.31x31 52 TM1 D => N 7.943↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 2.63x63 112 TM2 D => N 3.165↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 4.60x61 186 TM4 D => N 1.996↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 195 ECL2 D => N 1.585↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 196 ECL2 E => N 5.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => N 1.585↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.62x62 282 TM6 D => N Abolished pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.28x27 293 TM7 E => N 1.585↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.32x31 297 TM7 D => N 7.943↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.39x39 60 TM1 Y => A 10.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.39x39 60 TM1 Y => F 12.658↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 2.60x60 109 TM2 W => Q <31.25↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.29x29 128 TM3 G => H 15.873↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => A 31.25↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => H 7.937↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.36x36 135 TM3 F => A <31.25↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.48x48 268 TM6 W => Q 2.513↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => A 1.996↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.35x34 300 TM7 K => I 3.165↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.36x35 301 TM7 S => A 1.585↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => A <31.25↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => E <100.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => L 7.937↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => A 10.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => F 12.658↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL2181467 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.25x25 46 TM1 D => N 1.0 pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.31x31 52 TM1 D => N 1.995↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 2.63x63 112 TM2 D => N 1.0 pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 4.60x61 186 TM4 D => N 10.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 195 ECL2 D => N 1.585↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 196 ECL2 E => N 1.259↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.58x58 278 TM6 D => N 1.259↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.62x62 282 TM6 D => N Abolished pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.28x27 293 TM7 E => N 1.259↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.32x31 297 TM7 D => N 1.995↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.39x39 60 TM1 Y => A 1.996↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.39x39 60 TM1 Y => F 1.996↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 2.60x60 109 TM2 W => Q <500.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.29x29 128 TM3 G => H 1000.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => A 20.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => H 3.984↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 3.36x36 135 TM3 F => A 1.996↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.48x48 268 TM6 W => Q 6.329↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 6.51x51 271 TM6 Y => A 10.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.35x34 300 TM7 K => I 1.259↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.36x35 301 TM7 S => A 1.995↑ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => A 1.259↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => E 1.585↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.39x38 304 TM7 S => L 20.0↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => A 7.937↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => F 3.165↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL472288 Scholten DJ et al (2014) Arimont M et al (2017)
cxcr3_human 1.39x39 60 TM1 Y => A 4.278↑ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => A 7.0↑ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 202 ECL2 H => A 2.655↑ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 45.52x52 205 ECL2 Y => A 1.351↓ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 6.55x55 275 TM6 V => A 1.041↑ K(d) (Binding - Radioligand competition/displacement) CXCL11 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 1.39x39 60 TM1 Y => A 2.236↑ IC50 (Binding - Radioligand competition/displacement) TAK-779 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => A 1.343↑ IC50 (Binding - Radioligand competition/displacement) TAK-779 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 202 ECL2 H => A 1.237↑ IC50 (Binding - Radioligand competition/displacement) TAK-779 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 6.59x59 279 TM6 I => A 1.259↓ IC50 (Binding - Radioligand competition/displacement) TAK-779 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 7.43x42 308 TM7 Y => A 2.204↑ IC50 (Binding - Radioligand competition/displacement) TAK-779 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 1.39x39 60 TM1 Y => A 1.021↑ IC50 (Binding - Radioligand competition/displacement) AMG487 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 3.32x32 131 TM3 F => A 1.497↑ IC50 (Binding - Radioligand competition/displacement) AMG487 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 202 ECL2 H => A 1.241↓ IC50 (Binding - Radioligand competition/displacement) AMG487 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 6.59x59 279 TM6 I => A 2.004↓ IC50 (Binding - Radioligand competition/displacement) AMG487 Nedjai B et al (2015) Arimont M et al (2017)
cxcr3_human 7.35x34 300 TM7 K => A N/A N/A Rosenkilde MM et al (2004)
cxcr3_human 4.60x61 186 TM4 D => N N/A N/A Rosenkilde MM et al (2004)
cxcr3_human 6.58x58 278 TM6 D => N N/A N/A Rosenkilde MM et al (2004)
cxcr3_human 7.39x38 304 TM7 S => E N/A N/A Rosenkilde MM et al (2004)
cxcr3_human 6.51x51 271 TM6 Y => N N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 6.51x51 271 TM6 Y => A N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 6.51x51 271 TM6 Y => L N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 6.58x58 278 TM6 D => N N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 5.35x36 212 TM5 R => H N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 7.43x42 308 TM7 Y => A N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 3.29x29 128 TM3 G => H N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 7.35x34 300 TM7 K => A N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 6.48x48 268 TM6 W => A N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 6.51x51 271 TM6 Y => F N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 5.35x36 212 TM5 R => A N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 3.32x32 131 TM3 F => A N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 202 ECL2 H => A N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 4.60x61 186 TM4 D => N N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 3.36x36 135 TM3 F => L N/A N/A Rosenkilde MM et al (2007)
cxcr3_human 6.51x51 271 TM6 Y => H N/A N/A Rosenkilde MM et al (2007)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R T A L ICL1ECL1 Q W V F ECL1ICL2 A T Q L Y R R G P P ICL2ECL2 S A H H D E R L N A T H C Q Y N F ECL2ICL3 R G Q ICL3ECL3 A L A R ECL3N-term M V L E V S D H Q V L N D A E V A A L L E N F S S S Y D Y G E N E S D S C C T S P P C P N-termC-term G C P N Q R G L Q R Q P S S S R R D S S W S E T S E A S Y S G L C-term Q D F S L N F D R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A R V T L T C L A V W G L C L L F A L P D F I F L P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K M W M L F R E R L L L R
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
G N G L L G L L F L L S Y L A P L F A R 1 L H L A V A D T L L V L T L P L W A V D 2 C A L L L A G A Y F N I N F L A G A V K 3 V T L T C L A V W G L C L L F A L P D 4 Y C Y A M V L L P L L F G A V L Q L V R L 5 V V V V V A F A L C W T P Y H L V V L V 6 L P N L C C H M Y G L G S T V S K A V 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
CXCR3
TM1
1x25 1.25x25 D46
1x31 1.31x31 D52
1x39 1.39x39 Y60
TM2
2x60 2.60x60 W109
2x63 2.63x63 D112
TM3
3x29 3.29x29 G128
3x32 3.32x32 F131
3x36 3.36x36 F135
TM4
4x61 4.60x61 D186
TM5
5x36 5.35x36 R212
5x40 5.39x40 R216
TM6
6x48 6.48x48 W268
6x51 6.51x51 Y271
6x55 6.55x55 V275
6x58 6.58x58 D278
6x59 6.59x59 I279
6x62 6.62x62 D282
TM7
7x27 7.28x27 E293
7x31 7.32x31 D297
7x34 7.35x34 K300
7x35 7.36x35 S301
7x38 7.39x38 S304
7x42 7.43x42 Y308