GproteinDb

Mutant Browser

Protein name	Generic number	Position	Segment	Mutation	FoldChange or Qual	Exp Type	Ligand	Reference	Review

cxcr4_human	1.39x39	45	TM1	Y => A	15.873↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	145.0↑	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	8.286↑	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	34.483↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.33x33	117	TM3	T => A	2.9↑	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	2.137↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	Abolished	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	5.918↑	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.52x52	188	ECL2	R => A	3.448↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		189	ECL2	F => A	9.355↑	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	1.379↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.587↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.38x39	199	TM5	F => A	1.0	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	2.381↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	1.036↑	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	6.897↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.48x48	252	TM6	W => A	5.525↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	2.933↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	5.472↑	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	4.265↑	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	1.484↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	8.056↑	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	1.311↓	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	Abolished	EC50 (Functional - IP accumulation)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	1.115↑	IC50 (Binding - Radioligand competition/displacement)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	34.483↓	IC50 (Binding - Radioligand competition/displacement)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	31.25↓	IC50 (Binding - Radioligand competition/displacement)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	1.449↓	IC50 (Binding - Radioligand competition/displacement)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	20.714↑	IC50 (Binding - Radioligand competition/displacement)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	2.417↑	IC50 (Binding - Radioligand competition/displacement)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	Abolished	IC50 (Binding - Radioligand competition/displacement)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	IC50 (Binding - Radioligand competition/displacement)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	34.483↓	IC50 (Binding - Radioligand competition/displacement)	[Aib]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	33.333↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	5.682↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	17.647↑	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	6.818↑	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.33x33	117	TM3	T => A	1.401↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	8.333↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	Abolished	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	3.947↑	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.52x52	188	ECL2	R => A	14.706↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		189	ECL2	F => A	3.797↑	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	1.154↑	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.2↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.38x39	199	TM5	F => A	1.304↑	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	4.918↑	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	1.111↑	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	2.667↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.48x48	252	TM6	W => A	4.329↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	1.066↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	7.317↑	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	1.364↑	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	1.835↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.733↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	5.0↓	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	Abolished	EC50 (Functional - IP accumulation)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	1.14↑	IC50 (Binding - Radioligand competition/displacement)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	12.5↓	IC50 (Binding - Radioligand competition/displacement)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	6.329↓	IC50 (Binding - Radioligand competition/displacement)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	2.333↑	IC50 (Binding - Radioligand competition/displacement)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	18.148↑	IC50 (Binding - Radioligand competition/displacement)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	5.632↑	IC50 (Binding - Radioligand competition/displacement)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	20.408↓	IC50 (Binding - Radioligand competition/displacement)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	20.408↓	IC50 (Binding - Radioligand competition/displacement)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	9.615↓	IC50 (Binding - Radioligand competition/displacement)	[Cit]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => S	5.65↓	IC50 (Binding - Radioligand competition/displacement)	ALX40-4C	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => A	Abolished	IC50 (Binding - Radioligand competition/displacement)	ALX40-4C	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => D	Abolished	IC50 (Binding - Radioligand competition/displacement)	ALX40-4C	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => K	Abolished	IC50 (Binding - Radioligand competition/displacement)	ALX40-4C	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	1000.0↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	12.5↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => N	333.333↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	500.0↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.222↑	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	2.183↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human		176	ECL2	N => A	1.375↑	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	1.364↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	2.545↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	111.111↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	3.546↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.37x37	121	TM3	Y => A	1.727↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	1.182↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	40.0↓	K(i) (Binding - Radioligand competition/displacement)	mavorixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	250.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL28967	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	8.929↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL28967	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	10.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL127188	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	1.15↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL127188	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	90.909↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL5284797	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	5.236↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL5284797	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	2.725↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	200.0↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human		182	ECL2	D => N	5.65↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	5.32x33	193	TM5	D => N	5.814↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	3.817↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	200.0↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	21.154↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	7.45x45	294	TM7	H => A	1.692↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	1.757↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	38.462↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human		182	ECL2	D => N	1.757↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	5.32x33	193	TM5	D => N	1.094↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.088↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	14.925↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	3.083↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	7.45x45	294	TM7	H => A	1.89↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => S	32.258↓	IC50 (Binding - Radioligand competition/displacement)	plerixafor	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => A	21.277↓	IC50 (Binding - Radioligand competition/displacement)	plerixafor	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => D	1.297↑	IC50 (Binding - Radioligand competition/displacement)	plerixafor	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => K	1.584↑	IC50 (Binding - Radioligand competition/displacement)	plerixafor	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	1.401↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	12.048↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human		182	ECL2	D => N	3.205↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	5.32x33	193	TM5	D => N	1.099↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	2.041↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	17.544↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.1↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	7.45x45	294	TM7	H => A	1.961↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	1.757↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	90.909↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human		182	ECL2	D => N	1.757↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	5.32x33	193	TM5	D => N	1.094↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.088↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	17.544↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	3.083↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	7.45x45	294	TM7	H => A	1.89↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	2.024↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	3.33x33	117	TM3	T => A	1.935↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	4.57x57	168	TM4	T => A	1.203↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	14.706↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	4.63x64	174	TM4	F => A	3.546↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => F	40.0↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	5.181↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	1.589↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	5.46x461	207	TM5	G => W	3.39↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	10.87↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.52x52	256	TM6	Y => A	4.484↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	1.686↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	5.181↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	52.632↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.59x59	263	TM6	S => A	6.061↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	5.562↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	1.236↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	71.429↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	3.367↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.36x36	120	TM3	L => F	1.499↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	8.197↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.61x62	172	TM4	F => A	1.294↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => F	38.462↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.571↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	1.818↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	4.219↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.318↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	3.003↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	1.318↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	2.865↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	21.277↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.158↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	5.464↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.38x37	287	TM7	T => A	1.318↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	29.412↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	2.247↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	14.706↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.61x62	172	TM4	F => A	5.291↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.63x64	174	TM4	F => A	3.597↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => F	40.0↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human		176	ECL2	N => A	4.608↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human		182	ECL2	D => A	3.597↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	15.625↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	5.181↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	1.589↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	3.03↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	2.024↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.46x461	207	TM5	G => F	3.367↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.46x461	207	TM5	G => W	3.03↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	10.87↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.52x52	256	TM6	Y => A	4.484↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	1.686↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	5.181↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	52.632↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.59x59	263	TM6	S => A	6.061↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	5.562↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	1.236↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.38x37	287	TM7	T => A	3.484↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	71.429↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	10.101↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	14.085↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => N	3.509↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	9.615↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.37x37	121	TM3	Y => A	2.1↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	11.364↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human		176	ECL2	N => A	1.165↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	1.681↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.431↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.74↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	2.841↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	17.857↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	6.146↑	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	34.483↓	K(i) (Binding - Radioligand competition/displacement)	plerixafor	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	3.571↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	18.519↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human		182	ECL2	D => N	2.571↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	5.32x33	193	TM5	D => N	2.463↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.859↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	500.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.859↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	7.45x45	294	TM7	H => A	1.273↑	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	1.916↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	142.857↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human		182	ECL2	D => N	5.155↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	5.32x33	193	TM5	D => N	4.082↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	3.003↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	83.333↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.379↑	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	7.45x45	294	TM7	H => A	2.833↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	200.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL278054	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	21.739↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL278054	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	83.333↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL277955	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	2.591↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL277955	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	13.699↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.36x36	120	TM3	L => F	1.538↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	5.348↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.61x62	172	TM4	F => A	1.333↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => F	111.111↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.401↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	4.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	3.003↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.6↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	1.848↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	8.0↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	1.2↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	6.897↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.1↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	8.696↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.38x37	287	TM7	T => A	6.061↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	15.152↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL122226	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	12.987↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.36x36	120	TM3	L => F	1.0	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	17.857↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.61x62	172	TM4	F => A	1.0	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => F	125.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	2.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	22.222↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	14.925↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	4.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	2.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	3.003↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	8.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	1000.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	166.667↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	3.003↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.38x37	287	TM7	T => A	1.0	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	200.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	22.727↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	29.412↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.61x62	172	TM4	F => A	5.102↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.63x64	174	TM4	F => A	8.929↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => F	1000.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human		176	ECL2	N => A	1.1↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human		182	ECL2	D => A	2.725↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	4.808↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	16.393↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	10.87↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	Abolished	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	4.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.46x461	207	TM5	G => F	1.453↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.46x461	207	TM5	G => W	1.182↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	4.098↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.52x52	256	TM6	Y => A	2.907↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	166.667↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	N/A	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.59x59	263	TM6	S => A	4.808↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	N/A	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	500.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.38x37	287	TM7	T => A	18.182↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	100.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	21.739↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	90.909↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => N	3.597↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	15.873↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.37x37	121	TM3	Y => A	2.882↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	27.778↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human		176	ECL2	N => A	1.203↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	1.062↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	2.532↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.581↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	4.587↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	166.667↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	125.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	71.429↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	Abolished	K(i) (Binding - Radioligand competition/displacement)	CHEMBL477121	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	5.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	3.33x33	117	TM3	T => A	2.0↑	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	4.57x57	168	TM4	T => A	2.0↑	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	14.085↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	4.63x64	174	TM4	F => A	34.483↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => F	500.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	83.333↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	1.0	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	5.46x461	207	TM5	G => W	12.5↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	26.316↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.52x52	256	TM6	Y => A	9.524↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	1.499↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	41.667↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	500.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	6.59x59	263	TM6	S => A	4.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.499↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	11.494↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	111.111↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2004)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	10.638↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.36x36	120	TM3	L => F	3.864↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	8.264↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.61x62	172	TM4	F => A	1.417↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => F	76.923↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.308↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	7.042↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	4.237↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	4.237↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	5.181↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	1.868↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	1.825↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	1.353↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.059↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	4.048↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.38x37	287	TM7	T => A	5.0↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	6.452↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL478168	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	30.303↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.36x36	120	TM3	L => F	2.857↑	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	10.753↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.61x62	172	TM4	F => A	1.0	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => F	250.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.751↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	15.385↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	20.408↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	3.497↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	2.747↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	1.751↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	4.505↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	500.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	55.556↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	1.499↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.38x37	287	TM7	T => A	4.0↑	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	13.514↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	16.949↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.36x36	120	TM3	L => F	1.0	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	12.987↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.61x62	172	TM4	F => A	5.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => F	58.824↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	4.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	27.027↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	35.714↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	2.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	9.009↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	1.0	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	5.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	83.333↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	20.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	2.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.38x37	287	TM7	T => A	2.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	250.0↓	K(i) (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human		10	N-term	D => A	2.146↓	K(d) (Binding - Radioligand saturation)	CXCL12	Zhou H et al (2000)	Salam W et al (2025)
cxcr4_human		28	N-term	C => A	5.263↓	K(d) (Binding - Radioligand saturation)	CXCL12	Zhou H et al (2000)	Salam W et al (2025)
cxcr4_human	3.25x25	109	TM3	C => A	9.346↓	K(d) (Binding - Radioligand saturation)	CXCL12	Zhou H et al (2000)	Salam W et al (2025)
cxcr4_human	45.50x50	186	ECL2	C => A	8.13↓	K(d) (Binding - Radioligand saturation)	CXCL12	Zhou H et al (2000)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => A	4.386↓	K(d) (Binding - Radioligand saturation)	CXCL12	Zhou H et al (2000)	Salam W et al (2025)
cxcr4_human	6.64x64	268	TM6	E => A	1.03↑	K(d) (Binding - Radioligand saturation)	CXCL12	Zhou H et al (2000)	Salam W et al (2025)
cxcr4_human	7.25x24	274	TM7	C => A	5.348↓	K(d) (Binding - Radioligand saturation)	CXCL12	Zhou H et al (2000)	Salam W et al (2025)
cxcr4_human	7.26x25	275	TM7	E => A	4.608↓	K(d) (Binding - Radioligand saturation)	CXCL12	Zhou H et al (2000)	Salam W et al (2025)
cxcr4_human	7.28x27	277	TM7	E => A	5.405↓	K(d) (Binding - Radioligand saturation)	CXCL12	Zhou H et al (2000)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	1.75↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	1.183↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human		182	ECL2	D => N	1.14↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	5.32x33	193	TM5	D => N	1.114↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.081↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	2.451↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.75↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human	7.45x45	294	TM7	H => A	1.795↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Gerlach LO et al (2001)	Salam W et al (2025)
cxcr4_human		5	N-term	S => A	~95.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		5	N-term	S => A	~30.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		7	N-term	Y => A	~80.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		7	N-term	Y => A	Inversed (e.g. NAM to PAM)	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		20	N-term	D => A	~40.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		20	N-term	D => A	~20.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		21	N-term	Y => A	~10.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		21	N-term	Y => A	~25.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		26	N-term	E => A	~60.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		26	N-term	E => A	~110.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	~130.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	~80.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		184	ECL2	Y => A	~130.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		184	ECL2	Y => A	~120.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	~125.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	~75.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human	6.64x64	268	TM6	E => A	~50.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human	6.64x64	268	TM6	E => A	Inversed (e.g. NAM to PAM)	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		272	ECL3	Q => A	~130.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		272	ECL3	Q => A	~50.0↑	Single-point (Binding - Radioligand competition/displacement)	CXCL12	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => D	~1.19↓	Single-point (Functional - cAMP accumulation)	CXCL12	Berchiche YA et al (2007)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => K	~6.25↓	Single-point (Functional - cAMP accumulation)	CXCL12	Berchiche YA et al (2007)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => S	~1.471↓	Single-point (Functional - cAMP accumulation)	CXCL12	Berchiche YA et al (2007)	Salam W et al (2025)
cxcr4_human	3.49x49	133	TM3	D => N	~1.667↓	Single-point (Functional - cAMP accumulation)	CXCL12	Berchiche YA et al (2007)	Salam W et al (2025)
cxcr4_human	3.50x50	134	TM3	R => A	~2.5↓	Single-point (Functional - cAMP accumulation)	CXCL12	Berchiche YA et al (2007)	Salam W et al (2025)
cxcr4_human	3.51x51	135	TM3	Y => A	~1.471↓	Single-point (Functional - cAMP accumulation)	CXCL12	Berchiche YA et al (2007)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	1.157↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	3.36x36	120	TM3	L => F	3.46↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	5.181↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.61x62	172	TM4	F => A	2.101↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => F	2.222↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	2.591↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	1.209↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	2.469↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.198↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	1.605↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	8.13↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	2.841↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	9.259↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	4.329↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	4.444↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.38x37	287	TM7	T => A	2.591↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	66.667↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Rosenkilde MM et al (2007)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	1.57↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	1.003↑	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	1.534↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	1.323↓	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => N	1.33↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => N	Abolished	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	1.062↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.37x37	121	TM3	Y => A	2.41↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.37x37	121	TM3	Y => A	2.941↓	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	2.058↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	4.049↓	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human		176	ECL2	N => A	2.371↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human		176	ECL2	N => A	1.748↓	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	2.183↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	1.261↓	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.577↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	4.065↓	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.182↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.303↑	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	3.034↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	1.235↓	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	2.242↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	2.841↓	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	5.188↑	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	4.016↓	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	1.232↓	K(d) (Binding - Radioligand competition/displacement)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	Abolished	EC50 (Functional - Ca2+ accumulation)	CXCL12	Wong RS et al (2008)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	1.786↑	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	2.268↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	12.048↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	13.333↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.33x33	117	TM3	T => A	1.134↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	2.132↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	15.0↑	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	8.696↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.52x52	188	ECL2	R => A	2.83↑	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		189	ECL2	F => A	1.2↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	1.25↑	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.071↑	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.38x39	199	TM5	F => A	1.071↑	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	1.071↑	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	1.2↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.071↑	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.48x48	252	TM6	W => A	1.923↑	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	1.364↑	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	1.401↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	1.154↑	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	3.861↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.2↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	1.534↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	66.667↓	EC50 (Functional - IP accumulation)	CXCL12	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => N	Abolished	pEC50 (Functional - Ca2+ accumulation)	CXCL12	Kufareva I et al (2014)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => A	6.452↓	pEC50 (Functional - Ca2+ accumulation)	CXCL12	Kufareva I et al (2014)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	21.739↓	pEC50 (Functional - Ca2+ accumulation)	CXCL12	Kufareva I et al (2014)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	Abolished	pEC50 (Functional - Ca2+ accumulation)	CXCL12	Kufareva I et al (2014)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	2.268↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	12.048↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	13.333↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	1.786↑	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.33x33	117	TM3	T => A	1.134↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	2.132↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	15.0↑	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	8.696↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	45.52x52	188	ECL2	R => A	2.83↑	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		189	ECL2	F => A	1.2↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	1.25↑	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.071↑	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.38x39	199	TM5	F => A	1.071↑	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	1.071↑	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	1.2↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.071↑	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.48x48	252	TM6	W => A	1.923↑	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	1.364↑	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	1.401↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	1.154↑	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	3.861↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.2↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	1.534↓	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	Abolished	EC50 (Functional - IP accumulation)	CXCL12	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	2.2↑	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	2.45x45	79	TM2	H => A	1.375↑	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	2.53x53	87	TM2	F => A	Abolished	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	1.048↑	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => E	2.457↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	3.37x37	121	TM3	Y => A	1.045↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	4.50x50	161	TM4	W => A	5.682↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	4.52x52	163	TM4	P => A	3.906↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => A	Abolished	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human		182	ECL2	D => A	1.546↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	2.137↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human		189	ECL2	F => A	3.636↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human		191	ECL2	P => A	1.136↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	5.58x58	219	TM5	Y => A	2.137↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	6.48x48	252	TM6	W => A	2.092↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	3.597↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	6.52x52	256	TM6	Y => A	1.681↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => A	2.0↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => E	1.908↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => D	2.681↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	2.0↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	7.43x42	292	TM7	F => A	Abolished	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	7.45x45	294	TM7	H => A	1.272↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	7.49x49	298	TM7	N => A	1.692↑	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	7.53x53	302	TM7	Y => A	5.236↓	IC50 (Binding - Radioligand saturation)	CXCL12	N/A	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	1.529↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL125150	N/A	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	28.571↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL125150	N/A	Salam W et al (2025)
cxcr4_human		182	ECL2	D => N	1.083↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL125150	N/A	Salam W et al (2025)
cxcr4_human	5.32x33	193	TM5	D => N	1.413↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL125150	N/A	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.232↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL125150	N/A	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	1.354↑	K(i) (Binding - Radioligand competition/displacement)	CHEMBL125150	N/A	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	2.538↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL125150	N/A	Salam W et al (2025)
cxcr4_human	7.45x45	294	TM7	H => A	2.0↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL125150	N/A	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	1.767↓	K(i) (Binding - Radioligand competition/displacement)	Cyclam (Zn)	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	66.667↓	K(i) (Binding - Radioligand competition/displacement)	Cyclam (Zn)	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human		182	ECL2	D => N	1.875↑	K(i) (Binding - Radioligand competition/displacement)	Cyclam (Zn)	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	5.32x33	193	TM5	D => N	1.875↑	K(i) (Binding - Radioligand competition/displacement)	Cyclam (Zn)	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	2.308↑	K(i) (Binding - Radioligand competition/displacement)	Cyclam (Zn)	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	1.304↑	K(i) (Binding - Radioligand competition/displacement)	Cyclam (Zn)	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.667↓	K(i) (Binding - Radioligand competition/displacement)	Cyclam (Zn)	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	7.45x45	294	TM7	H => A	1.134↓	K(i) (Binding - Radioligand competition/displacement)	Cyclam (Zn)	Gerlach LO et al (2003)	Salam W et al (2025)
cxcr4_human	4.43x43	154	TM4	K => C	2.247↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.44x44	155	TM4	V => C	1.232↑	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.45x45	156	TM4	V => C	1.247↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.46x46	157	TM4	Y => C	2.532↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.47x47	158	TM4	V => C	1.214↑	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.48x48	159	TM4	G => C	1.147↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.49x49	160	TM4	V => C	2.088↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.50x50	161	TM4	W => C	1.288↑	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.51x51	162	TM4	I => C	1.25↑	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.52x52	163	TM4	P => C	2.653↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.53x53	164	TM4	A => C	1.869↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.54x54	165	TM4	L => C	1.748↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.55x55	166	TM4	L => C	1.277↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.56x56	167	TM4	L => C	1.083↑	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.57x57	168	TM4	T => C	1.518↑	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.58x59	169	TM4	I => C	1.954↑	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.59x60	170	TM4	P => C	1.389↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => C	2.331↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.61x62	172	TM4	F => C	1.3↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.62x63	173	TM4	I => C	1.395↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.63x64	174	TM4	F => C	1.977↑	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	4.64x65	175	TM4	A => C	Abolished	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human		176	ECL2	N => C	Abolished	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human		177	ECL2	V => C	1.153↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human		178	ECL2	S => C	1.241↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human		179	ECL2	E => C	1.153↓	K(d) (Binding - Radioligand saturation)	CHEMBL436283	Boulais PE et al (2013)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	4.0↓	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	40.0↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	10.0↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	125.0↓	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.33x33	117	TM3	T => A	2.857↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	11.494↓	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	1.225↓	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	2.857↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.52x52	188	ECL2	R => A	1.799↓	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		189	ECL2	F => A	4.0↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	1.175↓	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.175↓	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.38x39	199	TM5	F => A	1.905↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	1.111↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	1.212↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.449↓	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.48x48	252	TM6	W => A	1.776↓	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	1.481↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	5.0↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	2.667↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	15.152↓	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	2.0↓	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	1.481↑	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	Abolished	EC50 (Functional - IP accumulation)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	10.101↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	100.0↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	17.241↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	5.405↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	25.333↑	IC50 (Binding - Radioligand competition/displacement)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	4.471↑	IC50 (Binding - Radioligand competition/displacement)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	62.5↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	125.0↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	71.429↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL436283	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	8.0↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	8.333↑	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	2.381↑	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	26.316↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.33x33	117	TM3	T => A	2.941↑	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	5.405↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	2.0↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	1.429↑	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	45.52x52	188	ECL2	R => A	1.721↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		189	ECL2	F => A	3.846↑	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	1.852↑	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	2.801↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.38x39	199	TM5	F => A	1.379↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	7.407↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	20.0↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.42↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.48x48	252	TM6	W => A	7.576↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	3.401↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	5.208↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	3.003↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	26.316↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	62.5↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	6.803↓	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	N/A	EC50 (Functional - IP accumulation)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	6.579↓	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	15.455↑	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	15.741↑	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	11.765↓	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.33x33	117	TM3	T => A	9.77↑	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	8.0↓	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	2.073↑	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	45.52x52	188	ECL2	R => A	1.012↑	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		189	ECL2	F => A	11.486↑	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	1.412↓	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	2.024↑	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.38x39	199	TM5	F => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	2.0↓	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	1.647↓	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	N/A	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.48x48	252	TM6	W => A	3.175↓	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	Abolished	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	3.175↓	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	6.25↓	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	4.0↓	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-5	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	15.152↓	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	18.75↑	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	8.571↑	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	8.333↓	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.33x33	117	TM3	T => A	8.571↑	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	19.231↓	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	2.222↑	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	45.52x52	188	ECL2	R => A	2.083↓	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		189	ECL2	F => A	12.0↑	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	1.0	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	1.083↓	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.38x39	199	TM5	F => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	20.833↓	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	7.092↓	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	N/A	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.48x48	252	TM6	W => A	14.493↓	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	Abolished	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	1.091↑	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	12.987↓	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	25.641↓	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	Abolished	EC50 (Functional - IP accumulation)	KRH1636-6	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	4.706↑	IC50 (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	1.063↓	IC50 (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	12.5↓	IC50 (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	IC50 (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	8.403↓	IC50 (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	3.247↓	IC50 (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	12.5↓	IC50 (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	7.874↓	IC50 (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	12.5↓	IC50 (Binding - Radioligand competition/displacement)	10,10-difluoro TXA₂	Zachariassen ZG et al (2015)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => S	1.724↓	IC50 (Binding - Radioligand competition/displacement)	T140	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => A	1.194↑	IC50 (Binding - Radioligand competition/displacement)	T140	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => D	1.037↓	IC50 (Binding - Radioligand competition/displacement)	T140	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human	3.35x35	119	TM3	N => K	1.905↑	IC50 (Binding - Radioligand competition/displacement)	T140	Zhang WB et al (2002)	Salam W et al (2025)
cxcr4_human		5	N-term	S => A	105.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		5	N-term	S => A	100.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		7	N-term	Y => A	75.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		7	N-term	Y => A	75.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		20	N-term	D => A	50.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		20	N-term	D => A	60.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		21	N-term	Y => A	10.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		21	N-term	Y => A	40.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		26	N-term	E => A	65.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		26	N-term	E => A	100.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	110.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	100.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		184	ECL2	Y => A	115.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		184	ECL2	Y => A	125.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	120.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	230.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human	6.64x64	268	TM6	E => A	50.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human	6.64x64	268	TM6	E => A	Inversed (e.g. NAM to PAM)	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		272	ECL3	Q => A	130.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human		272	ECL3	Q => A	80.0↑	Single-point (Binding - Radioligand competition/displacement)	vMIP-II	Zhou N et al (2001)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	200.0↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	1.39x39	45	TM1	Y => A	3.077↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	10.4↑	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	8.667↑	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	Abolished	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.33x33	117	TM3	T => A	1.422↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	52.632↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		183	ECL2	R => A	Abolished	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	1.486↑	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.52x52	188	ECL2	R => A	4.237↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		189	ECL2	F => A	3.467↑	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human		190	ECL2	Y => A	1.269↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.35x36	196	TM5	V => A	3.077↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.38x39	199	TM5	F => A	1.677↑	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => A	1.096↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.39x40	200	TM5	Q => W	1.653↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	5.42x43	203	TM5	H => A	1.883↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.48x48	252	TM6	W => A	5.952↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.51x51	255	TM6	Y => A	1.538↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => A	1.3↑	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.55x55	259	TM6	I => W	1.269↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	19.231↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	1.153↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.35x34	284	TM7	I => A	5.0↓	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	Abolished	EC50 (Functional - IP accumulation)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.60x60	94	TM2	W => A	12.667↑	IC50 (Binding - Radioligand competition/displacement)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	2.63x63	97	TM2	D => A	Abolished	IC50 (Binding - Radioligand competition/displacement)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.29x29	113	TM3	H => A	Abolished	IC50 (Binding - Radioligand competition/displacement)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	3.32x32	116	TM3	Y => A	250.0↓	IC50 (Binding - Radioligand competition/displacement)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	4.60x61	171	TM4	D => N	250.0↓	IC50 (Binding - Radioligand competition/displacement)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	45.51x51	187	ECL2	D => A	31.25↓	IC50 (Binding - Radioligand competition/displacement)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	6.58x58	262	TM6	D => N	250.0↓	IC50 (Binding - Radioligand competition/displacement)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.32x31	281	TM7	H => A	250.0↓	IC50 (Binding - Radioligand competition/displacement)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	7.39x38	288	TM7	E => A	250.0↓	IC50 (Binding - Radioligand competition/displacement)	[D-Arg]FC131	Thiele S et al (2014)	Salam W et al (2025)
cxcr4_human	8.59x59	318	H8	T => A	N/A	N/A		Haribabu B et al (1997)
cxcr4_human		11	N-term	N => I	N/A	N/A		Potempa S et al (1997)
cxcr4_human		176	ECL2	N => Q	N/A	N/A		Potempa S et al (1997)
cxcr4_human	4.60x61	171	TM4	D => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		179	ECL2	E => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		181	ECL2	D => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		182	ECL2	D => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		183	ECL2	R => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	45.51x51	187	ECL2	D => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	45.52x52	188	ECL2	R => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	5.32x33	193	TM5	D => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	4.60x61	171	TM4	D => K	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		179	ECL2	E => K	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		181	ECL2	D => K	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		182	ECL2	D => K	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	45.51x51	187	ECL2	D => K	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	5.32x33	193	TM5	D => K	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	45.51x51	187	ECL2	D => V	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	45.51x51	187	ECL2	D => F	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	45.51x51	187	ECL2	D => S	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	45.51x51	187	ECL2	D => N	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		179	ECL2	E => Q	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		189	ECL2	F => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		190	ECL2	Y => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		11	N-term	N => Q	N/A	N/A		Brelot A et al (1997)
cxcr4_human		184	ECL2	Y => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human		185	ECL2	I => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human	45.51x51	187	ECL2	D => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human	45.52x52	188	ECL2	R => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.38x39	199	TM5	F => G	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.40x41	201	TM5	F => L	N/A	N/A		Brelot A et al (1999)
cxcr4_human		176	ECL2	N => D	N/A	N/A		Brelot A et al (1999)
cxcr4_human		182	ECL2	D => G	N/A	N/A		Brelot A et al (1999)
cxcr4_human		189	ECL2	F => L	N/A	N/A		Brelot A et al (1999)
cxcr4_human		192	ECL2	N => D	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.32x33	193	TM5	D => S	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.35x36	196	TM5	V => M	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.32x33	193	TM5	D => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.32x33	193	TM5	D => E	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.32x33	193	TM5	D => N	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.32x33	193	TM5	D => R	N/A	N/A		Brelot A et al (1999)
cxcr4_human		181	ECL2	D => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human		183	ECL2	R => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human	45.51x51	187	ECL2	D => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	6.58x58	262	TM6	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	6.64x64	268	TM6	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		271	ECL3	K => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	7.26x25	275	TM7	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	7.28x27	277	TM7	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	7.28x27	277	TM7	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	7.32x31	281	TM7	H => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	7.33x32	282	TM7	K => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		28	N-term	C => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	3.25x25	109	TM3	C => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	45.50x50	186	ECL2	C => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	7.25x24	274	TM7	C => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		2	N-term	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		10	N-term	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		11	N-term	N => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		14	N-term	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		15	N-term	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		20	N-term	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		22	N-term	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		25	N-term	K => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		26	N-term	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	1.24x24	30	TM1	R => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	1.25x25	31	TM1	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	1.26x26	32	TM1	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	2.63x63	97	TM2	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	3.26x26	110	TM3	K => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		176	ECL2	N => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		179	ECL2	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		181	ECL2	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		182	ECL2	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	45.51x51	187	ECL2	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	45.52x52	188	ECL2	R => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	5.32x33	193	TM5	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	5.40x41	201	TM5	F => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	6.58x58	262	TM6	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	6.64x64	268	TM6	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		271	ECL3	K => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	7.26x25	275	TM7	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	7.33x32	282	TM7	K => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	2.63x63	97	TM2	D => N	N/A	N/A		Brelot A et al (2000)
cxcr4_human	2.50x50	84	TM2	D => N	N/A	N/A		Brelot A et al (2000)
cxcr4_human		13	N-term	T => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human		11	N-term	N => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human		176	ECL2	N => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	4.60x61	171	TM4	D => N	N/A	N/A		Brelot A et al (2000)
cxcr4_human	7.39x38	288	TM7	E => Q	N/A	N/A		Brelot A et al (2000)
cxcr4_human		2	N-term	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		7	N-term	Y => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		10	N-term	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		11	N-term	N => Q	N/A	N/A		Brelot A et al (2000)
cxcr4_human		20	N-term	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		21	N-term	Y => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		22	N-term	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		25	N-term	K => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		26	N-term	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	1.32x32	38	TM1	K => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	3.26x26	110	TM3	K => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		179	ECL2	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		181	ECL2	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		182	ECL2	D => G	N/A	N/A		Brelot A et al (2000)
cxcr4_human		183	ECL2	R => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	45.51x51	187	ECL2	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	45.52x52	188	ECL2	R => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	5.32x33	193	TM5	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		2	N-term	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		2	N-term	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		5	N-term	S => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human		7	N-term	Y => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		7	N-term	Y => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human		10	N-term	D => A	N/A	N/A		Zhou H et al (2000)
cxcr4_human		10	N-term	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		10	N-term	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		11	N-term	N => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		11	N-term	N => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human		11	N-term	N => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human		11	N-term	N => L	N/A	N/A		Zhou H et al (1999)
cxcr4_human		11	N-term	N => Q	N/A	N/A		Brelot A et al (2000)
cxcr4_human		11	N-term	N => Q	N/A	N/A		Brelot A et al (1997)
cxcr4_human		12	N-term	Y => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		13	N-term	T => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human		14	N-term	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		14	N-term	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		15	N-term	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		15	N-term	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		20	N-term	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		20	N-term	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		20	N-term	D => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human		21	N-term	Y => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		21	N-term	Y => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human		22	N-term	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		22	N-term	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		25	N-term	K => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		25	N-term	K => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		26	N-term	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		26	N-term	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		26	N-term	E => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human		28	N-term	C => A	N/A	N/A		Zhou H et al (2000)
cxcr4_human		28	N-term	C => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		28	N-term	C => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	1.24x24	30	TM1	R => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	1.24x24	30	TM1	R => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	1.24x24	30	TM1	R => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	1.25x25	31	TM1	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	1.26x26	32	TM1	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	1.32x32	38	TM1	K => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	1.47x47	53	TM1	I => L	N/A	N/A		Schuller U et al (2005)
cxcr4_human	2.50x50	84	TM2	D => N	N/A	N/A		Brelot A et al (2000)
cxcr4_human	2.63x63	97	TM2	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	2.63x63	97	TM2	D => N	N/A	N/A		Brelot A et al (2000)
cxcr4_human	2.63x63	97	TM2	D => N	N/A	N/A		Schuller U et al (2005)
cxcr4_human	3.25x25	109	TM3	C => A	N/A	N/A		Zhou H et al (2000)
cxcr4_human	3.25x25	109	TM3	C => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	3.26x26	110	TM3	K => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	3.26x26	110	TM3	K => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	3.29x29	113	TM3	H => A	N/A	N/A		Gerlach LO et al (2001)
cxcr4_human	3.29x29	113	TM3	H => A	N/A	N/A		Gerlach LO et al (2003)
cxcr4_human	4.60x61	171	TM4	D => N	N/A	N/A		Brelot A et al (2000)
cxcr4_human	4.60x61	171	TM4	D => N	N/A	N/A		Gerlach LO et al (2001)
cxcr4_human	4.60x61	171	TM4	D => N	N/A	N/A		Hatse S et al (2001)
cxcr4_human	4.60x61	171	TM4	D => N	N/A	N/A		Gerlach LO et al (2003)
cxcr4_human		176	ECL2	N => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		176	ECL2	N => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human		176	ECL2	N => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human		176	ECL2	N => D	N/A	N/A		Brelot A et al (2000)
cxcr4_human		176	ECL2	N => L	N/A	N/A		Zhou H et al (1999)
cxcr4_human		178	ECL2	S => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human		179	ECL2	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		179	ECL2	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		179	ECL2	E => Q	N/A	N/A		Brelot A et al (2000)
cxcr4_human		179	ECL2	E => Q	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		181	ECL2	D => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human		181	ECL2	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		181	ECL2	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		181	ECL2	D => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		181	ECL2	D => K	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		182	ECL2	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		182	ECL2	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		182	ECL2	D => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		182	ECL2	D => G	N/A	N/A		Brelot A et al (1999)
cxcr4_human		182	ECL2	D => G	N/A	N/A		Brelot A et al (2000)
cxcr4_human		182	ECL2	D => K	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		182	ECL2	D => N	N/A	N/A		Brelot A et al (2000)
cxcr4_human		182	ECL2	D => N	N/A	N/A		Gerlach LO et al (2001)
cxcr4_human		182	ECL2	D => N	N/A	N/A		Gerlach LO et al (2003)
cxcr4_human		182	ECL2	D => N	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		183	ECL2	R => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human		183	ECL2	R => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		183	ECL2	R => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human		184	ECL2	Y => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human		184	ECL2	Y => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human		185	ECL2	I => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human	45.50x50	186	ECL2	C => A	N/A	N/A		Zhou H et al (2000)
cxcr4_human	45.50x50	186	ECL2	C => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	45.51x51	187	ECL2	D => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human	45.51x51	187	ECL2	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	45.51x51	187	ECL2	D => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	45.51x51	187	ECL2	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	45.51x51	187	ECL2	D => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	45.51x51	187	ECL2	D => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	45.51x51	187	ECL2	D => K	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	45.51x51	187	ECL2	D => S	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	45.51x51	187	ECL2	D => V	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	45.51x51	187	ECL2	D => V	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	45.52x52	188	ECL2	R => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human	45.52x52	188	ECL2	R => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	45.52x52	188	ECL2	R => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	45.52x52	188	ECL2	R => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		189	ECL2	F => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		190	ECL2	Y => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human		190	ECL2	Y => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human		192	ECL2	N => D	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.32x33	193	TM5	D => A	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.32x33	193	TM5	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	5.32x33	193	TM5	D => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	5.32x33	193	TM5	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	5.32x33	193	TM5	D => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	5.32x33	193	TM5	D => A	N/A	N/A		Labrosse B et al (2001)
cxcr4_human	5.32x33	193	TM5	D => A	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	5.32x33	193	TM5	D => E	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.32x33	193	TM5	D => N	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.32x33	193	TM5	D => N	N/A	N/A		Gerlach LO et al (2001)
cxcr4_human	5.32x33	193	TM5	D => N	N/A	N/A		Gerlach LO et al (2003)
cxcr4_human	5.32x33	193	TM5	D => R	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.32x33	193	TM5	D => R	N/A	N/A		Labrosse B et al (2001)
cxcr4_human	5.32x33	193	TM5	D => S	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.34x35	195	TM5	W => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human	5.35x36	196	TM5	V => M	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.36x37	197	TM5	V => N	N/A	N/A		Wang ZX et al (1998)
cxcr4_human	5.38x39	199	TM5	F => G	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.39x40	200	TM5	Q => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human	5.40x41	201	TM5	F => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	5.40x41	201	TM5	F => G	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.40x41	201	TM5	F => L	N/A	N/A		Brelot A et al (1999)
cxcr4_human	5.42x43	203	TM5	H => A	N/A	N/A		Gerlach LO et al (2001)
cxcr4_human	5.42x43	203	TM5	H => A	N/A	N/A		Gerlach LO et al (2003)
cxcr4_human	6.58x58	262	TM6	D => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	6.58x58	262	TM6	D => A	N/A	N/A		Zhou H et al (2000)
cxcr4_human	6.58x58	262	TM6	D => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	6.58x58	262	TM6	D => N	N/A	N/A		Gerlach LO et al (2001)
cxcr4_human	6.58x58	262	TM6	D => N	N/A	N/A		Hatse S et al (2001)
cxcr4_human	6.58x58	262	TM6	D => N	N/A	N/A		Gerlach LO et al (2003)
cxcr4_human	6.64x64	268	TM6	E => A	N/A	N/A		Zhou H et al (2000)
cxcr4_human	6.64x64	268	TM6	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	6.64x64	268	TM6	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	6.64x64	268	TM6	E => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human		271	ECL3	K => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human		271	ECL3	K => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human		272	ECL3	Q => A	N/A	N/A		Zhou N et al (2001)
cxcr4_human	7.25x24	274	TM7	C => A	N/A	N/A		Zhou H et al (2000)
cxcr4_human	7.25x24	274	TM7	C => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	7.25x24	274	TM7	C => A	N/A	N/A		Chabot DJ et al (2000)
cxcr4_human	7.26x25	275	TM7	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	7.26x25	275	TM7	E => A	N/A	N/A		Zhou H et al (2000)
cxcr4_human	7.26x25	275	TM7	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	7.28x27	277	TM7	E => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	7.28x27	277	TM7	E => A	N/A	N/A		Zhou H et al (2000)
cxcr4_human	7.28x27	277	TM7	E => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	7.32x31	281	TM7	H => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	7.32x31	281	TM7	H => A	N/A	N/A		Gerlach LO et al (2001)
cxcr4_human	7.32x31	281	TM7	H => A	N/A	N/A		Hatse S et al (2001)
cxcr4_human	7.32x31	281	TM7	H => A	N/A	N/A		Gerlach LO et al (2003)
cxcr4_human	7.33x32	282	TM7	K => A	N/A	N/A		Chabot DJ et al (1999)
cxcr4_human	7.33x32	282	TM7	K => A	N/A	N/A		Brelot A et al (2000)
cxcr4_human	7.39x38	288	TM7	E => Q	N/A	N/A		Brelot A et al (2000)
cxcr4_human	7.45x45	294	TM7	H => A	N/A	N/A		Gerlach LO et al (2001)
cxcr4_human	7.45x45	294	TM7	H => A	N/A	N/A		Gerlach LO et al (2003)
cxcr4_human	8.53x53	312	H8	S => A	N/A	N/A		Lu Z et al (1997)
cxcr4_human	8.59x59	318	H8	T => A	N/A	N/A		Lu Z et al (1997)
cxcr4_human		324	C-term	S => A	N/A	N/A		Signoret N et al (1998)
cxcr4_human		325	C-term	S => A	N/A	N/A		Signoret N et al (1998)
cxcr4_human		328	C-term	I => A	N/A	N/A		Signoret N et al (1998)
cxcr4_human		328	C-term	I => S	N/A	N/A		Roland J et al (2003)
cxcr4_human		329	C-term	L => A	N/A	N/A		Fan GH et al (2002)
cxcr4_human		329	C-term	L => A	N/A	N/A		Signoret N et al (1998)
cxcr4_human		329	C-term	L => S	N/A	N/A		Roland J et al (2003)
cxcr4_human		330	C-term	S => A	N/A	N/A		Orsini MJ et al (1999)
cxcr4_human		334	C-term	R => X	N/A	N/A		Hernandez PA et al (2003)
cxcr4_human		334	C-term	R => X	N/A	N/A		Kawai T et al (2005)
cxcr4_human		343	C-term	E => X	N/A	N/A		Hernandez PA et al (2003)
cxcr4_human		344	C-term	S => A	N/A	N/A		Orsini MJ et al (1999)
cxcr4_human	7.35x34	284	TM7	I => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	4.63x64	174	TM4	F => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	5.46x461	207	TM5	G => W	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	6.59x59	263	TM6	S => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	7.39x38	288	TM7	E => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	6.51x51	255	TM6	Y => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	3.29x29	113	TM3	H => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	6.58x58	262	TM6	D => N	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	4.60x61	171	TM4	D => N	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	4.64x65	175	TM4	A => F	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	5.35x36	196	TM5	V => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	6.52x52	256	TM6	Y => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	4.57x57	168	TM4	T => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	6.55x55	259	TM6	I => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	7.32x31	281	TM7	H => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	5.39x40	200	TM5	Q => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	6.55x55	259	TM6	I => W	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	3.33x33	117	TM3	T => A	N/A	N/A		Rosenkilde MM et al (2004)
cxcr4_human	2.50x50	84	TM2	D => N	N/A	N/A		Lebon G et al (2011)
cxcr4_human	7.39x38	288	TM7	E => A	N/A	N/A		Kufareva I et al (2011)
cxcr4_human	6.36x36	240	TM6	T => P	N/A	N/A		Lebon G et al (2011)
cxcr4_human	3.41x41	125	TM3	L => W	N/A	N/A		Lebon G et al (2011)
cxcr4_human	4.63x64	174	TM4	F => A	N/A	N/A		Forfar R et al (2011)
Protein name	Generic number	Segment	Position	Mutation	FoldChange or Qual	Exp Type	Ligand	Reference	Review

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Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

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Residue Table

GPCRdb(A)	GPCRdb(A)	CXCR4
TM1
1x24	1.24x24	R30
1x25	1.25x25	E31
1x26	1.26x26	E32
1x32	1.32x32	K38
1x39	1.39x39	Y45
1x47	1.47x47	I53
TM2
2x45	2.45x45	H79
2x50	2.50x50	D84
2x53	2.53x53	F87
2x60	2.60x60	W94
2x63	2.63x63	D97
TM3
3x25	3.25x25	C109
3x26	3.26x26	K110
3x29	3.29x29	H113
3x32	3.32x32	Y116
3x33	3.33x33	T117
3x35	3.35x35	N119
3x36	3.36x36	L120
3x37	3.37x37	Y121
3x41	3.41x41	L125
3x49	3.49x49	D133
3x50	3.50x50	R134
3x51	3.51x51	Y135
TM4
4x43	4.43x43	K154
4x44	4.44x44	V155
4x45	4.45x45	V156
4x46	4.46x46	Y157
4x47	4.47x47	V158
4x48	4.48x48	G159
4x49	4.49x49	V160
4x50	4.50x50	W161
4x51	4.51x51	I162
4x52	4.52x52	P163
4x53	4.53x53	A164
4x54	4.54x54	L165
4x55	4.55x55	L166
4x56	4.56x56	L167
4x57	4.57x57	T168
4x59	4.58x59	I169
4x60	4.59x60	P170
4x61	4.60x61	D171
4x62	4.61x62	F172
4x63	4.62x63	I173
4x64	4.63x64	F174
4x65	4.64x65	A175
TM5
5x33	5.32x33	D193
5x35	5.34x35	W195
5x36	5.35x36	V196
5x37	5.36x37	V197
5x39	5.38x39	F199
5x40	5.39x40	Q200
5x41	5.40x41	F201
5x43	5.42x43	H203
5x461	5.46x461	G207
5x58	5.58x58	Y219
TM6
6x36	6.36x36	T240
6x48	6.48x48	W252
6x51	6.51x51	Y255
6x52	6.52x52	Y256
6x55	6.55x55	I259
6x58	6.58x58	D262
6x59	6.59x59	S263
6x64	6.64x64	E268
TM7
7x24	7.25x24	C274
7x25	7.26x25	E275
7x27	7.28x27	E277
7x31	7.32x31	H281
7x32	7.33x32	K282
7x34	7.35x34	I284
7x37	7.38x37	T287
7x38	7.39x38	E288
7x42	7.43x42	F292
7x45	7.45x45	H294
7x49	7.49x49	N298
7x53	7.53x53	Y302
H8
8x53	8.53x53	S312
8x59	8.59x59	T318

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Residue Table