Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
fshr_human 26 N-term S => A 1.02↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=26
fshr_human 27 N-term N => A 1.075↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=27
fshr_human 28 N-term R => A 1.042↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=28
fshr_human 29 N-term V => A 1.02↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=29
fshr_human 30 N-term F => A 1.21↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=30
fshr_human 31 N-term L => A 1.205↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=31
fshr_human 32 N-term C => A N/A N/A Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=32
fshr_human 32 N-term C => A N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=32
fshr_human 32 N-term C => A N/A Specific-binding (binding) FSH Ji I et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=32
fshr_human 33 N-term Q => A 1.031↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=33
fshr_human 34 N-term E => A 1.053↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=34
fshr_human 35 N-term S => A 1.01↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=35
fshr_human 36 N-term K => A 1.136↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=36
fshr_human 37 N-term V => A 1.01↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=37
fshr_human 38 N-term T => A 1.064↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=38
fshr_human 39 N-term E => A 1.16↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=39
fshr_human 40 N-term I => A 2.778↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=40
fshr_human 41 N-term P => A N/A N/A Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=41
fshr_human 41 N-term P => A N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=41
fshr_human 41 N-term P => A N/A Specific-binding (binding) FSH Ji I et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=41
fshr_human 42 N-term S => A 1.299↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=42
fshr_human 43 N-term D => A N/A N/A Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=43
fshr_human 43 N-term D => A N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=43
fshr_human 43 N-term D => A N/A Specific-binding (binding) FSH Ji I et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=43
fshr_human 44 N-term L => A N/A N/A Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=44
fshr_human 44 N-term L => A N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=44
fshr_human 44 N-term L => A N/A Specific-binding (binding) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=44
fshr_human 44 N-term L => A N/A Specific-binding (binding) FSH Ji I et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=44
fshr_human 45 N-term P => A 1.08↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=45
fshr_human 46 N-term R => A 1.05↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=46
fshr_human 47 N-term N => A 1.16↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=47
fshr_human 48 N-term A => G 1.16↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=48
fshr_human 49 N-term I => A 1.02↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=49
fshr_human 50 N-term E => A 1.09↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=50
fshr_human 51 N-term L => A 14.286↓ Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=51
fshr_human 53 N-term F => A N/A N/A Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=53
fshr_human 53 N-term F => A N/A Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=53
fshr_human 53 N-term F => A N/A Specific-binding (binding) FSH Ji I et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=53
fshr_human 74 N-term K => A 1.19↓ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=74
fshr_human 74 N-term K => A 1.149↓ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=74
fshr_human 74 N-term K => E 2.1↑ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=74
fshr_human 74 N-term K => E 1.02↑ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=74
fshr_human 75 N-term I => A N/A N/A Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=75
fshr_human 75 N-term I => A N/A Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=75
fshr_human 77 N-term I => A 16.667↓ Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=77
fshr_human 78 N-term S => A 1.124↓ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=78
fshr_human 78 N-term S => A 1.515↓ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=78
fshr_human 100 N-term I => A N/A N/A Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=100
fshr_human 100 N-term I => A N/A Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=100
fshr_human 102 N-term I => A N/A N/A Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=102
fshr_human 102 N-term I => A N/A Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=102
fshr_human 124 N-term Y => A 1.389↓ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=124
fshr_human 124 N-term Y => A 1.923↓ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=124
fshr_human 125 N-term L => A 12.5↓ Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=125
fshr_human 127 N-term I => A N/A N/A Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=127
fshr_human 127 N-term I => A N/A Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=127
fshr_human 129 N-term N => A 2.222↓ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=129
fshr_human 130 N-term T => A 2.58↑ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=130
fshr_human 130 N-term T => A 3.1↑ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=130
fshr_human 146 N-term K => N 1.01↓ Single-point (Functional - cAMP accumulation) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=146
fshr_human 146 N-term K => N 1.053↓ Specific-binding (binding) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=146
fshr_human 149 N-term L => A 8.333↓ Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=149
fshr_human 150 N-term D => A 1.15↑ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=150
fshr_human 150 N-term D => A 1.667↓ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=150
fshr_human 150 N-term D => E 2.24↑ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=150
fshr_human 150 N-term D => E 1.65↑ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=150
fshr_human 150 N-term D => K 1.05↑ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=150
fshr_human 150 N-term D => N 2.31↑ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=150
fshr_human 150 N-term D => N 2.49↑ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=150
fshr_human 151 N-term I => A 3.03↓ Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=151
fshr_human 153 N-term D => A 1.06↑ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=153
fshr_human 153 N-term D => A 2.041↓ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=153
fshr_human 153 N-term D => E 2.03↑ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=153
fshr_human 153 N-term D => E 1.111↓ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=153
fshr_human 153 N-term D => K N/A Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=153
fshr_human 153 N-term D => K 2.128↓ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=153
fshr_human 153 N-term D => Q 1.3↑ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=153
fshr_human 153 N-term D => Q 2.1↑ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=153
fshr_human 160 N-term I => T 10.0↓ Specific-binding (binding) FSH Beau I et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=160
fshr_human 175 N-term L => A N/A N/A Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=175
fshr_human 175 N-term L => A N/A Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=175
fshr_human 177 N-term L => A 7.692↓ Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=177
fshr_human 189 N-term A => V N/A Single-point (Functional - cAMP accumulation) FSH Aittomaki K et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=189
fshr_human 191 N-term N => I N/A Single-point (Functional - cAMP accumulation) FSH Gromoll J et al (1996) http://www.ssfa-gphr.de/mutation_result.php?id=191
fshr_human 197 N-term E => S 1.471↓ Single-point (Functional - cAMP accumulation) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=197
fshr_human 197 N-term E => S 3.226↓ Specific-binding (binding) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=197
fshr_human 198 N-term L => A N/A N/A Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=198
fshr_human 198 N-term L => A N/A Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=198
fshr_human 200 N-term L => A N/A N/A Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=200
fshr_human 200 N-term L => A N/A Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=200
fshr_human 221 N-term V => G 1.587↓ Single-point (Functional - cAMP accumulation) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=221
fshr_human 221 N-term V => G 2.941↓ Specific-binding (binding) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=221
fshr_human 221 N-term V => K 3.03↓ Single-point (Functional - cAMP accumulation) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=221
fshr_human 221 N-term V => K 2.564↓ Specific-binding (binding) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=221
fshr_human 222 N-term I => T 1.449↓ Single-point (Functional - cAMP accumulation) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=222
fshr_human 222 N-term I => T 1.887↓ Specific-binding (binding) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=222
fshr_human 223 N-term L => A N/A N/A Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=223
fshr_human 223 N-term L => A N/A Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=223
fshr_human 224 N-term D => A 2.439↓ Single-point (Functional - cAMP accumulation) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=224
fshr_human 224 N-term D => A 2.564↓ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=224
fshr_human 224 N-term D => K 1.19↓ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=224
fshr_human 224 N-term D => V N/A N/A Touraine P et al (1999) http://www.ssfa-gphr.de/mutation_result.php?id=224
fshr_human 224 N-term D => V N/A Single-point (Functional - cAMP accumulation) FSH Touraine P et al (1999) http://www.ssfa-gphr.de/mutation_result.php?id=224
fshr_human 225 N-term I => A N/A N/A Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=225
fshr_human 225 N-term I => A N/A Single-point (Functional - cAMP accumulation) FSH Song YS et al (2001) http://www.ssfa-gphr.de/mutation_result.php?id=225
fshr_human 226 N-term S => A 20.0↓ Specific-binding (binding) FSH Angelova K et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=226
fshr_human 243 N-term K => R 1.0 Single-point (Functional - cAMP accumulation) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=243
fshr_human 243 N-term K => R 1.71↑ Specific-binding (binding) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=243
fshr_human 330 N-term Y => F 1.22↓ Single-point (Functional - cAMP accumulation) FSH Bonomi M et al (2006) http://www.ssfa-gphr.de/mutation_result.php?id=330
fshr_human 333 N-term F => Y 1.075↓ Single-point (Functional - cAMP accumulation) FSH Bonomi M et al (2006) http://www.ssfa-gphr.de/mutation_result.php?id=333
fshr_human 335 N-term Y => F 1.282↓ Single-point (Functional - cAMP accumulation) FSH Bonomi M et al (2006) http://www.ssfa-gphr.de/mutation_result.php?id=335
fshr_human 348 N-term P => R N/A Specific-binding (binding) FSH Allen LA et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=348
fshr_human 2.50x50 408 TM2 D => Y 1.961↓ Single-point (Functional - cAMP accumulation) FSH Bramble MS et al (2016) http://www.ssfa-gphr.de/mutation_result.php?id=408
fshr_human 2.61x61 419 TM2 A => T N/A Single-point (Functional - cAMP accumulation) FSH Doherty E et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=419
fshr_human 2.64x64 422 TM2 D => A N/A Single-point (Functional - cAMP accumulation) FSH Ji I et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=422
fshr_human 2.64x64 422 TM2 D => E 9.091↓ Single-point (Functional - cAMP accumulation) FSH Ji I et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=422
fshr_human 2.64x64 422 TM2 D => K N/A Single-point (Functional - cAMP accumulation) FSH Ji I et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=422
fshr_human 2.64x64 422 TM2 D => R N/A Single-point (Functional - cAMP accumulation) FSH Ji I et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=422
fshr_human 2.64x64 422 TM2 D => S N/A Single-point (Functional - cAMP accumulation) FSH Ji I et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=422
fshr_human 2.64x64 422 TM2 D => V N/A Single-point (Functional - cAMP accumulation) FSH Ji I et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=422
fshr_human 2.64x64 422 TM2 D => Y N/A Single-point (Functional - cAMP accumulation) FSH Ji I et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=422
fshr_human 2.65x65 423 TM2 I => A 1.0 Single-point (Functional - cAMP accumulation) FSH Ji I et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=423
fshr_human 2.66x66 424 TM2 H => A 1.0 Single-point (Functional - cAMP accumulation) FSH Ji I et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=424
fshr_human 2.67x67 425 TM2 T => A 2.041↓ Single-point (Functional - cAMP accumulation) FSH Ji I et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=425
fshr_human 2.68x68 426 TM2 K => A N/A Single-point (Functional - cAMP accumulation) FSH Ji I et al (1995) http://www.ssfa-gphr.de/mutation_result.php?id=426
fshr_human 431 ECL1 N => I 1.47↑ Single-point (Functional - cAMP accumulation) FSH Casas-Gonzalez P et al (2012) http://www.ssfa-gphr.de/mutation_result.php?id=431
fshr_human 431 ECL1 N => I 2.703↓ Specific-binding (binding) FSH Casas-Gonzalez P et al (2012) http://www.ssfa-gphr.de/mutation_result.php?id=431
fshr_human 3.32x32 449 TM3 T => A 1.5↑ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => D 1.2↑ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => F 1.39↑ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => G 1.4↑ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => I 1.149↓ Single-point (Functional - cAMP accumulation) FSH Vasseur C et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => I 1.429↓ Specific-binding (binding) FSH Vasseur C et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => I 1.52↑ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => N 1.053↓ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => N 1.01↑ Single-point (Functional - cAMP accumulation) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => N 1.48↑ Specific-binding (binding) FSH Banerjee AA et al (2017) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => R N/A Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => S 1.053↓ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.32x32 449 TM3 T => Y 1.17↑ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=449
fshr_human 3.43x43 460 TM3 L => A 2.0↓ Single-point (Functional - cAMP accumulation) FSH Tao YX et al (2000) http://www.ssfa-gphr.de/mutation_result.php?id=460
fshr_human 3.43x43 460 TM3 L => D 4.0↓ Single-point (Functional - cAMP accumulation) FSH Tao YX et al (2000) http://www.ssfa-gphr.de/mutation_result.php?id=460
fshr_human 3.43x43 460 TM3 L => K 4.0↓ Single-point (Functional - cAMP accumulation) FSH Tao YX et al (2000) http://www.ssfa-gphr.de/mutation_result.php?id=460
fshr_human 3.43x43 460 TM3 L => R 4.0↓ Single-point (Functional - cAMP accumulation) FSH Tao YX et al (2000) http://www.ssfa-gphr.de/mutation_result.php?id=460
fshr_human 3.50x50 467 TM3 R => A 11.111↓ Single-point (Functional - cAMP accumulation) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=467
fshr_human 3.50x50 467 TM3 R => A 1.01↓ Specific-binding (binding) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=467
fshr_human 3.50x50 467 TM3 R => H 10.0↓ Single-point (Functional - cAMP accumulation) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=467
fshr_human 3.50x50 467 TM3 R => H 1.163↓ Specific-binding (binding) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=467
fshr_human 3.50x50 467 TM3 R => K 1.17↑ Single-point (Functional - cAMP accumulation) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=467
fshr_human 3.50x50 467 TM3 R => K 1.163↓ Specific-binding (binding) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=467
fshr_human 3.53x53 470 TM3 T => A 10.0↓ Single-point (Functional - cAMP accumulation) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=470
fshr_human 3.53x53 470 TM3 T => A 1.01↓ Specific-binding (binding) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=470
fshr_human 34.53x53 477 ICL2 L => A 1.07↑ Single-point (Functional - cAMP accumulation) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=477
fshr_human 34.53x53 477 ICL2 L => A 1.01↓ Specific-binding (binding) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=477
fshr_human 34.53x53 477 ICL2 L => D 1.493↓ Single-point (Functional - cAMP accumulation) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=477
fshr_human 34.53x53 477 ICL2 L => D 1.299↓ Specific-binding (binding) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=477
fshr_human 34.53x53 477 ICL2 L => K 6.25↓ Single-point (Functional - cAMP accumulation) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=477
fshr_human 34.53x53 477 ICL2 L => K 2.083↓ Specific-binding (binding) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=477
fshr_human 34.53x53 477 ICL2 L => P 2.941↓ Single-point (Functional - cAMP accumulation) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=477
fshr_human 34.53x53 477 ICL2 L => P 1.124↓ Specific-binding (binding) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=477
fshr_human 34.53x53 477 ICL2 L => R 2.083↓ Single-point (Functional - cAMP accumulation) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=477
fshr_human 34.53x53 477 ICL2 L => R 1.37↓ Specific-binding (binding) FSH Timossi C et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=477
fshr_human 4.61x61 505 TM4 I => V 1.266↓ Single-point (Functional - cAMP accumulation) FSH Banerjee AA et al (2015) http://www.ssfa-gphr.de/mutation_result.php?id=505
fshr_human 4.61x61 505 TM4 I => V 1.35↑ Specific-binding (binding) FSH Banerjee AA et al (2015) http://www.ssfa-gphr.de/mutation_result.php?id=505
fshr_human 514 ECL2 V => A 1.163↓ Single-point (Functional - cAMP accumulation) FSH Desai SS et al (2015) http://www.ssfa-gphr.de/mutation_result.php?id=514
fshr_human 514 ECL2 V => A 1.0 Specific-binding (binding) FSH Desai SS et al (2015) http://www.ssfa-gphr.de/mutation_result.php?id=514
fshr_human 45.52x52 519 ECL2 P => T N/A N/A Meduri G et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=519
fshr_human 45.52x52 519 ECL2 P => T N/A Single-point (Functional - cAMP accumulation) FSH Meduri G et al (2003) http://www.ssfa-gphr.de/mutation_result.php?id=519
fshr_human 5.54x54 545 TM5 I => A 1.25↓ Single-point (Functional - cAMP accumulation) FSH De Leener A et al (2006) http://www.ssfa-gphr.de/mutation_result.php?id=545
fshr_human 5.54x54 545 TM5 I => F 1.0 Single-point (Functional - cAMP accumulation) FSH De Leener A et al (2006) http://www.ssfa-gphr.de/mutation_result.php?id=545
fshr_human 5.54x54 545 TM5 I => L 2.5↓ Single-point (Functional - cAMP accumulation) FSH De Leener A et al (2006) http://www.ssfa-gphr.de/mutation_result.php?id=545
fshr_human 5.54x54 545 TM5 I => N 1.0 Single-point (Functional - cAMP accumulation) FSH De Leener A et al (2006) http://www.ssfa-gphr.de/mutation_result.php?id=545
fshr_human 5.54x54 545 TM5 I => T 1.0 Single-point (Functional - cAMP accumulation) FSH De Leener A et al (2006) http://www.ssfa-gphr.de/mutation_result.php?id=545
fshr_human 5.54x54 545 TM5 I => V 1.0 Single-point (Functional - cAMP accumulation) FSH De Leener A et al (2006) http://www.ssfa-gphr.de/mutation_result.php?id=545
fshr_human 6.30x30 567 TM6 D => A 1.587↓ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => G 1.449↓ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => G 2.0↓ Single-point (Functional - cAMP accumulation) FSH Schulz A et al (1999) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => G 2.5↓ Specific-binding (binding) FSH Schulz A et al (1999) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => H 1.429↓ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => K 1.818↓ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => N 1.1↑ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => Q 1.667↓ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => R 2.0↓ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => T 2.128↓ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => V 4.0↓ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => W N/A Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.30x30 567 TM6 D => Y 3.333↓ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=567
fshr_human 6.36x36 573 TM6 R => C 3.333↓ Single-point (Functional - cAMP accumulation) FSH Beau I et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=573
fshr_human 6.36x36 573 TM6 R => C 1.22↓ Specific-binding (binding) FSH Beau I et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=573
fshr_human 6.38x38 575 TM6 A => V 3.226↓ Single-point (Functional - cAMP accumulation) FSH Desai SS et al (2015) http://www.ssfa-gphr.de/mutation_result.php?id=575
fshr_human 6.38x38 575 TM6 A => V 1.0 Specific-binding (binding) FSH Desai SS et al (2015) http://www.ssfa-gphr.de/mutation_result.php?id=575
fshr_human 6.44x44 581 TM6 D => G 1.235↓ Specific-binding (binding) FSH Tao YX et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=581
fshr_human 6.50x50 587 TM6 P => H N/A N/A Kuechler A et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=587
fshr_human 6.50x50 587 TM6 P => H N/A Single-point (Functional - cAMP accumulation) FSH Kuechler A et al (2010) http://www.ssfa-gphr.de/mutation_result.php?id=587
fshr_human 6.54x54 591 TM6 F => S N/A Single-point (Functional - cAMP accumulation) FSH Kotlar TJ et al (1997) http://www.ssfa-gphr.de/mutation_result.php?id=591
fshr_human 6.54x54 591 TM6 F => S 2.857↓ Specific-binding (binding) FSH Kotlar TJ et al (1997) http://www.ssfa-gphr.de/mutation_result.php?id=591
fshr_human 6.61x61 598 TM6 K => A 7.692↓ Single-point (Functional - cAMP accumulation) FSH Ryu K et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=598
fshr_human 599 ECL3 V => A 1.724↓ Single-point (Functional - cAMP accumulation) FSH Ryu K et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=599
fshr_human 600 ECL3 P => A 5.882↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=600
fshr_human 600 ECL3 P => A 6.25↓ Single-point (Functional - cAMP accumulation) FSH Ryu K et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=600
fshr_human 600 ECL3 P => C 8.333↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=600
fshr_human 600 ECL3 P => D 1.408↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=600
fshr_human 600 ECL3 P => E 7.143↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=600
fshr_human 600 ECL3 P => F N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=600
fshr_human 600 ECL3 P => L N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=600
fshr_human 600 ECL3 P => Q 1.695↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=600
fshr_human 600 ECL3 P => R N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=600
fshr_human 600 ECL3 P => S 1.562↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=600
fshr_human 600 ECL3 P => Y 2.941↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=600
fshr_human 601 ECL3 L => A N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => A N/A Single-point (Functional - IP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => A N/A Single-point (Functional - cAMP accumulation) FSH Ryu K et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => C N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => D N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => E N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => E N/A Single-point (Functional - IP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => F 1.333↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => F N/A Single-point (Functional - IP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => P N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => Q 8.333↓ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => R N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => R N/A Single-point (Functional - IP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => V 8.333↓ Single-point (Functional - cAMP accumulation) FSH Touraine P et al (1999) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => Y 1.41↑ Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 601 ECL3 L => Y 3.704↓ Single-point (Functional - IP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=601
fshr_human 602 ECL3 I => A N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=602
fshr_human 602 ECL3 I => A N/A Single-point (Functional - cAMP accumulation) FSH Ryu K et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=602
fshr_human 602 ECL3 I => C N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=602
fshr_human 602 ECL3 I => D N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=602
fshr_human 602 ECL3 I => E N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=602
fshr_human 602 ECL3 I => P N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=602
fshr_human 602 ECL3 I => Q N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=602
fshr_human 602 ECL3 I => R N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=602
fshr_human 602 ECL3 I => S N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=602
fshr_human 602 ECL3 I => Y N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=602
fshr_human 7.30x29 603 TM7 T => A 2.564↓ Single-point (Functional - cAMP accumulation) FSH Ryu K et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=603
fshr_human 7.31x30 604 TM7 V => A 4.545↓ Single-point (Functional - cAMP accumulation) FSH Ryu K et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=604
fshr_human 7.32x31 605 TM7 S => A 1.176↓ Single-point (Functional - cAMP accumulation) FSH Ryu K et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=605
fshr_human 7.33x32 606 TM7 K => A 1.852↓ Single-point (Functional - cAMP accumulation) FSH Ryu K et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=606
fshr_human 7.34x33 607 TM7 A => G 2.703↓ Single-point (Functional - cAMP accumulation) FSH Ryu K et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=607
fshr_human 7.35x34 608 TM7 K => A N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.35x34 608 TM7 K => A N/A Single-point (Functional - cAMP accumulation) FSH Ryu K et al (1998) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.35x34 608 TM7 K => C N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.35x34 608 TM7 K => D N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.35x34 608 TM7 K => E N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.35x34 608 TM7 K => F N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.35x34 608 TM7 K => L N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.35x34 608 TM7 K => P N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.35x34 608 TM7 K => Q N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.35x34 608 TM7 K => R N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.35x34 608 TM7 K => S N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.35x34 608 TM7 K => Y N/A Single-point (Functional - cAMP accumulation) FSH Sohn J et al (2002) http://www.ssfa-gphr.de/mutation_result.php?id=608
fshr_human 7.42x41 615 TM7 H => A 1.35↑ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=615
fshr_human 7.42x41 615 TM7 H => F 1.17↑ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=615
fshr_human 7.42x41 615 TM7 H => Y 1.42↑ Single-point (Functional - cAMP accumulation) FSH Montanelli L et al (2004) http://www.ssfa-gphr.de/mutation_result.php?id=615
fshr_human 189 N-term A => V N/A N/A Aittomaki K et al (1995)
fshr_human 43 N-term D => A N/A N/A Ji I et al (1995)
fshr_human 2.64x64 422 TM2 D => R N/A N/A Ji I et al (1995)
fshr_human 2.64x64 422 TM2 D => E N/A N/A Ji I et al (1995)
fshr_human 2.64x64 422 TM2 D => K N/A N/A Ji I et al (1995)
fshr_human 2.64x64 422 TM2 D => S N/A N/A Ji I et al (1995)
fshr_human 2.64x64 422 TM2 D => Y N/A N/A Ji I et al (1995)
fshr_human 2.64x64 422 TM2 D => V N/A N/A Ji I et al (1995)
fshr_human 2.66x66 424 TM2 H => A N/A N/A Ji I et al (1995)
fshr_human 2.65x65 423 TM2 I => A N/A N/A Ji I et al (1995)
fshr_human 2.68x68 426 TM2 K => A N/A N/A Ji I et al (1995)
fshr_human 2.67x67 425 TM2 T => A N/A N/A Ji I et al (1995)
fshr_human 6.44x44 581 TM6 D => G N/A N/A Kudo M et al (1996)
fshr_human 6.44x44 581 TM6 D => Y N/A N/A Kudo M et al (1996)
fshr_human 6.47x47 584 TM6 C => R N/A N/A Kudo M et al (1996)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Gromoll J et al (1996)
fshr_human 191 N-term N => I N/A N/A Gromoll J et al (1996)
fshr_human 189 N-term A => V N/A N/A Gromoll J et al (1996)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Gromoll J et al (1996)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Schulz A et al (1999)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Schulz A et al (1999)
fshr_human 601 ECL3 L => V N/A N/A Touraine P et al (1999)
fshr_human 224 N-term D => V N/A N/A Touraine P et al (1999)
fshr_human 160 N-term I => T N/A N/A Touraine P et al (1999)
fshr_human 6.36x36 573 TM6 R => D N/A N/A Touraine P et al (1999)
fshr_human 3.43x43 460 TM3 L => R N/A N/A Tao YX et al (2000)
fshr_human 3.43x43 460 TM3 L => K N/A N/A Tao YX et al (2000)
fshr_human 3.43x43 460 TM3 L => A N/A N/A Tao YX et al (2000)
fshr_human 3.43x43 460 TM3 L => D N/A N/A Tao YX et al (2000)
fshr_human 6.54x54 591 TM6 F => S N/A N/A Kotlar TJ et al (1997)
fshr_human 6.36x36 573 TM6 R => C N/A N/A Beau I et al (1998)
fshr_human 160 N-term I => T N/A N/A Beau I et al (1998)
fshr_human 680 C-term N => S N/A N/A Simoni M et al (1999)
fshr_human 682 C-term S => T N/A N/A Beau I et al (1998)
fshr_human 681 C-term G => A N/A N/A Beau I et al (1998)
fshr_human 682 C-term S => A N/A N/A Beau I et al (1998)
fshr_human 678 C-term V => A N/A N/A Beau I et al (1998)
fshr_human 679 C-term T => A N/A N/A Beau I et al (1998)
fshr_human 680 C-term N => A N/A N/A Beau I et al (1998)
fshr_human 681 C-term G => A N/A N/A Beau I et al (1998)
fshr_human 682 C-term S => A N/A N/A Beau I et al (1998)
fshr_human 683 C-term T => A N/A N/A Beau I et al (1998)
fshr_human 684 C-term Y => A N/A N/A Beau I et al (1998)
fshr_human 685 C-term I => A N/A N/A Beau I et al (1998)
fshr_human 686 C-term L => A N/A N/A Beau I et al (1998)
fshr_human 687 C-term V => A N/A N/A Beau I et al (1998)
fshr_human 688 C-term P => A N/A N/A Beau I et al (1998)
fshr_human 689 C-term L => A N/A N/A Beau I et al (1998)
fshr_human 690 C-term S => A N/A N/A Beau I et al (1998)
fshr_human 691 C-term H => A N/A N/A Beau I et al (1998)
fshr_human 273 N-term S => I N/A N/A Nakabayashi K et al (2000)
fshr_human 6.61x61 598 TM6 K => A N/A N/A Ryu K et al (1998)
fshr_human 599 ECL3 V => A N/A N/A Ryu K et al (1998)
fshr_human 600 ECL3 P => A N/A N/A Ryu K et al (1998)
fshr_human 601 ECL3 L => A N/A N/A Ryu K et al (1998)
fshr_human 602 ECL3 I => A N/A N/A Ryu K et al (1998)
fshr_human 7.30x29 603 TM7 T => A N/A N/A Ryu K et al (1998)
fshr_human 7.31x30 604 TM7 V => A N/A N/A Ryu K et al (1998)
fshr_human 7.32x31 605 TM7 S => A N/A N/A Ryu K et al (1998)
fshr_human 7.33x32 606 TM7 K => A N/A N/A Ryu K et al (1998)
fshr_human 7.35x34 608 TM7 K => A N/A N/A Ryu K et al (1998)
fshr_human 7.34x33 607 TM7 A => G N/A N/A Ryu K et al (1998)
fshr_human 20 N-term H => W N/A N/A Sairam MR et al (2001)
fshr_human 23 N-term C => A N/A N/A Costagliola S et al (2002)
fshr_human 51 N-term L => A N/A N/A Song YS et al (2001)
fshr_human 53 N-term F => A N/A N/A Song YS et al (2001)
fshr_human 108 N-term L => S N/A N/A Liu C et al (1996)
fshr_human 160 N-term I => T N/A N/A Touraine P et al (1999)
fshr_human 160 N-term I => T N/A N/A Levallet J et al (1999)
fshr_human 160 N-term I => T N/A N/A Layman LC et al (2000)
fshr_human 160 N-term I => T N/A N/A Takakura K et al (2001)
fshr_human 160 N-term I => T N/A N/A Doherty E et al (2002)
fshr_human 160 N-term I => T N/A N/A Rannikko A et al (2002)
fshr_human 160 N-term I => T N/A N/A Allen LA et al (2003)
fshr_human 160 N-term I => T N/A N/A Beau I et al (1998)
fshr_human 189 N-term A => V N/A N/A Simoni M et al (1999)
fshr_human 189 N-term A => V N/A N/A Touraine P et al (1999)
fshr_human 189 N-term A => V N/A N/A Levallet J et al (1999)
fshr_human 189 N-term A => V N/A N/A Layman LC et al (2000)
fshr_human 189 N-term A => V N/A N/A Takakura K et al (2001)
fshr_human 189 N-term A => V N/A N/A de Roux N et al (2001)
fshr_human 189 N-term A => V N/A N/A Achermann JC et al (2001)
fshr_human 189 N-term A => V N/A N/A Hovatta O et al (2002)
fshr_human 189 N-term A => V N/A N/A Doherty E et al (2002)
fshr_human 189 N-term A => V N/A N/A Rannikko A et al (2002)
fshr_human 189 N-term A => V N/A N/A Vaskivuo TE et al (2002)
fshr_human 189 N-term A => V N/A N/A Gromoll J et al (2002)
fshr_human 189 N-term A => V N/A N/A Allen LA et al (2003)
fshr_human 189 N-term A => V N/A N/A Gromoll J et al (1996)
fshr_human 189 N-term A => V N/A N/A Beau I et al (1998)
fshr_human 189 N-term A => V N/A N/A Layman LC et al (1999)
fshr_human 191 N-term N => I N/A N/A Levallet J et al (1999)
fshr_human 191 N-term N => I N/A N/A Gromoll J et al (2002)
fshr_human 224 N-term D => V N/A N/A Touraine P et al (1999)
fshr_human 224 N-term D => V N/A N/A Levallet J et al (1999)
fshr_human 224 N-term D => V N/A N/A Takakura K et al (2001)
fshr_human 224 N-term D => V N/A N/A Doherty E et al (2002)
fshr_human 224 N-term D => V N/A N/A Allen LA et al (2003)
fshr_human 273 N-term S => I N/A N/A Nakabayashi K et al (2000)
fshr_human 273 N-term S => I N/A N/A Montanelli L et al (2004)
fshr_human 341 N-term V => A N/A N/A Levallet J et al (1999)
fshr_human 341 N-term V => A N/A N/A Sundblad V et al (2004)
fshr_human 348 N-term P => R N/A N/A Allen LA et al (2003)
fshr_human 2.61x61 419 TM2 A => T N/A N/A Doherty E et al (2002)
fshr_human 2.61x61 419 TM2 A => T N/A N/A Allen LA et al (2003)
fshr_human 3.32x32 449 TM3 T => A N/A N/A Montanelli L et al (2004)
fshr_human 3.32x32 449 TM3 T => A N/A N/A Montanelli L et al (2004)
fshr_human 3.32x32 449 TM3 T => A N/A N/A Montanelli L et al (2004)
fshr_human 3.32x32 449 TM3 T => I N/A N/A Montanelli L et al (2004)
fshr_human 3.32x32 449 TM3 T => I N/A N/A Montanelli L et al (2004)
fshr_human 3.32x32 449 TM3 T => I N/A N/A Montanelli L et al (2004)
fshr_human 3.43x43 460 TM3 L => A N/A N/A Tao YX et al (2000)
fshr_human 3.43x43 460 TM3 L => D N/A N/A Tao YX et al (2000)
fshr_human 3.43x43 460 TM3 L => K N/A N/A Tao YX et al (2000)
fshr_human 3.43x43 460 TM3 L => R N/A N/A Tao YX et al (2000)
fshr_human 3.50x50 467 TM3 R => A N/A N/A Timossi C et al (2002)
fshr_human 3.50x50 467 TM3 R => H N/A N/A Timossi C et al (2002)
fshr_human 3.50x50 467 TM3 R => K N/A N/A Timossi C et al (2002)
fshr_human 3.53x53 470 TM3 T => A N/A N/A Timossi C et al (2002)
fshr_human 34.53x53 477 ICL2 L => A N/A N/A Timossi C et al (2002)
fshr_human 34.53x53 477 ICL2 L => D N/A N/A Timossi C et al (2002)
fshr_human 34.53x53 477 ICL2 L => K N/A N/A Timossi C et al (2002)
fshr_human 34.53x53 477 ICL2 L => P N/A N/A Timossi C et al (2002)
fshr_human 34.53x53 477 ICL2 L => R N/A N/A Timossi C et al (2002)
fshr_human 509 ECL2 S => A N/A N/A Tao YX et al (2000)
fshr_human 45.52x52 519 ECL2 P => T N/A N/A Meduri G et al (2003)
fshr_human 5.39x39 530 TM5 Y => F N/A N/A Krishnamurthy H et al (2003)
fshr_human 5.42x42 533 TM5 S => A N/A N/A Tao YX et al (2002)
fshr_human 5.59x59 550 TM5 I => T N/A N/A Tao YX et al (2002)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Arnhold IJ et al (1999)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Levallet J et al (1999)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Layman LC et al (2000)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Tao YX et al (2000)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Tao YX et al (2002)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Haywood M et al (2002)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Nordhoff V et al (2003)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Kudo M et al (1996)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Gromoll J et al (1996)
fshr_human 6.30x30 567 TM6 D => G N/A N/A Layman LC et al (1999)
fshr_human 6.30x30 567 TM6 D => N N/A N/A Montanelli L et al (2004)
fshr_human 6.30x30 567 TM6 D => N N/A N/A Montanelli L et al (2004)
fshr_human 6.30x30 567 TM6 D => N N/A N/A Montanelli L et al (2004)
fshr_human 6.30x30 567 TM6 D => R N/A N/A Layman LC et al (2000)
fshr_human 6.36x36 573 TM6 R => C N/A N/A Touraine P et al (1999)
fshr_human 6.36x36 573 TM6 R => C N/A N/A Levallet J et al (1999)
fshr_human 6.36x36 573 TM6 R => C N/A N/A Layman LC et al (2000)
fshr_human 6.36x36 573 TM6 R => C N/A N/A Takakura K et al (2001)
fshr_human 6.36x36 573 TM6 R => C N/A N/A Doherty E et al (2002)
fshr_human 6.36x36 573 TM6 R => C N/A N/A Rannikko A et al (2002)
fshr_human 6.36x36 573 TM6 R => C N/A N/A Allen LA et al (2003)
fshr_human 6.36x36 573 TM6 R => C N/A N/A Beau I et al (1998)
fshr_human 6.36x36 573 TM6 R => D N/A N/A Touraine P et al (1999)
fshr_human 6.39x39 576 TM6 M => T N/A N/A Tao YX et al (2002)
fshr_human 6.44x44 581 TM6 D => G N/A N/A Tao YX et al (2002)
fshr_human 6.44x44 581 TM6 D => G N/A N/A Kudo M et al (1996)
fshr_human 6.44x44 581 TM6 D => Y N/A N/A Kudo M et al (1996)
fshr_human 6.46x46 583 TM6 L => Y N/A N/A Sohn J et al (2002)
fshr_human 6.47x47 584 TM6 C => R N/A N/A Kudo M et al (1996)
fshr_human 6.49x49 586 TM6 A => V N/A N/A Layman LC et al (1999)
fshr_human 6.54x54 591 TM6 F => S N/A N/A Levallet J et al (1999)
fshr_human 6.54x54 591 TM6 F => S N/A N/A Giacaglia LR et al (2000)
fshr_human 6.54x54 591 TM6 F => S N/A N/A Kotlar TJ et al (1997)
fshr_human 6.61x61 598 TM6 K => A N/A N/A Ryu K et al (1998)
fshr_human 599 ECL3 V => A N/A N/A Sohn J et al (2002)
fshr_human 599 ECL3 V => A N/A N/A Ryu K et al (1998)
fshr_human 600 ECL3 P => A N/A N/A Sohn J et al (2002)
fshr_human 600 ECL3 P => A N/A N/A Ryu K et al (1998)
fshr_human 601 ECL3 L => A N/A N/A Sohn J et al (2002)
fshr_human 601 ECL3 L => A N/A N/A Ryu K et al (1998)
fshr_human 601 ECL3 L => F N/A N/A Sohn J et al (2002)
fshr_human 601 ECL3 L => Q N/A N/A Sohn J et al (2002)
fshr_human 601 ECL3 L => V N/A N/A Touraine P et al (1999)
fshr_human 601 ECL3 L => V N/A N/A Levallet J et al (1999)
fshr_human 601 ECL3 L => V N/A N/A Takakura K et al (2001)
fshr_human 601 ECL3 L => V N/A N/A Doherty E et al (2002)
fshr_human 601 ECL3 L => V N/A N/A Allen LA et al (2003)
fshr_human 602 ECL3 I => A N/A N/A Sohn J et al (2002)
fshr_human 602 ECL3 I => A N/A N/A Ryu K et al (1998)
fshr_human 602 ECL3 I => Y N/A N/A Sohn J et al (2002)
fshr_human 7.30x29 603 TM7 T => A N/A N/A Ryu K et al (1998)
fshr_human 7.31x30 604 TM7 V => A N/A N/A Ryu K et al (1998)
fshr_human 7.32x31 605 TM7 S => A N/A N/A Ryu K et al (1998)
fshr_human 7.33x32 606 TM7 K => A N/A N/A Ryu K et al (1998)
fshr_human 7.34x33 607 TM7 A => G N/A N/A Sohn J et al (2002)
fshr_human 7.34x33 607 TM7 A => G N/A N/A Ryu K et al (1998)
fshr_human 7.35x34 608 TM7 K => A N/A N/A Sohn J et al (2002)
fshr_human 7.35x34 608 TM7 K => A N/A N/A Ryu K et al (1998)
fshr_human 7.35x34 608 TM7 K => F N/A N/A Sohn J et al (2002)
fshr_human 7.35x34 608 TM7 K => L N/A N/A Sohn J et al (2002)
fshr_human 7.35x34 608 TM7 K => R N/A N/A Sohn J et al (2002)
fshr_human 7.42x41 615 TM7 H => Y N/A N/A Tao YX et al (2002)
fshr_human 678 C-term V => A N/A N/A Beau I et al (1998)
fshr_human 679 C-term T => A N/A N/A Beau I et al (1998)
fshr_human 680 C-term N => S N/A N/A Simoni M et al (1999)
fshr_human 680 C-term N => S N/A N/A Al-Hendy A et al (2000)
fshr_human 680 C-term N => S N/A N/A Montgomery GW et al (2001)
fshr_human 681 C-term G => A N/A N/A Beau I et al (1998)
fshr_human 682 C-term S => A N/A N/A Beau I et al (1998)
fshr_human 683 C-term T => A N/A N/A Beau I et al (1998)
fshr_human 684 C-term Y => A N/A N/A Beau I et al (1998)
fshr_human 685 C-term I => A N/A N/A Beau I et al (1998)
fshr_human 686 C-term L => A N/A N/A Beau I et al (1998)
fshr_human 687 C-term V => A N/A N/A Beau I et al (1998)
fshr_human 688 C-term P => A N/A N/A Beau I et al (1998)
fshr_human 689 C-term L => A N/A N/A Beau I et al (1998)
fshr_human 690 C-term S => A N/A N/A Beau I et al (1998)
fshr_human 691 C-term H => A N/A N/A Beau I et al (1998)
fshr_human 148 N-term L => T N/A N/A Wacker JL et al (2008)
fshr_human 148 N-term L => R N/A N/A Wacker JL et al (2008)
fshr_human 148 N-term L => A N/A N/A Wacker JL et al (2008)
fshr_human 148 N-term L => F N/A N/A Wacker JL et al (2008)
fshr_human 148 N-term L => S N/A N/A Wacker JL et al (2008)
fshr_human 148 N-term L => E N/A N/A Wacker JL et al (2008)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 Q Y K L T ICL1ECL1 S Q Y H N Y A I D W Q T ECL1ICL2 A M Q L D C K V ICL2ECL2 I S S Y M K V S I C L P M D I D ECL2ICL3 N P N I V ICL3ECL3 V P L I ECL3N-term M A L L L V S L L A F L S L G S G C H H R I C H C S N R V F L C Q E S K V T E I P S D L P R N A I E L R F V L T K L R V I Q K G A F S G F G D L E K I E I S Q N D V L E V I E A D V F S N L P K L H E I R I E K A N N L L Y I N P E A F Q N L P N L Q Y L L I S N T G I K H L P D V H K I H S L Q K V L L D I Q D N I N I H T I E R N S F V G L S F E S V I L W L N K N G I Q E I H N C A F N G T Q L D E L N L S D N N N L E E L P N D V F H G A S G P V I L D I S R T R I H S L P S Y G L E N L K K L R A R S T Y N L K K L P T L E K L V A L M E A S L T Y P S H C C A F A N W R R Q I S E L H P I C N K S I L R Q E V D Y M T Q A R G Q R S S L A E D N E S S Y S R G F D M T Y T E F D Y D L C N E V V D V T C S P K P D A F N P C E D I M G N-termC-term C Y E M Q A Q I Y R T E T S S T V H N T H P R N G H C S S A P R V T N G S T Y I L V P L S H L A Q N C-term Y N I L R V L I W F I S I L A I T G N I I V L V I L T T S V P R F L M C N L A F A D L C I G I Y L L L I A S V D I H T K G A G C D A A G F F T V F A S E L S V Y T L T A I T L E R W H T I T H Q L R H A A S V M V M G W I F A F A A A L F P I F G S P L S Q L Y V M S L L V L N V L A F V V I C G C Y I H I Y L T V R S S S S D T R I A K R M A M L I F T D F L C M A P I S F F A I S A S L K T V S K A K I L L V L F H P I N S C A N P F L Y A I F T K N F F I C G F R R D L L S K
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
I N G T I A L I S I F W I L V R L I N Y 1 C N L A F A D L C I G I Y L L L I A S V 2 A T L T Y V S L E S A F V T F F G A A D 3 A A S V M V M G W I F A F A A A L F P I 4 Y C G C I V V F A L V N L V L L S M V Y 5 A M L I F T D F L C M A P I S F F A I S 6 F P N A C S N I P H F L V L L I K A K 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
FSH receptor
TM1
1x46 1.46x46 A376
TM2
2x43 2.43x43 M401
2x50 2.50x50 D408
2x61 2.61x61 A419
2x64 2.64x64 D422
2x65 2.65x65 I423
2x66 2.66x66 H424
2x67 2.67x67 T425
2x68 2.68x68 K426
TM3
3x32 3.32x32 T449
3x43 3.43x43 L460
3x50 3.50x50 R467
3x53 3.53x53 T470
TM4
4x61 4.61x61 I505
TM5
5x39 5.39x39 Y530
5x42 5.42x42 S533
5x52 5.52x52 V543
5x54 5.54x54 I545
5x59 5.59x59 I550
TM6
6x30 6.30x30 D567
6x34 6.34x34 A571
6x36 6.36x36 R573
6x37 6.37x37 M574
6x38 6.38x38 A575
6x39 6.39x39 M576
6x41 6.41x41 I578
6x43 6.43x43 T580
6x44 6.44x44 D581
6x46 6.46x46 L583
6x47 6.47x47 C584
6x49 6.49x49 A586
6x50 6.50x50 P587
6x54 6.54x54 F591
6x61 6.61x61 K598
TM7
7x29 7.30x29 T603
7x30 7.31x30 V604
7x31 7.32x31 S605
7x32 7.33x32 K606
7x33 7.34x33 A607
7x34 7.35x34 K608
7x41 7.42x41 H615