Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
hrh3_human 5.46x461 206 TM5 E => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.46x461 206 TM5 E => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.44x45 204 TM5 T => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.44x45 204 TM5 T => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.42x43 202 TM5 A => Q N/A N/A Uveges AJ et al (2002)
hrh3_human 5.42x43 202 TM5 A => Q N/A N/A Uveges AJ et al (2002)
hrh3_human 5.39x40 199 TM5 L => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.39x40 199 TM5 L => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.36x37 196 TM5 W => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.36x37 196 TM5 W => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.46x461 206 TM5 E => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.46x461 206 TM5 E => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.46x461 206 TM5 E => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.46x461 206 TM5 E => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.44x45 204 TM5 T => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.44x45 204 TM5 T => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.44x45 204 TM5 T => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.44x45 204 TM5 T => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.42x43 202 TM5 A => Q N/A N/A Uveges AJ et al (2002)
hrh3_human 5.42x43 202 TM5 A => Q N/A N/A Uveges AJ et al (2002)
hrh3_human 5.42x43 202 TM5 A => Q N/A N/A Uveges AJ et al (2002)
hrh3_human 5.42x43 202 TM5 A => Q N/A N/A Uveges AJ et al (2002)
hrh3_human 5.39x40 199 TM5 L => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.39x40 199 TM5 L => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.39x40 199 TM5 L => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.36x37 196 TM5 W => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.36x37 196 TM5 W => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.36x37 196 TM5 W => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.36x37 196 TM5 W => A N/A N/A Uveges AJ et al (2002)
hrh3_human 5.47x47 207 TM5 F => A N/A N/A Uveges AJ et al (2002)
hrh3_human 3.37x37 119 TM3 T => A 2.8↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL1180120 Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.40x40 122 TM3 A => V 10.5↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL1180120 Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.37x37 119 TM3 T => A 10.0↑ K(i) (Binding - Radioligand competition/displacement) ciproxifan Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.40x40 122 TM3 A => V 14.773↑ K(i) (Binding - Radioligand competition/displacement) ciproxifan Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.37x37 119 TM3 T => A 2.165↓ K(i) (Binding - Radioligand competition/displacement) clobenpropit Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.40x40 122 TM3 A => V 12.0↑ K(i) (Binding - Radioligand competition/displacement) clobenpropit Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 5.36x37 196 TM5 W => A 7.299↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.36x37 196 TM5 W => A 142.857↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.39x40 199 TM5 L => A 3.03↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.39x40 199 TM5 L => A 62.5↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.41x42 201 TM5 T => A 5.988↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.41x42 201 TM5 T => A 125.0↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.42x43 202 TM5 A => Q 11.494↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.42x43 202 TM5 A => Q 250.0↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.44x45 204 TM5 T => A 9.259↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.44x45 204 TM5 T => A 200.0↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.46x461 206 TM5 E => A 90.909↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.46x461 206 TM5 E => A 1000.0↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.48x48 208 TM5 F => A 7.519↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.48x48 208 TM5 F => A 166.667↓ K(i) (Binding - Radioligand competition/displacement) imetit Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 3.37x37 119 TM3 T => A 2.062↑ K(i) (Binding - Radioligand competition/displacement) thioperamide Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.40x40 122 TM3 A => V 23.571↑ K(i) (Binding - Radioligand competition/displacement) thioperamide Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.37x37 119 TM3 T => A 1.143↑ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.40x40 122 TM3 A => V 1.089↓ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 5.36x37 196 TM5 W => A 2.243↑ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.36x37 196 TM5 W => A 7.353↓ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.39x40 199 TM5 L => A 4.599↑ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.39x40 199 TM5 L => A 3.597↓ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.41x42 201 TM5 T => A 1.927↑ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.41x42 201 TM5 T => A 8.621↓ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.42x43 202 TM5 A => Q 2.359↑ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.42x43 202 TM5 A => Q 6.993↓ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.44x45 204 TM5 T => A 1.094↓ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.44x45 204 TM5 T => A 18.182↓ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.46x461 206 TM5 E => A N/A K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.46x461 206 TM5 E => A N/A K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.48x48 208 TM5 F => A 5.871↑ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.48x48 208 TM5 F => A 2.817↓ K(i) (Binding - Radioligand competition/displacement) (R)-α-methylhistamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 3.37x37 119 TM3 T => A 1.062↑ K(d) (Binding - Radioligand competition/displacement) N-α-methylhistamine Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.40x40 122 TM3 A => V 1.558↓ K(d) (Binding - Radioligand competition/displacement) N-α-methylhistamine Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.37x37 119 TM3 T => A 31.609↑ K(i) (Binding - Radioligand competition/displacement) A-304121 Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.40x40 122 TM3 A => V 18.641↑ K(i) (Binding - Radioligand competition/displacement) A-304121 Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.37x37 119 TM3 T => A 5.571↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL354374 Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.40x40 122 TM3 A => V 2.294↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL354374 Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 5.36x37 196 TM5 W => A 1.403↑ K(i) (Binding - Radioligand competition/displacement) impentamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.39x40 199 TM5 L => A 1.522↑ K(i) (Binding - Radioligand competition/displacement) impentamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.41x42 201 TM5 T => A 1.081↑ K(i) (Binding - Radioligand competition/displacement) impentamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.42x43 202 TM5 A => Q 1.2↑ K(i) (Binding - Radioligand competition/displacement) impentamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.44x45 204 TM5 T => A 2.278↓ K(i) (Binding - Radioligand competition/displacement) impentamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.46x461 206 TM5 E => A 18.868↓ K(i) (Binding - Radioligand competition/displacement) impentamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.48x48 208 TM5 F => A 1.096↑ K(i) (Binding - Radioligand competition/displacement) impentamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 3.37x37 119 TM3 T => A 1.217↑ K(i) (Binding - Radioligand competition/displacement) histamine Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 3.40x40 122 TM3 A => V 1.143↓ K(i) (Binding - Radioligand competition/displacement) histamine Yao BB et al (2003) Kooistra AJ et al (2013)
hrh3_human 5.36x37 196 TM5 W => A 1.6↓ K(i) (Binding - Radioligand competition/displacement) histamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.39x40 199 TM5 L => A 1.178↓ K(i) (Binding - Radioligand competition/displacement) histamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.41x42 201 TM5 T => A 1.129↓ K(i) (Binding - Radioligand competition/displacement) histamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.42x43 202 TM5 A => Q 4.202↓ K(i) (Binding - Radioligand competition/displacement) histamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.44x45 204 TM5 T => A 5.747↓ K(i) (Binding - Radioligand competition/displacement) histamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.46x461 206 TM5 E => A N/A K(i) (Binding - Radioligand competition/displacement) histamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
hrh3_human 5.48x48 208 TM5 F => A 2.32↓ K(i) (Binding - Radioligand competition/displacement) histamine Uveges AJ et al (2002) Kooistra AJ et al (2013)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 S S L R ICL1ECL1 G R W T F ECL1ICL2 A V S Y R A Q Q G ICL2ECL2 W E Y L S G G S S I P E G H C Y A E F F Y ECL2ICL3 A R E A A G P E P P P E A Q P S P P P P P G C W G C W Q K G H G E A M P L H R Y G V G E A A V G A E A G E A T L G G G G G G G S V A S P T S S S G S S S R G T E R P R S L K R G S K P S A S S A S L E K R M K M V S Q S F T Q ICL3ECL3 H G H C V ECL3N-term M E R A P P D G P L N A S G A L A G E A A A A G G A R G F S A A W T A N-termC-term P Q K L K I Q P H S S L E H C W K C-term V L A A L M A L L I V A T V L G N A L V M L A F V A D T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R D T R R A V R K M L L V W V L A F L L Y G P A I L S N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F T K F R R A L L C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A N G L V T A V I L L A M L A A L V 1 L N L A I S D F L V G F A C I P L Y V P Y 2 L V I N F A S S T C L L Y D V V L W L K 3 A V R K M L L V W V L A F L L Y G P A 4 N F F T V S L F P T F F E L T S A T I L F 5 A V I V S I F G L C W A P Y T L L M I I 6 V P N V A S N A W L L W F S T E Y W Y 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
H3 receptor
TM3
3x37 3.37x37 T119
3x40 3.40x40 A122
TM5
5x37 5.36x37 W196
5x40 5.39x40 L199
5x42 5.41x42 T201
5x43 5.42x43 A202
5x45 5.44x45 T204
5x461 5.46x461 E206
5x47 5.47x47 F207
5x48 5.48x48 F208