Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
oprk_human 6.58x58 297 TM6 E => Q N/A N/A Coward P et al (1998)
oprk_human 363 C-term T => A N/A N/A Cheng ZJ et al (1998)
oprk_human 6.58x58 297 TM6 E => Q N/A N/A Coward P et al (1998)
oprk_human 2.64x64 119 TM2 Y => A N/A N/A Yan F et al (2005)
oprk_human 2.64x64 119 TM2 Y => C N/A N/A Yan F et al (2005)
oprk_human 2.64x64 119 TM2 Y => F N/A N/A Yan F et al (2005)
oprk_human 3.33x33 139 TM3 Y => A N/A N/A Yan F et al (2005)
oprk_human 3.33x33 139 TM3 Y => F N/A N/A Yan F et al (2005)
oprk_human 6.55x55 294 TM6 I => C N/A N/A Yan F et al (2005)
oprk_human 6.58x58 297 TM6 E => A N/A N/A Coward P et al (1998)
oprk_human 6.58x58 297 TM6 E => C N/A N/A Yan F et al (2005)
oprk_human 6.58x58 297 TM6 E => Q N/A N/A Coward P et al (1998)
oprk_human 7.32x31 309 TM7 L => C N/A N/A Yan F et al (2005)
oprk_human 7.33x32 310 TM7 S => C N/A N/A Yan F et al (2005)
oprk_human 7.35x34 312 TM7 Y => A N/A N/A Yan F et al (2005)
oprk_human 7.35x34 312 TM7 Y => F N/A N/A Yan F et al (2005)
oprk_human 7.36x35 313 TM7 Y => A N/A N/A Yan F et al (2005)
oprk_human 7.36x35 313 TM7 Y => C N/A N/A Yan F et al (2005)
oprk_human 7.36x35 313 TM7 Y => F N/A N/A Yan F et al (2005)
oprk_human 7.38x37 315 TM7 C => S N/A N/A Yan F et al (2005)
oprk_human 7.43x42 320 TM7 Y => A N/A N/A Yan F et al (2005)
oprk_human 7.43x42 320 TM7 Y => F N/A N/A Yan F et al (2005)
oprk_human 356 C-term S => A N/A N/A Cheng ZJ et al (1998)
oprk_human 357 C-term T => G N/A N/A Cheng ZJ et al (1998)
oprk_human 358 C-term S => G N/A N/A Cheng ZJ et al (1998)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
κ receptor
TM2
2x64 2.64x64 Y119
TM3
3x33 3.33x33 Y139
TM6
6x55 6.55x55 I294
6x58 6.58x58 E297
TM7
7x31 7.32x31 L309
7x32 7.33x32 S310
7x34 7.35x34 Y312
7x35 7.36x35 Y313
7x37 7.38x37 C315
7x42 7.43x42 Y320