Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
vipr1_human 207 ECL1 Q => H N/A N/A Couvineau A et al (1996)
vipr1_human 211 ECL1 G => A N/A N/A Couvineau A et al (1996)
vipr1_human 3.33x33 219 TM3 M => V N/A N/A Couvineau A et al (1996)
vipr1_human 2.50x50 178 TM2 H => R N/A N/A Gaudin P et al (1998)
vipr1_human 2.50x50 178 TM2 H => A N/A N/A Gaudin P et al (1998)
vipr1_human 2.50x50 178 TM2 H => D N/A N/A Gaudin P et al (1998)
vipr1_human 2.50x50 178 TM2 H => K N/A N/A Gaudin P et al (1998)
vipr1_human 36 N-term E => A N/A N/A Gaudin P et al (1998)
vipr1_human 68 N-term D => A N/A N/A Gaudin P et al (1998)
vipr1_human 1.29x29 132 TM1 D => A N/A N/A Gaudin P et al (1998)
vipr1_human 2.68x68 196 TM2 D => A N/A N/A Du K et al (1997)
vipr1_human 2.71x71 199 TM2 L => A N/A N/A Du K et al (1997)
vipr1_human 45.51x51 286 ECL2 W => A N/A N/A Du K et al (1997)
vipr1_human 5.36x37 294 TM5 W => A N/A N/A Du K et al (1997)
vipr1_human 6.42x42 343 TM6 T => K N/A N/A Gaudin P et al (1999)
vipr1_human 6.42x42 343 TM6 T => C N/A N/A Gaudin P et al (1999)
vipr1_human 6.42x42 343 TM6 T => P N/A N/A Gaudin P et al (1999)
vipr1_human 6.42x42 343 TM6 T => E N/A N/A Gaudin P et al (1999)
vipr1_human 6.42x42 343 TM6 T => A N/A N/A Gaudin P et al (1999)
vipr1_human 6.42x42 343 TM6 T => F N/A N/A Gaudin P et al (1999)
vipr1_human 36 N-term E => A N/A N/A Gaudin P et al (1999)
vipr1_human 68 N-term D => A N/A N/A Gaudin P et al (1999)
vipr1_human 1.29x29 132 TM1 D => A N/A N/A Gaudin P et al (1999)
vipr1_human 37 N-term C => G N/A N/A Gaudin P et al (1995)
vipr1_human 50 N-term C => G N/A N/A Gaudin P et al (1995)
vipr1_human 63 N-term C => G N/A N/A Gaudin P et al (1995)
vipr1_human 68 N-term D => G N/A N/A Couvineau A et al (1995)
vipr1_human 72 N-term C => G N/A N/A Gaudin P et al (1995)
vipr1_human 73 N-term W => G N/A N/A Couvineau A et al (1995)
vipr1_human 86 N-term C => G N/A N/A Gaudin P et al (1995)
vipr1_human 87 N-term P => G N/A N/A Couvineau A et al (1995)
vipr1_human 105 N-term C => G N/A N/A Gaudin P et al (1995)
vipr1_human 110 N-term W => G N/A N/A Couvineau A et al (1995)
vipr1_human 122 N-term C => G N/A N/A Gaudin P et al (1995)
vipr1_human 2.68x68 196 TM2 D => A N/A N/A Du K et al (1997)
vipr1_human 2.71x71 199 TM2 L => A N/A N/A Du K et al (1997)
vipr1_human 208 ECL1 C => G N/A N/A Gaudin P et al (1995)
vipr1_human 3.29x29 215 TM3 C => A N/A N/A Knudsen SM et al (1997)
vipr1_human 3.29x29 215 TM3 C => G N/A N/A Gaudin P et al (1995)
vipr1_human 3.29x29 215 TM3 C => G N/A N/A Knudsen SM et al (1997)
vipr1_human 3.29x29 215 TM3 C => S N/A N/A Knudsen SM et al (1997)
vipr1_human 45.50x50 285 ECL2 C => A N/A N/A Knudsen SM et al (1997)
vipr1_human 45.50x50 285 ECL2 C => G N/A N/A Knudsen SM et al (1997)
vipr1_human 45.50x50 285 ECL2 C => S N/A N/A Knudsen SM et al (1997)
vipr1_human 45.51x51 286 ECL2 W => A N/A N/A Du K et al (1997)
vipr1_human 5.36x37 294 TM5 W => A N/A N/A Du K et al (1997)
vipr1_human 73 N-term W => G Abolished effect K(d) (Binding - Radioligand saturation) VIP Couvineau A et al (1995) Salam W et al (2025)
vipr1_human 87 N-term P => G 1.017↑ K(d) (Binding - Radioligand saturation) VIP Couvineau A et al (1995) Salam W et al (2025)
vipr1_human 109 N-term G => W Abolished effect K(d) (Binding - Radioligand saturation) VIP Couvineau A et al (1995) Salam W et al (2025)
vipr1_human 109 N-term G => D Abolished effect K(d) (Binding - Radioligand saturation) VIP Couvineau A et al (1995) Salam W et al (2025)
vipr1_human 109 N-term G => W Abolished effect K(d) (Binding - Radioligand saturation) VIP Couvineau A et al (1995) Salam W et al (2025)
vipr1_human 110 N-term W => G 1.033↓ K(d) (Binding - Radioligand saturation) VIP Couvineau A et al (1995) Salam W et al (2025)
vipr1_human 2.60x60 188 TM2 R => Q 1.25↓ IC50 (Binding - Radioligand competition/displacement) PG 97-269 Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 1.499↓ IC50 (Binding - Radioligand competition/displacement) PG 97-269-[Asp3Asn] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 100.0↓ IC50 (Binding - Radioligand competition/displacement) VIP Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 5.988↓ EC50 (Functional - cAMP accumulation) VIP Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 20.0↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Asn] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 37.5↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 25.0↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Gln] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 60.0↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Gln] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 6.667↓ EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 25.0↓ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Glu] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 50.0↓ EC50 (Functional - cAMP accumulation) VIP-[Thr16Arg] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 25.0↓ IC50 (Binding - Radioligand competition/displacement) VIP-[Thr16Arg] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 5.0↑ IC50 (Binding - Radioligand competition/displacement) VIP(1-7)[Asp3Asn]/GRF(8-27)-amide Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 40.0↑ EC50 (Functional - cAMP accumulation) VIP(1-7)[Asp3Asn]/GRF(8-27)-amide Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 10.0↓ IC50 (Binding - Radioligand competition/displacement) [Lys15,Arg16,Leu27]VIP-(1-7)/GRF-(8-27)-NH2 Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.60x60 188 TM2 R => Q 4.0↓ EC50 (Functional - cAMP accumulation) [Lys15,Arg16,Leu27]VIP-(1-7)/GRF-(8-27)-NH2 Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 4.0↑ IC50 (Binding - Radioligand competition/displacement) PG 97-269 Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 6.667↑ IC50 (Binding - Radioligand competition/displacement) PG 97-269-[Asp3Asn] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 66.667↓ IC50 (Binding - Radioligand competition/displacement) VIP Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 40.0↓ EC50 (Functional - cAMP accumulation) VIP Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 3.333↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Asn] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 1.5↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 3.333↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Gln] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 20.0↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Gln] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 6.667↓ EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 3.745↓ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Glu] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 100.0↓ EC50 (Functional - cAMP accumulation) VIP-[Thr16Arg] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 33.333↓ IC50 (Binding - Radioligand competition/displacement) VIP-[Thr16Arg] Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 20.0↑ IC50 (Binding - Radioligand competition/displacement) VIP(1-7)[Asp3Asn]/GRF(8-27)-amide Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q Abolished effect EC50 (Functional - cAMP accumulation) [Lys15,Arg16,Leu27]VIP-(1-7)/GRF-(8-27)-NH2 Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 2.67x67 195 TM2 K => Q 1.0 IC50 (Binding - Radioligand competition/displacement) [Lys15,Arg16,Leu27]VIP-(1-7)/GRF-(8-27)-NH2 Solano RM et al (2001) Hollenstein K et al (2014)
vipr1_human 41 N-term Q => A 2.0↑ K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 46 N-term Q => A 2.0↓ K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 47 N-term H => A 1.667↓ K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 48 N-term K => A 1.667↓ K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 49 N-term Q => A 1.667↓ K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 53 N-term E => A 1.5↑ K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 55 N-term Q => A 1.167↓ K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 57 N-term E => A 1.2↑ K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 58 N-term N => A 1.167↓ K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 59 N-term E => A 1.0 K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 67 N-term W => E Abolished effect K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 67 N-term W => A Abolished effect K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 67 N-term W => A Abolished effect K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 67 N-term W => H Abolished effect K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 67 N-term W => K Abolished effect K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 67 N-term W => F Abolished effect K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 69 N-term N => A 1.333↓ K(d) (Binding - Radioligand saturation) VIP Nicole P et al (2000) Salam W et al (2025)
vipr1_human 1.43x43 146 TM1 Y => A 3.745↓ IC50 (Binding - Radioligand competition/displacement) PG 97-269 Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 8.0↓ EC50 (Functional - cAMP accumulation) VIP Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 62.5↓ IC50 (Binding - Radioligand competition/displacement) VIP Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 1.333↓ EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 1.143↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Asn] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 1.555↓ EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 2.747↓ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Glu] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 13.333↓ EC50 (Functional - cAMP accumulation) VIP-[Thr16Arg] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 27.778↓ IC50 (Binding - Radioligand competition/displacement) VIP-[Thr16Arg] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 33.333↓ EC50 (Functional - cAMP accumulation) VIP-[His1Ala] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 5.988↓ IC50 (Binding - Radioligand competition/displacement) VIP-[His1Ala] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 25.0↓ EC50 (Functional - cAMP accumulation) VIP-[His1Phe] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 7.194↓ IC50 (Binding - Radioligand competition/displacement) VIP-[His1Phe] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Phe6Cys] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 2.6↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Phe6Cys] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Phe6His] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 1.667↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Phe6His] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 333.333↓ EC50 (Functional - cAMP accumulation) VIP-[Phe6Tyr] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.43x43 146 TM1 Y => A 2.5↓ IC50 (Binding - Radioligand competition/displacement) VIP-[Phe6Tyr] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 5.0↓ IC50 (Binding - Radioligand competition/displacement) PG 97-269 Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 16.129↓ EC50 (Functional - cAMP accumulation) VIP Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 3.247↓ IC50 (Binding - Radioligand competition/displacement) VIP Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 3.774↓ EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 2.105↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Asn] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 1.277↓ EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 1.333↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Glu] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 27.027↓ EC50 (Functional - cAMP accumulation) VIP-[Thr16Arg] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 4.5↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Thr16Arg] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 15.385↓ EC50 (Functional - cAMP accumulation) VIP-[His1Ala] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 1.149↓ IC50 (Binding - Radioligand competition/displacement) VIP-[His1Ala] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 10.0↓ EC50 (Functional - cAMP accumulation) VIP-[His1Phe] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 1.499↓ IC50 (Binding - Radioligand competition/displacement) VIP-[His1Phe] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 500.0↓ EC50 (Functional - cAMP accumulation) VIP-[Phe6Cys] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 3.25↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Phe6Cys] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 55.556↓ EC50 (Functional - cAMP accumulation) VIP-[Phe6His] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 2.5↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Phe6His] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 47.619↓ EC50 (Functional - cAMP accumulation) VIP-[Phe6Tyr] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 1.47x47 150 TM1 Y => A 1.5↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Phe6Tyr] Perret J et al (2002) Hollenstein K et al (2014)
vipr1_human 200 ECL1 F => Y 1.175↓ pK(i) (Binding - Radioligand competition/displacement) VIP Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr1_human 200 ECL1 F => Y Abolished effect pEC50 (Functional - cAMP accumulation) VIP Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr1_human 200 ECL1 F => Y Abolished effect pEC50 (Functional - cAMP accumulation) VIP-[Thr11Arg] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr1_human 200 ECL1 F => Y 45.455↓ pK(i) (Binding - Radioligand competition/displacement) VIP-[Thr11Arg] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr1_human 200 ECL1 F => Y Abolished effect pEC50 (Functional - cAMP accumulation) VIP-[Thr11Citrullinel] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr1_human 200 ECL1 F => Y 12.658↓ pK(i) (Binding - Radioligand competition/displacement) VIP-[Thr11Citrullinel] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr1_human 200 ECL1 F => Y 1.0 pK(i) (Binding - Radioligand competition/displacement) VIP-[Thr11Val] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr1_human 200 ECL1 F => Y Abolished effect pEC50 (Functional - cAMP accumulation) VIP-[Thr11Val] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr1_human 4.37x38 250 TM4 S => A 2.455↑ EC50 (Functional - cAMP accumulation) VIP Marie JC et al (2003) Salam W et al (2025)
vipr1_human 4.37x38 250 TM4 S => A 2.331↓ K(d) (Binding - Radioligand saturation) VIP Marie JC et al (2003) Salam W et al (2025)
vipr1_human 4.37x38 250 TM4 S => A 2.917↑ EC50 (Functional - cAMP accumulation) VIP Marie JC et al (2003) Salam W et al (2025)
vipr1_human 447 C-term S => A 2.11↓ EC50 (Functional - cAMP accumulation) VIP Marie JC et al (2003) Salam W et al (2025)
vipr1_human 447 C-term S => D 1.37↓ EC50 (Functional - cAMP accumulation) VIP Marie JC et al (2003) Salam W et al (2025)
vipr1_human 447 C-term S => A 1.667↓ K(d) (Binding - Radioligand saturation) VIP Marie JC et al (2003) Salam W et al (2025)
vipr1_human 447 C-term S => D 2.667↓ K(d) (Binding - Radioligand saturation) VIP Marie JC et al (2003) Salam W et al (2025)
vipr1_human 447 C-term S => A 5.727↑ EC50 (Functional - cAMP accumulation) VIP Marie JC et al (2003) Salam W et al (2025)
vipr1_human 447 C-term S => D 5.833↑ EC50 (Functional - cAMP accumulation) VIP Marie JC et al (2003) Salam W et al (2025)
vipr1_human 80 N-term Q => A 1.988↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 80 N-term Q => A 3.597↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 104 N-term S => A 1.054↑ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 104 N-term S => A 1.028↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 106 N-term T => A 4.762↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 106 N-term T => A 7.874↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 108 N-term E => A 1.087↑ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 108 N-term E => A 1.077↑ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 112 N-term H => A 83.333↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 112 N-term H => A 90.909↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 117 N-term P => A 4.065↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 117 N-term P => A 8.333↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 119 N-term P => A 1.145↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 119 N-term P => A 1.055↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 120 N-term I => A 1.014↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 120 N-term I => A 1.086↑ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 125 N-term D => A 1.104↑ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 125 N-term D => A 1.451↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 126 N-term D => A 1.125↑ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 126 N-term D => A 1.431↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.28x28 131 TM1 L => A 71.429↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.28x28 131 TM1 L => A 100.0↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.29x29 132 TM1 D => A 1.011↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.29x29 132 TM1 D => A 1.443↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.31x31 134 TM1 Q => A 90.909↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.31x31 134 TM1 Q => A 111.111↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.32x32 135 TM1 Q => A 1.572↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.32x32 135 TM1 Q => A 1.004↑ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.40x40 143 TM1 K => A 1.479↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.40x40 143 TM1 K => A 500.0↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.41x41 144 TM1 T => A 2.933↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.41x41 144 TM1 T => A 333.333↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.44x44 147 TM1 T => A 2.427↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 1.44x44 147 TM1 T => A 1000.0↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 2.65x65 193 TM2 F => A 1.138↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 2.65x65 193 TM2 F => A 1.391↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 7.42x41 373 TM7 E => A 1.808↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 7.42x41 373 TM7 E => A 2.469↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 7.43x42 374 TM7 L => A 1.443↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 7.43x42 374 TM7 L => A 166.667↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 7.47x46 378 TM7 S => A 1.043↓ EC50 (Functional - cAMP accumulation) PG 97-269 Ceraudo E et al (2012) Hollenstein K et al (2014)
vipr1_human 7.47x46 378 TM7 S => A 4.566↓ EC50 (Functional - cAMP accumulation) VIP Ceraudo E et al (2012) Hollenstein K et al (2014)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R K L H ICL1ECL1 F D S G E S D Q C S E G ECL1ICL2 S F F ICL2ECL2 D Y G C W D T I ECL2ICL3 R P P D I R K ICL3ECL3 P D N F K ECL3N-term M R P P S P L P A R W L C V L A G A L A W A L G P A G G Q A A R L Q E E C D Y V Q M I E V Q H K Q C L E E A Q L E N E T I G C S K M W D N L T C W P A T P R G Q V V V L A C P L I F K L F S S I Q G R N V S R S C T D E G W T H L E P G P Y P I A C G L D D K A N-termC-term Y R H P S G G S N G A T C S T Q V S M L T R V S P G A R R S S S F Q A E V S L V C-term A S L D E Q Q T M F Y G S V K T G Y T I G Y G L S L A T L L V A T A I L S L F C T R N Y I H M H L F I S F I L R A A A V F I K D L A L S V G C K A A M V F F Q Y C V M A N F F W L L V E G L Y L Y T L L A V S E R K Y F W G Y I L I G W G V P S T F T M V W T I A R I H F E N S S L W W I I K G P I L T S I L V N F I L F I C I I R I L L Q K L S D S S P Y S R L A R S T L L L I P L F G V H Y I M F A F F P E V K M V F E L V V G S F Q G F V V A I L Y C F L N G E L R R W H L G W N V Q A E K W R R Q G V L P K
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L L T A L S L G Y G I T Y G T K V S G Y 1 M H L F I S F I L R A A A V F I K D L A 2 V L L W F F N A M V C Y Q F F V M A A K 3 Y F W G Y I L G I W G V P S T F T M V W T 4 F L I F N V L I S T L I P G K I I W W L S 5 L L L I P L F G V H Y I M F A F F 6 I A V V F G Q F S G V V L E F V M K V 7
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Residue Table


GPCRdb(A)
GPCRdb(B)
VPAC1 receptor
TM1
1x24 1.28x28 L131
1x25 1.29x29 D132
1x27 1.31x31 Q134
1x28 1.32x32 Q135
1x36 1.40x40 K143
1x37 1.41x41 T144
1x39 1.43x43 Y146
1x40 1.44x44 T147
1x43 1.47x47 Y150
TM2
2x43 2.50x50 H178
2x53 2.60x60 R188
2x58 2.65x65 F193
2x60 2.67x67 K195
2x61 2.68x68 D196
2x64 2.71x71 L199
TM3
3x25 3.29x29 C215
3x29 3.33x33 M219
TM4
4x38 4.37x38 S250
TM5
5x41 5.36x37 W294
TM6
6x37 6.42x42 T343
TM7
7x37 7.42x41 E373
7x38 7.43x42 L374
7x42 7.47x46 S378