Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
vipr2_human 87 N-term G => P N/A N/A Couvineau A et al (1995)
vipr2_human 2.60x60 172 TM2 R => Q 18.868↓ EC50 (Functional - cAMP accumulation) C6-VIP Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => L 55.556↓ EC50 (Functional - cAMP accumulation) C6-VIP Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => Q 12.987↓ IC50 (Binding - Radioligand competition/displacement) C6-VIP Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => Q 30.303↓ IC50 (Binding - Radioligand competition/displacement) Ro 25-1553 Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => Q >1000.0↓ EC50 (Functional - cAMP accumulation) Ro 25-1553 Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => L Abolished effect EC50 (Functional - cAMP accumulation) Ro 25-1553 Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => Q 50.0↓ IC50 (Binding - Radioligand competition/displacement) VIP Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => Q 27.027↓ EC50 (Functional - cAMP accumulation) VIP Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => L 21.277↓ EC50 (Functional - cAMP accumulation) VIP Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => Q 100.0↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Asn] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => Q 1000.0↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => L 166.667↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => Q 66.667↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Gln] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => Q 100.0↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Gln] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => L 25.0↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Gln] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => Q 17.857↓ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Glu] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => Q 10.0↓ EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.60x60 172 TM2 R => L 2.571↓ EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => I 1000.0↓ EC50 (Functional - cAMP accumulation) C6-VIP Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => Q 1000.0↓ EC50 (Functional - cAMP accumulation) C6-VIP Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => I Abolished effect EC50 (Functional - cAMP accumulation) Ro 25-1553 Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => Q Abolished effect EC50 (Functional - cAMP accumulation) Ro 25-1553 Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => I Abolished effect EC50 (Functional - cAMP accumulation) VIP Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => Q Abolished effect EC50 (Functional - cAMP accumulation) VIP Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => I Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => Q Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => I Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Gln] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => Q Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Gln] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => I Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 2.67x67 179 TM2 K => Q Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Vertongen P et al (2001) Salam W et al (2025)
vipr2_human 184 ECL1 Y => F 5.128↓ pK(i) (Binding - Radioligand competition/displacement) VIP Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 184 ECL1 Y => F Abolished effect pEC50 (Functional - cAMP accumulation) VIP Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 184 ECL1 Y => F 8.128↑ pK(i) (Binding - Radioligand competition/displacement) VIP-[Thr11Arg] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 184 ECL1 Y => F Abolished effect pEC50 (Functional - cAMP accumulation) VIP-[Thr11Arg] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 184 ECL1 Y => F 14.791↑ pK(i) (Binding - Radioligand competition/displacement) VIP-[Thr11Citrullinel] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 184 ECL1 Y => F Abolished effect pEC50 (Functional - cAMP accumulation) VIP-[Thr11Citrullinel] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 184 ECL1 Y => F 12.589↑ pK(i) (Binding - Radioligand competition/displacement) VIP-[Thr11Val] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 184 ECL1 Y => F Abolished effect pEC50 (Functional - cAMP accumulation) VIP-[Thr11Val] Nachtergael I et al (2003) Hollenstein K et al (2014)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R K L H ICL1ECL1 Y S S S G T L H C P D Q P S S ECL1ICL2 M L ICL2ECL2 D T G C W D T N D ECL2ICL3 T S P D V G G ICL3ECL3 P I S I S ECL3N-term M R T L L P P A L L T C W L L A P V N S I H P E C R F H L E I Q E E E T K C A E L L R S Q T E K H K A C S G V W D N I T C W R P A N V G E T V T V P C P K V F S N F Y S K A G N I S K N C T S D G W S E T F P D F V D A C G Y S N-termC-term V C G S S F S R N G S E G A L Q F H R G S R A Q S F L Q T E T S V I C-term D P E D E S K I T F Y I L V K A I Y T L G Y S V S L M S L A T G S I I L C L F C T R N Y I H L N L F L S F I L R A I S V L V K D D V L W V G C K L S L V F L Q Y C I M A N F F W L L V E G L Y L H T L L V A P P R R C F L A Y L L I G W G L P T V C I G A W T A A R L Y L E H S V P W W V I R I P I L I S I I V N F V L F I S I I R I L L Q K L N D Q S Q Y K R L A K S T L L L I P L F G V H Y M V F A V F S K Y Q I L F E L C L G S F Q G L V V A V L Y C F L N S E L K R R C P S R D V Q C E K W R S T P S A Y R
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A L S M L S V S Y G L T Y I A K V L I Y 1 L N L F L S F I L R A I S V L V K D D V 2 V L L W F F N A M I C Y Q L F V L S L K 3 C F L A Y L L G I W G L P T V C I G A W T 4 F L V F N V I I S I L I P I R I V W W P V 5 L L L I P L F G V H Y M V F A V F 6 V A V V L G Q F S G L C L E F L I Q Y 7
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Residue Table


GPCRdb(A)
GPCRdb(B)
VPAC2 receptor
TM2
2x53 2.60x60 R172
2x60 2.67x67 K179